Synthesis, characterization, biodegradability and biocompatibility of a temperature-sensitive PBLA-PEG-PBLA hydrogel as protein delivery system with low critical gelation concentration

Drug Development and Industrial Pharmacy

Volumn 40, Issue 9, 2014, Pages 1264-1275

  Xu, Yourui ^a   Shen, Yan ^a   Xiong, Yerong ^a   Li, Chang ^a   Sun, Chunmeng ^a   Ouahab, Ammar ^a   Tu, Jiasheng ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Biocompatible; Biodegradable; Hydrogel; Protein drugs; Temperature sensitive

Indexed keywords

COPOLYMER; LYSOZYME; MACROGOL; POLY(BETA BUTYROLACTONE CO LACTIC ACID); UNCLASSIFIED DRUG; BETA-BUTYROLACTONE; BIOMATERIAL; DELAYED RELEASE FORMULATION; GAMMA BUTYROLACTONE; HYDROGEL; LACTIC ACID; MACROGOL DERIVATIVE; MICELLE; POLYMER; SOLUTION AND SOLUBILITY;

ANIMAL CELL; ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; BIOLOGICAL ACTIVITY; CATALYST; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY TEST; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; FLOW KINETICS; GEL PERMEATION CHROMATOGRAPHY; GELATION; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; IN VITRO STUDY; LIGHT SCATTERING; MALE; MICELLIZATION; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHASE TRANSITION; RAT; RING OPENING METATHESIS POLYMERIZATION; SEDIMENTATION; SUSTAINED DRUG RELEASE; SYNTHESIS; TEMPERATURE; TEMPERATURE SENSITIVITY; ANALOGS AND DERIVATIVES; ANIMAL; BIOREMEDIATION; CHEMICAL PHENOMENA; CHEMISTRY; DELAYED RELEASE FORMULATION; MICELLE; PROCEDURES; SOLUTION AND SOLUBILITY; SPRAGUE DAWLEY RAT;

4-BUTYROLACTONE; ANIMALS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; HYDROGEL; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LACTIC ACID; MALE; MICELLES; MOLECULAR WEIGHT; MURAMIDASE; PHASE TRANSITION; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUTIONS; TEMPERATURE;

EID: 84906212627     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2013.814066     Document Type: Article

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