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Volumn 43, Issue 3, 2014, Pages 872-883

EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: Patient outcome, interplay with morphology and immunophenotype

Author keywords

[No Author keywords available]

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANTINEOPLASTIC AGENT; B RAF KINASE; CYTOKERATIN 7; EPIDERMAL GROWTH FACTOR RECEPTOR; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; K RAS PROTEIN; PLATINUM COMPLEX; THYMIDYLATE SYNTHASE; THYROID TRANSCRIPTION FACTOR 1;

EID: 84895512912     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00018013     Document Type: Article
Times cited : (101)

References (45)
  • 2
    • 84865361647 scopus 로고    scopus 로고
    • Assessment of thymidylate synthase expression in biopsy specimens and corresponding resection specimens of non-small-cell lung cancer
    • Herpel E, Schnabel PA, Steins M, et al. Assessment of thymidylate synthase expression in biopsy specimens and corresponding resection specimens of non-small-cell lung cancer. Histopathology 2012; 61: 465-472.
    • (2012) Histopathology , vol.61 , pp. 465-472
    • Herpel, E.1    Schnabel, P.A.2    Steins, M.3
  • 3
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010; 363: 1693-1703.
    • (2010) N Engl J Med , vol.363 , pp. 1693-1703
    • Kwak, E.L.1    Bang, Y.J.2    Camidge, D.R.3
  • 4
    • 84875851448 scopus 로고    scopus 로고
    • Correlation of radio-and histomorphological pattern of pulmonary adenocarcinoma
    • Lederlin M, Puderbach M, Muley T, et al. Correlation of radio-and histomorphological pattern of pulmonary adenocarcinoma. Eur Respir J 2013; 41: 943-951.
    • (2013) Eur Respir J , vol.41 , pp. 943-951
    • Lederlin, M.1    Puderbach, M.2    Muley, T.3
  • 5
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009; 361: 947-957.
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thongprasert, S.3
  • 6
    • 84862865652 scopus 로고    scopus 로고
    • A novel EML4-ALK variant: Exon 6 of EML4 fused to exon 19 of ALK
    • Penzel R, Schirmacher P, Warth A. A novel EML4-ALK variant: exon 6 of EML4 fused to exon 19 of ALK. J Thorac Oncol 2012; 7: 1198-1199.
    • (2012) J Thorac Oncol , vol.7 , pp. 1198-1199
    • Penzel, R.1    Schirmacher, P.2    Warth, A.3
  • 7
    • 84861872352 scopus 로고    scopus 로고
    • Clonality of multifocal nonsmall cell lung cancer: Implications for staging and therapy
    • Warth A, Macher-Goeppinger S, Muley T, et al. Clonality of multifocal nonsmall cell lung cancer: implications for staging and therapy. Eur Respir J 2012; 39: 1437-1442.
    • (2012) Eur Respir J , vol.39 , pp. 1437-1442
    • Warth, A.1    Macher-Goeppinger, S.2    Muley, T.3
  • 8
    • 84870391117 scopus 로고    scopus 로고
    • Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies
    • Warth A, Muley T, Herpel E, et al. Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies. Histopathology 2012; 61: 1017-1025.
    • (2012) Histopathology , vol.61 , pp. 1017-1025
    • Warth, A.1    Muley, T.2    Herpel, E.3
  • 9
    • 84860379332 scopus 로고    scopus 로고
    • The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stageindependent predictor of survival
    • Warth A, Muley T, Meister M, et al. The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stageindependent predictor of survival. J Clin Oncol 2012; 30: 1438-1446.
    • (2012) J Clin Oncol , vol.30 , pp. 1438-1446
    • Warth, A.1    Muley, T.2    Meister, M.3
  • 10
    • 84863726241 scopus 로고    scopus 로고
    • Optimized algorithm for Sanger sequencing-based EGFR mutation analyses in NSCLC biopsies
    • Warth A, Penzel R, Brandt R, et al. Optimized algorithm for Sanger sequencing-based EGFR mutation analyses in NSCLC biopsies. Virchows Arch 2012; 460: 407-414.
    • (2012) Virchows Arch , vol.460 , pp. 407-414
    • Warth, A.1    Penzel, R.2    Brandt, R.3
  • 11
    • 33748435058 scopus 로고    scopus 로고
    • DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
    • Olaussen KA, Dunant A, Fouret P, et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med 2006; 355: 983-991.
    • (2006) N Engl J Med , vol.355 , pp. 983-991
    • Olaussen, K.A.1    Dunant, A.2    Fouret, P.3
  • 12
