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Volumn 89, Issue 2, 2015, Pages 181-188

PD-L1 expression is a favorable prognostic factor in early stage non-small cell carcinoma

Author keywords

Biomarker; Immunohistochemistry; Immunotherapy; Lung cancer; NSCLC; Programmed death ligand 1

Indexed keywords

K RAS PROTEIN; PROGRAMMED DEATH 1 LIGAND 1; VASCULOTROPIN; EPIDERMAL GROWTH FACTOR RECEPTOR; KRAS PROTEIN, HUMAN; PROTEIN P21; TUMOR MARKER;

EID: 84937629074     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2015.05.007     Document Type: Article
Times cited : (261)

References (47)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.2
  • 2
    • 53549087527 scopus 로고    scopus 로고
    • How tumours escape mass destruction
    • Stewart T.J., Abrams S.I. How tumours escape mass destruction. Oncogene 2008, 27:5894-5903.
    • (2008) Oncogene , vol.27 , pp. 5894-5903
    • Stewart, T.J.1    Abrams, S.I.2
  • 3
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: from immunosurveillance to tumor escape
    • Dunn G., Bruce A., Ikeda H., Old L., Schreiber R. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 2002, 3:991-998.
    • (2002) Nat Immunol , vol.3 , pp. 991-998
    • Dunn, G.1    Bruce, A.2    Ikeda, H.3    Old, L.4    Schreiber, R.5
  • 4
    • 13744253833 scopus 로고    scopus 로고
    • Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy
    • Blank C., Gajewski T., Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother 2005, 54:307-314.
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 307-314
    • Blank, C.1    Gajewski, T.2    Mackensen, A.3
  • 5
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation
    • Freeman G.J., Long A.J., Iwai Y., Bourque K., Chernova T., Nishimura H., et al. Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation. J Exp Med 2000, 192:1027-1034.
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 7
    • 84896713991 scopus 로고    scopus 로고
    • The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone
    • Afreen S., Dermime S. The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone. Hematol Oncol Stem Cell Ther 2014, 7:1-17.
    • (2014) Hematol Oncol Stem Cell Ther , vol.7 , pp. 1-17
    • Afreen, S.1    Dermime, S.2
  • 8
    • 84923072443 scopus 로고    scopus 로고
    • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer
    • Azuma K., Ota K., Kawahara A., Hattori S., Iwama E., Harada T., et al. Association of PD-L1 overexpression with activating EGFR mutations in surgically resected non-small cell lung cancer. Ann Oncol 2014, 25:1935-1940.
    • (2014) Ann Oncol , vol.25 , pp. 1935-1940
    • Azuma, K.1    Ota, K.2    Kawahara, A.3    Hattori, S.4    Iwama, E.5    Harada, T.6
  • 10
    • 84873666114 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study
    • Chen Y., Mu C., Huang J. Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study. Tumori 2012, 98:751-755.
    • (2012) Tumori , vol.98 , pp. 751-755
    • Chen, Y.1    Mu, C.2    Huang, J.3
  • 11
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu C., Huang J., Chen Y., Chen C., Zhang X. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 2011, 28:682-688.
    • (2011) Med Oncol , vol.28 , pp. 682-688
    • Mu, C.1    Huang, J.2    Chen, Y.3    Chen, C.4    Zhang, X.5
  • 12
    • 84897404380 scopus 로고    scopus 로고
    • Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
    • Yang C., Lin M., Chang Y., Wu C., Yang P. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer 2014, 50:1361-1369.
    • (2014) Eur J Cancer , vol.50 , pp. 1361-1369
    • Yang, C.1    Lin, M.2    Chang, Y.3    Wu, C.4    Yang, P.5
  • 13
    • 34247532726 scopus 로고    scopus 로고
    • Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    • Nomi T., Sho M., Akahori T., Hamada K., Kubo A., Kanehiro H., et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007, 13:2151-2157.
    • (2007) Clin Cancer Res , vol.13 , pp. 2151-2157
    • Nomi, T.1    Sho, M.2    Akahori, T.3    Hamada, K.4    Kubo, A.5    Kanehiro, H.6
  • 14
    • 84877704099 scopus 로고    scopus 로고
    • Clinical impact of programmed cell death ligand 1 expression in colorectal cancer
