-
1
-
-
2342624080
-
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
-
COI: 1:CAS:528:DC%2BD2cXksVGmsbs%3D, PID: 15118125
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004;304(5676):1497–500.
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
2
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
COI: 1:CAS:528:DC%2BD2cXktF2js7c%3D, PID: 15118073
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350(21):2129–39.
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
3
-
-
34249860227
-
Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China
-
PID: 17473659
-
Wu YL, Zhong WZ, Li LY, Zhang XT, Zhang L, Zhou CC, et al. Epidermal growth factor receptor mutations and their correlation with gefitinib therapy in patients with non-small cell lung cancer: a meta-analysis based on updated individual patient data from six medical centers in mainland China. J Thorac Oncol. 2007;2(5):430–9.
-
(2007)
J Thorac Oncol
, vol.2
, Issue.5
, pp. 430-439
-
-
Wu, Y.L.1
Zhong, W.Z.2
Li, L.Y.3
Zhang, X.T.4
Zhang, L.5
Zhou, C.C.6
-
4
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
COI: 1:CAS:528:DC%2BD1MXhtVOqsL7M, PID: 19692684
-
Rosell R, Moran T, Queralt C, Porta R, Cardenal F, Camps C, et al. Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med. 2009;361(10):958–67.
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
Porta, R.4
Cardenal, F.5
Camps, C.6
-
5
-
-
20044364933
-
EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment
-
COI: 1:CAS:528:DC%2BD2MXitVKit7o%3D, PID: 15681531
-
Marchetti A, Martella C, Felicioni L, Barassi F, Salvatore S, Chella A, et al. EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol. 2005;23(4):857–65.
-
(2005)
J Clin Oncol
, vol.23
, Issue.4
, pp. 857-865
-
-
Marchetti, A.1
Martella, C.2
Felicioni, L.3
Barassi, F.4
Salvatore, S.5
Chella, A.6
-
6
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC3cXhtlGgtbo%3D, PID: 20022809
-
Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11(2):121–8.
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
-
7
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study
-
COI: 1:CAS:528:DC%2BC3MXpslKhsbY%3D, PID: 21783417
-
Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 2011;12(8):735–42.
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
-
8
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
-
COI: 1:CAS:528:DC%2BC38XjsVCgsbk%3D, PID: 22285168
-
Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13(3):239–46.
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
-
9
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
COI: 1:CAS:528:DC%2BD1MXhtVygsbfK, PID: 19692680
-
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10):947–57.
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
-
10
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
COI: 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D, PID: 20573926
-
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362(25):2380–8.
-
(2010)
N Engl J Med
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
-
11
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
COI: 1:CAS:528:DC%2BC3sXhs1KrsrzP, PID: 23816960
-
Sequist LV, Yang JC, Yamamoto N, O’Byrne K, Hirsh V, Mok T, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327–34.
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
O’Byrne, K.4
Hirsh, V.5
Mok, T.6
-
12
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
COI: 1:CAS:528:DC%2BD1cXpvVWmtLg%3D, PID: 18506025
-
Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol. 2008;26(21):3543–51.
-
(2008)
J Clin Oncol
, vol.26
, Issue.21
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
von Pawel, J.3
Biesma, B.4
Vansteenkiste, J.5
Manegold, C.6
-
13
-
-
2442661845
-
Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
-
COI: 1:CAS:528:DC%2BD2cXpsVWmurk%3D, PID: 15117980
-
Hanna N, Shepherd FA, Fossella FV, Pereira JR, De Marinis F, von Pawel J, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol. 2004;22(9):1589–97.
-
(2004)
J Clin Oncol
, vol.22
, Issue.9
, pp. 1589-1597
-
-
Hanna, N.1
Shepherd, F.A.2
Fossella, F.V.3
Pereira, J.R.4
De Marinis, F.5
von Pawel, J.6
-
14
-
-
67349088399
-
Pemetrexed in first-line treatment of non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BD1MXmtlOqtro%3D, PID: 19269106
-
Esteban E, Casillas M, Cassinello A. Pemetrexed in first-line treatment of non-small cell lung cancer. Cancer Treat Rev. 2009;35(4):364–73.
-
(2009)
Cancer Treat Rev
, vol.35
, Issue.4
, pp. 364-373
-
-
Esteban, E.1
Casillas, M.2
Cassinello, A.3
-
15
-
-
79955474006
-
Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations
-
PID: 21111508
-
Wu SG, Yang CH, Yu CJ, Lee JH, Hsu YC, Chang YL, et al. Good response to pemetrexed in patients of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Lung Cancer. 2011;72(3):333–9.
-
(2011)
Lung Cancer
, vol.72
, Issue.3
, pp. 333-339
-
-
Wu, S.G.1
Yang, C.H.2
Yu, C.J.3
Lee, J.H.4
Hsu, Y.C.5
Chang, Y.L.6
-
16
-
-
84883290944
-
Pemetrexed and cisplatin for advanced non-squamous non-small cell lung cancer in Japanese patients: phase II study
-
COI: 1:CAS:528:DC%2BC3sXhsVaqsbzN, PID: 23898099
-
Kawano Y, Ohyanagi F, Yanagitani N, Kudo K, Horiike A, Tanimoto A, et al. Pemetrexed and cisplatin for advanced non-squamous non-small cell lung cancer in Japanese patients: phase II study. Anticancer Res. 2013;33(8):3327–33.
