메뉴 건너뛰기




Volumn 34, Issue 7, 2016, Pages 726-737

Quantitative comparison of DNA methylation assays for biomarker development and clinical applications

(58)  Bock, Christoph a,b,c   Halbritter, Florian a   Carmona, Francisco J d   Tierling, Sascha e   Datlinger, Paul a   Assenov, Yassen f   Berdasco, María d   Bergmann, Anke K g,h   Booher, Keith i   Busato, Florence j   Campan, Mihaela k   Dahl, Christina l   Dahmcke, Christina M l   Diep, Dinh m   Fernández, Agustín F n,o,p   Gerhauser, Clarissa f   Haake, Andrea g   Heilmann, Katharina f   Holcomb, Thomas q   Hussmann, Dianna r   more..


Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; BENCHMARKING; BIOMARKERS; DIAGNOSIS; DNA; METHYLATION;

EID: 84978435580     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.3605     Document Type: Article
Times cited : (254)

References (72)
  • 1
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome - biological and translational implications
    • Baylin, S.B. & Jones, P.A. A decade of exploring the cancer epigenome - biological and translational implications. Nat. Rev. Cancer 11, 726-734 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 2
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela, A. & Esteller, M. Epigenetic modifications and human disease. Nat. Biotechnol. 28, 1057-1068 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 3
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: Emerging patterns and implications
    • Feil, R. & Fraga, M.F. Epigenetics and the environment: emerging patterns and implications. Nat. Rev. Genet. 13, 97-109 (2011).
    • (2011) Nat. Rev. Genet. , vol.13 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 4
    • 84942294112 scopus 로고    scopus 로고
    • Epigenetic regulation of ageing: Linking environmental inputs to genomic stability
    • Benayoun, B.A., Pollina, E.A. & Brunet, A. Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat. Rev. Mol. Cell Biol. 16, 593-610 (2015).
    • (2015) Nat. Rev. Mol. Cell Biol. , vol.16 , pp. 593-610
    • Benayoun, B.A.1    Pollina, E.A.2    Brunet, A.3
  • 5
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • Reik, W. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447, 425-432 (2007).
    • (2007) Nature , vol.447 , pp. 425-432
    • Reik, W.1
  • 6
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird, P.W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 3, 253-266 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 7
    • 76349113184 scopus 로고    scopus 로고
    • Epigenetic biomarker development
    • Bock, C. Epigenetic biomarker development. Epigenomics 1, 99-110 (2009).
    • (2009) Epigenomics , vol.1 , pp. 99-110
    • Bock, C.1
  • 8
    • 84904011188 scopus 로고    scopus 로고
    • Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia
    • Claus, R. et al. Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia. Blood 124, 42-48 (2014).
    • (2014) Blood , vol.124 , pp. 42-48
    • Claus, R.1
  • 9
    • 67650077151 scopus 로고    scopus 로고
    • Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer
    • deVos, T. et al. Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer. Clin. Chem. 55, 1337-1346 (2009).
    • (2009) Clin. Chem. , vol.55 , pp. 1337-1346
    • DeVos, T.1
  • 10
    • 84855755065 scopus 로고    scopus 로고
    • TFAP2E-DKK4 and chemoresistance in colorectal cancer
    • Ebert, M.P. et al. TFAP2E-DKK4 and chemoresistance in colorectal cancer. N. Engl. J. Med. 366, 44-53 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 44-53
    • Ebert, M.P.1
  • 11
    • 84856555311 scopus 로고    scopus 로고
    • A DNA methylation fingerprint of 1628 human samples
    • Fernandez, A.F. et al. A DNA methylation fingerprint of 1628 human samples. Genome Res. 22, 407-419 (2012).
