Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

Autophagy

Volumn 12, Issue 9, 2016, Pages 1521-1537

  Li, Xu ^a   Zhu, Feng ^a   Jiang, Jianxin ^b   Sun, Chengyi ^c   Zhong, Qing ^d   Shen, Ming ^a   Wang, Xin ^a   Tian, Rui ^a   Shi, Chengjian ^a   Xu, Meng ^a   Peng, Feng ^a   Guo, Xingjun ^a   Hu, Jun ^e   Ye, Dawei ^a   Wang, Min ^a   Qin, Renyi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUBEI CANCER HOSPITAL   (China)

^c GUIZHOU MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

autophagy; ER stress; proteasome; SNAREs; withaferin A

Indexed keywords

ALOXISTATIN; BAFILOMYCIN A1; BORTEZOMIB; CHLOROQUINE; CISPLATIN; EPIRUBICIN; FLUOROURACIL; GEMCITABINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PACLITAXEL; PEPSTATIN; PROTEASOME; RAB PROTEIN; RAB11 PROTEIN; RAPAMYCIN; SNARE PROTEIN; UBIQUITIN; UBIQUITINATED PROTEIN; WITHAFERIN A; ANTINEOPLASTIC AGENT; PLANT EXTRACT; PROTEASOME INHIBITOR; SEQUESTOSOME 1; SQSTM1 PROTEIN, HUMAN; WITHANOLIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CELL VIABILITY; CELL VIABILITY ASSAY; COMPARATIVE STUDY; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYSOSOME; MOUSE; NONHUMAN; PANCREAS CANCER; TRANSIENT TRANSFECTION; TRANSMISSION ELECTRON MICROSCOPY; TUMOR XENOGRAFT; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; WITHANIA SOMNIFERA; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL DEATH; CELL SURVIVAL; DRUG EFFECTS; HOMEOSTASIS; MALE; METABOLISM; PANCREAS TUMOR; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGOSOMES; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; HOMEOSTASIS; HUMANS; LYSOSOMES; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PLANT EXTRACTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; RNA INTERFERENCE; SEQUESTOSOME-1 PROTEIN; UBIQUITIN; WITHANOLIDES;

EID: 84978513118     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2016.1191722     Document Type: Article

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