메뉴 건너뛰기




Volumn 34, Issue 7, 2016, Pages 1105-1110

Functional genomics in osteoarthritis: Past, present, and future

Author keywords

functional genomics; gene expression; methylation; osteoarthritis; proteomics

Indexed keywords

WNT PROTEIN;

EID: 84978477080     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.23296     Document Type: Review
Times cited : (25)

References (48)
  • 1
    • 0029792745 scopus 로고    scopus 로고
    • Occurrence of osteoarthritis of the peripheral joints in European populations
    • Petersson IF. 1996. Occurrence of osteoarthritis of the peripheral joints in European populations. Ann Rheum Dis 55:659–661.
    • (1996) Ann Rheum Dis , vol.55 , pp. 659-661
    • Petersson, I.F.1
  • 4
    • 84883445177 scopus 로고    scopus 로고
    • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
    • Evangelou E, Kerkhof HJ, Styrkarsdottir U, et al. 2014. A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis 73:2130–2136.
    • (2014) Ann Rheum Dis , vol.73 , pp. 2130-2136
    • Evangelou, E.1    Kerkhof, H.J.2    Styrkarsdottir, U.3
  • 5
    • 84890168801 scopus 로고    scopus 로고
    • Advances in osteoarthritis genetics
    • Panoutsopoulou K, Zeggini E. 2013. Advances in osteoarthritis genetics. J Med Genet 50:715–724.
    • (2013) J Med Genet , vol.50 , pp. 715-724
    • Panoutsopoulou, K.1    Zeggini, E.2
  • 6
    • 84899638695 scopus 로고    scopus 로고
    • Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
    • Styrkarsdottir U, Thorleifsson G, Helgadottir HT, et al. 2014. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nat Genet 46:498–502.
    • (2014) Nat Genet , vol.46 , pp. 498-502
    • Styrkarsdottir, U.1    Thorleifsson, G.2    Helgadottir, H.T.3
  • 7
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen H, Estrada K, Lettre G, et al. 2010. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467:832–838.
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3
  • 8
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ, Berndt SI, et al. 2010. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42:937–948.
    • (2010) Nat Genet , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 9
    • 84922240639 scopus 로고    scopus 로고
    • Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches
    • den Hollander W, Ramos YFM, Bos SD, et al. 2014. Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches. Ann Rheum Dis 73:2208–2212.
    • (2014) Ann Rheum Dis , vol.73 , pp. 2208-2212
    • den Hollander, W.1    Ramos, Y.F.M.2    Bos, S.D.3
  • 10
    • 84895419805 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
    • Fernández-Tajes J, Soto-Hermida A, Vázquez-Mosquera ME, et al. 2014. Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis 73:668–677.
    • (2014) Ann Rheum Dis , vol.73 , pp. 668-677
    • Fernández-Tajes, J.1    Soto-Hermida, A.2    Vázquez-Mosquera, M.E.3
  • 11
    • 84908381697 scopus 로고    scopus 로고
    • Genome-eide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
    • Jeffries MA, Donica M, Baker LW, et al. 2014. Genome-eide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol 66:2804–2815.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2804-2815
    • Jeffries, M.A.1    Donica, M.2    Baker, L.W.3
  • 12
    • 84911447416 scopus 로고    scopus 로고
    • Epigenetic differences in human cartilage between mild and severe OA
    • Moazedi-Fuerst FC, Hofner M, Gruber G, et al. 2014. Epigenetic differences in human cartilage between mild and severe OA. J Orthop Res 32:1636–1645.
    • (2014) J Orthop Res , vol.32 , pp. 1636-1645
    • Moazedi-Fuerst, F.C.1    Hofner, M.2    Gruber, G.3
  • 13
    • 84904667534 scopus 로고    scopus 로고
    • Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
    • Rushton MD, Reynard LN, Barter MJ, et al. 2014. Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol 66:2450–2460.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 2450-2460
    • Rushton, M.D.1    Reynard, L.N.2    Barter, M.J.3
  • 14
    • 84897020095 scopus 로고    scopus 로고
    • A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes
