메뉴 건너뛰기




Volumn 11, Issue 7, 2016, Pages 1140-1152

Efficacy of pemetrexed-based chemotherapy in patients with ROS1 fusion-positive lung adenocarcinoma compared with in patients harboring other driver mutations in East Asian populations

Author keywords

EGFR mutation; EML4 ALK fusion; KRAS mutation; Pemetrexed based therapy; ROS1 fusion

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; CARBOPLATIN; CISPLATIN; ECHINODERM MICROTUBULE ASSOCIATED PROTEIN LIKE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; PEMETREXED; PROTEIN TYROSINE KINASE; ROS PROTOONCOGENE 1; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; EML4-ALK FUSION PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN P21; ROS1 PROTEIN, HUMAN;

EID: 84978291112     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2016.03.022     Document Type: Article
Times cited : (67)

References (52)
  • 2
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 3
    • 34547638047 scopus 로고    scopus 로고
    • Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    • Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448:561-566.
    • (2007) Nature , vol.448 , pp. 561-566
    • Soda, M.1    Choi, Y.L.2    Enomoto, M.3
  • 4
    • 84886290631 scopus 로고    scopus 로고
    • The impact of genomic changes on treatment of lung cancer
    • Cardarella S, Johnson BE. The impact of genomic changes on treatment of lung cancer. Am J Respir Crit Care Med. 2013;188:770-775.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 770-775
    • Cardarella, S.1    Johnson, B.E.2
  • 5
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361:947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 6
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multi-centre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multi-centre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13:239-246.
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 7
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non- small cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non- small cell lung cancer. N Engl J Med. 2010;363:1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 8
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013;368:2385-2394.
    • (2013) N Engl J Med , vol.368 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 9
    • 36849065315 scopus 로고    scopus 로고
    • Global survey of phosphotyrosine signalling identifies oncogenic kinases in lung cancer
    • Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signalling identifies oncogenic kinases in lung cancer. Cell. 2007;131:1190-1203.
    • (2007) Cell , vol.131 , pp. 1190-1203
    • Rikova, K.1    Guo, A.2    Zeng, Q.3
  • 10
    • 84863338079 scopus 로고    scopus 로고
    • ROS1 rearrangements define a unique molecular class of lung cancers
    • Bergethon K, Shaw AT, Ou SH, et al. ROS1 rearrangements define a unique molecular class of lung cancers. J Clin Oncol. 2012;30:863-870.
    • (2012) J Clin Oncol , vol.30 , pp. 863-870
    • Bergethon, K.1    Shaw, A.T.2    Ou, S.H.3
  • 11
    • 84857985225 scopus 로고    scopus 로고
    • RET ROS1 and ALK fusions in lung cancer
    • Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012;18:378-381.
    • (2012) Nat Med , vol.18 , pp. 378-381
    • Takeuchi, K.1    Soda, M.2    Togashi, Y.3
  • 12
    • 84865441368 scopus 로고    scopus 로고
    • Identifying and targeting ROS1 gene fusions in non-small cell lung cancer
    • Davies KD, Le AT, Theodoro M, et al. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer. Clin Cancer Res. 2012;18:4570-4579.
    • (2012) Clin Cancer Res , vol.18 , pp. 4570-4579
    • Davies, K.D.1    Le, A.T.2    Theodoro, M.3
  • 13
    • 84865089246 scopus 로고    scopus 로고
    • Analysis of receptor tyrosine kinase ROS1-positive tumours in non-small cell lung cancer: Identification of a FIG-ROS1 fusion
    • Rimkunas VM, Crosby KE, Li D, et al. Analysis of receptor tyrosine kinase ROS1-positive tumours in non-small cell lung cancer: identification of a FIG-ROS1 fusion. Clin Cancer Res. 2012;8:4449-4457.
    • (2012) Clin Cancer Res , vol.8 , pp. 4449-4457
    • Rimkunas, V.M.1    Crosby, K.E.2    Li, D.3
  • 14
    • 84905815103 scopus 로고    scopus 로고
    • Clinical and the prognostic characteristics of lung adenocarcinoma patients with ROS1 fusion in comparison with other driver mutations in East Asian populations
