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Volumn 38, Issue , 2016, Pages 86-97

13C Metabolic Flux Analysis of acetate conversion to lipids by Yarrowia lipolytica

Author keywords

13C Metabolic Flux Analysis; Acetate metabolism; Biodiesel; Gluconeogenesis; NADPH; Yarrowa lipolytica

Indexed keywords

ANAEROBIC DIGESTION; BIODIESEL; FATTY ACIDS; METABOLISM; PHYSIOLOGY; STRAIN;

EID: 84979293956     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.06.006     Document Type: Article
Times cited : (65)

References (44)
  • 1
    • 80052032471 scopus 로고    scopus 로고
    • Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry
    • Ahn, W.S., Antoniewicz, M.R., Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry. Metab. Eng. 13:5 (2011), 598–609.
    • (2011) Metab. Eng. , vol.13 , Issue.5 , pp. 598-609
    • Ahn, W.S.1    Antoniewicz, M.R.2
  • 2
    • 35348941242 scopus 로고    scopus 로고
    • Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis
    • Antoniewicz, M.R., Kelleher, J.K., Stephanopoulos, G., Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. Anal. Chem. 79:19 (2007), 7554–7559.
    • (2007) Anal. Chem. , vol.79 , Issue.19 , pp. 7554-7559
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 3
    • 33745155105 scopus 로고    scopus 로고
    • Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements
    • Antoniewicz, M.R., Kelleher, J.K., Stephanopoulos, G., Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. Metab. Eng. 8:4 (2006), 324–337.
    • (2006) Metab. Eng. , vol.8 , Issue.4 , pp. 324-337
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 4
    • 33845679072 scopus 로고    scopus 로고
    • Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions
    • Antoniewicz, M.R., Kelleher, J.K., Stephanopoulos, G., Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions. Metab. Eng. 9:1 (2007), 68–86.
    • (2007) Metab. Eng. , vol.9 , Issue.1 , pp. 68-86
    • Antoniewicz, M.R.1    Kelleher, J.K.2    Stephanopoulos, G.3
  • 6
    • 70350205608 scopus 로고    scopus 로고
    • Yarrowia lipolytica as a model for bio-oil production
    • Beopoulos, A., Cescut, J., et al. Yarrowia lipolytica as a model for bio-oil production. Progress Lipid Res. 48:6 (2009), 375–387.
    • (2009) Progress Lipid Res. , vol.48 , Issue.6 , pp. 375-387
    • Beopoulos, A.1    Cescut, J.2
  • 7
    • 67349169778 scopus 로고    scopus 로고
    • Yarrowia lipolytica: a model and a tool to understand the mechanisms implicated in lipid accumulation
    • Beopoulos, A., Chardot, T., Nicaud, J.M., Yarrowia lipolytica: a model and a tool to understand the mechanisms implicated in lipid accumulation. Biochimie 91:6 (2009), 692–696.
    • (2009) Biochimie , vol.91 , Issue.6 , pp. 692-696
    • Beopoulos, A.1    Chardot, T.2    Nicaud, J.M.3
  • 8
    • 79955560245 scopus 로고    scopus 로고
    • An overview of lipid metabolism in yeasts and its impact on biotechnological processes
    • Beopoulos, A., Nicaud, J.M., Gaillardin, C., An overview of lipid metabolism in yeasts and its impact on biotechnological processes. Appl. Microbiol. Biotechnol. 90:4 (2011), 1193–1206.
    • (2011) Appl. Microbiol. Biotechnol. , vol.90 , Issue.4 , pp. 1193-1206
    • Beopoulos, A.1    Nicaud, J.M.2    Gaillardin, C.3
  • 9
    • 84892840633 scopus 로고    scopus 로고
    • Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production
    • Blazeck, J., et al. Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production. Nat. Commun., 5, 2014, 3131.
    • (2014) Nat. Commun. , vol.5 , pp. 3131
    • Blazeck, J.1
  • 10
    • 0019836936 scopus 로고
    • Correlation of lipid accumulation in yeasts with possession of ATP: citrate lyase
    • Boulton, C.A., Ratledge, C., Correlation of lipid accumulation in yeasts with possession of ATP: citrate lyase. Microbiology 127:1 (1981), 169–176.
    • (1981) Microbiology , vol.127 , Issue.1 , pp. 169-176
    • Boulton, C.A.1    Ratledge, C.2
  • 11
    • 51649104270 scopus 로고    scopus 로고
    • Leakage-free rapid quenching technique for yeast metabolomics