    • 34249819963 scopus 로고    scopus 로고
    • ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer
    • Olaussen KA, Mountzios G, Soria JC. ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer. Curr Opin Pulm Med 2007; 13: 284-289.
    • (2007) Curr Opin Pulm Med , vol.13 , pp. 284-289
    • Olaussen, K.A.1    Mountzios, G.2    Soria, J.C.3
  • 13
    • 84868607952 scopus 로고    scopus 로고
    • Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression
    • Igawa S, Ryuge S, Wada M, et al. Pemetrexed for previously treated patients with non-small cell lung cancer and differences in efficacy according to thymidylate synthase expression. Chemotherapy 2012; 58: 313-320.
    • (2012) Chemotherapy , vol.58 , pp. 313-320
    • Igawa, S.1    Ryuge, S.2    Wada, M.3
  • 14
    • 80051785282 scopus 로고    scopus 로고
    • Significance of thymidylate synthase and thyroid transcription factor 1 expression in patients with nonsquamous non-small cell lung cancer treated with pemetrexed-based chemotherapy
    • Sun JM, Han J, Ahn JS, et al. Significance of thymidylate synthase and thyroid transcription factor 1 expression in patients with nonsquamous non-small cell lung cancer treated with pemetrexed-based chemotherapy. J Thorac Oncol 2011; 6: 1392-1399.
    • (2011) J Thorac Oncol , vol.6 , pp. 1392-1399
    • Sun, J.M.1    Han, J.2    Ahn, J.S.3
  • 15
    • 84866434919 scopus 로고    scopus 로고
    • Genomic landscape of non-small cell lung cancer in smokers and neversmokers
    • Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and neversmokers. Cell 2012; 150: 1121-1134.
    • (2012) Cell , vol.150 , pp. 1121-1134
    • Govindan, R.1    Ding, L.2    Griffith, M.3
  • 16
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski M, Berger AH, Hammerman PS, et al. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 2012; 150: 1107-1120.
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1    Berger, A.H.2    Hammerman, P.S.3
  • 18
    • 79551563284 scopus 로고    scopus 로고
    • International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol 2011; 6: 244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 19
    • 77649091118 scopus 로고    scopus 로고
    • A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry
    • Mino-Kenudson M, Chirieac LR, Law K, et al. A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry. Clin Cancer Res 2010; 16: 1561-1571.
    • (2010) Clin Cancer Res , vol.16 , pp. 1561-1571
    • Mino-Kenudson, M.1    Chirieac, L.R.2    Law, K.3
  • 20
    • 84867404458 scopus 로고    scopus 로고
    • Training increases concordance in classifying pulmonary adenocarcinomas according to the novel IASLC/ATS/ERS classification
    • Warth A, Cortis J, Fink L, et al. Training increases concordance in classifying pulmonary adenocarcinomas according to the novel IASLC/ATS/ERS classification. Virchows Arch 2012; 461: 185-193.
    • (2012) Virchows Arch , vol.461 , pp. 185-193
    • Warth, A.1    Cortis, J.2    Fink, L.3
  • 21
    • 84868592268 scopus 로고    scopus 로고
    • Interobserver variability in the application of the novel IASLC/ATS/ERS classification for pulmonary adenocarcinomas
    • Warth A, Stenzinger A, von Brünneck AC, et al. Interobserver variability in the application of the novel IASLC/ATS/ERS classification for pulmonary adenocarcinomas. Eur Respir J 2012; 40: 1221-1227.
    • (2012) Eur Respir J , vol.40 , pp. 1221-1227
    • Warth, A.1    Stenzinger, A.2    Von Brünneck, A.C.3
  • 22
    • 80052261903 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase translocation: A predictive biomarker of pemetrexed in patients with non-small cell lung cancer
    • Lee JO, Kim TM, Lee SH, et al. Anaplastic lymphoma kinase translocation: a predictive biomarker of pemetrexed in patients with non-small cell lung cancer. J Thorac Oncol 2011; 6: 1474-1480.
    • (2011) J Thorac Oncol , vol.6 , pp. 1474-1480
    • Lee, J.O.1    Kim, T.M.2    Lee, S.H.3
  • 23
    • 44249119366 scopus 로고    scopus 로고
    • ERCC1 expression by immunohistochemistry and EGFR mutations in resected non-small cell lung cancer
    • Lee KH, Min HS, Han SW, et al. ERCC1 expression by immunohistochemistry and EGFR mutations in resected non-small cell lung cancer. Lung Cancer 2008; 60: 401-407.
