-
1
-
-
84884368877
-
Influence of tumour micro-environment heterogeneity on therapeutic response
-
Junttila, M. R. & de Sauvage, F. J. Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 501, 346-354 (2013).
-
(2013)
Nature
, vol.501
, pp. 346-354
-
-
Junttila, M.R.1
De Sauvage, F.J.2
-
2
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
Straussman, R. et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 487, 500-504 (2012).
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
-
3
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nature reviews. Cancer 9, 239-252 (2009).
-
(2009)
Nature Reviews. Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
4
-
-
84925652325
-
Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation
-
Frick, P. L., Paudel, B. B., Tyson, D. R. & Quaranta, V. Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. Journal of cellular physiology 230, 1403-1412 (2015).
-
(2015)
Journal of Cellular Physiology
, vol.230
, pp. 1403-1412
-
-
Frick, P.L.1
Paudel, B.B.2
Tyson, D.R.3
Quaranta, V.4
-
5
-
-
84866139606
-
Fractional proliferation: A method to deconvolve cell population dynamics from single-cell data
-
Tyson, D. R., Garbett, S. P., Frick, P. L. & Quaranta, V. Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data. Nature methods 9, 923-928 (2012).
-
(2012)
Nature Methods
, vol.9
, pp. 923-928
-
-
Tyson, D.R.1
Garbett, S.P.2
Frick, P.L.3
Quaranta, V.4
-
6
-
-
57149142495
-
The impact of O2 availability on human cancer
-
Bertout, J. A., Patel, S. A. & Simon, M. C. The impact of O2 availability on human cancer. Nature reviews. Cancer 8, 967-975 (2008).
-
(2008)
Nature Reviews. Cancer
, vol.8
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
7
-
-
4444240302
-
Inaccuracies in MTS assays: Major distorting effects of medium, serum albumin, and fatty acids
-
Huang, K. T., Chen, Y. H. & Walker, A. M. Inaccuracies in MTS assays: major distorting effects of medium, serum albumin, and fatty acids. BioTechniques 37, 406, 408, 410-402 (2004).
-
(2004)
BioTechniques
, vol.37
, Issue.406-408
, pp. 410-412
-
-
Huang, K.T.1
Chen, Y.H.2
Walker, A.M.3
-
8
-
-
84925832811
-
Cell shape and the microenvironment regulate nuclear translocation of NF-kappaB in breast epithelial and tumor cells
-
Sero, J. E. et al. Cell shape and the microenvironment regulate nuclear translocation of NF-kappaB in breast epithelial and tumor cells. Molecular systems biology 11, 790 (2015).
-
(2015)
Molecular Systems Biology
, vol.11
, pp. 790
-
-
Sero, J.E.1
-
9
-
-
84940959297
-
Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases
-
Chen, J. F. et al. Subclassification of prostate cancer circulating tumor cells by nuclear size reveals very small nuclear circulating tumor cells in patients with visceral metastases. Cancer 121, 3240-3251 (2015).
-
(2015)
Cancer
, vol.121
, pp. 3240-3251
-
-
Chen, J.F.1
-
10
-
-
8444223104
-
Multidimensional drug profiling by automated microscopy
-
Perlman, Z. E. et al. Multidimensional drug profiling by automated microscopy. Science 306, 1194-1198 (2004).
-
(2004)
Science
, vol.306
, pp. 1194-1198
-
-
Perlman, Z.E.1
-
11
-
-
84949495449
-
Microscopy-Based High-Content screening
-
Boutros, M.e.a. Microscopy-Based High-Content Screening. Cell 163, 1314-1325 (2015).
-
(2015)
Cell
, vol.163
, pp. 1314-1325
-
-
Boutros, M.E.A.1
-
12
-
-
84949086543
-
Tissue matrix arrays for high-throughput screening and systems analysis of cell function
-
Beachley, V. Z. et al. Tissue matrix arrays for high-throughput screening and systems analysis of cell function. Nature methods 12, 1197-204 (2015).
-
(2015)
Nature Methods
, vol.12
, pp. 1197-1204
-
-
Beachley, V.Z.1
-
13
-
-
84945156700
-
Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention
-
Akerfelt, M. et al. Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-30056 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 30035-30056
-
-
Akerfelt, M.1
-
14
-
-
84868580668
-
High-Content single-cell analysis on-chip using a laser microarray scanner
-
Zhou, J., Wu, Y., Lee, S. K. & Fan, R. High-content single-cell analysis on-chip using a laser microarray scanner. Lab on a chip 12, 5025-5033 (2012).
-
(2012)
Lab on A Chip
, vol.12
, pp. 5025-5033
-
-
Zhou, J.1
Wu, Y.2
Lee, S.K.3
Fan, R.4
-
15
-
-
84950240054
-
Evolution of cellular morpho-phenotypes in cancer metastasis
-
Wu, P. H. et al. Evolution of cellular morpho-phenotypes in cancer metastasis. Scientific reports 5, 18437 (2015).
-
(2015)
Scientific Reports
, vol.5
, pp. 18437
-
-
Wu, P.H.1
-
16
-
-
84902210226
-
Increasing the Content of High-Content Screening: An Overview
-
Singh, S., Carpenter, A. E. & Genovesio, A. Increasing the Content of High-Content Screening: An Overview. Journal of biomolecular screening 19, 640-650 (2014).
-
(2014)
Journal of Biomolecular Screening
, vol.19
, pp. 640-650
-
-
Singh, S.1
Carpenter, A.E.2
Genovesio, A.3
-
17
-
-
84901501094
-
Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis
-
Harma, V. et al. Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis. PloS one 9, e96426 (2014).
