메뉴 건너뛰기




Volumn 13, Issue 2, 2016, Pages 157-170

Programmed cell death ligand-1 (PD-L1) expression by immunohistochemistry: could it be predictive and/or prognostic in non-small cell lung cancer?

Author keywords

Biomarker; Immunohistochemistry; PD 1; PD L1; Predictive

Indexed keywords

BIOLOGICAL MARKER; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 1 INHIBITOR; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84978786133     PISSN: 20953941     EISSN: None     Source Type: Journal    
DOI: 10.20892/j.issn.2095-3941.2016.0009     Document Type: Review
Times cited : (83)

References (61)
  • 1
    • 84897019813 scopus 로고    scopus 로고
    • Clinical cancer advances 2013: annual report on progress against cancer from the American society of clinical oncology
    • Patel JD, Krilov L, Adams S, Aghajanian C, Basch E, Brose MS, et al. Clinical cancer advances 2013: annual report on progress against cancer from the American society of clinical oncology. J Clin Oncol. 2014; 32: 129-60.
    • (2014) J Clin Oncol , vol.32 , pp. 129-160
    • Patel, J.D.1    Krilov, L.2    Adams, S.3    Aghajanian, C.4    Basch, E.5    Brose, M.S.6
  • 3
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris MG, Johnson BE, Berry LD, Kwiatkowski DJ, Iafrate AJ, Wistuba 2, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA. 2014; 311: 1998-2006.
    • (2014) JAMA , vol.311 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3    Kwiatkowski, D.J.4    Iafrate, A.J.5    Wistuba6
  • 4
    • 85016864689 scopus 로고    scopus 로고
    • Cancer dormancy: a regulatory role for endogenous immunity in establishing and maintaining the tumor dormant state
    • Baxevanis CN, Perez SA. Cancer dormancy: a regulatory role for endogenous immunity in establishing and maintaining the tumor dormant state. Vaccines (Basel). 2015; 3: 597-619.
    • (2015) Vaccines (Basel) , vol.3 , pp. 597-619
    • Baxevanis, C.N.1    Perez, S.A.2
  • 5
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012; 12: 252-64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 7
    • 84920956735 scopus 로고    scopus 로고
    • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
    • Herbst RS, Soria JC, Kowanetz M, Fine GD, Hamid O, Gordon MS, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014; 515: 563-7.
    • (2014) Nature , vol.515 , pp. 563-567
    • Herbst, R.S.1    Soria, J.C.2    Kowanetz, M.3    Fine, G.D.4    Hamid, O.5    Gordon, M.S.6
  • 10
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus Docetaxel in advanced nonsquamous nonsmall- cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, et al. Nivolumab versus Docetaxel in advanced nonsquamous nonsmall- cell lung cancer. N Engl J Med. 2015; 373: 1627-39.
    • (2015) N Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3    Spigel, D.R.4    Steins, M.5    Ready, N.E.6
  • 11
    • 84960187594 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated, PD-L1- positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial
    • Dec 18. p2: S0140-6736(15)01281-7. [Epub ahead of print]
    • Herbst RS, Baas P, Kim DW, Felip E, Pérez-Gracia JL, Han JY, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1- positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet. 2015 Dec 18. p2: S0140-6736(15)01281-7. [Epub ahead of print]
    • (2015) Lancet
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3    Felip, E.4    Pérez-Gracia, J.L.5    Han, J.Y.6
  • 12
    • 84978857706 scopus 로고    scopus 로고
    • Efficacy, safety and predictive biomarker results from a randomized phase 2 study comparing MPDL3280A vs docetaxel in 2L/3L NSCLC (POPLAR)
    • abstr 8010
    • Spira AI, Park K, Mazieres J, Vansteenkiste JF, Rittmeyer A, Ballinger M, et al. Efficacy, safety and predictive biomarker results from a randomized phase 2 study comparing MPDL3280A vs docetaxel in 2L/3L NSCLC (POPLAR). J Clin oncol. 2015; 33 (suppl): abstr 8010.