    • (2008) Lung Cancer , vol.60 , pp. 401-407
    • Lee, K.H.1    Min, H.S.2    Han, S.W.3
  • 24
    • 41849136922 scopus 로고    scopus 로고
    • Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: Role of gefitinib-induced down-regulation of thymidylate synthase
    • Okabe T, Okamoto I, Tsukioka S, et al. Synergistic antitumor effect of S-1 and the epidermal growth factor receptor inhibitor gefitinib in non-small cell lung cancer cell lines: role of gefitinib-induced down-regulation of thymidylate synthase. Mol Cancer Ther 2008; 7: 599-606.
    • (2008) Mol Cancer Ther , vol.7 , pp. 599-606
    • Okabe, T.1    Okamoto, I.2    Tsukioka, S.3
  • 25
    • 41149096042 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in nonsmall-cell lung cancer cells
    • Giovannetti E, Lemos C, Tekle C, et al. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in nonsmall-cell lung cancer cells. Mol Pharmacol 2008; 73: 1290-1300.
    • (2008) Mol Pharmacol , vol.73 , pp. 1290-1300
    • Giovannetti, E.1    Lemos, C.2    Tekle, C.3
  • 26
    • 84864524696 scopus 로고    scopus 로고
    • Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1
    • Ohashi K, Sequist LV, Arcila ME, et al. Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. Proc Natl Acad Sci USA 2012; 109: E2127-E2133.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • Ohashi, K.1    Sequist, L.V.2    Arcila, M.E.3
  • 27
    • 84864280988 scopus 로고    scopus 로고
    • ERCC1 expression as a prognostic and predictive factor in patients with non-small cell lung cancer: A meta-analysis
    • Jiang J, Liang X, Zhou X, et al. ERCC1 expression as a prognostic and predictive factor in patients with non-small cell lung cancer: a meta-analysis. Mol Biol Rep 2012; 39: 6933-6942.
    • (2012) Mol Biol Rep , vol.39 , pp. 6933-6942
    • Jiang, J.1    Liang, X.2    Zhou, X.3
  • 28
    • 79955813242 scopus 로고    scopus 로고
    • Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
    • Takezawa K, Okamoto I, Okamoto W, et al. Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer. Br J Cancer 2011; 104: 1594-1601.
    • (2011) Br J Cancer , vol.104 , pp. 1594-1601
    • Takezawa, K.1    Okamoto, I.2    Okamoto, W.3
  • 29
    • 84861337347 scopus 로고    scopus 로고
    • Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer
    • Wynes MW, Konopa K, Singh S, et al. Thymidylate synthase protein expression by IHC and gene copy number by SISH correlate and show great variability in non-small cell lung cancer. J Thorac Oncol 2012; 7: 982-992.
    • (2012) J Thorac Oncol , vol.7 , pp. 982-992
    • Wynes, M.W.1    Konopa, K.2    Singh, S.3
  • 30
    • 15844372318 scopus 로고    scopus 로고
    • ERCC1 expression is a predictor of survival in resected patients with nonsmall cell lung cancer
    • Simon GR, Sharma S, Cantor A, et al. ERCC1 expression is a predictor of survival in resected patients with nonsmall cell lung cancer. Chest 2005; 127: 978-983.
    • (2005) Chest , vol.127 , pp. 978-983
    • Simon, G.R.1    Sharma, S.2    Cantor, A.3
  • 31
    • 46049107879 scopus 로고    scopus 로고
    • Thymidylate synthase in situ protein expression and survival in stage i nonsmall-cell lung cancer
    • Zheng Z, Li X, Schell MJ, et al. Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer. Cancer 2008; 112: 2765-2773.
    • (2008) Cancer , vol.112 , pp. 2765-2773
    • Zheng, Z.1    Li, X.2    Schell, M.J.3
  • 32
    • 33847127528 scopus 로고    scopus 로고
    • DNA repair and survival in lung cancer-the two faces of Janus
    • Gazdar AF. DNA repair and survival in lung cancer-the two faces of Janus. N Engl J Med 2007; 356: 771-773.
    • (2007) N Engl J Med , vol.356 , pp. 771-773
    • Gazdar, A.F.1
  • 33
    • 84865561266 scopus 로고    scopus 로고
    • Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: Theranostic modeling by NSCLC constituent histological subclasses
    • Pierceall WE, Olaussen KA, Rousseau V, et al. Cisplatin benefit is predicted by immunohistochemical analysis of DNA repair proteins in squamous cell carcinoma but not adenocarcinoma: theranostic modeling by NSCLC constituent histological subclasses. Ann Oncol 2012; 23: 2245-2252.
    • (2012) Ann Oncol , vol.23 , pp. 2245-2252
