Development of a long-acting, protein-loaded, redox-active, injectable gel formed by a polyion complex for local protein therapeutics

Biomaterials

Volumn 84, Issue , 2016, Pages 210-218

  Ishii, Shiro ^a   Kaneko, Junya ^a   Nagasaki, Yukio ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cancer immunotherapy; Injectable hydrogel; Local protein delivery; Polyion complex flower micelle; Reactive oxygen species

Indexed keywords

COMPLEX NETWORKS; DISEASES; DRUG PRODUCTS; HYDROGELS; MAMMALS; MICELLES; POLYETHYLENE GLYCOLS; REDOX REACTIONS; TUMORS;

CANCER IMMUNOTHERAPY; INJECTABLE HYDROGELS; POLYION COMPLEX; PROTEIN DELIVERY; REACTIVE OXYGEN SPECIES;

PROTEINS;

COPOLYMER; INTERLEUKIN 12; ION; MACROGOL; POLYACRYLIC ACID; POLYAMINE; POLYION COMPLEX; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FLUORESCEIN; GEL; MICELLE; NITROGEN OXIDE; NITROXYL; POLYMER; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CANCER INHIBITION; COLON ADENOCARCINOMA; ENCAPSULATION; GEL; IN VITRO STUDY; INJECTION SITE; MALE; MICELLE; MOUSE; NONHUMAN; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SECRETION; REDOX ACTIVE INJECTABLE GEL; ROOM TEMPERATURE; STATIC ELECTRICITY; STRENGTH; TRANSITION TEMPERATURE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; FLOW KINETICS; IMMUNOTHERAPY; INJECTION; NUDE MOUSE; OXIDATION REDUCTION REACTION; PARTICLE SIZE; PROCEDURES; TEMPERATURE; TUMOR CELL LINE; VISCOSITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FLUORESCEIN; GELS; IMMUNOTHERAPY; INJECTIONS; INTERLEUKIN-12; IONS; MALE; MICE, INBRED BALB C; MICE, NUDE; MICELLES; NITROGEN OXIDES; OXIDATION-REDUCTION; PARTICLE SIZE; PHASE TRANSITION; POLYMERS; PROTEINS; RHEOLOGY; TEMPERATURE; TRANSITION TEMPERATURE; VISCOSITY;

EID: 84978802754     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.01.029     Document Type: Article

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