Large-scale gene expression in bone marrow mesenchymal stem cells: A putative role for COL10A1 in osteoarthritis

Annals of the Rheumatic Diseases

Volumn 69, Issue 10, 2010, Pages 1880-1885

  Lamas, José Ramón ^a   Rodríguez Rodríguez, Luis ^a   Vigo, Ana G ^a   Álvarez Lafuente, Roberto ^a   López Romero, Pedro ^b   Marco, Fernando ^a   Camafeita, Emilio ^b   Dopazo, Ana ^b   Callejas, Sergio ^b   Villafuertes, Esther ^a   Hoyas, José Antonio ^a   Tornero Esteban, María Pilar ^a   Urcelay, Elena ^a   Fernández Gutiérrez, Benjamín ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CATENIN; WNT PROTEIN; COLLAGEN TYPE 10;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CLINICAL ARTICLE; COL10A1 GENE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HIP FRACTURE; HUMAN; HUMAN TISSUE; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; UPREGULATION; BIOSYNTHESIS; BONE MARROW CELL; CELL CULTURE; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BONE MARROW CELLS; CELLS, CULTURED; CLUSTER ANALYSIS; COLLAGEN TYPE X; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77957263965     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.122564     Document Type: Article

References (47)

1. Driban JB, Sitler MR, Barbe MF, et al. Is osteoarthritis a heterogeneous disease that can be stratified into subsets? Clin Rheumatol 2010;29:123-31.
2. Brandt KD, Radin EL, Dieppe PA, et al. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 2006;65:1261-4.
3. Dieppe P. Subchondral bone should be the main target for the treatment of pain and disease progression in osteoarthritis. Osteoarthr Cartil 1999;7:325-6. (Pubitemid 29244113)
4. Valdes AM, Spector TD. The genetic epidemiology of osteoarthritis. Curr Opin Rheumatol 2010;22:139-43.
5. Aspden RM. Osteoarthritis: a problem of growth not decay? Rheumatology (Oxford) 2008;47:1452-60.
6. Newman B, Wallis GA. Skeletal dysplasias caused by a disruption of skeletal patterning and endochondral ossification. Clin Genet 2003;63:241-51.
7. Bruder SP, Jaiswal N, Haynesworth SE. Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 1997;64:278-94.
8. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
9. Caplan AI. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng 2005;11:1198-211.
10. Djouad F, Bouffi C, Ghannam S, et al. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheumatol 2009;5:392-9.
11. Murphy JM, Fink DJ, Hunziker EB, et al. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003;48:3464-74.
12. Barbash IM, Chouraqui P, Baron J, et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 2003;108:863-8.
13. Hofstetter CP, Schwarz EJ, Hess D, et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc Natl Acad Sci USA 2002;99:2199-204.
14. Liu G, Zhao L, Zhang W, et al. Repair of goat tibial defects with bone marrow stromal cells and beta-tricalcium phosphate. J Mater Sci Mater Med 2008;19:2367-76.
15. Petite H, Viateau V, Bensaïd W, et al. Tissue-engineered bone regeneration. Nat Biotechnol 2000;18:959-63.
16. Licatalosi DD, Darnell RB. RNA processing and its regulation: global insights into biological networks. Nat Rev Genet 2010;11:75-87.
17. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986;29:1039-49.
18. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
19. Rollín R, Alvarez-Lafuente R, Marco F, et al. Human parvovirus B19, varicella zoster virus, and human herpesvirus-6 in mesenchymal stem cells of patients with osteoarthritis: analysis with quantitative real-time polymerase chain reaction. Osteoarthr Cartil 2007;15:475-8.
20. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80.
21. Pachner A, Narayan K, Price N, et al. MxA gene expression analysis as an interferonbeta bioactivity measurement in patients with multiple sclerosis and the identification of antibody-mediated decreased bioactivity. Mol Diagn 2003;7:17-25.
22. Carmona-Saez P, Chagoyen M, Tirado F, et al. GENECODIS: a web-based tool for finding significant concurrent annotations in gene lists. Genome Biol 2007;8:R3.
23. Nogales-Cadenas R, Carmona-Saez P, Vazquez M, et al. GeneCodis: interpreting gene lists through enrichment analysis and integration of diverse biological information. Nucl Acids Res 2009;37:W317-22.
24. Zheng Q, Zhou G, Morello R, et al. Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo. J Cell Biol 2003;162:833-42.
25. Aigner T, Söder S, Gebhard PM, et al. Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence. Nat Clin Pract Rheumatol 2007;3:391-9.
26. Tchetina EV, Squires G, Poole AR. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J Rheumatol 2005;32:876-86.
27. Giachelli CM, Steitz S. Osteopontin: a versatile regulator of inflammation and biomineralization. Matrix Biol 2000;19:615-22.
28. Tamamura Y, Otani T, Kanatani N, et al. Developmental regulation of Wnt/ beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 2005;280:19185-95. (Pubitemid 41379625)
29. Day TF, Guo X, Garrett-Beal L, et al. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 2005;8:739-50.
30. Christodoulides C, Lagathu C, Sethi JK, et al. Adipogenesis and WNT signalling. Trends Endocrinol Metab 2009;20:16-24.
31. Baksh D, Boland GM, Tuan RS. Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. J Cell Biochem 2007;101:1109-24.
32. Zhu M, Tang D, Wu Q, et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res 2009;24:12-21.
33. Alfaro MP, Pagni M, Vincent A, et al. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci USA 2008;105:18366-71.
34. Yoshida CA, Komori T. Role of Runx proteins in chondrogenesis. Crit Rev Eukaryot Gene Expr 2005;15:243-54.
35. Ito Y, Miyazono K. RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr Opin Genet Dev 2003;13:43-7. (Pubitemid 36143926)
36. Soung do Y, Dong Y, Wang Y, et al. Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation. J Bone Miner Res 2007;22:1260-70.
37. Domínguez-Soto A, Relloso M, Vega MA, et al. RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters. Immunobiology 2005;210:133-9.
38. Sperber SM, Dawid IB. barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches. Dev Biol 2008;321:101-10.
39. Friedman MS, Oyserman SM, Hankenson KD. Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem 2009;284:14117-25.
40. Kim KA, Wagle M, Tran K, et al. R-Spondin family members regulate the Wnt pathway by a common mechanism. Mol Biol Cell 2008;19:2588-96.
41. Brott BK, Sokol SY. Frodo proteins: modulators of Wnt signaling in vertebrate development. Differentiation 2005;73:323-9.
42. Lane NE, Lian K, Nevitt MC, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 2006;54:1246-54.
43. Loughlin J. The genetic epidemiology of human primary osteoarthritis: current status. Expert Rev Mol Med 2005;7:1-12. (Pubitemid 43118230)
44. Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 2004;101:9757-62.
45. Min JL, Meulenbelt I, Riyazi N, et al. Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005;52:1077-80.
46. Ralston SH. New developments in the search for genetic determinants of osteoarthritis. Osteoarthr Cartil 2007;15:117-19.
47. Bateman JF, Wilson R, Freddi S, et al. Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia. Hum Mutat 2005;25:525-34. (Pubitemid 40780986)