    • (2015) J Clin oncol , vol.33
    • Spira, A.I.1    Park, K.2    Mazieres, J.3    Vansteenkiste, J.F.4    Rittmeyer, A.5    Ballinger, M.6
  • 13
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa AT, Waldron JS, Panner A, Crane CA, Parney IF, Barry JJ, et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med. 2007; 13: 84-8.
    • (2007) Nat Med , vol.13 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3    Crane, C.A.4    Parney, I.F.5    Barry, J.J.6
  • 14
    • 58549102319 scopus 로고    scopus 로고
    • Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
    • Marzec M, Zhang Q, Goradia A, Raghunath PN, Liu X, Paessler M, et al. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci U S A. 2008; 105: 20852-7.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20852-20857
    • Marzec, M.1    Zhang, Q.2    Goradia, A.3    Raghunath, P.N.4    Liu, X.5    Paessler, M.6
  • 15
    • 84942849158 scopus 로고    scopus 로고
    • Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in Non-Small cell lung cancer
    • Ota K, Azuma K, Kawahara A, Hattori S, Iwama E, Tanizaki J, et al. Induction of PD-L1 expression by the EML4-ALK oncoprotein and downstream signaling pathways in Non-Small cell lung cancer. Clin Cancer Res. 2015; 21: 4014-21.
    • (2015) Clin Cancer Res , vol.21 , pp. 4014-4021
    • Ota, K.1    Azuma, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Tanizaki, J.6
  • 17
    • 84938289871 scopus 로고    scopus 로고
    • Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-Driven NSCLC: implication for optional immune targeted therapy for NSCLC patients with EGFR mutation
    • Chen N, Fang W, Zhan J, Hong S, Tang Y, Kang S, et al. Upregulation of PD-L1 by EGFR activation mediates the immune escape in EGFR-Driven NSCLC: implication for optional immune targeted therapy for NSCLC patients with EGFR mutation. J Thorac Oncol. 2015; 10: 910-23.
    • (2015) J Thorac Oncol , vol.10 , pp. 910-923
    • Chen, N.1    Fang, W.2    Zhan, J.3    Hong, S.4    Tang, Y.5    Kang, S.6
  • 18
    • 84931054440 scopus 로고    scopus 로고
    • The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
    • Tang Y, Fang W, Zhang Y, Hong S, Kang S, Yan Y, et al. The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Oncotarget. 2015; 6: 14209-19.
    • (2015) Oncotarget , vol.6 , pp. 14209-14219
    • Tang, Y.1    Fang, W.2    Zhang, Y.3    Hong, S.4    Kang, S.5    Yan, Y.6
  • 19
    • 84940722192 scopus 로고    scopus 로고
    • Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status
    • Koh J, Go H, Keam B, Kim MY, Nam SJ, Kim TM, et al. Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration status. Mod Pathol. 2015; 28: 1154-66.
    • (2015) Mod Pathol , vol.28 , pp. 1154-1166
    • Koh, J.1    Go, H.2    Keam, B.3    Kim, M.Y.4    Nam, S.J.5    Kim, T.M.6
  • 20
    • 84938491216 scopus 로고    scopus 로고
    • Programmed Death-Ligand 1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with epidermal growth factor receptor Mutation-Positive lung adenocarcinoma
    • Lin C, Chen X, Li M, Liu J, Qi X, Yang W, et al. Programmed Death-Ligand 1 expression predicts tyrosine kinase inhibitor response and better prognosis in a cohort of patients with epidermal growth factor receptor Mutation-Positive lung adenocarcinoma. Clin Lung Cancer. 2015; 16: e25-35.
    • (2015) Clin Lung Cancer , vol.16 , pp. e25-e35
    • Lin, C.1    Chen, X.2    Li, M.3    Liu, J.4    Qi, X.5    Yang, W.6
  • 21
    • 84898843963 scopus 로고    scopus 로고
    • Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma
    • Zhang Y, Wang L, Li Y, Pan YJ, Wang R, Hu HC, et al. Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma. Onco Targets Ther. 2014; 7: 567-73.