    • Chen YF, Hsieh MS, Wu SG, et al. Clinical and the prognostic characteristics of lung adenocarcinoma patients with ROS1 fusion in comparison with other driver mutations in East Asian populations. J Thorac Oncol. 2014;9:1171-1179.
    • (2014) J Thorac Oncol , vol.9 , pp. 1171-1179
    • Chen, Y.F.1    Hsieh, M.S.2    Wu, S.G.3
  • 15
    • 84911372597 scopus 로고    scopus 로고
    • Crizotinib in ROS1- rearranged non-small-cell lung cancer
    • Shaw AT, Ou SH, Bang YJ, et al. Crizotinib in ROS1- rearranged non-small-cell lung cancer. N Engl J Med. 2014;371:1963-1971.
    • (2014) N Engl J Med , vol.371 , pp. 1963-1971
    • Shaw, A.T.1    Ou, S.H.2    Bang, Y.J.3
  • 16
    • 84927139647 scopus 로고    scopus 로고
    • Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: Results from the EUROS1 cohort
    • Mazières J, Zalcman G, Crinò L, et al. Crizotinib therapy for advanced lung adenocarcinoma and a ROS1 rearrangement: results from the EUROS1 cohort. J Clin Oncol. 2015;33:992-999.
    • (2015) J Clin Oncol , vol.33 , pp. 992-999
    • Mazières, J.1    Zalcman, G.2    Crinò, L.3
  • 18
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo [2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo [2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res. 1997;57: 1116-1123.
    • (1997) Cancer Res , vol.57 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 19
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol. 2008;26:3543-3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 20
    • 67650281462 scopus 로고    scopus 로고
    • Phase III study by the Norwegian lung cancer study group: Pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer
    • Grønberg BH, Bremnes RM, Fløtten O, et al. Phase III study by the Norwegian lung cancer study group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol. 2009;27:3217-3224.
    • (2009) J Clin Oncol , vol.27 , pp. 3217-3224
    • Grønberg, B.H.1    Bremnes, R.M.2    Fløtten, O.3
  • 21
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol. 2004;22: 1589-1597.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 22
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase 3 study
    • Ciuleanu T, Brodowicz T, Zielinski C, et al. Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet. 2009;374:1432-1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3
  • 23
    • 79955474006 scopus 로고    scopus 로고
    • Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations
    • Wu SG, Yang CH, Yu CJ, et al. Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Lung Cancer. 2011;72:333-339.
    • (2011) Lung Cancer , vol.72 , pp. 333-339
    • Wu, S.G.1    Yang, C.H.2    Yu, C.J.3
  • 24
    • 84925484050 scopus 로고    scopus 로고
    • Pemetrexed-based chemotherapy in advanced lung adenocarcinoma patients with different EGFR genotypes
    • Jiang X, Yang B, Lu J, et al. Pemetrexed-based chemotherapy in advanced lung adenocarcinoma patients with different EGFR genotypes. Tumour Biol. 2015;36: 861-869.
    • (2015) Tumour Biol , vol.36 , pp. 861-869
    • Jiang, X.1    Yang, B.2    Lu, J.3
  • 25
    • 79953029071 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase gene rearrangements in non-small-cell lung cancer are associated with prolonged progression-free survival on pemetrexed
    • Camidge DR, Kono SA, Lu X, et al. Anaplastic lymphoma kinase gene rearrangements in non-small-cell lung cancer are associated with prolonged progression-free survival on pemetrexed. J Thorac Oncol. 2011;6:774-780.
    • (2011) J Thorac Oncol , vol.6 , pp. 774-780
    • Camidge, D.R.1    Kono, S.A.2    Lu, X.3
  • 26
    • 80052261903 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase translocation: A predictive biomarker of pemetrexed in patients with non-small-cell lung cancer
    • Lee JO, Kim TM, Lee SH, et al. Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patients with non-small-cell lung cancer. J Thorac Oncol. 2011;6:1474-1480.
    • (2011) J Thorac Oncol , vol.6 , pp. 1474-1480
    • Lee, J.O.1    Kim, T.M.2    Lee, S.H.3
  • 27
    • 84876507123 scopus 로고    scopus 로고
    • Pemetrexedbased chemotherapy in patients with advanced ALKpositive non-small-cell lung cancer
    • Shaw AT, Varghese AM, Solomon BJ, et al. Pemetrexedbased chemotherapy in patients with advanced, ALKpositive non-small-cell lung cancer. Ann Oncol. 2013;24:59-66.
    • (2013) Ann Oncol , vol.24 , pp. 59-66
    • Shaw, A.T.1    Varghese, A.M.2    Solomon, B.J.3
  • 28
