Efficient biosynthesis of (2S)-pinocembrin from D-glucose by integrating engineering central metabolic pathways with a pH-shift control strategy

Bioresource Technology

Volumn 218, Issue , 2016, Pages 999-1007

  Wu, Junjun ^a,c   Zhang, Xia ^a,c   Zhou, Jingwen ^b   Dong, Mingsheng ^a,c  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b JIANGNAN UNIVERSITY   (China)

^c INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

CRISPRi; Gene repressing; Low cost production; Microorganisms; Plant natural products

Indexed keywords

BIOCHEMISTRY; CARBON; CATALYSIS; ESCHERICHIA COLI; MICROORGANISMS; PH; PH EFFECTS;

BUFFERING CAPACITIES; CONVENTIONAL EXTRACTION; CRISPRI; LOW COSTS; MICROBIAL FERMENTATION; NATURAL PRODUCTS; PH CONTROL STRATEGIES; PH-SHIFT CONTROL STRATEGIES;

FERMENTATION;

BIOTIN; GLUCOSE; MALONIC ACID; MALONYL COENZYME A; NARINGENIN; PINOCEMBRINE; FLAVANONE DERIVATIVE;

BACTERIUM; BIOTECHNOLOGY; CARBON FLUX; CATALYSIS; COST ANALYSIS; ENZYME ACTIVITY; FERMENTATION; GENE EXPRESSION; GENETIC ENGINEERING; GLUCOSE; MICROBIAL ACTIVITY; PLANT COMMUNITY;

ARTICLE; BACTERIUM CULTURE; CATALYSIS; CELL CULTURE; CELL ENGINEERING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROL STRATEGY; DRUG SYNTHESIS; NONHUMAN; PH; PRIORITY JOURNAL; BIOSYNTHESIS; CHEMISTRY; ESCHERICHIA COLI; FERMENTATION; METABOLISM;

ESCHERICHIA COLI;

ESCHERICHIA COLI; FERMENTATION; FLAVANONES; GLUCOSE; MALONYL COENZYME A; METABOLIC NETWORKS AND PATHWAYS;

EID: 84978698481     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2016.07.066     Document Type: Article

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