    • (2012) Genome Res. , vol.22 , pp. 407-419
    • Fernandez, A.F.1
  • 12
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi, M.E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352, 997-1003 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 997-1003
    • Hegi, M.E.1
  • 13
    • 84908548256 scopus 로고    scopus 로고
    • Methylated glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer
    • Mahon, K.L. et al. & PRIMe consortium. Methylated Glutathione S-transferase 1 (mGSTP1) is a potential plasma free DNA epigenetic marker of prognosis and response to chemotherapy in castrate-resistant prostate cancer. Br. J. Cancer 111, 1802-1809 (2014).
    • (2014) Br. J. Cancer , vol.111 , pp. 1802-1809
    • Mahon, K.L.1
  • 14
    • 84924540077 scopus 로고    scopus 로고
    • A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact
    • Queirós, A.C. et al. A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact. Leukemia 29, 598-605 (2015).
    • (2015) Leukemia , vol.29 , pp. 598-605
    • Queirós, A.C.1
  • 15
    • 79953739378 scopus 로고    scopus 로고
    • Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21
    • Papageorgiou, E.A. et al. Fetal-specific DNA methylation ratio permits noninvasive prenatal diagnosis of trisomy 21. Nat. Med. 17, 510-513 (2011).
    • (2011) Nat. Med. , vol.17 , pp. 510-513
    • Papageorgiou, E.A.1
  • 16
    • 79551677421 scopus 로고    scopus 로고
    • Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
    • Bock, C. et al. Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 144, 439-452 (2011).
    • (2011) Cell , vol.144 , pp. 439-452
    • Bock, C.1
  • 17
    • 84907342137 scopus 로고    scopus 로고
    • Identification of body fluid-specific DNA methylation markers for use in forensic science
    • Park, J.L. et al. Identification of body fluid-specific DNA methylation markers for use in forensic science. Forensic Sci. Int. Genet. 13, 147-153 (2014).
    • (2014) Forensic Sci. Int. Genet. , vol.13 , pp. 147-153
    • Park, J.L.1
  • 18
    • 84898626533 scopus 로고    scopus 로고
    • Isolation and identification of age-related DNA methylation markers for forensic age-prediction
    • Yi, S.H., Xu, L.C., Mei, K., Yang, R.Z. & Huang, D.X. Isolation and identification of age-related DNA methylation markers for forensic age-prediction. Forensic Sci. Int. Genet. 11, 117-125 (2014).
    • (2014) Forensic Sci. Int. Genet. , vol.11 , pp. 117-125
    • Yi, S.H.1    Xu, L.C.2    Mei, K.3    Yang, R.Z.4    Huang, D.X.5
  • 19
    • 84871688621 scopus 로고    scopus 로고
    • Analysing and interpreting DNA methylation data
    • Bock, C. Analysing and interpreting DNA methylation data. Nat. Rev. Genet. 13, 705-719 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 705-719
    • Bock, C.1
  • 20
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird, P.W. Principles and challenges of genomewide DNA methylation analysis. Nat. Rev. Genet. 11, 191-203 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 21
    • 79960556965 scopus 로고    scopus 로고
    • Epigenome-wide association studies for common human diseases
    • Rakyan, V.K., Down, T.A., Balding, D.J. & Beck, S. Epigenome-wide association studies for common human diseases. Nat. Rev. Genet. 12, 529-541 (2011).
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 529-541
    • Rakyan, V.K.1    Down, T.A.2    Balding, D.J.3    Beck, S.4
  • 22
    • 84884828422 scopus 로고    scopus 로고
    • Recommendations for the design and analysis of epigenome-wide association studies
    • Michels, K.B. et al. Recommendations for the design and analysis of epigenome-wide association studies. Nat. Methods 10, 949-955 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 949-955
    • Michels, K.B.1
  • 23
    • 68149163117 scopus 로고    scopus 로고
    • PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment
    • Kristensen, L.S. & Hansen, L.L. PCR-based methods for detecting single-locus DNA methylation biomarkers in cancer diagnostics, prognostics, and response to treatment. Clin. Chem. 55, 1471-1483 (2009).