    • Droeser R.A., Hirt C., Viehl C.T., Frey D.M., Nebiker C., Huber X., et al. Clinical impact of programmed cell death ligand 1 expression in colorectal cancer. Eur J Cancer 2013, 49:2233-2242.
    • (2013) Eur J Cancer , vol.49 , pp. 2233-2242
    • Droeser, R.A.1    Hirt, C.2    Viehl, C.T.3    Frey, D.M.4    Nebiker, C.5    Huber, X.6
  • 15
    • 33745491116 scopus 로고    scopus 로고
    • Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance
    • Wu C., Zhu Y., Jiang J., Zhao J., Zhang X., Xu N. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 2006, 108:19-24.
    • (2006) Acta Histochem , vol.108 , pp. 19-24
    • Wu, C.1    Zhu, Y.2    Jiang, J.3    Zhao, J.4    Zhang, X.5    Xu, N.6
  • 16
    • 84901044976 scopus 로고    scopus 로고
    • In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas
    • Schalper K.A., Velcheti V., Carvajal D., Wimberly H., Brown J., Pusztai L., et al. In situ tumor PD-L1 mRNA expression is associated with increased TILs and better outcome in breast carcinomas. Clin Cancer Res 2014, 20:2773-2782.
    • (2014) Clin Cancer Res , vol.20 , pp. 2773-2782
    • Schalper, K.A.1    Velcheti, V.2    Carvajal, D.3    Wimberly, H.4    Brown, J.5    Pusztai, L.6
  • 17
    • 33847611968 scopus 로고    scopus 로고
    • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer
    • Hamanishi J., Mandai M., Iwasaki M., Okazaki T., Tanaka Y., Yamaguchi K., et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci 2007, 104:3360-3365.
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 3360-3365
    • Hamanishi, J.1    Mandai, M.2    Iwasaki, M.3    Okazaki, T.4    Tanaka, Y.5    Yamaguchi, K.6
  • 18
    • 70350247885 scopus 로고    scopus 로고
    • Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma
    • Karim R., Jordanova E.S., Piersma S.J., Kenter G.G., Chen L., Boer J.M., et al. Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma. Clin Cancer Res 2009, 15:6341-6347.
    • (2009) Clin Cancer Res , vol.15 , pp. 6341-6347
    • Karim, R.1    Jordanova, E.S.2    Piersma, S.J.3    Kenter, G.G.4    Chen, L.5    Boer, J.M.6
  • 19
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson R., Kuntz S., Leibovich B., Dong H., Lohse C., Webster W., et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 2006, 66:3381-3385.
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.1    Kuntz, S.2    Leibovich, B.3    Dong, H.4    Lohse, C.5    Webster, W.6
  • 20
    • 34248586083 scopus 로고    scopus 로고
    • Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers
    • Nakanishi J., Wada Y., Matsumoto K., Azuma M., Kikuchi K., Ueda S. Overexpression of B7-H1 (PD-L1) significantly associates with tumor grade and postoperative prognosis in human urothelial cancers. Cancer Immunol Immunother 2007, 56:1173-1182.
    • (2007) Cancer Immunol Immunother , vol.56 , pp. 1173-1182
    • Nakanishi, J.1    Wada, Y.2    Matsumoto, K.3    Azuma, M.4    Kikuchi, K.5    Ueda, S.6
  • 21
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • Hino R., Kabashima K., Kato Y., Yagi H., Nakamura M., Honjo T., et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer 2010, 116:1757-1766.
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3    Yagi, H.4    Nakamura, M.5    Honjo, T.6
  • 22
    • 84926678589 scopus 로고    scopus 로고
    • PD-L1 expression in melanoma has prognostic significance but shows marked heterogeneity within and between patients- implications for anti-PD-1/PD-L1 clinical trials
    • Madore J., Vilain R., Menzies A., Kakavand H., Willmott J., Hyman J., et al. PD-L1 expression in melanoma has prognostic significance but shows marked heterogeneity within and between patients- implications for anti-PD-1/PD-L1 clinical trials. Pigment Cell Melanoma Res 2015, 28:245-253.
    • (2015) Pigment Cell Melanoma Res , vol.28 , pp. 245-253
    • Madore, J.1    Vilain, R.2    Menzies, A.3    Kakavand, H.4    Willmott, J.5    Hyman, J.6
  • 23
    • 84859128199 scopus 로고    scopus 로고
    • Colocalization of Inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
    • Taube J., Anders R., Young G., Xu H., Sharma R., McMiller T., et al. Colocalization of Inflammatory response with B7-H1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med 2012, 4:127-137.
    • (2012) Sci Transl Med , vol.4 , pp. 127-137
    • Taube, J.1    Anders, R.2    Young, G.3    Xu, H.4    Sharma, R.5    McMiller, T.6