    • Taylor SEB, Smeriglio P, Dhulipala L, et al. 2014. A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes. Arthritis Rheumatol 66:90–100.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 90-100
    • Taylor, S.E.B.1    Smeriglio, P.2    Dhulipala, L.3
  • 15
    • 84903726760 scopus 로고    scopus 로고
    • Mouse models of osteoarthritis: modelling risk factors and assessing outcomes
    • Fang H, Beier F. 2014. Mouse models of osteoarthritis: modelling risk factors and assessing outcomes. Nat Rev Rheumatol 10:413–421.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 413-421
    • Fang, H.1    Beier, F.2
  • 16
    • 84872671475 scopus 로고    scopus 로고
    • Relevance of zebrafish as an OA research model
    • van der Kraan PM. 2013. Relevance of zebrafish as an OA research model. Osteoarthritis Cartilage 21:261–262.
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 261-262
    • van der Kraan, P.M.1
  • 17
    • 84924916657 scopus 로고    scopus 로고
    • Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments
    • Chou CH, Lee MTM, Song IW, et al. 2015. Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. Osteoarthritis Cartilage 23:571–580.
    • (2015) Osteoarthritis Cartilage , vol.23 , pp. 571-580
    • Chou, C.H.1    Lee, M.T.M.2    Song, I.W.3
  • 18
    • 60249098721 scopus 로고    scopus 로고
    • Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    • Geyer M, Grässel S, Straub RH, et al. 2009. Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 17:328–335.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 328-335
    • Geyer, M.1    Grässel, S.2    Straub, R.H.3
  • 19
    • 77950021301 scopus 로고    scopus 로고
    • Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis
    • Karlsson C, Dehne T, Lindahl A, et al. 2010. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 18:581–592.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 581-592
    • Karlsson, C.1    Dehne, T.2    Lindahl, A.3
  • 20
    • 84939458768 scopus 로고    scopus 로고
    • Transcriptome-wide analysis of messenger RNA decay in normal and osteoarthritic human articular chondrocytes
    • Tew SR, McDermott BT, Fentem RB, et al. 2014. Transcriptome-wide analysis of messenger RNA decay in normal and osteoarthritic human articular chondrocytes. Arthritis Rheumatol 66:3052–3061.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 3052-3061
    • Tew, S.R.1    McDermott, B.T.2    Fentem, R.B.3
  • 21
    • 84925118215 scopus 로고    scopus 로고
    • Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients
    • Fu M, Huang G, Zhang Z, et al. 2015. Expression profile of long noncoding RNAs in cartilage from knee osteoarthritis patients. Osteoarthritis Cartilage 23:423–432.
    • (2015) Osteoarthritis Cartilage , vol.23 , pp. 423-432
    • Fu, M.1    Huang, G.2    Zhang, Z.3
  • 22
    • 84898656101 scopus 로고    scopus 로고
    • Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis
    • Liu Q, Zhang X, Dai L, et al. 2014. Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol 66:969–978.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 969-978
    • Liu, Q.1    Zhang, X.2    Dai, L.3
  • 23
    • 84898670942 scopus 로고    scopus 로고
    • Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane
    • Lambert C, Dubuc J-E, Montell E, et al. 2014. Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane. Arthritis Rheumatol 66:960–968.
    • (2014) Arthritis Rheumatol , vol.66 , pp. 960-968
    • Lambert, C.1    Dubuc, J.-E.2    Montell, E.3
  • 24
    • 84887550824 scopus 로고    scopus 로고
    • Genome-wide expression profiles of subchondral bone in osteoarthritis
    • Chou CH, Wu CC, Song IW, et al. 2013. Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Res Ther 15:R190.
    • (2013) Arthritis Res Ther , vol.15 , pp. R190
    • Chou, C.H.1    Wu, C.C.2    Song, I.W.3
  • 25
    • 79959834855 scopus 로고    scopus 로고
    • Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis
    • Attur M, Belitskaya-Lévy I, Oh C, et al. 2011. Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheumatol 63:1908–1917.
    • (2011) Arthritis Rheumatol , vol.63 , pp. 1908-1917