    • (2009) Clin. Chem. , vol.55 , pp. 1471-1483
    • Kristensen, L.S.1    Hansen, L.L.2
  • 24
    • 84862535291 scopus 로고    scopus 로고
    • DNA methylation biomarkers in cancer: Progress towards clinical implementation
    • Mikeska, T., Bock, C., Do, H. & Dobrovic, A. DNA methylation biomarkers in cancer: progress towards clinical implementation. Expert Rev. Mol. Diagn. 12, 473-487 (2012).
    • (2012) Expert Rev. Mol. Diagn. , vol.12 , pp. 473-487
    • Mikeska, T.1    Bock, C.2    Do, H.3    Dobrovic, A.4
  • 25
    • 84876120904 scopus 로고    scopus 로고
    • Deciphering the epigenetic code: An overview of DNA methylation analysis methods
    • Umer, M. & Herceg, Z. Deciphering the epigenetic code: an overview of DNA methylation analysis methods. Antioxid. Redox Signal. 18, 1972-1986 (2013).
    • (2013) Antioxid. Redox Signal. , vol.18 , pp. 1972-1986
    • Umer, M.1    Herceg, Z.2
  • 26
    • 84857980747 scopus 로고    scopus 로고
    • BLUEPRINT to decode the epigenetic signature written in blood
    • Adams, D. et al. BLUEPRINT to decode the epigenetic signature written in blood. Nat. Biotechnol. 30, 224-226 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , pp. 224-226
    • Adams, D.1
  • 27
    • 77957943791 scopus 로고    scopus 로고
    • Tackling the epigenome: Challenges and opportunities for collaboration
    • Satterlee, J.S., Schübeler, D. & Ng, H.H. Tackling the epigenome: challenges and opportunities for collaboration. Nat. Biotechnol. 28, 1039-1044 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1039-1044
    • Satterlee, J.S.1    Schübeler, D.2    Ng, H.H.3
  • 28
    • 77957948773 scopus 로고    scopus 로고
    • Taking the measure of the methylome
    • Beck, S. Taking the measure of the methylome. Nat. Biotechnol. 28, 1026-1028 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1026-1028
    • Beck, S.1
  • 29
    • 77957937011 scopus 로고    scopus 로고
    • Quantitative comparison of genome-wide DNA methylation mapping technologies
    • Bock, C. et al. Quantitative comparison of genome-wide DNA methylation mapping technologies. Nat. Biotechnol. 28, 1106-1114 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1106-1114
    • Bock, C.1
  • 30
    • 77957932941 scopus 로고    scopus 로고
    • Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
    • Harris, R.A. et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat. Biotechnol. 28, 1097-1105 (2010).
    • (2010) Nat. Biotechnol. , vol.28 , pp. 1097-1105
    • Harris, R.A.1
  • 31
    • 84879642767 scopus 로고    scopus 로고
    • Bi-PROF: Bisulfite profiling of target regions using 454 GS FLX titanium technology
    • Gries, J. et al. Bi-PROF: bisulfite profiling of target regions using 454 GS FLX Titanium technology. Epigenetics 8, 765-771 (2013).
    • (2013) Epigenetics , vol.8 , pp. 765-771
    • Gries, J.1
  • 32
    • 84885368581 scopus 로고    scopus 로고
    • Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing
    • Masser, D.R., Berg, A.S. & Freeman, W.M. Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing. Epigenetics Chromatin 6, 33 (2013).
    • (2013) Epigenetics Chromatin , vol.6 , pp. 33
    • Masser, D.R.1    Berg, A.S.2    Freeman, W.M.3
  • 33
    • 77956296566 scopus 로고    scopus 로고
    • Bisulfite patch PCR enables multiplexed sequencing of promoter methylation across cancer samples
    • Varley, K.E. & Mitra, R.D. Bisulfite Patch PCR enables multiplexed sequencing of promoter methylation across cancer samples. Genome Res. 20, 1279-1287 (2010).