    • 84941414724 scopus 로고    scopus 로고
    • Relationship of driver oncogenes to long-term pemetrexed response in non-small-cell lung cancer
    • Liang Y, Wakelee HA, Neal JW, et al. Relationship of driver oncogenes to long-term pemetrexed response in non-small-cell lung cancer. Clin Lung Cancer. 2015;16:366-373.
    • (2015) Clin Lung Cancer , vol.16 , pp. 366-373
    • Liang, Y.1    Wakelee, H.A.2    Neal, J.W.3
  • 29
    • 84941413820 scopus 로고    scopus 로고
    • Survival benefit of pemetrexed in lung adenocarcinoma patients with anaplastic lymphoma kinase gene rearrangements
    • Park S, Park TS, Choi CM, et al. Survival benefit of pemetrexed in lung adenocarcinoma patients with anaplastic lymphoma kinase gene rearrangements. Clin Lung Cancer. 2015;16:e83-e89.
    • (2015) Clin Lung Cancer , vol.16 , pp. e83-e89
    • Park, S.1    Park, T.S.2    Choi, C.M.3
  • 30
    • 84899471648 scopus 로고    scopus 로고
    • ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: A comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features
    • Pan Y, Zhang Y, Li Y, et al. ALK, ROS1 and RET fusions in 1139 lung adenocarcinomas: a comprehensive study of common and fusion pattern-specific clinicopathologic, histologic and cytologic features. Lung Cancer. 2014;84:121-126.
    • (2014) Lung Cancer , vol.84 , pp. 121-126
    • Pan, Y.1    Zhang, Y.2    Li, Y.3
  • 31
    • 84883343307 scopus 로고    scopus 로고
    • The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma
    • Kim HR, Lim SM, Kim HJ, et al. The frequency and impact of ROS1 rearrangement on clinical outcomes in never smokers with lung adenocarcinoma. Ann Oncol. 2013;24:2364-2370.
    • (2013) Ann Oncol , vol.24 , pp. 2364-2370
    • Kim, H.R.1    Lim, S.M.2    Kim, H.J.3
  • 32
    • 84883816641 scopus 로고    scopus 로고
    • A case series of lengthy progression-free survival with pemetrexedcontaining therapy in metastatic non-small-cell lung cancer patients harboring ROS1 gene rearrangements
    • Riess JW, Padda SK, Bangs CD, et al. A case series of lengthy progression-free survival with pemetrexedcontaining therapy in metastatic non-small-cell lung cancer patients harboring ROS1 gene rearrangements. Clin Lung Cancer. 2013;14:592-595.
    • (2013) Clin Lung Cancer , vol.14 , pp. 592-595
    • Riess, J.W.1    Padda, S.K.2    Bangs, C.D.3
  • 33
    • 80052554890 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed
    • Chen CY, Chang YL, Shih JY, et al. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed. Lung Cancer. 2011;74:132-138.
    • (2011) Lung Cancer , vol.74 , pp. 132-138
    • Chen, C.Y.1    Chang, Y.L.2    Shih, J.Y.3
  • 34
    • 84878973389 scopus 로고    scopus 로고
    • Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin
    • Lee SH, Noh KB, Lee JS, et al. Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin. Lung Cancer. 2013;81:102-108.
    • (2013) Lung Cancer , vol.81 , pp. 102-108
    • Lee, S.H.1    Noh, K.B.2    Lee, J.S.3
  • 35
    • 84899121061 scopus 로고    scopus 로고
    • The pemetrexedcontaining treatments in the non-small cell lung cancer is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: A meta-analysis
    • Wang L, Wang R, Pan Y, et al. The pemetrexedcontaining treatments in the non-small cell lung cancer is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis. BMC Cancer. 2014;14:205.
    • (2014) BMC Cancer , vol.14 , pp. 205
    • Wang, L.1    Wang, R.2    Pan, Y.3
  • 36
    • 79551563284 scopus 로고    scopus 로고
    • International Association for the Study of Lung Cancer/American thoracic society/european respiratory society international multi-disciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multi-Disciplinary Classification of Lung Adenocarcinoma. J Thorac Oncol. 2011;6:244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 38
    • 34547419255 scopus 로고    scopus 로고
    • The IASLC Lung Cancer Staging Project: Proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer
    • Rami-Porta R, Ball D, Crowley J, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the T descriptors in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol. 2007;2:593-602.
    • (2007) J Thorac Oncol , vol.2 , pp. 593-602
    • Rami-Porta, R.1    Ball, D.2    Crowley, J.3
  • 39
    • 0020396015 scopus 로고
    • Toxicity and response criteria of the Eastern Cooperative Oncology Group
    • Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5:649-655.
