Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation

Biochemistry

Volumn 52, Issue 47, 2013, Pages 8527-8538

  Goh, Boon Chong ^a   Rynkiewicz, Michael J ^b   Cafarella, Tanya R ^b   White, Mitchell R ^b   Hartshorn, Kevan L ^b   Allen, Kimberly ^c   Crouch, Erika C ^c   Calin, Oliviana ^d,e   Seeberger, Peter H ^d,e   Schulten, Klaus ^a   Seaton, Barbara A ^b  

^a University of Illinois at Urbana Champaign   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MAX PLANCK INSTITUTE OF COLLOIDS AND INTERFACES   (Germany)

^e FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING MECHANISMS; CARBOHYDRATE-RECOGNITION DOMAINS; CRYSTALLOGRAPHIC DATA; HYDROPHOBIC INTERACTIONS; INFLUENZA A VIRUS; LARGE-SCALE MOLECULAR DYNAMICS; MOLECULAR MECHANISM; SURFACTANT PROTEINS;

BINDING ENERGY; HYDROGEN BONDS; MAMMALS; MOLECULAR DYNAMICS; SURFACE ACTIVE AGENTS; VIRUSES;

PROTEINS;

INFLUENZA VIRUS HEMAGGLUTININ; MANNOSIDE; MUTANT PROTEIN; SURFACTANT PROTEIN D; UNCLASSIFIED DRUG; VIRAL NONAMANNOSIDE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HOST RESISTANCE; HYDROGEN BOND; INFLUENZA VIRUS A; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR BLOCKING; VIRAL PHENOMENA AND FUNCTIONS; VIRUS AGGREGATION; VIRUS NEUTRALIZATION; WILD TYPE; X RAY CRYSTALLOGRAPHY;

ADHESIVENESS; AMINO ACID SUBSTITUTION; BINDING SITES; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INFLUENZA A VIRUS, H3N2 SUBTYPE; MICROBIAL VIABILITY; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; PEPTIDE FRAGMENTS; POLYSACCHARIDES; PROTEIN CONFORMATION; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS;

EID: 84888628250     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4010683     Document Type: Article

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