    • Canelas, A.B., et al. Leakage-free rapid quenching technique for yeast metabolomics. Metabolomics 4:3 (2008), 226–239.
    • (2008) Metabolomics , vol.4 , Issue.3 , pp. 226-239
    • Canelas, A.B.1
  • 12
    • 3042720475 scopus 로고    scopus 로고
    • Genome evolution in yeasts
    • Dujon, B., et al. Genome evolution in yeasts. Nature 430:6995 (2004), 35–44.
    • (2004) Nature , vol.430 , Issue.6995 , pp. 35-44
    • Dujon, B.1
  • 13
    • 0036154857 scopus 로고    scopus 로고
    • Control of mitochondrial β-oxidation flux
    • Eaton, S., Control of mitochondrial β-oxidation flux. Progress Lipid Res. 41:3 (2002), 197–239.
    • (2002) Progress Lipid Res. , vol.41 , Issue.3 , pp. 197-239
    • Eaton, S.1
  • 15
    • 0021229450 scopus 로고
    • Effect of nitrogen source on lipid accumulation in oleaginous yeasts
    • Evans, C.T., Ratledge, C., Effect of nitrogen source on lipid accumulation in oleaginous yeasts. Microbiology 130:April (1984), 1693–1704.
    • (1984) Microbiology , vol.130 , pp. 1693-1704
    • Evans, C.T.1    Ratledge, C.2
  • 16
    • 78650842936 scopus 로고    scopus 로고
    • The effect of volatile fatty acids as a sole carbon source on lipid accumulation by Cryptococcus albidus for biodiesel production
    • Fei, Q., et al. The effect of volatile fatty acids as a sole carbon source on lipid accumulation by Cryptococcus albidus for biodiesel production. Bioresour. Technol. 102:3 (2011), 2695–2701.
    • (2011) Bioresour. Technol. , vol.102 , Issue.3 , pp. 2695-2701
    • Fei, Q.1
  • 17
    • 13944278520 scopus 로고    scopus 로고
    • Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype
    • Flores, C.L., Gancedo, C., Yarrowia lipolytica mutants devoid of pyruvate carboxylase activity show an unusual growth phenotype. Eukaryot. Cell 4:2 (2005), 356–364.
    • (2005) Eukaryot. Cell , vol.4 , Issue.2 , pp. 356-364
    • Flores, C.L.1    Gancedo, C.2
  • 18
    • 84860428565 scopus 로고    scopus 로고
    • Bioconversion of volatile fatty acids into lipids by the oleaginous yeast Yarrowia lipolytica
    • Fontanille, P., et al. Bioconversion of volatile fatty acids into lipids by the oleaginous yeast Yarrowia lipolytica. Bioresour. Technol. 114 (2012), 443–449.
    • (2012) Bioresour. Technol. , vol.114 , pp. 443-449
    • Fontanille, P.1
  • 19
    • 54249139304 scopus 로고    scopus 로고
    • The gluconeogenic enzyme fructose-1,6-bisphosphatase is dispensable for growth of the yeast Yarrowia lipolytica in gluconeogenic substrates
    • Jardón, R., Gancedo, C., Flores, C.L., The gluconeogenic enzyme fructose-1,6-bisphosphatase is dispensable for growth of the yeast Yarrowia lipolytica in gluconeogenic substrates. Eukaryot. Cell 7:10 (2008), 1742–1749.
    • (2008) Eukaryot. Cell , vol.7 , Issue.10 , pp. 1742-1749
    • Jardón, R.1    Gancedo, C.2    Flores, C.L.3
  • 20
    • 1042276711 scopus 로고    scopus 로고
    • Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP
    • Jogl, G., Tong, L., Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry 43:6 (2004), 1425–1431.
    • (2004) Biochemistry , vol.43 , Issue.6 , pp. 1425-1431
    • Jogl, G.1    Tong, L.2
  • 21
    • 26244452731 scopus 로고    scopus 로고
    • Revisiting the13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence
    • Kleijn, R.J., et al. Revisiting the13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence. FEBS J. 272:19 (2005), 4970–4982.
    • (2005) FEBS J. , vol.272 , Issue.19 , pp. 4970-4982
    • Kleijn, R.J.1
  • 22
    • 0013894468 scopus 로고
    • The role and control of the glyoxylate cycle in Escherichia coli
    • Kornberg, H.L., The role and control of the glyoxylate cycle in Escherichia coli. Biochem. J. 99:1 (1966), 1–11.
    • (1966) Biochem. J. , vol.99 , Issue.1 , pp. 1-11
    • Kornberg, H.L.1
  • 23
    • 51849105034 scopus 로고    scopus 로고
    • Perspectives of microbial oils for biodiesel production
    • Li, Q., Du, W., Liu, D., Perspectives of microbial oils for biodiesel production. Appl. Microbiol. Biotechnol. 80:5 (2008), 749–756.
    • (2008) Appl. Microbiol. Biotechnol. , vol.80 , Issue.5 , pp. 749-756
    • Li, Q.1    Du, W.2    Liu, D.3
  • 24