    • (2014) Onco Targets Ther , vol.7 , pp. 567-573
    • Zhang, Y.1    Wang, L.2    Li, Y.3    Pan, Y.J.4    Wang, R.5    Hu, H.C.6
  • 22
    • 84941800472 scopus 로고    scopus 로고
    • Adaptive immune resistance: how cancer protects from immune attack
    • Ribas A. Adaptive immune resistance: how cancer protects from immune attack. Cancer Discov. 2015; 5: 915-9.
    • (2015) Cancer Discov , vol.5 , pp. 915-919
    • Ribas, A.1
  • 23
    • 34247157223 scopus 로고    scopus 로고
    • The new B7s: playing a pivotal role in tumor immunity
    • Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. J Immunother. 2007; 30: 251-60.
    • (2007) J Immunother , vol.30 , pp. 251-260
    • Flies, D.B.1    Chen, L.2
  • 24
    • 31444451661 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274)
    • Lee SJ, Jang BC, Lee SW, Yang Y, Suh SI, Park YM, et al. Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274) FEBS Lett. 2006; 580: 755-62.
    • (2006) FEBS Lett , vol.580 , pp. 755-762
    • Lee, S.J.1    Jang, B.C.2    Lee, S.W.3    Yang, Y.4    Suh, S.I.5    Park, Y.M.6
  • 25
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014; 20: 5064-74.
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmer, J.R.3    Xu, H.4    Pan, X.5    Kim, J.H.6
  • 26
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova TA, Fitz LJ, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000; 192: 1027-34.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.A.5    Fitz, L.J.6
  • 27
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • 127ra37
    • Taube JM, Anders RA, Young GD, Xu H, Sharma R, Mcmiller TL, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012; 4: 127ra37.
    • (2012) Sci Transl Med , vol.4
    • Taube, J.M.1    Anders, R.A.2    Young, G.D.3    Xu, H.4    Sharma, R.5    McMiller, T.L.6
  • 29
    • 84959351989 scopus 로고    scopus 로고
    • PD-L1 is upregulated by simultaneous amplification of the PD-L1 and JAK2 genes in Non-Small cell lung cancer
    • Ikeda S, Okamoto T, Okano S, Umemoto Y, Tagawa T, Morodomi Y, et al. PD-L1 is upregulated by simultaneous amplification of the PD-L1 and JAK2 genes in Non-Small cell lung cancer. J Thorac Oncol. 2016; 11: 62-71.
    • (2016) J Thorac Oncol , vol.11 , pp. 62-71
    • Ikeda, S.1    Okamoto, T.2    Okano, S.3    Umemoto, Y.4    Tagawa, T.5    Morodomi, Y.6
  • 30
    • 84895556999 scopus 로고    scopus 로고
    • MiR-20b, -21, and-130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer
    • Zhu JJ, Chen LX, Zou LT, Yang PP, Wu RR, Mao Y, et al. MiR-20b, -21, and-130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer. Hum Immunol. 2014; 75: 348-53.
    • (2014) Hum Immunol , vol.75 , pp. 348-353
    • Zhu, J.J.1    Chen, L.X.2    Zou, L.T.3    Yang, P.P.4    Wu, R.R.5    Mao, Y.6
  • 31
    • 84927005034 scopus 로고    scopus 로고
    • The clinical relevance of the miR-197/CKS1B/STAT3- mediated PD-L1 network in chemoresistant non-small-cell lung cancer
    • Fujita Y, Yagishita S, Hagiwara K, Yoshioka Y, Kosaka N, Takeshita F, et al. The clinical relevance of the miR-197/CKS1B/STAT3- mediated PD-L1 network in chemoresistant non-small-cell lung cancer. Mol Ther. 2015; 23: 717-27.
    • (2015) Mol Ther , vol.23 , pp. 717-727
    • Fujita, Y.1    Yagishita, S.2    Hagiwara, K.3    Yoshioka, Y.4    Kosaka, N.5    Takeshita, F.6
  • 32
    • 84923251407 scopus 로고    scopus 로고
    • Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
    • Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun. 2014; 5: 5241.
