Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Biochemistry

Volumn 55, Issue 26, 2016, Pages 3692-3701

  Goh, Boon Chong ^a   Wu, Huixing ^b   Rynkiewicz, Michael J ^c   Schulten, Klaus ^a   Seaton, Barbara A ^c   McCormack, Francis X ^b  

^a University of Illinois at Urbana Champaign   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BINDING SITES; BINS; BIOLOGICAL ORGANS; CRYSTALLOGRAPHY; MICROORGANISMS; MOLECULAR DYNAMICS; MUTAGENESIS; PATHOGENS; PHASE INTERFACES; PROTEINS; SURFACE ACTIVE AGENTS;

AIR LIQUID INTERFACES; CARBOHYDRATE-RECOGNITION DOMAINS; DIPALMITOYL PHOSPHATIDYLCHOLINE; MOLECULAR DYNAMICS SIMULATIONS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; SITE DIRECTED MUTAGENESIS; SURFACTANT MEMBRANES; SURFACTANT STRUCTURE;

X RAY CRYSTALLOGRAPHY;

CATION; CHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; LIPID A; SURFACTANT PROTEIN A; TYROSINE; LUNG SURFACTANT; PROTEOLIPID;

ARTICLE; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; FORCE; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; SITE DIRECTED MUTAGENESIS; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PROCEDURES; PROTEIN CONFORMATION; RAT;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEOLIPIDS; PULMONARY SURFACTANT-ASSOCIATED PROTEIN A; PULMONARY SURFACTANTS; RATS;

EID: 84978974824     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.6b00048     Document Type: Article

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