Redox-active injectable gel using thermo-responsive nanoscale polyion complex flower micelle for noninvasive treatment of local inflammation

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 914-920

  Pua, Min Ley ^a   Yoshitomi, Toru ^a   Chonpathompikunlert, Pennapa ^a   Hirayama, Aki ^b   Nagasaki, Yukio ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TSUKUBA UNIVERSITY OF TECHNOLOGY   (Japan)

Author keywords

Antioxidant; Inflammation; Injectable hydrogel; Micelle; Polyion complex; Sol gel process

Indexed keywords

ELECTRON SPIN RESONANCE IMAGING; INFLAMMATION; INJECTABLE HYDROGELS; NEUTROPHIL INFILTRATION; PHYSIOLOGICAL CONDITION; POLYION COMPLEX; QUANTITATIVE EVALUATION; REACTIVE OXYGEN SPECIES;

ANTIOXIDANTS; DYES; GELATION; HYDROGELS; MICELLES; NONINVASIVE MEDICAL PROCEDURES; PATHOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POLYOLS; SOL-GEL PROCESS;

DISEASES;

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CARRAGEENAN; COPOLYMER; POLY[4 (2,2,6,6 TETRAMETHYLPIPERIDIN N OXYL)AMINOMETHYLSTYRENE] B POLY(ETHYLENE GLYCOL) B POLY[4 (2,2,6,6 TETRAMETHYLPIPERIDIN N OXYL)AMINOMETHYLSTYRENE]; POLYACRYLIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOCOMPATIBILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DELIVERY SYSTEM; DRUG RETENTION; ELECTRON SPIN RESONANCE; GEL; GELATION; HEAT SENSITIVITY; HYDROGEL; HYPERALGESIA; IN VITRO STUDY; INFLAMMATION; INJECTION SITE; MALE; MICELLE; MOUSE; NEUTROPHIL CHEMOTAXIS; NON INVASIVE PROCEDURE; NONHUMAN; PRIORITY JOURNAL; REDOX ACTIVE INJECTABLE GEL; ZETA POTENTIAL;

2,2′-AZOBISISOBUTYRONITRILE (PUBCHEM CID: 6547); 4-AMINO-TEMPO (PUBCHEM CID: 550942); ANTIOXIDANT; CHLOROMETHYLSTYRENE (PUBCHEM CID: 16211416); INFLAMMATION; INJECTABLE HYDROGEL; MICELLE; POLY(ACRYLIC ACID) (PUBCHEM CID: 6581); POLY(ETHYLENE GLYCOL) (PUBCHEM CID: 174); POLYION COMPLEX; SOL-GEL PROCESS; Λ-CARRAGEENAN (PUBCHEM CID: 11966249);

ACRYLIC RESINS; ANIMALS; ANTIOXIDANTS; ARTHRITIS; DELAYED-ACTION PREPARATIONS; GELS; INFLAMMATION; INJECTIONS; IONS; MALE; MICE; MICELLES; NITROGEN OXIDES; OXIDATION-REDUCTION; PHASE TRANSITION; PIPERIDINES; POLYETHYLENE GLYCOLS; STYRENE; TEMPERATURE;

EID: 84887174052     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.10.009     Document Type: Article

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