    • (2014) Nat Commun , vol.5 , pp. 5241
    • Chen, L.1    Gibbons, D.L.2    Goswami, S.3    Cortez, M.A.4    Ahn, Y.H.5    Byers, L.A.6
  • 33
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    • Barsoum IB, Smallwood CA, Siemens DR, Graham CH. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res. 2014; 74: 665-74.
    • (2014) Cancer Res , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 34
    • 84899753178 scopus 로고    scopus 로고
    • PD-L1 is a novel direct target of HIF-1 alpha., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
    • Noman MZ, Desantis G, Janji BA, Karray S, Dessen P, Bronte V, et al. PD-L1 is a novel direct target of HIF-1 alpha., and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med. 2014; 211: 781-90.
    • (2014) J Exp Med , vol.211 , pp. 781-790
    • Noman, M.Z.1    Desantis, G.2    Janji, B.A.3    Karray, S.4    Dessen, P.5    Bronte, V.6
  • 35
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer
    • Azuma K, Ota K, Kawahara A, Hattori S, Iwama E, Harada T, et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer. Ann Oncol. 2014; 25: 1935-40.
    • (2014) Ann Oncol , vol.25 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Harada, T.6
  • 37
    • 84948092139 scopus 로고    scopus 로고
    • Expression of PD-1 and its ligands, PD-L1 and PD-L2, in smokers and never smokers with KRAS mutant lung cancer
    • Calles A, Liao X, Sholl LM, Rodig SJ, Freeman GJ, Butaney M, et al. Expression of PD-1 and its ligands, PD-L1 and PD-L2, in smokers and never smokers with KRAS mutant lung cancer. J Thorac Oncol. 2015;10:1726-35.
    • (2015) J Thorac Oncol , vol.10 , pp. 1726-1735
    • Calles, A.1    Liao, X.2    Sholl, L.M.3    Rodig, S.J.4    Freeman, G.J.5    Butaney, M.6
  • 38
    • 84873666114 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
    • Chen YB, Mu CY, Huang JA. Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study. Tumori. 2012; 98: 751-5.
    • (2012) Tumori , vol.98 , pp. 751-755
    • Chen, Y.B.1    Mu, C.Y.2    Huang, J.A.3
  • 39
    • 84885633682 scopus 로고    scopus 로고
    • Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients
    • Chen YY, Wang LB, Zhu HL, Li XY, Zhu YP, Yin YL, et al. Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients. Chin Med Sci J. 2013; 28: 147-51.
    • (2013) Chin Med Sci J , vol.28 , pp. 147-151
    • Chen, Y.Y.1    Wang, L.B.2    Zhu, H.L.3    Li, X.Y.4    Zhu, Y.P.5    Yin, Y.L.6
  • 41
    • 84920655625 scopus 로고    scopus 로고
    • PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients
    • D'incecco A, Andreozzi M, Ludovini V, Rossi E, Capodanno A, Landi L, et al. PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer. 2015; 112: 95-102.
    • (2015) Br J Cancer , vol.112 , pp. 95-102
    • D'Incecco, A.1    Andreozzi, M.2    Ludovini, V.3    Rossi, E.4    Capodanno, A.5    Landi, L.6
  • 42
    • 84924577386 scopus 로고    scopus 로고
    • Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers
    • Kim MY, Koh J, Kim S, Go HA, Chung DH. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Lung Cancer. 2015; 88: 24-33.
    • (2015) Lung Cancer , vol.88 , pp. 24-33
    • Kim, M.Y.1    Koh, J.2    Kim, S.3    Go, H.A.4    Chung, D.H.5
  • 43
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi J, Yamazaki K, Azuma M, Kinoshita I, Dosaka-Akita H, Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res. 2004; 10: 5094-100.
    • (2004) Clin Cancer Res , vol.10 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3    Kinoshita, I.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 44
    • 84923296216 scopus 로고    scopus 로고
    • B7-H1 and B7-H3 are Independent predictors of poor prognosis in patients with non-small cell lung cancer
    • Mao YX, Li W, Chen K, Xie YF, Liu Q, Yao M, et al. B7-H1 and B7-H3 are Independent predictors of poor prognosis in patients with non-small cell lung cancer. Oncotarget. 2015; 6: 3452-61.
