Structure-Guided Control of siRNA Off-Target Effects

Journal of the American Chemical Society

Volumn 138, Issue 28, 2016, Pages 8667-8669

  Suter, Scott R ^a   Sheu Gruttadauria, Jessica ^b   Schirle, Nicole T ^b,c   Valenzuela, Rachel ^a   Ball Jones, Alexi A ^a   Onizuka, Kazumitsu ^a   Macrae, Ian J ^b   Beal, Peter A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; INTEGRATED CIRCUITS; NUCLEIC ACIDS; NUCLEOTIDES; RNA; STRUCTURAL OPTIMIZATION;

DRUG DEVELOPMENT; MICRORNA (MIRNA); NEW APPROACHES; RNA BINDING; RNA INTERFERENCE; RNA STRUCTURES; SHORT INTERFERING RNA; STRUCTURAL CHARACTERIZATION;

CRYSTAL STRUCTURE;

ARGONAUTE 2 PROTEIN; HUMAN ARGONAUTE 2 PROTEIN; MICRORNA; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ARGONAUTE PROTEIN; NUCLEOTIDE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PIK3CB PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; GENE REPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; IC50; RNA BINDING; RNA INTERFERENCE; RNA STRUCTURE; CHEMISTRY; DEFICIENCY; GENETICS; METABOLISM;

ARGONAUTE PROTEINS; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; HUMANS; NUCLEOTIDES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRIAZOLES;

EID: 84979234392     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.6b06137     Document Type: Article

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