C-kit + precursors support postinfarction myogenesis in the neonatal, but not adult, heart

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 33, 2012, Pages 13380-13385

  Jesty, Sophy A ^a,c   Steffey, Michele A ^a,d   Lee, Frank K ^a   Breitbach, Martin ^b   Hesse, Michael ^b   Reining, Shaun ^a   Lee, Jane C ^a   Doran, Robert M ^a   Nikitin, Alexander Yu ^a   Fleischmann, Bernd K ^b   Kotlikoff, Michael I ^a  

^a Cornell University ^*  (United States)

^b UNIVERSITY OF BONN   (Germany)

^c UNIVERSITY OF TENNESSEE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Angiogenesis; Heart repair; Stem cell; Vasculogenesis

Indexed keywords

MESSENGER RNA; STEM CELL FACTOR; TRANSCRIPTION FACTOR NKX2.5;

ADOPTIVE TRANSFER; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR PRECURSOR CELL; CELL DIFFERENTIATION; CELL FATE; CONTROLLED STUDY; EXPLANT; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GROUPS BY AGE; HEART DEVELOPMENT; HEART INFARCTION; HEMATOPOIETIC STEM CELL; IMMUNOHISTOCHEMISTRY; MOUSE; MUSCLE DEVELOPMENT; MUSCLE REGENERATION; NEWBORN; NONHUMAN; PERINATAL PERIOD; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STEM CELL; STEM CELL EXPANSION;

AGING; ANIMALS; ANIMALS, NEWBORN; CELL LINEAGE; ENDOTHELIAL CELLS; GREEN FLUORESCENT PROTEINS; MICE; MUSCLE DEVELOPMENT; MYOCARDIAL INFARCTION; PROTO-ONCOGENE PROTEINS C-KIT; REGENERATION; STEM CELLS;

EID: 84865186978     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208114109     Document Type: Article

References (29)

1. Sussman MA, Anversa P (2004) Myocardial aging and senescence: Where have the stem cells gone? Annu Rev Physiol 66:29-48. (Pubitemid 40614438)
2. Anversa P, Kajstura J, Leri A, Bolli R (2006) Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation 113:1451-1463. (Pubitemid 43739442)
3. Rubart M, Field LJ (2006) Cardiac regeneration: Repopulating the heart. Annu Rev Physiol 68:29-49.
4. Murry CE, Reinecke H, Pabon LM (2006) Regeneration gaps: Observations on stem cells and cardiac repair. J Am Coll Cardiol 47:1777-1785.
5. Hsieh PC, et al. (2007) Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med 13:970-974. (Pubitemid 47222045)
6. Pouly J, et al. (2008) Cardiac stem cells in the real world. J Thorac Cardiovasc Surg 135: 673-678. (Pubitemid 351343809)
7. Wu SM, Chien KR, Mummery C (2008) Origins and fates of cardiovascular progenitor cells. Cell 132:537-543. (Pubitemid 351253695)
8. Bergmann O, et al. (2009) Evidence for cardiomyocyte renewal in humans. Science 324:98-102.
9. Moretti A, et al. (2006) Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127:1151-1165. (Pubitemid 44895618)
10. Wu SM, et al. (2006) Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell 127:1137-1150. (Pubitemid 44914005)
11. Kattman SJ, Huber TL, Keller GM (2006) Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell 11:723-732. (Pubitemid 44644969)
12. Yang L, et al. (2008) Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 453:524-528. (Pubitemid 351733312)
13. Christoforou N, et al. (2008) Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. J Clin Invest 118:894-903. (Pubitemid 351364597)
14. Tallini YN, et al. (2009) c-kit expression identifies cardiovascular precursors in the neonatal heart. Proc Natl Acad Sci USA 106:1808-1813.
15. Zaruba MM, Soonpaa M, Reuter S, Field LJ (2010) Cardiomyogenic potential of C-kit (+)-expressing cells derived from neonatal and adult mouse hearts. Circulation 121: 1992-2000.
16. Porrello ER, et al. (2011) Transient regenerative potential of the neonatal mouse heart. Science 331:1078-1080.
17. Beltrami AP, et al. (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763-776. (Pubitemid 37186770)
18. Kattman SJ, Adler ED, Keller GM (2007) Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends Cardiovasc Med 17:240-246. (Pubitemid 47532729)
19. Fransioli J, et al. (2008) Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells 26:1315-1324.
20. Fazel S, et al. (2006) Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116:1865-1877. (Pubitemid 44033311)
21. Murry CE, et al. (2004) Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428:664-668. (Pubitemid 38524810)
22. Nygren JM, et al. (2008) Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Nat Cell Biol 10:584-592. (Pubitemid 351627378)
23. Vintersten K, et al. (2004) Mouse in red: Red fluorescent protein expression in mouse ES cells, embryos, and adult animals. Genesis 40:241-246. (Pubitemid 40110709)
24. Hu Y, et al. (2004) Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest 113:1258-1265. (Pubitemid 39069924)
25. Pasquinelli G, et al. (2007) Thoracic aortas from multiorgan donors are suitable for obtaining resident angiogenic mesenchymal stromal cells. Stem Cells 25:1627-1634. (Pubitemid 47121839)
26. Passman JN, et al. (2008) A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells. Proc Natl Acad Sci USA 105: 9349-9354.
27. Phifer CB, Terry LM (1986) Use of hypothermia for general anesthesia in preweanling rodents. Physiol Behav 38:887-890. (Pubitemid 17207711)
28. Roell W, et al. (2007) Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 450:819-824. (Pubitemid 350237591)
29. Choi J, Curtis SJ, Roy DM, Flesken-Nikitin A, Nikitin AY (2010) Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency. Am J Pathol 177:2645-2658.