    • (2010) Genome Res. , vol.20 , pp. 1279-1287
    • Varley, K.E.1    Mitra, R.D.2
  • 34
    • 84857784165 scopus 로고    scopus 로고
    • Library-free methylation sequencing with bisulfite padlock probes
    • Diep, D. et al. Library-free methylation sequencing with bisulfite padlock probes. Nat. Methods 9, 270-272 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 270-272
    • Diep, D.1
  • 35
    • 84899874953 scopus 로고    scopus 로고
    • Assessment of RainDrop BS-seq as a method for large-scale, targeted bisulfite sequencing
    • Paul, D.S. et al. Assessment of RainDrop BS-seq as a method for large-scale, targeted bisulfite sequencing. Epigenetics 9, 678-684 (2014).
    • (2014) Epigenetics , vol.9 , pp. 678-684
    • Paul, D.S.1
  • 36
    • 35648937679 scopus 로고    scopus 로고
    • Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: Critical evaluation and improvements
    • Coolen, M.W., Statham, A.L., Gardiner-Garden, M. & Clark, S.J. Genomic profiling of CpG methylation and allelic specificity using quantitative high-throughput mass spectrometry: critical evaluation and improvements. Nucleic Acids Res. 35, e119 (2007).
    • (2007) Nucleic Acids Res. , vol.35 , pp. e119
    • Coolen, M.W.1    Statham, A.L.2    Gardiner-Garden, M.3    Clark, S.J.4
  • 37
    • 27644548948 scopus 로고    scopus 로고
    • Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry
    • Ehrich, M. et al. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc. Natl. Acad. Sci. USA 102, 15785-15790 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 15785-15790
    • Ehrich, M.1
  • 38
    • 42449129744 scopus 로고    scopus 로고
    • Cytosine methylation profiling of cancer cell lines
    • Ehrich, M. et al. Cytosine methylation profiling of cancer cell lines. Proc. Natl. Acad. Sci. USA 105, 4844-4849 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4844-4849
    • Ehrich, M.1
  • 39
    • 0032540905 scopus 로고    scopus 로고
    • A sequencing method based on real-time pyrophosphate
    • Ronaghi, M., Uhlén, M. & Nyrén, P. A sequencing method based on real-time pyrophosphate. Science 281, 363-365 (1998).
    • (1998) Science , vol.281 , pp. 363-365
    • Ronaghi, M.1    Uhlén, M.2    Nyrén, P.3
  • 40
    • 0038002236 scopus 로고    scopus 로고
    • Analysis and quantification of multiple methylation variable positions in CpG islands by pyrosequencing
    • Tost, J., Dunker, J. & Gut, I.G. Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing. Biotechniques 35, 152-156 (2003).
    • (2003) Biotechniques , vol.35 , pp. 152-156
    • Tost, J.1    Dunker, J.2    Gut, I.G.3
  • 41
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • Tost, J. & Gut, I.G. DNA methylation analysis by pyrosequencing. Nat. Protoc. 2, 2265-2275 (2007).
    • (2007) Nat. Protoc. , vol.2 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 43
    • 0034654669 scopus 로고    scopus 로고
    • Methy light: A high-throughput assay to measure DNA methylation
    • Eads, C.A. et al. Methy Light: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 28, E32 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , pp. E32
    • Eads, C.A.1
  • 44
    • 0036315386 scopus 로고    scopus 로고
    • Profiling DNA methylation by melting analysis
    • Guldberg, P., Worm, J. & Grønbaek, K. Profiling DNA methylation by melting analysis. Methods 27, 121-127 (2002).
    • (2002) Methods , vol.27 , pp. 121-127
    • Guldberg, P.1    Worm, J.2    Grønbaek, K.3
  • 45
    • 63349097282 scopus 로고    scopus 로고
    • Methylation-sensitive high-resolution melting
    • Wojdacz, T.K., Dobrovic, A. & Hansen, L.L. Methylation-sensitive high-resolution melting. Nat. Protoc. 3, 1903-1908 (2008).