  • 24
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwa Y., Ishida M., Tanaka Y., Okazaki T., Honjo T., Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 2002, 99:12293-12297.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12293-12297
    • Iwa, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 25
    • 0141953992 scopus 로고    scopus 로고
    • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    • Strome S.E., Dong H., Tamura H., Voss S.G., Flies D.B., Tamada K., et al. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res 2003, 63:6501-6505.
    • (2003) Cancer Res , vol.63 , pp. 6501-6505
    • Strome, S.E.1    Dong, H.2    Tamura, H.3    Voss, S.G.4    Flies, D.B.5    Tamada, K.6
  • 26
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    • Zhang Y., Huang S., Gong D., Qin Y., Shen Q. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. Cell Mol Immunol 2010, 7:389-395.
    • (2010) Cell Mol Immunol , vol.7 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3    Qin, Y.4    Shen, Q.5
  • 27
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • Brahmer J.R., Drake C.G., Wollner I., Powderly J.D., Picus J., Sharfman W.H., et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol 2010, 28:3167-3175.
    • (2010) J Clin Oncol , vol.28 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3    Powderly, J.D.4    Picus, J.5    Sharfman, W.H.6
  • 28
  • 30
    • 15744373791 scopus 로고    scopus 로고
    • IARC Press, Lyon, W.D. Travis, E. Brambilla, H.K. Muller-Hermelink, C.C. Harris (Eds.)
    • World Health Organisation Classification of Tumours Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart 2004, IARC Press, Lyon. W.D. Travis, E. Brambilla, H.K. Muller-Hermelink, C.C. Harris (Eds.).
    • (2004) Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart
  • 31
    • 64249099411 scopus 로고    scopus 로고
    • Springer, New York
    • American Joint Committee on Cancer AJCC Cancer Staging Manual 2010, Springer, New York. 7th ed.
    • (2010) AJCC Cancer Staging Manual
  • 32
  • 33
    • 47149091701 scopus 로고    scopus 로고
    • Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions
    • Cooper W., Kohonen-Corish M., Zhuang L., McCaughan B., Kennedy C., Screaton G., et al. Role and prognostic significance of tumor necrosis factor-related apoptosis-inducing ligand death receptor DR5 in nonsmall-cell lung cancer and precursor lesions. Cancer 2008, 113:135-142.
    • (2008) Cancer , vol.113 , pp. 135-142
    • Cooper, W.1    Kohonen-Corish, M.2    Zhuang, L.3    McCaughan, B.4    Kennedy, C.5    Screaton, G.6
  • 34
    • 79959908105 scopus 로고    scopus 로고
    • Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer
    • Selinger C., Cooper W., Al-Sohaily S., Mladenova D., Pangon L., Kennedy C., et al. Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer. J Thorac Oncol 2011, 6:1-11.
    • (2011) J Thorac Oncol , vol.6 , pp. 1-11
    • Selinger, C.1    Cooper, W.2    Al-Sohaily, S.3    Mladenova, D.4    Pangon, L.5    Kennedy, C.6
  • 35
    • 84875392086 scopus 로고    scopus 로고
    • Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma
    • Yip P., Yu B., Cooper W., Selinger C., Ng C., Kennedy C., et al. Patterns of DNA mutations and ALK rearrangement in resected node negative lung adenocarcinoma. J Thorac Oncol 2013, 8:408-414.
    • (2013) J Thorac Oncol , vol.8 , pp. 408-414
    • Yip, P.1    Yu, B.2    Cooper, W.3    Selinger, C.4    Ng, C.5    Kennedy, C.6
  • 36
    • 84889078337 scopus 로고    scopus 로고
    • Testing for ALK rearrangement in lung adenocarcinoma - a multicenter comparison of immunohistochemisty and fluorescent in situ hybridization
    • Selinger C.I., Rogers T.M., Russell P.A., O'Toole S.A., Yip P.Y., Wright G.M., et al. Testing for ALK rearrangement in lung adenocarcinoma - a multicenter comparison of immunohistochemisty and fluorescent in situ hybridization. Mod Pathol 2013, 26:1545-1633.
    • (2013) Mod Pathol , vol.26 , pp. 1545-1633
    • Selinger, C.I.1    Rogers, T.M.2    Russell, P.A.3    O'Toole, S.A.4    Yip, P.Y.5    Wright, G.M.6
  • 37
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • Konishi J., Yamazaki K., Azuma M., Kinoshita I., Dosaka-Akita H., Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res 2004, 10:5094-5100.
