Novel 1H-Pyrrolo[3,2-c]quinoline Based 5-HT6 Receptor Antagonists with Potential Application for the Treatment of Cognitive Disorders Associated with Alzheimer's Disease

ACS Chemical Neuroscience

Volumn 7, Issue 7, 2016, Pages 972-983

  Grychowska, Katarzyna ^a   Satała, Grzegorz ^b   Kos, Tomasz ^b   Partyka, Anna ^a   Colacino, Evelina ^c   Chaumont Dubel, Severine ^d   Bantreil, Xavier ^c   Wesołowska, Anna ^a   Pawłowski, Maciej ^a   Martinez, Jean ^c   Marin, Philippe ^d   Subra, Gilles ^c   Bojarski, Andrzej J ^b   Lamaty, Frédéric ^c   Popik, Piotr ^b   Zajdel, Paweł ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

^c UNIVERSITÉ DE MONTPELLIER   (France)

^d UNIV MONTPELLIER   (France)

Author keywords

5 HT6R antagonist; 5 HT6R inverse agonist; Alzheimer's disease; forced swim test; memory; novel object recognition test; pyrrolo 3,2 c quinoline; SB 742457, cognition; Vogel test

Indexed keywords

1 [(3 CHLOROPHENYL)SULFONYL] 4 (PYRROLIDINE 3 YL AMINO) 1H PYRROLO[3,2 C ]QUINOLINE; 1H PYRROLO[3,2 C]QUINOLINE; 4 (PYRROLIDINE 3 YL AMINO) 1H PYRROLO[3,2 C]QUINOLINE; INTEPIRDINE; PHENCYCLIDINE; PROCOGNITIVE AGENT; QUINOLINE; QUINOLINE DERIVATIVE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; UNCLASSIFIED DRUG; 1H-PYRROLO(3,2-H)QUINOLINE; 3-BENZENESULFONYL-8-PIPERAZIN-1-YLQUINOLINE; CYCLIC AMP; PYRROLE DERIVATIVE; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SULFONE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ARTICLE; BINDING AFFINITY; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY; VOGEL TEST; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; CHEMISTRY; CHO CELL LINE; COGNITION DISORDERS; COMPLICATION; CRICETULUS; DISEASE MODEL; HEK293 CELL LINE; HUMAN; METABOLISM; NEUROBLASTOMA; PATHOLOGY; SPRAGUE DAWLEY RAT; SYNTHESIS; WISTAR RAT;

ALZHEIMER DISEASE; ANIMALS; CHO CELLS; COGNITION DISORDERS; CRICETULUS; CYCLIC AMP; DISEASE MODELS, ANIMAL; HEK293 CELLS; HUMANS; MALE; NEUROBLASTOMA; PHENCYCLIDINE; PYRROLES; QUINOLINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONES;

EID: 84979518318     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.6b00090     Document Type: Article

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