FDG-PET reveals improved cardiac regeneration and attenuated adverse remodelling following Sitagliptin 1 G-CSF therapy after acute myocardial infarction

European Heart Journal Cardiovascular Imaging

Volumn 17, Issue 2, 2016, Pages 136-145

  Gross, Lisa ^a   Paintmayer, Lisa ^a   Lehner, Sebastian ^a   Brandl, Lydia ^a   Brenner, Christoph ^b   Grabmaier, Ulrich ^a   Huber, Bruno ^a   Bartenstein, Peter ^a   Theiss, Hans Diogenes ^a   Franz, Wolfgang Michael ^b   Massberg, Steffen ^a   Todica, Andrei ^a   Brunner, Stefan ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

acute myocardial infarction; C kit; cardiac remodelling; G CSF; positron emission tomography; Sitagliptin

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GRANULOCYTE COLONY STIMULATING FACTOR; SITAGLIPTIN; RADIOPHARMACEUTICAL AGENT;

ACUTE HEART INFARCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CARDIAC MUSCLE CELL; CELL REGENERATION; CONTROLLED STUDY; FLOW CYTOMETRY; HEART VENTRICLE HYPERTROPHY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PET SCANNER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEM CELL; TREATMENT RESPONSE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; COMBINATION DRUG THERAPY; DIAGNOSTIC IMAGING; DISEASE MODEL; DRUG EFFECTS; HEART VENTRICLE REMODELING; HUMAN; MYOCARDIAL INFARCTION; PROCEDURES; REGENERATION;

ANIMALS; BONE MARROW CELLS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; FLUORODEOXYGLUCOSE F18; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REGENERATION; SITAGLIPTIN PHOSPHATE; VENTRICULAR REMODELING;

EID: 84978924567     PISSN: 20472404     EISSN: 20472412     Source Type: Journal    
DOI: 10.1093/ehjci/jev237     Document Type: Article

References (38)