    • (1982) Am J Clin Oncol , vol.5 , pp. 649-655
    • Oken, M.M.1    Creech, R.H.2    Tormey, D.C.3
  • 41
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12:175-180.
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 42
    • 84886545743 scopus 로고    scopus 로고
    • Clinico-pathologic analysis of ROS1-rearranged non-small-cell lung cancer and proposal of a diagnostic algorithm
    • Go H, Kim DW, Kim D, et al. Clinico-pathologic analysis of ROS1-rearranged non-small-cell lung cancer and proposal of a diagnostic algorithm. J Thorac Oncol. 2013;8:1445-1450.
    • (2013) J Thorac Oncol , vol.8 , pp. 1445-1450
    • Go, H.1    Kim, D.W.2    Kim, D.3
  • 43
    • 84860335902 scopus 로고    scopus 로고
    • RNA is favorable for analyzing EGFR mutations in malignant pleural effusion of lung cancer
    • Tsai TH, Su KY, Wu SG, et al. RNA is favorable for analyzing EGFR mutations in malignant pleural effusion of lung cancer. Eur Respir J. 2011;39:677-684.
    • (2011) Eur Respir J , vol.39 , pp. 677-684
    • Tsai, T.H.1    Su, K.Y.2    Wu, S.G.3
  • 44
    • 84887615354 scopus 로고    scopus 로고
    • Multi-gene analyses from waste brushing specimens for patients with peripheral lung cancer receiving EBUS-assisted bronchoscopy
    • Tsai TH, Yang CY, Ho CC, et al. Multi-gene analyses from waste brushing specimens for patients with peripheral lung cancer receiving EBUS-assisted bronchoscopy. Lung Cancer. 2013;82:420-425.
    • (2013) Lung Cancer , vol.82 , pp. 420-425
    • Tsai, T.H.1    Yang, C.Y.2    Ho, C.C.3
  • 45
    • 77951894575 scopus 로고    scopus 로고
    • Thymidylate synthase but not excision repair cross complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy
    • Righi L, Papotti MG, Ceppi P, et al. Thymidylate synthase but not excision repair cross complementation group 1 tumor expression predicts outcome in patients with malignant pleural mesothelioma treated with pemetrexed-based chemotherapy. J Clin Oncol. 2010;28:1534-1539.
    • (2010) J Clin Oncol , vol.28 , pp. 1534-1539
    • Righi, L.1    Papotti, M.G.2    Ceppi, P.3
  • 46
    • 57849117384 scopus 로고    scopus 로고
    • New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)
    • Eisenhauer EA, Therasse P, Bogaerts J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45:228-247.
    • (2009) Eur J Cancer , vol.45 , pp. 228-247
    • Eisenhauer, E.A.1    Therasse, P.2    Bogaerts, J.3
  • 47
    • 84895512912 scopus 로고    scopus 로고
    • EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: Patient outcome, interplay with morphology and immunophenotype
    • Warth A, Penzel R, Lindenmaier H, et al. EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype. Eur Respir J. 2014;43:872-883.
    • (2014) Eur Respir J , vol.43 , pp. 872-883
    • Warth, A.1    Penzel, R.2    Lindenmaier, H.3
  • 49
    • 84953888757 scopus 로고    scopus 로고
    • Clinicopathologic characteristics of patients with ROS1 fusion gene in non- small cell lung cancer: A meta-analysis
    • Zhu Q, Zhan P, Zhang X, et al. Clinicopathologic characteristics of patients with ROS1 fusion gene in non- small cell lung cancer: a meta-analysis. Transl Lung Cancer Res. 2015;4:300-309.
    • (2015) Transl Lung Cancer Res , vol.4 , pp. 300-309
    • Zhu, Q.1    Zhan, P.2    Zhang, X.3
  • 50
    • 84884736973 scopus 로고    scopus 로고
    • Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
    • Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31:3327-3334.
    • (2013) J Clin Oncol , vol.31 , pp. 3327-3334
    • Sequist, L.V.1    Yang, J.C.2    Yamamoto, N.3
  • 51
    • 84938208051 scopus 로고    scopus 로고
    • Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): A phase 3 randomised trial
    • Soria JC, Wu YL, Nakagawa K, et al. Gefitinib plus chemotherapy versus placebo plus chemotherapy in EGFR-mutation-positive non-small-cell lung cancer after progression on first-line gefitinib (IMPRESS): a phase 3 randomised trial. Lancet Oncol. 2015;16:990-998.
    • (2015) Lancet Oncol , vol.16 , pp. 990-998
    • Soria, J.C.1    Wu, Y.L.2    Nakagawa, K.3
  • 52
    • 41149096042 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small cell lung cancer cells
    • Giovannetti E, Lemos C, Tekle C, et al. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small cell lung cancer cells. Mol Pharmacol. 2008;73:1290-1300.
    • (2008) Mol Pharmacol , vol.73 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.