Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

Oncotarget

Volumn 6, Issue 30, 2015, Pages 30035-30056

  Åkerfelt, Malin ^a,b   Bayramoglu, Neslihan ^c   Robinson, Sean ^a,d,e,f   Toriseva, Mervi ^a,b   Schukov, Hannu Pekka ^a   Härmä, Ville ^b   Virtanen, Johannes ^b   Sormunen, Raija ^c   Kaakinen, Mika ^c   Kannala, Juho ^c   Eklund, Lauri ^c   Heikkilä, Janne ^c   Nees, Matthias ^a,b  

^a UNIVERSITY OF TURKU   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c UNIVERSITY OF OULU   (Finland)

^d UNIV GRENOBLE ALPES   (France)

^e CEA GRENOBLE   (France)

^f INSERM   (France)

Author keywords

3D co culture; Cancer associated fibroblast (CAF); Focal adhesion kinase (FAK); Invasion; Phenotypic screening

Indexed keywords

FOCAL ADHESION KINASE INHIBITOR; COLLAGEN; FOCAL ADHESION KINASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN KINASE INHIBITOR;

ARTICLE; AUTOMATION; CANCER ASSOCIATED FIBROBLAST; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL GROWTH; CELL MOTILITY; CELL TRACKING; CONTROLLED STUDY; DRUG MECHANISM; EXTRACELLULAR MATRIX; FIBROBLAST; MOLECULAR DYNAMICS; MOLECULAR IMAGING; PROCESS DEVELOPMENT; PROSTATE CANCER CELL LINE; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING; TISSUE CHARACTERIZATION; TUMOR CELL; TUMOR MICROENVIRONMENT; ALGORITHM; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CELL COMMUNICATION; CELL CULTURE TECHNIQUE; CELL LINE; CELL MOTION; CELL PROLIFERATION; COCULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; HUMAN; MALE; METABOLISM; PATHOLOGY; PROCEDURES; PROSTATE TUMOR; TIME LAPSE IMAGING; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRASTRUCTURE;

ALGORITHMS; CELL COMMUNICATION; CELL CULTURE TECHNIQUES; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRACKING; COCULTURE TECHNIQUES; COLLAGEN; FIBROBLASTS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, BIOLOGICAL; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; TIME-LAPSE IMAGING; TUMOR MICROENVIRONMENT;

EID: 84945156700     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5046     Document Type: Article

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