1. Balsam LB,Wagers AJ, Christensen JL, Kofidis T,Weissman IL, Robbins RC. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004;428:668-73.
2. Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P et al. Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 2006;116:1865-77.
3. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004;428:664-8.
4. Zaruba MM, Huber BC, Brunner S, Deindl E, David R, Fischer R et al. Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival. Cardiovasc Res 2008;77:722-31.
5. Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R et al. Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction. Cell Stem Cell 2009;4:313-23.
6. Theiss HD, Vallaster M, Rischpler C, Krieg L, ZarubaMM, Brunner S et al. Dual stem cell therapy after myocardial infarction acts specifically by enhanced homing via the SDF-1/CXCR4 axis. Stem Cell Res 2011;7:244-55.
7. Theiss HD, Gross L, Vallaster M, David R, Brunner S, Brenner C et al. Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. Int J Cardiol 2013;168:3359-69.
8. Deindl E, Zaruba MM, Brunner S, Huber B, Mehl U, Assmann G et al. G-CSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis. FASEB J 2006;20:956-8.
9. Theiss HD, Gross L, Vallaster M, David R, Brunner S, Brenner C et al. Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. Int J Cardiol 2013;168:3359-3369.
10. Brunner S, Todica A, Boning G, Nekolla SG, Wildgruber M, Lehner S et al. Left ventricular functional assessment in murine models of ischemic and dilated cardiomyopathy using [18 F]FDG-PET: Comparison with cardiac MRI and monitoring erythropoietin therapy. EJNMMI Res 2012;2:43.
11. Todica A, Zacherl MJ,Wang H, Boning G, Jansen NL,Wangler C et al. In-vivo monitoring of erythropoietin treatment after myocardial infarction in mice with [(6)(8)Ga]Annexin A5 and [(1)(8)F]FDG PET. J Nucl Cardiol 2014;21:1191-9.
12. Slomka PJ, Dey D, Przetak C, Aladl UE, Baum RP. Automated 3-dimensional registration of stand-alone (18)F-FDG whole-body PET with CT. J Nucl Med 2003;44: 1156-67.
13. Lehner S, Sussebach C, Todica A, Uebleis C, Brunner S, Bartenstein P et al. Influence of SPECT attenuation correction on the quantification of hibernating myocardium as derived from combined myocardial perfusion SPECT and (1)(8)F-FDG PET. J Nucl Cardiol 2014;21:578-87.
14. Croteau E, Benard F, Cadorette J, Gauthier ME, Aliaga A, Bentourkia M et al. Quantitative gated PET for the assessment of left ventricular function in small animals. J Nucl Med 2003;44:1655-61.
15. Todica A, Brunner S, Boning G, Lehner S, Nekolla SG, Wildgruber M et al. [68Ga]-albumin-PET in the monitoring of left ventricular function in murine models of ischemic and dilated cardiomyopathy: Comparison with cardiac MRI. Mol Imaging Biol 2013;15:441-9.
16. Zhou YY, Wang SQ, Zhu WZ, Chruscinski A, Kobilka BK, Ziman B et al. Culture and adenoviral infection of adult mouse cardiac myocytes: Methods for cellular genetic physiology. Am J Physiol Heart Circ Physiol 2000;279:H429-36.
17. Satoh-Asahara N, Sasaki Y, Wada H, Tochiya M, Iguchi A, Nakagawachi R et al. A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients. Metabolism 2013;62:347-51.
18. Brenner C, Franz W, Kühlenthal S, Kuschnerus K, Remm F, Gross L et al. DPP-4 inhibition ameliorates atherosclerosis by priming monocytes into M2 macrophages. Int J Cardiol 2015;199:163-169.
19. Nadal-Ginard B, Ellison GM, Torella D. The cardiac stem cell compartment is indispensable for myocardial cell homeostasis, repair and regeneration in the adult. Stem Cell Res 2014;13(3 Pt B):615-30.
20. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res 2012;110:159-73.
21. Ruparelia N, Digby JE, Jefferson A, Medway DJ, Neubauer S, Lygate CA et al. Myocardial infarction causes inflammation and leukocyte recruitment at remote sites in the myocardium and in the renal glomerulus. Inflamm Res 2013;62:515-25.
22. Scheepers A, Joost HG, Schurmann A. The glucose transporter families SGLT and GLUT: Molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 2004;28:364-71.
23. Brosius FC III, Liu Y, Nguyen N, Sun D, Bartlett J, Schwaiger M. Persistent myocardial ischemia increases GLUT1 glucose transporter expression in both ischemic and non-ischemic heart regions. J Mol Cell Cardiol 1997;29:1675-85.
24. Jimenez-Amilburu V, Jong-Raadsen S, Bakkers J, Spaink HP, Marin-Juez R. GLUT12 deficiency during early development results in heart failure and a diabetic phenotype in zebrafish. J Endocrinol 2015;224:1-15.
25. Frantz S, Nahrendorf M. Cardiac macrophages and their role in ischaemic heart disease. Cardiovasc Res 2014;102:240-8.
26. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 2012;59: 153-63.
27. Frangogiannis NG, Mendoza LH, Ren G, Akrivakis S, Jackson PL, Michael LH et al. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol 2003;285: H483-92.
28. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 2002;23:549-55.
29. Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: Cancer as a paradigm. Nat Immunol 2010;11:889-96.
30. Satomi T, Ogawa M, Mori I, Ishino S, Kubo K, Magata Y et al. Comparison of contrast agents for atherosclerosis imaging using cultured macrophages: FDG versus ultrasmall superparamagnetic iron oxide. J Nucl Med 2013;54:999-1004.
31. Makdissi A, Ghanim H, Vora M, Green K, Abuaysheh S, Chaudhuri A et al. Sitagliptin exerts an antinflammatory action. J Clin Endocrinol Metab 2012;97: 3333-41.
32. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol 2000;35: 569-82.
33. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res 2008;58: 88-111.
34. ChanW, Duffy SJ, White DA, Gao XM, Du XJ, Ellims AH et al. Acute left ventricular remodeling following myocardial infarction: Coupling of regional healing with remote extracellular matrix expansion. JACC Cardiovasc Imaging 2012;5:884-93.
35. Ellison GM, Vicinanza C, Smith AJ, Aquila I, Leone A, Waring CD et al. Adult c-kit(pos) cardiac stem cells are necessary and sufficient for functional cardiac regeneration and repair. Cell 2013;154:827-42.
36. Urbanek K, Torella D, Sheikh F, De Angelis A, Nurzynska D, Silvestri F et al. Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 2005;102:8692-7.
37. van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature 2014;509:337-41.
38. Jesty SA, Steffey MA, Lee FK, Breitbach M, Hesse M, Reining S et al. c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci USA 2012;109:13380-5.