-
(2014)
PloS One
, vol.9
, pp. e96426
-
-
Harma, V.1
-
18
-
-
84928974420
-
Prospective derivation of a living organoid biobank of colorectal cancer patients
-
van de Wetering, M. et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 161, 933-945 (2015).
-
(2015)
Cell
, vol.161
, pp. 933-945
-
-
Van De Wetering, M.1
-
19
-
-
84937400567
-
The impact of microenvironmental heterogeneity on the evolution of drug resistance in cancer cells
-
Mumenthaler, S. M. et al. The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells. Cancer informatics 14, 19-31 (2015).
-
(2015)
Cancer Informatics
, vol.14
, pp. 19-31
-
-
Mumenthaler, S.M.1
-
20
-
-
0042237781
-
Rethinking clinical trials for cytostatic drugs Nature reviews
-
Millar, A. W. & Lynch, K. P. Rethinking clinical trials for cytostatic drugs. Nature reviews. Cancer 3, 540-545 (2003).
-
(2003)
Cancer
, vol.3
, pp. 540-545
-
-
Millar, A.W.1
Lynch, K.P.2
-
21
-
-
84937761544
-
Studying clonal dynamics in response to cancer therapy using high-complexity barcoding
-
Bhang, H. E. et al. Studying clonal dynamics in response to cancer therapy using high-complexity barcoding. Nature medicine 21, 440-448 (2015).
-
(2015)
Nature Medicine
, vol.21
, pp. 440-448
-
-
Bhang, H.E.1
-
22
-
-
84879638500
-
Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution
-
Chambliss, A. B., Wu, P. H., Chen, W. C., Sun, S. X. & Wirtz, D. Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27, 2667-2676 (2013).
-
(2013)
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
, vol.27
, pp. 2667-2676
-
-
Chambliss, A.B.1
Wu, P.H.2
Chen, W.C.3
Sun, S.X.4
Wirtz, D.5
-
23
-
-
33751217466
-
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
-
Anderson, A. R., Weaver, A. M., Cummings, P. T. & Quaranta, V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127, 905-915 (2006).
-
(2006)
Cell
, vol.127
, pp. 905-915
-
-
Anderson, A.R.1
Weaver, A.M.2
Cummings, P.T.3
Quaranta, V.4
-
24
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves, M. & Maley, C. C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.C.2
-
25
-
-
34250216344
-
Image-Based multivariate profiling of drug responses from single cells
-
Loo, L. H., Wu, L. F. & Altschuler, S. J. Image-based multivariate profiling of drug responses from single cells. Nature methods 4, 445-453 (2007).
-
(2007)
Nature Methods
, vol.4
, pp. 445-453
-
-
Loo, L.H.1
Wu, L.F.2
Altschuler, S.J.3
-
26
-
-
23044515069
-
Feature point tracking and trajectory analysis for video imaging in cell biology
-
Sbalzarini, I. F. & Koumoutsakos, P. Feature point tracking and trajectory analysis for video imaging in cell biology. Journal of structural biology 151, 182-195 (2005).
-
(2005)
Journal of Structural Biology
, vol.151
, pp. 182-195
-
-
Sbalzarini, I.F.1
Koumoutsakos, P.2
-
27
-
-
0034711405
-
Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane
-
Verveer, P. J., Wouters, F. S., Reynolds, A. R. & Bastiaens, P. I. Quantitative imaging of lateral ErbB1 receptor signal propagation in the plasma membrane. Science 290, 1567-1570 (2000).
-
(2000)
Science
, vol.290
, pp. 1567-1570
-
-
Verveer, P.J.1
Wouters, F.S.2
Reynolds, A.R.3
Bastiaens, P.I.4
-
28
-
-
33845792555
-
CellProfiler: Image analysis software for identifying and quantifying cell phenotypes
-
Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome biology 7, R100 (2006).
-
(2006)
Genome Biology
, vol.7
, pp. R100
-
-
Carpenter, A.E.1
-
29
-
-
84945156700
-
Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention
-
Akerfelt, M. et al. Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention. Oncotarget 6, 30035-56 (2015).
-
(2015)
Oncotarget
, vol.6
, pp. 30035-30056
-
-
Akerfelt, M.1
-
30
-
-
84893454645
-
Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules
-
Leder, K. et al. Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell 156, 603-616 (2014).
-
(2014)
Cell
, vol.156
, pp. 603-616
-
-
Leder, K.1
-
31
-
-
79960085862
-
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
-
Chmielecki, J. et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Science translational medicine 3, 90-59 (2011).
-
(2011)
Science Translational Medicine
, vol.3
, pp. 90-159
-
-
Chmielecki, J.1
-
32
-
-
82955240672
-
Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in Non-Small cell lung cancer
-
Mumenthaler, S. M. et al. Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Molecular pharmaceutics 8, 2069-2079 (2011).
-
(2011)
Molecular Pharmaceutics
, vol.8
, pp. 2069-2079
-
-
Mumenthaler, S.M.1
-
33
-
-
84948685988
-
The mathematics of Cancer: Integrating quantitative models
-
Altrock, P. M., Liu, L. L. & Michor, F. The mathematics of cancer: integrating quantitative models. Nature reviews. Cancer 15, 730-745 (2015).
-
(2015)
Nature Reviews. Cancer
, vol.15
, pp. 730-745
-
-
Altrock, P.M.1
Liu, L.L.2
Michor, F.3
-
34
-
-
84864524696
-
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
-
Ohashi, K. et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proceedings of the National Academy of Sciences of the United States of America 109, E2127-2133 (2012).
-
(2012)
Proceedings of the National Academy of Sciences of the United States of America
, vol.109
, pp. E2127-E2133
-
-
Ohashi, K.1
|