    • (2008) Nat. Protoc. , vol.3 , pp. 1903-1908
    • Wojdacz, T.K.1    Dobrovic, A.2    Hansen, L.L.3
  • 46
    • 0034949862 scopus 로고    scopus 로고
    • In-tube DNA methylation profiling by fluorescence melting curve analysis
    • Worm, J., Aggerholm, A. & Guldberg, P. In-tube DNA methylation profiling by fluorescence melting curve analysis. Clin. Chem. 47, 1183-1189 (2001).
    • (2001) Clin. Chem. , vol.47 , pp. 1183-1189
    • Worm, J.1    Aggerholm, A.2    Guldberg, P.3
  • 48
    • 84859847507 scopus 로고    scopus 로고
    • DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer
    • Walter, K. et al. DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer. Clin. Cancer Res. 18, 2360-2373 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2360-2373
    • Walter, K.1
  • 49
    • 77954661906 scopus 로고    scopus 로고
    • DNA hypomethylation in cancer cells
    • Ehrlich, M. DNA hypomethylation in cancer cells. Epigenomics 1, 239-259 (2009).
    • (2009) Epigenomics , vol.1 , pp. 239-259
    • Ehrlich, M.1
  • 50
    • 66449125866 scopus 로고    scopus 로고
    • LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors
    • Aparicio, A. et al. LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors. Epigenetics 4, 176-184 (2009).
    • (2009) Epigenetics , vol.4 , pp. 176-184
    • Aparicio, A.1
  • 51
    • 61449396661 scopus 로고    scopus 로고
    • Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry
    • Berdasco, M., Fraga, M.F. & Esteller, M. Quantification of global DNA methylation by capillary electrophoresis and mass spectrometry. Methods Mol. Biol. 507, 23-34 (2009).
    • (2009) Methods Mol. Biol. , vol.507 , pp. 23-34
    • Berdasco, M.1    Fraga, M.F.2    Esteller, M.3
  • 52
    • 84857912089 scopus 로고    scopus 로고
    • Quantitative measurement of genome-wide DNA methylation by a reliable and cost-efficient enzyme-linked immunosorbent assay technique
    • Kremer, D., Metzger, S., Kolb-Bachofen, V. & Kremer, D. Quantitative measurement of genome-wide DNA methylation by a reliable and cost-efficient enzyme-linked immunosorbent assay technique. Anal. Biochem. 422, 74-78 (2012).
    • (2012) Anal. Biochem. , vol.422 , pp. 74-78
    • Kremer, D.1    Metzger, S.2    Kolb-Bachofen, V.3    Kremer, D.4
  • 53
    • 33847026146 scopus 로고    scopus 로고
    • Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    • Bollati, V. et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res. 67, 876-880 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 876-880
    • Bollati, V.1
  • 54
    • 67650067284 scopus 로고    scopus 로고
    • Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer
    • Choi, S.H. et al. Changes in DNA methylation of tandem DNA repeats are different from interspersed repeats in cancer. Int. J. Cancer 125, 723-729 (2009).
    • (2009) Int. J. Cancer , vol.125 , pp. 723-729
    • Choi, S.H.1
  • 55
    • 84870051490 scopus 로고    scopus 로고
    • Hypomethylation of LINE-1, and not centromeric SAT-α, is associated with centromeric instability in head and neck squamous cell carcinoma
    • Martínez, J.G. et al. Hypomethylation of LINE-1, and not centromeric SAT-α, is associated with centromeric instability in head and neck squamous cell carcinoma. Cell Oncol. (Dordr.) 35, 259-267 (2012).
    • (2012) Cell Oncol. (Dordr.) , vol.35 , pp. 259-267
    • Martínez, J.G.1
  • 56
    • 2342557977 scopus 로고    scopus 로고
    • A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    • Yang, A.S. et al. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 32, e38 (2004).
