Barley sprouts extract attenuates alcoholic fatty liver injury in mice by reducing inflammatory response

Nutrients

Volumn 8, Issue 7, 2016, Pages

  Lee, Yun Hee ^a   Kim, Joung Hee ^b   Kim, Sou Hyun ^c   Oh, Ji Youn ^c   Seo, Woo Duck ^d   Kim, Kyung Mi ^e   Jung, Jae Chul ^e   Jung, Young Suk ^c  

^a Yonsei University   (South Korea)

^b Changwon National University   (South Korea)

^c Pusan National University   (South Korea)

^d National Institute of Crop Science   (South Korea)

^e Novarex Co Ltd   (South Korea)

Author keywords

Alcohol induced liver injury; Barley sprouts; Glutathione; Inflammation; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLOOXYGENASE 2; GLUTATHIONE; NITRIC OXIDE SYNTHASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; APIGENIN; AUTACOID; BIOLOGICAL MARKER; GLUCOSIDE; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PLANT EXTRACT; SAPONARIN;

ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARLEY; CELL VIABILITY ASSAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOPATHOLOGY; INFLAMMATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CELL SURVIVAL; CHEMISTRY; DIETARY SUPPLEMENT; DISEASE MODEL; DRUG EFFECTS; FATTY LIVER, ALCOHOLIC; GROWTH, DEVELOPMENT AND AGING; HORDEUM; IMMUNOLOGY; ISOLATION AND PURIFICATION; LIVER; MACROPHAGE; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; RAW 264.7 CELL LINE; SEEDLING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; APIGENIN; BIOMARKERS; CELL SURVIVAL; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; FATTY LIVER, ALCOHOLIC; GLUCOSIDES; HORDEUM; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PLANT EXTRACTS; RAW 264.7 CELLS; SEEDLINGS;

EID: 84979202527     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8070440     Document Type: Article

References (36)

