Process development for oxidations of hydrophobic compounds applying cytochrome P450 monooxygenases in-vitro

Journal of Biotechnology

Volumn 233, Issue , 2016, Pages 143-150

  Brummund, Jan ^a   Müller, Monika ^b   Schmitges, Thomas ^b   Kaluzna, Iwona ^b   Mink, Daniel ^b   Hilterhaus, Lutz ^a   Liese, Andreas ^a  

^a HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

^b DSM RESOLVE   (Netherlands)

Author keywords

Biocatalytic oxidations; Cofactor regeneration; Cytochrome P450 monooxygenases; Hydrophobic substrates; Oxidative enzyme stability; Oxygen supply

Indexed keywords

ENZYMES; HYDROPHOBICITY; OXIDATION; OXYGEN; REACTION RATES; SUBSTRATES;

BIOCATALYTIC OXIDATION; COFACTOR REGENERATION; CYTOCHROME P450 MONOOXYGENASES; HYDROPHOBIC SUBSTRATE; OXIDATIVE ENZYMES;

OXYGEN SUPPLY;

CYTOCHROME P450; ALPHA-IONONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NORISOPRENOID; OXYGEN; RECOMBINANT PROTEIN;

ARTICLE; BIOCATALYST; CONTROLLED STUDY; EMULSION; HYDROPHOBICITY; IN VITRO STUDY; OXIDATION; OXYGEN SUPPLY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SOLUBILITY; SPECTROPHOTOMETRY; STIRRED REACTOR; BIOLOGICAL MODEL; CHEMICAL PHENOMENA; ENZYME STABILITY; ESCHERICHIA COLI; GENETICS; METABOLIC ENGINEERING; METABOLISM; OXIDATION REDUCTION REACTION; PROCEDURES;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME STABILITY; ESCHERICHIA COLI; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; METABOLIC ENGINEERING; MODELS, BIOLOGICAL; NADP; NORISOPRENOIDS; OXIDATION-REDUCTION; OXYGEN; RECOMBINANT PROTEINS;

EID: 84978374750     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.07.002     Document Type: Article

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