    • Attur, M.1    Belitskaya-Lévy, I.2    Oh, C.3
  • 26
    • 39149086750 scopus 로고    scopus 로고
    • Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis
    • Ruiz-Romero C, Carreira V, Rego I, et al. 2008. Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis. Proteomics 8:495–507.
    • (2008) Proteomics , vol.8 , pp. 495-507
    • Ruiz-Romero, C.1    Carreira, V.2    Rego, I.3
  • 27
    • 38949207162 scopus 로고    scopus 로고
    • Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis
    • Lambrecht S, Verbruggen G, Verdonk PCM, et al. 2008. Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis. Osteoarthritis Cartilage 16:163–173.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 163-173
    • Lambrecht, S.1    Verbruggen, G.2    Verdonk, P.C.M.3
  • 28
    • 84884943914 scopus 로고    scopus 로고
    • Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients
    • Stenberg J, Rüetschi U, Skiöldebrand E, et al. 2013. Quantitative proteomics reveals regulatory differences in the chondrocyte secretome from human medial and lateral femoral condyles in osteoarthritic patients. Proteome Sci 11:43–43.
    • (2013) Proteome Sci , vol.11 , pp. 43
    • Stenberg, J.1    Rüetschi, U.2    Skiöldebrand, E.3
  • 29
    • 84875734633 scopus 로고    scopus 로고
    • Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues
    • Ritter SY, Subbaiah R, Bebek G, et al. 2013. Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheumatol 65:981–992.
    • (2013) Arthritis Rheumatol , vol.65 , pp. 981-992
    • Ritter, S.Y.1    Subbaiah, R.2    Bebek, G.3
  • 30
    • 34247847988 scopus 로고    scopus 로고
    • High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis
    • Gobezie R, Kho A, Krastins B, et al. 2007. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther 9:R36.
    • (2007) Arthritis Res Ther , vol.9 , pp. R36
    • Gobezie, R.1    Kho, A.2    Krastins, B.3
  • 31
    • 84871770976 scopus 로고    scopus 로고
    • Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
    • Delgado-Calle J, Fernández AF, Sainz J, et al. 2013. Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheumatol 65:197–205.
    • (2013) Arthritis Rheumatol , vol.65 , pp. 197-205
    • Delgado-Calle, J.1    Fernández, A.F.2    Sainz, J.3
  • 32
    • 84891790401 scopus 로고    scopus 로고
    • The NHGRI GWAS catalog, a curated resource of SNP-trait associations
    • Welter D, MacArthur J, Morales J, et al. 2014. The NHGRI GWAS catalog, a curated resource of SNP-trait associations. Nucl Acids Res 42:D1001–D1006.
    • (2014) Nucl Acids Res , vol.42 , pp. D1001-D1006
    • Welter, D.1    MacArthur, J.2    Morales, J.3
  • 33
    • 84864383496 scopus 로고    scopus 로고
    • Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA
    • Xu Y, Barter MJ, Swan DC, et al. 2012. Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA. Osteoarthritis Cartilage 20:1029–1038.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1029-1038
    • Xu, Y.1    Barter, M.J.2    Swan, D.C.3
  • 34
    • 36949023800 scopus 로고    scopus 로고
    • Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling
    • Hopwood B, Tsykin A, Findlay DM, et al. 2007. Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling. Arthritis Res Ther 9:R100.
    • (2007) Arthritis Res Ther , vol.9 , pp. R100
    • Hopwood, B.1    Tsykin, A.2    Findlay, D.M.3
  • 35
    • 77957263965 scopus 로고    scopus 로고
    • Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis
    • Lamas JR, Rodríguez-Rodríguez L, Vigo AG, et al. 2010. Large-scale gene expression in bone marrow mesenchymal stem cells: a putative role for COL10A1 in osteoarthritis. Ann Rheum Dis 69:1880–1885.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1880-1885
    • Lamas, J.R.1    Rodríguez-Rodríguez, L.2    Vigo, A.G.3
  • 36
    • 46749083910 scopus 로고    scopus 로고
    • Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients
    • Rollín R, Marco F, Camafeita E, et al. 2008. Differential proteome of bone marrow mesenchymal stem cells from osteoarthritis patients. Osteoarthritis Cartilage 16:929–935.
    • (2008) Osteoarthritis Cartilage , vol.16 , pp. 929-935