    • (2015) Oncotarget , vol.6 , pp. 3452-3461
    • Mao, Y.X.1    Li, W.2    Chen, K.3    Xie, Y.F.4    Liu, Q.5    Yao, M.6
  • 45
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer May contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu CY, Huang JA, Chen Y, Chen C, Zhang XG. High expression of PD-L1 in lung cancer May contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol. 2011; 28: 682-8.
    • (2011) Med Oncol , vol.28 , pp. 682-688
    • Mu, C.Y.1    Huang, J.A.2    Chen, Y.3    Chen, C.4    Zhang, X.G.5
  • 47
    • 84897404380 scopus 로고    scopus 로고
    • Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
    • Yang CY, Lin MW, Chang YL, Wu CT, Yang PC. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer. 2014; 50: 1361-9.
    • (2014) Eur J Cancer , vol.50 , pp. 1361-1369
    • Yang, C.Y.1    Lin, M.W.2    Chang, Y.L.3    Wu, C.T.4    Yang, P.C.5
  • 48
    • 84928615785 scopus 로고    scopus 로고
    • Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a metaanalysis
    • Pan ZK, Ye F, Wu X, An HX, Wu JX. Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a metaanalysis. J Thorac Dis. 2015; 7: 462-70.
    • (2015) J Thorac Dis , vol.7 , pp. 462-470
    • Pan, Z.K.1    Ye, F.2    Wu, X.3    An, H.X.4    Wu, J.X.5
  • 49
    • 84947704341 scopus 로고    scopus 로고
    • Clinicopathological and molecular parameters of lung adenocarcinomas (ADC) associated with programmed cell death ligand 1 (PD-L1) protein expression
    • abstr 7555
    • Huynh T, Oyarvide VM, Uruga H, Bozkurtlar E, Gainor JF, Hata AN, et al. Clinicopathological and molecular parameters of lung adenocarcinomas (ADC) associated with programmed cell death ligand 1 (PD-L1) protein expression. J Clin Oncol. 2015; 33 (supple): abstr 7555.
    • (2015) J Clin Oncol , vol.33
    • Huynh, T.1    Oyarvide, V.M.2    Uruga, H.3    Bozkurtlar, E.4    Gainor, J.F.5    Hata, A.N.6
  • 50
    • 84996429919 scopus 로고    scopus 로고
    • Characterization of PD-L1 expression and assessment of association with tumor histology and gene expression status in pretreatment non-small cell lung cancer (NSCLC) tumor specimens
    • Harbison CT, Kurland JF, Horak CE, Cogswell JP, Inzunza HD, Hu X, et al. Characterization of PD-L1 expression and assessment of association with tumor histology and gene expression status in pretreatment non-small cell lung cancer (NSCLC) tumor specimens. J Thorac Oncol. 2014; 9 (Supplement 9): S7-S52.
    • (2014) J Thorac Oncol , vol.9 , pp. S7-S52
    • Harbison, C.T.1    Kurland, J.F.2    Horak, C.E.3    Cogswell, J.P.4    Inzunza, H.D.5    Hu, X.6
  • 51
    • 84949663097 scopus 로고    scopus 로고
    • Prognostic value of programmed cell death-ligand 1 expression in patients with nonsmall- cell lung cancer: evidence from an updated meta-analysis
    • Zhong A, Xing Y, Pan X, Shi M, Xu H. Prognostic value of programmed cell death-ligand 1 expression in patients with nonsmall- cell lung cancer: evidence from an updated meta-analysis. Onco Targets Ther. 2015; 8: 3595-601.
    • (2015) Onco Targets Ther , vol.8 , pp. 3595-3601
    • Zhong, A.1    Xing, Y.2    Pan, X.3    Shi, M.4    Xu, H.5
  • 52
    • 84944734156 scopus 로고    scopus 로고
    • Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC)
    • abstr 8032.
    • Rizvi NA, Brahmer JR, Ou S-HI, Segal NH, Khleif S, Hwu WJ, et al. Safety and clinical activity of MEDI4736, an anti-programmed cell death-ligand 1 (PD-L1) antibody, in patients with non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33:suppl; abstr 8032.