-
(2013)
Anticancer Res
, vol.33
, Issue.8
, pp. 3327-3333
-
-
Kawano, Y.1
Ohyanagi, F.2
Yanagitani, N.3
Kudo, K.4
Horiike, A.5
Tanimoto, A.6
-
17
-
-
84857784041
-
The value of biomarkers in patients with sarcomatoid carcinoma of the lung: molecular analysis of 33 cases
-
COI: 1:CAS:528:DC%2BC38Xnsl2qurY%3D, PID: 22169481
-
Jiang X, Liu Y, Chen C, Zhan Z, Yan Q, Guo Y, et al. The value of biomarkers in patients with sarcomatoid carcinoma of the lung: molecular analysis of 33 cases. Clin Lung Cancer. 2012;13(4):288–96.
-
(2012)
Clin Lung Cancer
, vol.13
, Issue.4
, pp. 288-296
-
-
Jiang, X.1
Liu, Y.2
Chen, C.3
Zhan, Z.4
Yan, Q.5
Guo, Y.6
-
18
-
-
57849117384
-
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
-
COI: 1:STN:280:DC%2BD1M%2Fgs12rug%3D%3D, PID: 19097774
-
Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228–47.
-
(2009)
Eur J Cancer
, vol.45
, Issue.2
, pp. 228-247
-
-
Eisenhauer, E.A.1
Therasse, P.2
Bogaerts, J.3
Schwartz, L.H.4
Sargent, D.5
Ford, R.6
-
19
-
-
79955813242
-
Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
-
COI: 1:CAS:528:DC%2BC3MXlvFGgu7k%3D, PID: 21487406
-
Takezawa K, Okamoto I, Okamoto W, Takeda M, Sakai K, Tsukioka S, et al. Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer. Br J Cancer. 2011;104(10):1594–601.
-
(2011)
Br J Cancer
, vol.104
, Issue.10
, pp. 1594-1601
-
-
Takezawa, K.1
Okamoto, I.2
Okamoto, W.3
Takeda, M.4
Sakai, K.5
Tsukioka, S.6
-
20
-
-
33749587054
-
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
-
COI: 1:CAS:528:DC%2BD28XhtFersLjK, PID: 16955506
-
Ceppi P, Volante M, Saviozzi S, Rapa I, Novello S, Cambieri A, et al. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer. 2006;107(7):1589–96.
-
(2006)
Cancer
, vol.107
, Issue.7
, pp. 1589-1596
-
-
Ceppi, P.1
Volante, M.2
Saviozzi, S.3
Rapa, I.4
Novello, S.5
Cambieri, A.6
-
21
-
-
39749121476
-
Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors
-
COI: 1:CAS:528:DC%2BD1cXhvF2gu7w%3D, PID: 18281538
-
Ceppi P, Volante M, Ferrero A, Righi L, Rapa I, Rosas R, et al. Thymidylate synthase expression in gastroenteropancreatic and pulmonary neuroendocrine tumors. Clin Cancer Res. 2008;14(4):1059–64.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.4
, pp. 1059-1064
-
-
Ceppi, P.1
Volante, M.2
Ferrero, A.3
Righi, L.4
Rapa, I.5
Rosas, R.6
-
22
-
-
0034029995
-
Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: a multicenter phase II trial
-
COI: 1:STN:280:DC%2BD3cvotVGntQ%3D%3D, PID: 10847462
-
Manegold C, Gatzemeier U, von Pawel J, Pirker R, Malayeri R, Blatter J, et al. Front-line treatment of advanced non-small-cell lung cancer with MTA (LY231514, pemetrexed disodium, ALIMTA) and cisplatin: a multicenter phase II trial. Ann Oncol. 2000;11(4):435–40.
-
(2000)
Ann Oncol
, vol.11
, Issue.4
, pp. 435-440
-
-
Manegold, C.1
Gatzemeier, U.2
von Pawel, J.3
Pirker, R.4
Malayeri, R.5
Blatter, J.6
-
23
-
-
19944426696
-
Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small cell lung cancer: a multicenter, randomized, phase II trial
-
COI: 1:CAS:528:DC%2BD2MXislWgtbk%3D, PID: 15701857
-
Scagliotti GV, Kortsik C, Dark GG, Price A, Manegold C, Rosell R, et al. Pemetrexed combined with oxaliplatin or carboplatin as first-line treatment in advanced non-small cell lung cancer: a multicenter, randomized, phase II trial. Clin Cancer Res. 2005;11(2 Pt 1):690–6.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.2
, pp. 690-696
-
-
Scagliotti, G.V.1
Kortsik, C.2
Dark, G.G.3
Price, A.4
Manegold, C.5
Rosell, R.6
-
24
-
-
28044463139
-
Phase II study of pemetrexed in combination with carboplatin in the first-line treatment of advanced nonsmall cell lung cancer
-
COI: 1:CAS:528:DC%2BD2MXhtlWgt7bE, PID: 16258975
-
Zinner RG, Fossella FV, Gladish GW, Glisson BS, Blumenschein Jr GR, Papadimitrakopoulou VA, et al. Phase II study of pemetrexed in combination with carboplatin in the first-line treatment of advanced nonsmall cell lung cancer. Cancer. 2005;104(11):2449–56.