    • Pierceall, W.E.1    Olaussen, K.A.2    Rousseau, V.3
  • 34
    • 84875181563 scopus 로고    scopus 로고
    • ERCC1 isoform expression and DNA repair in non-small-cell lung cancer
    • Friboulet L, Olaussen KA, Pignon JP, et al. ERCC1 isoform expression and DNA repair in non-small-cell lung cancer. N Engl J Med 2013; 368: 1101-1110.
    • (2013) N Engl J Med , vol.368 , pp. 1101-1110
    • Friboulet, L.1    Olaussen, K.A.2    Pignon, J.P.3
  • 35
    • 84859397680 scopus 로고    scopus 로고
    • Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis
    • Zhang Y, Sun Y, Pan Y, et al. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res 2012; 18: 1947-1953.
    • (2012) Clin Cancer Res , vol.18 , pp. 1947-1953
    • Zhang, Y.1    Sun, Y.2    Pan, Y.3
  • 36
    • 37549050186 scopus 로고    scopus 로고
    • Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung
    • Kim YT, Kim TY, Lee DS, et al. Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung. Lung Cancer 2008; 59: 111-118.
    • (2008) Lung Cancer , vol.59 , pp. 111-118
    • Kim, Y.T.1    Kim, T.Y.2    Lee, D.S.3
  • 37
    • 34249810645 scopus 로고    scopus 로고
    • KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
    • Massarelli E, Varella-Garcia M, Tang X, et al. KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer. Clin Cancer Res 2007; 13: 2890-2896.
    • (2007) Clin Cancer Res , vol.13 , pp. 2890-2896
    • Massarelli, E.1    Varella-Garcia, M.2    Tang, X.3
  • 38
    • 84859324636 scopus 로고    scopus 로고
    • Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with nonsmall cell lung cancer
    • Xu J, He J, Yang H, et al. Somatic mutation analysis of EGFR, KRAS, BRAF and PIK3CA in 861 patients with nonsmall cell lung cancer. Cancer Biomark 2011-2012; 10: 63-69.
    • (2011) Cancer Biomark , vol.10 , pp. 63-69
    • Xu, J.1    He, J.2    Yang, H.3
  • 39
    • 69249173084 scopus 로고    scopus 로고
    • Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status
    • Pesek M, Benesova L, Belsanova B, et al. Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status. Anticancer Res 2009; 29: 2767-2773.
    • (2009) Anticancer Res , vol.29 , pp. 2767-2773
    • Pesek, M.1    Benesova, L.2    Belsanova, B.3
  • 40
    • 84861083983 scopus 로고    scopus 로고
    • Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: A phase 1 dose-escalation trial
    • Falchook GS, Long GV, Kurzrock R, et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. Lancet 2012; 379: 1893-1901.
    • (2012) Lancet , vol.379 , pp. 1893-1901
    • Falchook, G.S.1    Long, G.V.2    Kurzrock, R.3
  • 41
    • 84861740806 scopus 로고    scopus 로고
    • Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib
    • Sen B, Peng S, Tang X, et al. Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. Sci Transl Med 2012; 4: 136ra170.
    • (2012) Sci Transl Med , vol.4
    • Sen, B.1    Peng, S.2    Tang, X.3
  • 42
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011; 29: 2046-2051.
    • (2011) J Clin Oncol , vol.29 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 43
    • 80053014471 scopus 로고    scopus 로고
    • Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations
    • Marchetti A, Felicioni L, Malatesta S, et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J Clin Oncol 2011; 29: 3574-3579.
    • (2011) J Clin Oncol , vol.29 , pp. 3574-3579
    • Marchetti, A.1    Felicioni, L.2    Malatesta, S.3
  • 44
    • 84874274525 scopus 로고    scopus 로고
    • Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage i lung adenocarcinoma
    • Kadota K, Nitadori JI, Sarkaria IS, et al. Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma. Cancer 2013; 119: 931-938.
    • (2013) Cancer , vol.119 , pp. 931-938
    • Kadota, K.1    Nitadori, J.I.2    Sarkaria, I.S.3
  • 45
    • 84862799074 scopus 로고    scopus 로고
    • Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung
    • Lee JG, Kim S, Shim HS. Napsin A is an independent prognostic factor in surgically resected adenocarcinoma of the lung. Lung Cancer 2012; 77: 156-161.
    • (2012) Lung Cancer , vol.77 , pp. 156-161
    • Lee, J.G.1    Kim, S.2    Shim, H.S.3


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