    • 71749101823 scopus 로고    scopus 로고
    • Identification of the mitochondrial carrier that provides Yarrowia lipolytica with a fatty acid-induced and nucleotide-sensitive uncoupling protein-like activity
    • Luévano-Martínez, L.A., et al. Identification of the mitochondrial carrier that provides Yarrowia lipolytica with a fatty acid-induced and nucleotide-sensitive uncoupling protein-like activity. Biochim. et Biophys. Acta – Bioenerg. 1797:1 (2010), 81–88.
    • (2010) Biochim. et Biophys. Acta – Bioenerg. , vol.1797 , Issue.1 , pp. 81-88
    • Luévano-Martínez, L.A.1
  • 25
    • 33947503169 scopus 로고    scopus 로고
    • Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography–mass spectrometry
    • Luo, B., et al. Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography–mass spectrometry. J. Chromatogr. A 1147:2 (2007), 153–164.
    • (2007) J. Chromatogr. A , vol.1147 , Issue.2 , pp. 153-164
    • Luo, B.1
  • 26
    • 0035014718 scopus 로고    scopus 로고
    • Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids
    • Maaheimo, H., et al. Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional 13C labeling of common amino acids. Eur. J. Biochem. 268:8 (2001), 2464–2479.
    • (2001) Eur. J. Biochem. , vol.268 , Issue.8 , pp. 2464-2479
    • Maaheimo, H.1
  • 27
    • 51649092075 scopus 로고    scopus 로고
    • Biodiesel production from oleaginous microorganisms
    • Meng, X., et al. Biodiesel production from oleaginous microorganisms. Renew. Energy 34:1 (2009), 1–5.
    • (2009) Renew. Energy , vol.34 , Issue.1 , pp. 1-5
    • Meng, X.1
  • 28
    • 78650821126 scopus 로고    scopus 로고
    • Production of volatile fatty acids by fermentation of waste activated sludge pre-treated in full-scale thermal hydrolysis plants
    • Morgan-Sagastume, F., et al. Production of volatile fatty acids by fermentation of waste activated sludge pre-treated in full-scale thermal hydrolysis plants. Bioresour. Technol. 102:3 (2011), 3089–3097.
    • (2011) Bioresour. Technol. , vol.102 , Issue.3 , pp. 3089-3097
    • Morgan-Sagastume, F.1
  • 29
    • 77958081733 scopus 로고    scopus 로고
    • Production of liquid biofuels from renewable resources
    • Nigam, P.S., Singh, A., Production of liquid biofuels from renewable resources. Progress Energy Combust. Sci. 37:1 (2011), 52–68.
    • (2011) Progress Energy Combust. Sci. , vol.37 , Issue.1 , pp. 52-68
    • Nigam, P.S.1    Singh, A.2
  • 30
    • 0033529639 scopus 로고    scopus 로고
    • Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate
    • Palmieri, L., et al. Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate. J. Biol. Chem. 274:32 (1999), 22184–22190.
    • (1999) J. Biol. Chem. , vol.274 , Issue.32 , pp. 22184-22190
    • Palmieri, L.1
  • 31
    • 84870867053 scopus 로고    scopus 로고
    • Reconstruction and in silico analysis of metabolic network for an oleaginous yeast, Yarrowia lipolytica
    • Pan, P. cheng, Hua, Q., Reconstruction and in silico analysis of metabolic network for an oleaginous yeast, Yarrowia lipolytica. PLoS One 7:12 (2012), 1–11.
    • (2012) PLoS One , vol.7 , Issue.12 , pp. 1-11
    • Pan, P.C.1    Hua, Q.2
  • 32
    • 74749090203 scopus 로고    scopus 로고
    • Biosynthesis of lipids and organic acids by Yarrowia lipolytica strains cultivated on glucose
    • Papanikolaou, S., et al. Biosynthesis of lipids and organic acids by Yarrowia lipolytica strains cultivated on glucose. Eur. J. Lipid Sci. Technol. 111:12 (2009), 1221–1232.
    • (2009) Eur. J. Lipid Sci. Technol. , vol.111 , Issue.12 , pp. 1221-1232
    • Papanikolaou, S.1
  • 33
    • 48649108016 scopus 로고    scopus 로고
    • Towards sustainable production of biofuels from microalgae
    • Patil, V., Tran, K.Q., Giselrød, H.R., Towards sustainable production of biofuels from microalgae. Int. J. Mol. Sci. 9:7 (2008), 1188–1195.
    • (2008) Int. J. Mol. Sci. , vol.9 , Issue.7 , pp. 1188-1195
    • Patil, V.1    Tran, K.Q.2    Giselrød, H.R.3
  • 34
    • 0019948257 scopus 로고
    • Isolation and characterization of a mutant of Saccharomyces cerevisiae defective in phosphoenolpyruvate carboxykinase