    • (2004) Clin Cancer Res , vol.10 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3    Kinoshita, I.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 39
    • 84973390256 scopus 로고    scopus 로고
    • Characterization of PD-L1 expression and assessment of association with tumor histology and gene expression status in pretreatment non-small cell lung cancer (NSCLC) tumor specimens
    • Harbison C., Kurland J., Cogswell J., Hu X., Han X., Horak C., et al. Characterization of PD-L1 expression and assessment of association with tumor histology and gene expression status in pretreatment non-small cell lung cancer (NSCLC) tumor specimens. J Thorac Oncol 2013, 8:s1092.
    • (2013) J Thorac Oncol , vol.8 , pp. s1092
    • Harbison, C.1    Kurland, J.2    Cogswell, J.3    Hu, X.4    Han, X.5    Horak, C.6
  • 40
    • 84929713513 scopus 로고    scopus 로고
    • PD-L1 expression and survival in patients with non-small cell lung cancer (NSCLC) in Korea
    • [suppl; abstr 8066]
    • Sun J., Zhou W., Choi Y., Choi S., Kim S., Wang Z., et al. PD-L1 expression and survival in patients with non-small cell lung cancer (NSCLC) in Korea. J Clin Oncol 2014, 32(5s). [suppl; abstr 8066].
    • (2014) J Clin Oncol , vol.32 , Issue.5 s
    • Sun, J.1    Zhou, W.2    Choi, Y.3    Choi, S.4    Kim, S.5    Wang, Z.6
  • 41
    • 84937635456 scopus 로고    scopus 로고
    • Immunotherapy prospects in the treatment of lung cancer and mesothelioma
    • Aerts J., Lievense L., Hoogsteden H., Hegmans J. Immunotherapy prospects in the treatment of lung cancer and mesothelioma. Transl Lung Cancer Res 2014, 3:34-45.
    • (2014) Transl Lung Cancer Res , vol.3 , pp. 34-45
    • Aerts, J.1    Lievense, L.2    Hoogsteden, H.3    Hegmans, J.4
  • 43
    • 84926421308 scopus 로고    scopus 로고
    • Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer
    • [E-pub ahead of print]
    • Ishii H., Azuma K., Kawahara A., Yamada K., Imamura Y., Tokito T., et al. Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer. J Thorac Oncol 2014, [E-pub ahead of print].
    • (2014) J Thorac Oncol
    • Ishii, H.1    Azuma, K.2    Kawahara, A.3    Yamada, K.4    Imamura, Y.5    Tokito, T.6
  • 44
    • 84973333260 scopus 로고    scopus 로고
    • Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications
    • Zheng X., Bu Z., Liu X., Zhang L., Li Z., Wu A., et al. Level of circulating PD-L1 expression in patients with advanced gastric cancer and its clinical implications. Chin J Cancer Res 2014, 10:4-11.
    • (2014) Chin J Cancer Res , vol.10 , pp. 4-11
    • Zheng, X.1    Bu, Z.2    Liu, X.3    Zhang, L.4    Li, Z.5    Wu, A.6
  • 45
    • 84973390497 scopus 로고    scopus 로고
    • PD-L1 expression and survival among advanced non-small cell lung cancer (NSCLC) patients treated with chemotherapy
    • Sorenson S., Zhou W., Dolled-Filhart M., Georgsen J., Wang Z., Emancipator K., et al. PD-L1 expression and survival among advanced non-small cell lung cancer (NSCLC) patients treated with chemotherapy. Ann Oncol 2014, 25(Suppl. 4):iv426-iv470.
    • (2014) Ann Oncol , vol.25 , pp. iv426-iv470
    • Sorenson, S.1    Zhou, W.2    Dolled-Filhart, M.3    Georgsen, J.4    Wang, Z.5    Emancipator, K.6
  • 46
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death ligand-1 and programmed death ligand-2 expression in human esophageal cancer
    • Ohigashi Y., Sho M., Yamada Y., Tsurui Y., Hamada K., Ikeda N., et al. Clinical significance of programmed death ligand-1 and programmed death ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005, 11:2947-2953.
    • (2005) Clin Cancer Res , vol.11 , pp. 2947-2953
    • Ohigashi, Y.1    Sho, M.2    Yamada, Y.3    Tsurui, Y.4    Hamada, K.5    Ikeda, N.6
  • 47
    • 61549122071 scopus 로고    scopus 로고
    • Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma
    • Gao Q., Wang X.-Y., Qiu S.-J., Yamato I., Sho M., Nakajima Y., et al. Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma. Clin Cancer Res 2009, 15:971-979.
    • (2009) Clin Cancer Res , vol.15 , pp. 971-979
    • Gao, Q.1    Wang, X.-Y.2    Qiu, S.-J.3    Yamato, I.4    Sho, M.5    Nakajima, Y.6


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