    • (2015) J Clin Oncol , vol.33
    • Rizvi, N.A.1    Brahmer, J.R.2    Ou, S.-H.I.3    Segal, N.H.4    Khleif, S.5    Hwu, W.J.6
  • 53
    • 84901744815 scopus 로고    scopus 로고
    • Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics
    • Hato SV, Khong A, De Vries IJ, Lesterhuis WJ. Molecular pathways: the immunogenic effects of platinum-based chemotherapeutics. Clin Cancer Res. 2014; 20: 2831-7.
    • (2014) Clin Cancer Res , vol.20 , pp. 2831-2837
    • Hato, S.V.1    Khong, A.2    De Vries, I.J.3    Lesterhuis, W.J.4
  • 54
    • 85028479799 scopus 로고    scopus 로고
    • Comparison of programmed cell death ligand 1 (PDL1) expression in main tumor and lymph node metastasis of stage 2 and 3 lung adenocarcinomas
    • Bozkurtlar E, Uruga H, Huynh T, Lanuti M, Mark E, Mino-Kenudson M. Comparison of programmed cell death ligand 1 (PDL1) expression in main tumor and lymph node metastasis of stage 2 and 3 lung adenocarcinomas. Mod Pathol. 2015; 28: 474A.
    • (2015) Mod Pathol , vol.28 , pp. 474A
    • Bozkurtlar, E.1    Uruga, H.2    Huynh, T.3    Lanuti, M.4    Mark, E.5    Mino-Kenudson, M.6
  • 55
    • 84954538129 scopus 로고    scopus 로고
    • Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage 3 non-small cell lung cancer patients receiving concurrent chemoradiotherapy
    • Tokito T, Azuma K, Kawahara A, Ish2 H, Yamada K, Matsuo N, et al. Predictive relevance of PD-L1 expression combined with CD8+ TIL density in stage 3 non-small cell lung cancer patients receiving concurrent chemoradiotherapy. Eur J Cancer. 2016; 55: 7-14.
    • (2016) Eur J Cancer , vol.55 , pp. 7-14
    • Tokito, T.1    Azuma, K.2    Kawahara, A.3    Ish, H.4    Yamada, K.5    Matsuo, N.6
  • 58
    • 84960080350 scopus 로고    scopus 로고
    • Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies
    • Ilie M, Long-Mira E, Bence C, Butori C, Lassalle S, Bouhlel L, et al. Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies. Ann Oncol. 2016; 27: 147-53.
    • (2016) Ann Oncol , vol.27 , pp. 147-153
    • Ilie, M.1    Long-Mira, E.2    Bence, C.3    Butori, C.4    Lassalle, S.5    Bouhlel, L.6
  • 59
    • 84978854813 scopus 로고    scopus 로고
    • PDL1 expression in paired nonsmall cell lung cancer tumor samples
    • abstr 570.
    • Kim J, Sorensen SF, Choi Y-L, Wang Z, Sun JM, Chio H, et al. PDL1 expression in paired nonsmall cell lung cancer tumor samples. Cancer Res. 2015;75 (15 suppl): abstr 570.
    • (2015) Cancer Res , vol.75 , Issue.15
    • Kim, J.1    Sorensen, S.F.2    Choi, Y.-L.3    Wang, Z.4    Sun, J.M.5    Chio, H.6
  • 60
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi NA, Hellmann MD, Snyder A, Kvistborg P, Makarov V, Havel JJ, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science. 2015; 348: 124-8.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3    Kvistborg, P.4    Makarov, V.5    Havel, J.J.6
  • 61
    • 84936821508 scopus 로고    scopus 로고
    • Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferoninflammatory immune gene signature
    • abstr 3001.
    • Ribas A, Robert C, Hodi FS, Wolchok JD, Joshua AM, Hwu WJ, et al. Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferoninflammatory immune gene signature. J Clin Oncol. 2015; 33(suppl): abstr 3001.
    • (2015) J Clin Oncol , vol.33
    • Ribas, A.1    Robert, C.2    Hodi, F.S.3    Wolchok, J.D.4    Joshua, A.M.5    Hwu, W.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.