    • 283021548
    • Perea, J., Gancedo, C., Isolation and characterization of a mutant of Saccharomyces cerevisiae defective in phosphoenolpyruvate carboxykinase. Arch. Microbiol. 132:283021548 (1982), 141–143.
    • (1982) Arch. Microbiol. , vol.132 , pp. 141-143
    • Perea, J.1    Gancedo, C.2
  • 35
    • 84924657793 scopus 로고    scopus 로고
    • Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica
    • Qiao, K., et al. Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metab. Eng. 29 (2015), 56–65.
    • (2015) Metab. Eng. , vol.29 , pp. 56-65
    • Qiao, K.1
  • 36
    • 0032485569 scopus 로고    scopus 로고
    • 13C tracer experiments and metabolite balancing for metabolic flux analysis: Comparing two approaches
    • Schmidt, K., et al. 13C tracer experiments and metabolite balancing for metabolic flux analysis: Comparing two approaches. Biotechnol. Bioeng. 58:2–3 (1998), 254–257.
    • (1998) Biotechnol. Bioeng. , vol.58 , Issue.2-3 , pp. 254-257
    • Schmidt, K.1
  • 37
    • 84870674137 scopus 로고    scopus 로고
    • Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production
    • Tai, M., Stephanopoulos, G., Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production. Metab. Eng. 15:1 (2013), 1–9.
    • (2013) Metab. Eng. , vol.15 , Issue.1 , pp. 1-9
    • Tai, M.1    Stephanopoulos, G.2
  • 38
    • 84929314719 scopus 로고    scopus 로고
    • The oxidative pentose phosphate pathway is the primary source of NADPH for Lipid Overproduction from Glucose in Yarrowia lipolytica
    • Wasylenko, T.M., Ahn, W.S., Stephanopoulos, G., The oxidative pentose phosphate pathway is the primary source of NADPH for Lipid Overproduction from Glucose in Yarrowia lipolytica. Metab. Eng. 30 (2015), 27–39.
    • (2015) Metab. Eng. , vol.30 , pp. 27-39
    • Wasylenko, T.M.1    Ahn, W.S.2    Stephanopoulos, G.3
  • 39
    • 84883803981 scopus 로고    scopus 로고
    • Kinetic isotope effects significantly influence intracellular metabolite 13C labeling patterns and flux determination
    • Wasylenko, T.M., Stephanopoulos, G., Kinetic isotope effects significantly influence intracellular metabolite 13C labeling patterns and flux determination. Biotechnol. J. 8:9 (2013), 1080–1089.
    • (2013) Biotechnol. J. , vol.8 , Issue.9 , pp. 1080-1089
    • Wasylenko, T.M.1    Stephanopoulos, G.2
  • 40
    • 0034741983 scopus 로고    scopus 로고
    • 13C metabolic flux analysis
    • Wiechert, W., 13C metabolic flux analysis. Metab. Eng. 3:3 (2001), 195–206.
    • (2001) Metab. Eng. , vol.3 , Issue.3 , pp. 195-206
    • Wiechert, W.1
  • 41
    • 0031554635 scopus 로고    scopus 로고
    • Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments
    • Wiechert, W., de Graaf, A.A, Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments. Biotechnol. Bioeng. 55:1 (1997), 101–117.
    • (1997) Biotechnol. Bioeng. , vol.55 , Issue.1 , pp. 101-117
    • Wiechert, W.1    de Graaf, A.A.2
  • 42
    • 15044347498 scopus 로고    scopus 로고
    • Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites
    • Van Winden, W.A., et al. Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites. FEMS Yeast Res. 5:6–7 (2005), 559–568.
    • (2005) FEMS Yeast Res. , vol.5 , Issue.6-7 , pp. 559-568
    • Van Winden, W.A.1
  • 43
    • 0033586461 scopus 로고    scopus 로고
    • Mass spectrometry for metabolic flux analysis
    • Wittmann, C., Heinzle, E., Mass spectrometry for metabolic flux analysis. Biotechnol. Bioeng. 62:6 (1999), 739–750.
    • (1999) Biotechnol. Bioeng. , vol.62 , Issue.6 , pp. 739-750
    • Wittmann, C.1    Heinzle, E.2
  • 44
    • 84887316623 scopus 로고    scopus 로고
    • Regulatory properties of malic enzyme in the oleaginous yeast, Yarrowia lipolytica, and its non-involvement in lipid accumulation
    • Zhang, H., et al. Regulatory properties of malic enzyme in the oleaginous yeast, Yarrowia lipolytica, and its non-involvement in lipid accumulation. Biotechnol. Lett. 35:12 (2013), 2091–2098.
    • (2013) Biotechnol. Lett. , vol.35 , Issue.12 , pp. 2091-2098
    • Zhang, H.1


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