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Leslie JL, Young VB. The rest of the story: the microbiome and gastrointestinal infections. Curr Opin Microbiol. 2015;23:121–5. doi:10.1016/j.mib.2014.11.010. A good review of susceptibility to enteric infection based on the gut microbiome’s varied colonization.
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Leslie, J.L.1
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den Besten G, van Eunen K, Groen AK, Venema K, Reijngoud DJ, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J Lipid Res. 2013;54(9):2325–40. doi:10.1194/jlr.R036012.
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Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic
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COI: 1:CAS:528:DC%2BD28XmsVWjsbY%3D, PID: 16740661, In this landmark paper, the Shigella-mediated downregulation of the host endogenous antibacterial peptide cathelicidin CAP-18 was shown to be reversed by short chain fatty acids, in this case oral butyrate, resulting in disease amelioratio
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Raqib R, Sarker P, Bergman P, Ara G, Lindh M, Sack DA, et al. Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A. 2006;103(24):9178–83. doi:10.1073/pnas.0602888103. In this landmark paper, the Shigella-mediated downregulation of the host endogenous antibacterial peptide cathelicidin CAP-18 was shown to be reversed by short chain fatty acids, in this case oral butyrate, resulting in disease amelioration.
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PID: 19319017, The authors institute human field trials using foods which are substrates for the production of butyrate by intestinal bacteria, demonstrating a significant reduction in disease outcome among children with severe shigellosi
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Rabbani GH, Ahmed S, Hossain I, Islam R, Marni F, Akhtar M, et al. Green banana reduces clinical severity of childhood shigellosis: a double-blind, randomized, controlled clinical trial. Pediatr Infect Dis J. 2009;28(5):420–5. doi:10.1097/INF.0b013e31819510b5. The authors institute human field trials using foods which are substrates for the production of butyrate by intestinal bacteria, demonstrating a significant reduction in disease outcome among children with severe shigellosis.
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24
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84894055913
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The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria
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COI: 1:CAS:528:DC%2BC2cXitVentLo%3D, PID: 24508234, The authors present a series of studies showing salmonella interact with natigen presenting cells of the gut to stimulate host immune responses promoting production of antimicrobialmolecules. This is significant in that it demonstrates bacterial manipulation of host immune response anti-commensa
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Behnsen J, Jellbauer S, Wong CP, Edwards RA, George MD, Ouyang W, et al. The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity. 2014;40(2):262–73. doi:10.1016/j.immuni.2014.01.003. The authors present a series of studies showing salmonella interact with natigen presenting cells of the gut to stimulate host immune responses promoting production of antimicrobialmolecules. This is significant in that it demonstrates bacterial manipulation of host immune response anti-commensal.
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Immunity
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Behnsen, J.1
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Monack, D.M.1
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COI: 1:CAS:528:DC%2BC3sXhtFaksbvO, PID: 2387031
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Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers
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PID: 1846973
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Henker J, Laass MW, Blokhin BM, Maydannik VG, Bolbot YK, Elze M, et al. Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers. Pediatr Infect Dis J. 2008;27(6):494–9. doi:10.1097/INF.0b013e318169034c.
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Composition of human faecal microbiota in resistance to Campylobacter infection
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A demonstration that travlers to high risk destinations for enteric infection are more susceptible to infection with Camplyobacter if their pre-travel microbiome demonstrates lower bacterial specie
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Kampmann C, Dicksved J, Engstrand L, Rautelin H. Composition of human faecal microbiota in resistance to Campylobacter infection. Clin Microbiol Infect. 2016;22(1):61.e1–8. doi:10.1016/j.cmi.2015.09.004. A demonstration that travlers to high risk destinations for enteric infection are more susceptible to infection with Camplyobacter if their pre-travel microbiome demonstrates lower bacterial species.
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PID: 25695334, A well-designed study comparing gut microbiota of individuals with TD associated with ETEC, norovirus, mixed pathogens, TD with no pathogen identified to healthy travelers demostrating a dysbiotic profile in all travelers regardless of the development of T
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Youmans BP, Ajami NJ, Jiang ZD, Campbell F, Wadsworth WD, Petrosino JF, et al. Characterization of the human gut microbiome during travelers’ diarrhea. Gut Microbes. 2015;6(2):110–9. doi:10.1080/19490976.2015.1019693. A well-designed study comparing gut microbiota of individuals with TD associated with ETEC, norovirus, mixed pathogens, TD with no pathogen identified to healthy travelers demostrating a dysbiotic profile in all travelers regardless of the development of TD.
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Susceptibility to Campylobacter infection is associated with the species composition of the human fecal microbiota
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COI: 1:CAS:528:DC%2BC2MXhslKit7o%3D, PID: 2522746
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Dicksved J, Ellstrom P, Engstrand L, Rautelin H. Susceptibility to Campylobacter infection is associated with the species composition of the human fecal microbiota. mBio. 2014;5(5):e01212–4. doi:10.1128/mBio.01212-14.
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Disruption of the human gut microbiota following Norovirus infection
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COI: 1:CAS:528:DC%2BC38Xhs12qs7rM, PID: 23118957, Although not in a traveler setting, this study of acute norovirus infection showed a significant change in diversity characterized by increased Proteobacteriacia
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Nelson AM, Walk ST, Taube S, Taniuchi M, Houpt ER, Wobus CE, et al. Disruption of the human gut microbiota following Norovirus infection. PLoS One. 2012;7(10):e48224. doi:10.1371/journal.pone.0048224. Although not in a traveler setting, this study of acute norovirus infection showed a significant change in diversity characterized by increased Proteobacteriaciae.
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PLoS One
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Nelson, A.M.1
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84979212748
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, search terms “Travel*” and “ESBL”, can be retrieved at
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Public Library of Medicine Collection, search terms “Travel*” and “ESBL”, can be retrieved at http://www.ncbi.nlm.nih.gov/sites/myncbi/1Zq3a6-m-qsQd/collections/49647045/public/.
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Hassing RJ, Alsma J, Arcilla MS, van Genderen PJ, Stricker BH, Verbon A. . Euro Surveill: Bull Euro Mal Transmissibles = Euro Commun Dis Bull. 2015;20(47). . Most up-to-date qualitative review of observational studies across multiple traveler populatons. Major findings are that travel particularly to Asia, and among those who developed TD and/or take antibiotics while traveling, consistently demonstrate the increased risk of acquiring ESBL bacteri
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Hassing RJ, Alsma J, Arcilla MS, van Genderen PJ, Stricker BH, Verbon A. International travel and acquisition of multidrug-resistant Enterobacteriaceae: a systematic review. Euro Surveill: Bull Euro Mal Transmissibles = Euro Commun Dis Bull. 2015;20(47). doi:10.2807/1560-7917.ES.2015.20.47.30074. Most up-to-date qualitative review of observational studies across multiple traveler populatons. Major findings are that travel particularly to Asia, and among those who developed TD and/or take antibiotics while traveling, consistently demonstrate the increased risk of acquiring ESBL bacteria
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International travel and acquisition of multidrug-resistant Enterobacteriaceae: a systematic review
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35
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Extended-spectrum beta-lactamase-producing enterobacteriaceae among travelers from the Netherlands
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