    • (2004) Nucleic Acids Res. , vol.32 , pp. e38
    • Yang, A.S.1
  • 57
    • 84875457313 scopus 로고    scopus 로고
    • Conventional and nanotechniques for DNA methylation profiling
    • Shanmuganathan, R. et al. Conventional and nanotechniques for DNA methylation profiling. J. Mol. Diagn. 15, 17-26 (2013).
    • (2013) J. Mol. Diagn. , vol.15 , pp. 17-26
    • Shanmuganathan, R.1
  • 58
    • 84856306090 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiling using infinium® assay
    • Bibikova, M. et al. Genome-wide DNA methylation profiling using Infinium® assay. Epigenomics 1, 177-200 (2009).
    • (2009) Epigenomics , vol.1 , pp. 177-200
    • Bibikova, M.1
  • 61
    • 84885012678 scopus 로고    scopus 로고
    • Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine
    • Booth, M.J. et al. Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine. Nat. Protoc. 8, 1841-1851 (2013).
    • (2013) Nat. Protoc. , vol.8 , pp. 1841-1851
    • Booth, M.J.1
  • 62
    • 84879547408 scopus 로고    scopus 로고
    • Chemical modification-assisted bisulfite sequencing (CAB-seq) for 5-carboxylcytosine detection in DNA
    • Lu, X. et al. Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J. Am. Chem. Soc. 135, 9315-9317 (2013).
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 9315-9317
    • Lu, X.1
  • 63
    • 84876907152 scopus 로고    scopus 로고
    • Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming
    • Song, C.X. et al. Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 153, 678-691 (2013).
    • (2013) Cell , vol.153 , pp. 678-691
    • Song, C.X.1
  • 64
    • 77955450160 scopus 로고    scopus 로고
    • The implications of heterogeneous DNA methylation for the accurate quantification of methylation
    • Mikeska, T., Candiloro, I.L. & Dobrovic, A. The implications of heterogeneous DNA methylation for the accurate quantification of methylation. Epigenomics 2, 561-573 (2010).
    • (2010) Epigenomics , vol.2 , pp. 561-573
    • Mikeska, T.1    Candiloro, I.L.2    Dobrovic, A.3
  • 65
    • 0018255012 scopus 로고
    • Acute myelogenous leukemia: A human cell line responsive to colony-stimulating activity
    • Koeffler, H.P. & Golde, D.W. Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity. Science 200, 1153-1154 (1978).
    • (1978) Science , vol.200 , pp. 1153-1154
    • Koeffler, H.P.1    Golde, D.W.2
  • 66
    • 0018940849 scopus 로고
    • An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1)
    • Koeffler, H.P., Billing, R., Lusis, A.J., Sparkes, R. & Golde, D.W. An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1). Blood 56, 265-273 (1980).
    • (1980) Blood , vol.56 , pp. 265-273
    • Koeffler, H.P.1    Billing, R.2    Lusis, A.J.3    Sparkes, R.4    Golde, D.W.5
  • 67
    • 84908566266 scopus 로고    scopus 로고
    • Comprehensive analysis of DNA methylation data with RnBeads
    • Assenov, Y. et al. Comprehensive analysis of DNA methylation data with RnBeads. Nat. Methods 11, 1138-1140 (2014).
    • (2014) Nat. Methods , vol.11 , pp. 1138-1140
    • Assenov, Y.1
  • 68
    • 85027954125 scopus 로고    scopus 로고
    • DNA methylation profiling in the clinic: Applications and challenges
    • Heyn, H. & Esteller, M. DNA methylation profiling in the clinic: applications and challenges. Nat. Rev. Genet. 13, 679-692 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 679-692
    • Heyn, H.1    Esteller, M.2
  • 70
    • 84899444670 scopus 로고    scopus 로고
    • Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine
    • Holmes, E.E. et al. Performance evaluation of kits for bisulfite-conversion of DNA from tissues, cell lines, FFPE tissues, aspirates, lavages, effusions, plasma, serum, and urine. PLoS One 9, e93933 (2014).
    • (2014) PLoS One , vol.9 , pp. e93933
    • Holmes, E.E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.