Inhibition of CBLB protects from lethal Candida albicans sepsis

Nature Medicine

Volumn 22, Issue 8, 2016, Pages 915-923

  Wirnsberger, Gerald ^a   Zwolanek, Florian ^b   Asaoka, Tomoko ^a   Kozieradzki, Ivona ^a   Tortola, Luigi ^a   Wimmer, Reiner A ^a   Kavirayani, Anoop ^c   Fresser, Friedrich ^d   Baier, Gottfried ^d   Langdon, Wallace Y ^e   Ikeda, Fumiyo ^a   Kuchler, Karl ^b   Penninger, Josef M ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Vienna Biocenter   (Austria)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA GLUCAN; C TYPE LECTIN RECEPTOR; CBLB ENZYME; DECTIN 1; DECTIN 2; DYNASORE; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; LECTIN RECEPTOR; PROTEIN KINASE SYK; PROTEIN TYROSINE PHOSPHATASE SHP 2; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CASP8 PROTEIN, MOUSE; CASPASE 8; CBL PROTEIN; CBLB PROTEIN, MOUSE; CYTOKINE; LECTIN; PEPTIDE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; B LYMPHOCYTE; BONE MARROW; CANDIDA ALBICANS; CANDIDA DUBLINIENSIS; CANDIDA GLABRATA; CANDIDEMIA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FUNGICIDAL ACTIVITY; GENE DELETION; IMMUNOCOMPETENT CELL; IMMUNOPRECIPITATION; LISTERIA MONOCYTOGENES; MACROPHAGE; MASS SPECTROMETRY; MONOCYTE; MORBIDITY; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PICHIA KUDRIAVZEVII; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN INFECTION; SURVIVAL; T LYMPHOCYTE; UBIQUITINATION; WILD TYPE; YEAST CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOLOGY; INVASIVE CANDIDIASIS; KIDNEY; KNOCKOUT MOUSE; METABOLISM; POLYMERASE CHAIN REACTION; SEPSIS; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CANDIDA ALBICANS; CANDIDIASIS, INVASIVE; CASPASE 8; CYTOKINES; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOPRECIPITATION; KIDNEY; LECTINS, C-TYPE; MACROPHAGES; MICE; MICE, KNOCKOUT; MONOCYTES; NEUTROPHILS; PEPTIDES; PHAGOCYTOSIS; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-CBL; REACTIVE OXYGEN SPECIES; SEPSIS; UBIQUITINATION;

EID: 84978741609     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4134     Document Type: Article

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