1. Kumar, R.; Rastogi, A.; Sharma, M.K.; Bhatia, V.; Garg, H.; Bihari, C.; Sarin, S.K. Clinicopathological characteristics and metabolic profiles of non-alcoholic fatty liver disease in indian patients with normal body mass index: Do they differ from obese or overweight non-alcoholic fatty liver disease? Indian J. Endocrinol. Metab. 2013, 17, 665-671. [CrossRef] [PubMed]
2. Rehm, J.; Samokhvalov, A.V.; Shield, K.D. Global burden of alcoholic liver diseases. J. Hepatol. 2013, 59, 160-168. [CrossRef] [PubMed]
3. Nagata, K.; Suzuki, H.; Sakaguchi, S. Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis. J. Toxicol. Sci. 2007, 32, 453-468. [CrossRef] [PubMed]
4. Jones, D.P. Redefining oxidative stress. Antioxid. Redox Signal. 2006, 8, 1865-1879. [CrossRef] [PubMed]
5. Bailey, S.M.; Mantena, S.K.; Millender-Swain, T.; Cakir, Y.; Jhala, N.C.; Chhieng, D.; Pinkerton, K.E.; Ballinger, S.W. Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic ApoE(-/-) mouse: Implications for a "multihit" hypothesis of fatty liver disease. Free Radic. Biol. Med. 2009, 46, 928-938. [CrossRef] [PubMed]
6. Albano, E.; Clot, P.; Morimoto, M.; Tomasi, A.; Ingelman-Sundberg, M.; French, S.W. Role of cytochrome p4502e1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 1996, 23, 155-163. [CrossRef] [PubMed]
7. McClain, C.J.; Shedlofsky, S.; Barve, S.; Hill, D.B. Cytokines and alcoholic liver disease. Alcohol. Health Res. World 1997, 21, 317-320. [PubMed]
8. Tilg, H.; Moschen, A.R.; Kaneider, N.C. Pathways of liver injury in alcoholic liver disease. J. Hepatol. 2011, 55, 1159-1161. [CrossRef] [PubMed]
9. Miller, A.M.; Horiguchi, N.; Jeong,W.I.; Radaeva, S.; Gao, B. Molecular mechanisms of alcoholic liver disease: Innate immunity and cytokines. Alcohol. Clin. Exp. Res. 2011, 35, 787-793. [CrossRef] [PubMed]
10. Tsukamoto, H.; Lu, S.C. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J. 2001, 15, 1335-1349. [CrossRef] [PubMed]
11. Li, Y.; Liu, L.; Wang, B.; Wang, J.; Chen, D. Simple steatosis is a more relevant source of serum inflammatory markers than omental adipose tissue. Clin. Res. Hepatol. Gastroenterol. 2014, 38, 46-54. [CrossRef] [PubMed]
12. Kamiyama, M.; Shibamoto, T. Flavonoids with potent antioxidant activity found in young green barley leaves. J. Agric. Food Chem. 2012, 60, 6260-6267. [CrossRef] [PubMed]
13. Yu, Y.M.;Wu, C.H.; Tseng, Y.H.; Tsai, C.E.; Chang,W.C. Antioxidative and hypolipidemic effects of barley leaf essence in a rabbit model of atherosclerosis. Jpn. J. Pharmacol. 2002, 89, 142-148. [CrossRef] [PubMed]
14. Seo, W.D.; Yuk, H.J.; Curtis-Long, M.J.; Jang, K.C.; Lee, J.H.; Han, S.I.; Kang, H.W.; Nam, M.H.; Lee, S.J.; Lee, J.H.; et al. Effect of the growth stage and cultivar on policosanol profiles of barley sproutss and their adenosine 5'-monophosphate-activated protein kinase activation. J. Agric. Food Chem. 2013, 61, 1117-1123. [CrossRef] [PubMed]
15. Seo, K.H.; Park, M.J.; Ra, J.E.; Han, S.I.; Nam, M.H.; Kim, J.H.; Lee, J.H.; Seo,W.D. Saponarin from barley sproutss inhibits NF-kappab and mapk on LPS-induced raw 264.7 cells. Food Funct. 2014, 5, 3005-3013. [CrossRef] [PubMed]
16. Vitcheva, V.; Simeonova, R.; Krasteva, I.; Yotova, M.; Nikolov, S.; Mitcheva, M. Hepatoprotective effects of saponarin, isolated from gypsophila trichotoma wend. on cocaine-induced oxidative stress in rats. Redox Rep. 2011, 16, 56-61. [CrossRef] [PubMed]
17. Simeonova, R.; Vitcheva, V.; Kondeva-Burdina, M.; Krasteva, I.; Manov, V.; Mitcheva, M. Hepatoprotective and antioxidant effects of saponarin, isolated from gypsophila trichotoma wend. on paracetamol-induced liver damage in rats. Biomed. Res. Int. 2013, 2013, 757126. [CrossRef] [PubMed]
18. Neuschwander-Tetri, B.A.; Roll, F.J. Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct. Anal. Biochem. 1989, 179, 236-241. [CrossRef]
19. Arteel, G.E. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 2003, 124, 778-790. [CrossRef] [PubMed]
20. Colell, A.; Garcia-Ruiz, C.; Miranda, M.; Ardite, E.; Mari, M.; Morales, A.; Corrales, F.; Kaplowitz, N.; Fernandez-Checa, J.C. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 1998, 115, 1541-1551. [CrossRef]
21. Bode, C.; Bode, J.C. Activation of the innate immune system and alcoholic liver disease: Effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol? Alcohol. Clin. Exp. Res. 2005, 29, 166S-171S. [CrossRef] [PubMed]
22. Fernandez-Checa, J.C.; Kaplowitz, N.; Garcia-Ruiz, C.; Colell, A.; Miranda, M.; Mari, M.; Ardite, E.; Morales, A. GSH transport in mitochondria: Defense against TNF-induced oxidative stress and alcohol-induced defect. Am. J. Physiol. 1997, 273, G7-G17. [PubMed]
23. Wheeler, M.D.; Kono, H.; Yin, M.; Rusyn, I.; Froh, M.; Connor, H.D.; Mason, R.P.; Samulski, R.J.; Thurman, R.G. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology 2001, 120, 1241-1250. [CrossRef] [PubMed]
24. Wheeler, M.D.; Nakagami, M.; Bradford, B.U.; Uesugi, T.; Mason, R.P.; Connor, H.D.; Dikalova, A.; Kadiiska, M.; Thurman, R.G. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. J. Biol. Chem. 2001, 276, 36664-36672. [CrossRef] [PubMed]
25. Kim, S.J.; Lee, J.W.; Jung, Y.S.; Kwon do, Y.; Park, H.K.; Ryu, C.S.; Kim, S.K.; Oh, G.T.; Kim, Y.C. Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice. J. Hepatol. 2009, 50, 1184-1191. [CrossRef] [PubMed]
26. Kono, H.; Rusyn, I.; Bradford, B.U.; Connor, H.D.; Mason, R.P.; Thurman, R.G. Allopurinol prevents early alcohol-induced liver injury in rats. J. Pharmacol. Exp. Ther. 2000, 293, 296-303. [PubMed]
27. Kono, H.; Arteel, G.E.; Rusyn, I.; Sies, H.; Thurman, R.G. Ebselen prevents early alcohol-induced liver injury in rats. Free Radic. Biol. Med. 2001, 30, 403-411. [CrossRef]
28. Kono, H.; Rusyn, I.; Uesugi, T.; Yamashina, S.; Connor, H.D.; Dikalova, A.; Mason, R.P.; Thurman, R.G. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280, G1005-G1012. [PubMed]
29. McKim, S.E.; Konno, A.; Gabele, E.; Uesugi, T.; Froh, M.; Sies, H.; Thurman, R.G.; Arteel, G.E. Cocoa extract protects against early alcohol-induced liver injury in the rat. Arch. Biochem. Biophys. 2002, 406, 40-46. [CrossRef]
30. Yin, M.; Wheeler, M.D.; Kono, H.; Bradford, B.U.; Gallucci, R.M.; Luster, M.I.; Thurman, R.G. Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice. Gastroenterology 1999, 117, 942-952. [CrossRef]
31. Rao, R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 2009, 50, 638-644. [CrossRef] [PubMed]
32. Ji, C.; Deng, Q.; Kaplowitz, N. Role of TNF-α in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 2004, 40, 442-451. [CrossRef] [PubMed]
33. Feingold, K.R.; Grunfeld, C. Tumor necrosis factor-α stimulates hepatic lipogenesis in the rat in vivo. J. Clin. Investig. 1987, 80, 184-190. [CrossRef] [PubMed]
34. Hardardottir, I.; Doerrler, W.; Feingold, K.R.; Grunfeld, C. Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem. Biophys. Res. Commun. 1992, 186, 237-243. [CrossRef]
35. Nachiappan, V.; Curtiss, D.; Corkey, B.E.; Kilpatrick, L. Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: Synergy among TNF, IL-6, and IL-1. Shock 1994, 1, 123-129. [CrossRef] [PubMed]
36. Endo, M.; Masaki, T.; Seike, M.; Yoshimatsu, H. TNF-α induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (srebp-1c). Exp. Biol. Med. 2007, 232, 614-621.