A novel combination of withaferin A and sorafenib shows synergistic efficacy against both papillary and anaplastic thyroid cancers

American Journal of Surgery

Volumn 204, Issue 6, 2012, Pages 895-901

  Cohen, Stephanie M ^a   Mukerji, Ridhwi ^a   Timmermann, Barbara N ^b   Samadi, Abbas K ^a   Cohen, Mark S ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Anaplastic thyroid cancer; Novel therapy; Papillary thyroid cancer; Sorafenib; Synergistic effects; Withaferin A

Indexed keywords

B RAF KINASE; CASPASE 3; RAF PROTEIN; SORAFENIB; WITHAFERIN A;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE ARREST; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONCENTRATION; DRUG EFFICACY; DRUG POTENTIATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; OUTCOME ASSESSMENT; PRIORITY JOURNAL; THYROID CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZENESULFONATES; BLOTTING, WESTERN; CARCINOMA; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; PYRIDINES; THYROID NEOPLASMS; WITHANOLIDES;

EID: 84870975246     PISSN: 00029610     EISSN: 18791883     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2012.07.027     Document Type: Article

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