MiR-20b, -21, and -130b inhibit PTEN expression resulting in B7-H1 over-expression in advanced colorectal cancer

Human Immunology

Volumn 75, Issue 4, 2014, Pages 348-353

  Zhu, Jianjie ^a,c   Chen, Lanxin ^a   Zou, Lingting ^a   Yang, Panpan ^b   Wu, Ruirong ^b   Mao, Yong ^b   Zhou, Huan ^b   Li, Rui ^c   Wang, Kaicai ^d   Wang, Weipeng ^a   Hua, Dong ^b   Zhang, Xueguang ^c  

^a SOOCHOW UNIVERSITY   (China)

^b Soochow University   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^d Hospital of Orthopedics of Guizhou Province   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 130B; MICRORNA 20B; MICRORNA 21; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROGRAMMED DEATH 1 LIGAND 1; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUCIFERASE ASSAY; MALE; MIDDLE AGED; NONHUMAN; PRIORITY JOURNAL;

3' UNTRANSLATED REGIONS; ADULT; AGED; ANIMALS; ANTIGENS, CD274; CELL LINE; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PTEN PHOSPHOHYDROLASE; RNA INTERFERENCE;

EID: 84895556999     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2014.01.006     Document Type: Article

References (30)

1. Parkin D.M., Bray F., Ferlay J., et al. Global cancer statistics, 2002. CA Cancer J Clin 2005, 55:74-108.
2. Zou W., Chen L. Inhibitory B7-family molecules in the tumour microenvironment. Nat Rev Immunol 2008, 8:467-477.
3. Dong H., Zhu G., Tamada K., et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999, 5:1365-1369.
4. Dong H., Strome S.E., Salomao D.R., et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8:793-800.
5. Thompson R.H., Gillett M.D., Cheville J.C., et al. Costimulatory B7-H1 in renal cell carcinoma patients: indicator of tumor aggressiveness and potential therapeutic target. Proc Natl Acad Sci U S A 2004, 101:17174-17179.
6. Ohigashi Y., Sho M., Yamada Y., et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005, 11:2947-2953.
7. Wu C., Zhu Y., Jiang J., et al. Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem 2006, 108:19-24.
8. Ghebeh H., Mohammed S., Al-Omair A., et al. The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia 2006, 8:190-198.
9. Hamanishi J., Mandai M., Iwasaki M., et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci U S A 2007, 104:3360-3365.
10. Inman B.A., Sebo T.J., Frigola X., et al. PD-L1 (B7-H1) expression by urothelial carcinoma of the bladder and BCG-induced granulomata: associations with localized stage progression. Cancer 2007, 109:1499-1505.
11. Nomi T., Sho M., Akahori T., et al. Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res 2007, 13:2151-2157.
12. Hua D., Sun J., Mao Y., et al. B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma. World J Gastroenterol 2012, 18:971-978.
13. Makeyev E.V., Maniatis T. Multilevel regulation of gene expression by microRNAs. Science 2008, 319:1789-1790.
14. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136:215-233.
15. Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269.
16. Parsa A.T., Waldron J.S., Panner A., et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med 2007, 13:84-88.
17. Wang W., Sun J., Li F., et al. A frequent somatic mutation in CD274 3'-UTR leads to protein over-expression in gastric cancer by disrupting miR-570 binding. Hum Mutat 2012, 33:480-484.
18. Gong A.Y., Zhou R., Hu G., et al. MicroRNA-513 regulates B7-H1 translation and is involved in IFN-gamma-induced B7-H1 expression in cholangiocytes. J Immunol 2009, 182:1325-1333.
19. Sun J., Xu K., Wu C., et al. PD-L1 expression analysis in gastric carcinoma tissue and blocking of tumor-associated PD-L1 signaling by two functional monoclonal antibodies. Tissue antigens 2007, 69:19-27.
20. Ma Y., Zhang P., Yang J., et al. Candidate microRNA biomarkers in human colorectal cancer: systematic review profiling studies and experimental validation. Int J Cancer 2012, 130:2077-2087.
21. Xu X.D., Song X.W., Li Q., et al. Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy. J Cell Physiol 2012, 227:1391-1398.
22. Kong G., Zhang J., Zhang S., et al. Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model. PLoS One 2011, 6:e19518.
23. Yang H., Kong W., He L., et al. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res 2008, 68:425-433.
24. Meng F., Henson R., Wehbe-Janek H., et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007, 133:647-658.
25. Liu J., Hamrouni A., Wolowiec D., et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 2007, 110:296-304.
26. Marzec M., Zhang Q., Goradia A., et al. Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1). Proc Natl Acad Sci U S A 2008, 105:20852-20857.
27. Kondo A., Yamashita T., Tamura H., et al. Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes. Blood 2010, 116:1124-1131.
28. Wu H., Goel V., Haluska F.G. PTEN signaling pathways in melanoma. Oncogene 2003, 22:3113-3122.
29. Sawai H., Yasuda A., Ochi N., et al. Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survival. BMC Gastroenterol 2008, 8:56.
30. Li D., Ilnytskyy Y., Kovalchuk A., et al. Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer. Oncotarget 2013, 4:1373-1387.