    • Rollín, R.1    Marco, F.2    Camafeita, E.3
  • 37
    • 84925232257 scopus 로고    scopus 로고
    • Genes expressed in blood link osteoarthritis with apoptotic pathways
    • Ramos YFM, Bos SD, Lakenberg N, et al. 2014. Genes expressed in blood link osteoarthritis with apoptotic pathways. Ann Rheum Dis 73:1844–1853.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1844-1853
    • Ramos, Y.F.M.1    Bos, S.D.2    Lakenberg, N.3
  • 38
    • 0036090197 scopus 로고    scopus 로고
    • High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects
    • Felson DT, Nevitt MC, Zhang Y, et al. 2002. High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects. Arthritis Rheumatol 46:1217–1222.
    • (2002) Arthritis Rheumatol , vol.46 , pp. 1217-1222
    • Felson, D.T.1    Nevitt, M.C.2    Zhang, Y.3
  • 39
    • 84960876747 scopus 로고    scopus 로고
    • Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients
    • Zhang W, Sun G, Likhodii S, et al. 2016. Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients. Osteoarthritis Cartilage 24:827–834.
    • (2016) Osteoarthritis Cartilage , vol.24 , pp. 827-834
    • Zhang, W.1    Sun, G.2    Likhodii, S.3
  • 40
    • 84960130200 scopus 로고    scopus 로고
    • Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis
    • Prasadam I, Batra J, Perry S, et al. 2016. Systematic identification, characterization and target gene analysis of microRNAs involved in osteoarthritis subchondral bone pathogenesis. Calcif Tissue Int.
    • (2016) Calcif Tissue Int
    • Prasadam, I.1    Batra, J.2    Perry, S.3
  • 41
    • 84959213184 scopus 로고    scopus 로고
    • Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
    • Rushton MD, Reynard LN, Young DA, et al. 2015. Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk. Hum Mol Genet 24:7432–7444.
    • (2015) Hum Mol Genet , vol.24 , pp. 7432-7444
    • Rushton, M.D.1    Reynard, L.N.2    Young, D.A.3
  • 42
    • 0037083376 scopus 로고    scopus 로고
    • Capturing chromosome conformation
    • Dekker J, Rippe K, Dekker M, et al. 2002. Capturing chromosome conformation. Science 295:1306–1311.
    • (2002) Science , vol.295 , pp. 1306-1311
    • Dekker, J.1    Rippe, K.2    Dekker, M.3
  • 43
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, et al. 2007. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316:889–894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3
  • 44
    • 84940830979 scopus 로고    scopus 로고
    • FTO obesity variant circuitry and adipocyte browning in humans
    • Claussnitzer M, Dankel SN, Kim K-H, et al. 2015. FTO obesity variant circuitry and adipocyte browning in humans. N Engl J Med 373:895–907.
    • (2015) N Engl J Med , vol.373 , pp. 895-907
    • Claussnitzer, M.1    Dankel, S.N.2    Kim, K.-H.3
  • 45
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, Chylinski K, Fonfara I, et al. 2012. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337:816–821.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3
  • 46
    • 84900314611 scopus 로고    scopus 로고
    • CRISPR-Cas systems for editing, regulating and targeting genomes
    • Sander JD, Joung JK. 2014. CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol 32:347–355.
    • (2014) Nat Biotechnol , vol.32 , pp. 347-355
    • Sander, J.D.1    Joung, J.K.2
  • 47
    • 84938150955 scopus 로고    scopus 로고
    • Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage
    • den Hollander W, Ramos YFM, Bomer N, et al. 2015. Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage. Arthritis Rheumatol 67:2108–2116.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2108-2116
    • den Hollander, W.1    Ramos, Y.F.M.2    Bomer, N.3
  • 48
    • 84878237995 scopus 로고    scopus 로고
    • Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis
    • Mahjoub M, Berenbaum F, Houard X. 2012. Why subchondral bone in osteoarthritis? The importance of the cartilage bone interface in osteoarthritis. Osteoporos Int 23:841–846.
    • (2012) Osteoporos Int , vol.23 , pp. 841-846
    • Mahjoub, M.1    Berenbaum, F.2    Houard, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.