-
(2005)
Cancer
, vol.104
, Issue.11
, pp. 2449-2456
-
-
Zinner, R.G.1
Fossella, F.V.2
Gladish, G.W.3
Glisson, B.S.4
Blumenschein, G.R.5
Papadimitrakopoulou, V.A.6
-
25
-
-
0035985288
-
Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer
-
COI: 1:STN:280:DC%2BD38zjtlWrtA%3D%3D, PID: 12075742
-
Clarke SJ, Abratt R, Goedhals L, Boyer MJ, Millward MJ, Ackland SP. Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapy-naive patients with advanced non-small-cell lung cancer. Ann Oncol. 2002;13(5):737–41.
-
(2002)
Ann Oncol
, vol.13
, Issue.5
, pp. 737-741
-
-
Clarke, S.J.1
Abratt, R.2
Goedhals, L.3
Boyer, M.J.4
Millward, M.J.5
Ackland, S.P.6
-
26
-
-
41149096042
-
Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells
-
COI: 1:CAS:528:DC%2BD1cXjvFels7k%3D, PID: 18187583
-
Giovannetti E, Lemos C, Tekle C, Smid K, Nannizzi S, Rodriguez JA, et al. Molecular mechanisms underlying the synergistic interaction of erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, with the multitargeted antifolate pemetrexed in non-small-cell lung cancer cells. Mol Pharmacol. 2008;73(4):1290–300.
-
(2008)
Mol Pharmacol
, vol.73
, Issue.4
, pp. 1290-1300
-
-
Giovannetti, E.1
Lemos, C.2
Tekle, C.3
Smid, K.4
Nannizzi, S.5
Rodriguez, J.A.6
-
27
-
-
73449084433
-
Platinum-based chemotherapy in lung cancer affects the expression of certain biomarkers including ERCC1
-
COI: 1:CAS:528:DC%2BD1MXhsFCltrnL
-
Papay J, Sapi Z, Egri G, Gyulai M, Szende B, Losonczy G, et al. Platinum-based chemotherapy in lung cancer affects the expression of certain biomarkers including ERCC1. Pathol Oncol Res POR. 2009;15(3):445–50.
-
(2009)
Pathol Oncol Res POR
, vol.15
, Issue.3
, pp. 445-450
-
-
Papay, J.1
Sapi, Z.2
Egri, G.3
Gyulai, M.4
Szende, B.5
Losonczy, G.6
-
28
-
-
84881161098
-
Prognostic value of EGFR mutation and ERCC1 in patients with non-small cell lung cancer undergoing platinum-based chemotherapy
-
COI: 1:CAS:528:DC%2BC3sXhtlWgtrjK, PID: 23940741
-
Yamashita F, Azuma K, Yoshida T, Yamada K, Kawahara A, Hattori S, et al. Prognostic value of EGFR mutation and ERCC1 in patients with non-small cell lung cancer undergoing platinum-based chemotherapy. PLoS One. 2013;8(8):e71356.
-
(2013)
PLoS One
, vol.8
, Issue.8
, pp. 71356
-
-
Yamashita, F.1
Azuma, K.2
Yoshida, T.3
Yamada, K.4
Kawahara, A.5
Hattori, S.6
-
29
-
-
84887215068
-
Response to first-line chemotherapy in patients with non-small-cell lung cancer according to epidermal growth factor receptor and K-RAS mutation status
-
COI: 1:CAS:528:DC%2BC3sXht1eks7zE, PID: 23910066
-
Dong X, Zhao X, Hao Y, Wei Y, Yin Q, Du J. Response to first-line chemotherapy in patients with non-small-cell lung cancer according to epidermal growth factor receptor and K-RAS mutation status. Clin Lung Cancer. 2013;14(6):680–7.
-
(2013)
Clin Lung Cancer
, vol.14
, Issue.6
, pp. 680-687
-
-
Dong, X.1
Zhao, X.2
Hao, Y.3
Wei, Y.4
Yin, Q.5
Du, J.6
-
30
-
-
84899493745
-
Response to pemetrexed rechallenge after acquired resistance of EGFR-TKI in a patient with advanced NSCLC
-
PID: 24636847
-
Li S, Zhou F, Ren S, Zhou C. Response to pemetrexed rechallenge after acquired resistance of EGFR-TKI in a patient with advanced NSCLC. Lung Cancer. 2014;84(2):203–5.
-
(2014)
Lung Cancer
, vol.84
, Issue.2
, pp. 203-205
-
-
Li, S.1
Zhou, F.2
Ren, S.3
Zhou, C.4
|