A three-phase approach for the early identification of acute lung injury induced by severe sepsis

In Vivo

Volumn 30, Issue 4, 2016, Pages 341-349

  Miyashita, Tomoharu ^a   Ahmed, Ali Karim ^b   Nakanuma, Shinichi ^a   Okamoto, Koichi ^a   Sakai, Seisho ^a   Kinoshita, Jun ^a   Makino, Isamu ^a   Nakamura, Keishi ^a   Hayashi, Hironori ^a   Oyama, Katsunobu ^a   Tajima, Hidehiro ^a   Takamura, Hiroyuki ^a   Ninomiya, Itasu ^a   Fushida, Sachio ^a   Harmon, John W ^b   Ohta, Tetsuo ^a  

^a KANAZAWA UNIVERSITY HOSPITAL   (Japan)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute lung injury (ALI); Acute respiratory distress syndrome (ARDS); Extravasated platelet aggregation (EPA); Neutrophil extracellular trap (NET); Review; Sepsis; Veno occlusive disease

Indexed keywords

BERAPROST; DOPAMINE; IMMUNOGLOBULIN; LEVOFLOXACIN; PHOSPHODIESTERASE III INHIBITOR; PLASMIN INHIBITOR; SIVELESTAT; THROMBIN ANTITHROMBIN COMPLEX;

ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; CASE REPORT; CELL DAMAGE; CELL INTERACTION; CHROMATIN STRUCTURE; CLINICAL PRACTICE; DISEASE COURSE; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTHELIUM CELL; EXTRACELLULAR TRAP; EXTRAVASATED PLATELET AGGREGATION; FEMALE; FOLLOW UP; HUMAN; HYPOTENSION; INTRAVASATED PLATELET AGGREGATION; LABORATORY TEST; LUNG FIBROSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTALITY; MULTIPLE ORGAN FAILURE; NEUTROPHIL; NONHUMAN; PULMONARY VENO-OCCLUSIVE DISEASE; REVIEW; RISK FACTOR; SEPSIS; SEPTIC SHOCK; SEVERE SEPSIS; THROMBOCYTE; THROMBOCYTE AGGREGATION; VERY ELDERLY; COMPLICATION; PATHOPHYSIOLOGY;

ACUTE LUNG INJURY; HUMANS; SEPSIS;

EID: 84978288318     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Kuhlen R and Dembinski R: Mechanical ventilation of acute lung injury. Pneumologie 61(4): 249-255, 2007 (in German).
2. Niederman MS and Fein AM: Sepsis syndrome, the adult respiratory distress syndrome, and nosocomial pneumonia. A common clinical sequence. Clin Chest Med 11(4): 633-656, 1990.
3. Johnson ER and Matthay MA: Acute lung injury: Epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv 23(4): 243-252, 2010.
4. Proudfoot AG, McAuley DF, Griffiths MJ and Hind M: Human models of acute lung injury. Dis Model Mech 4(2): 145-153, 2011.
5. Hudson LD, Milberg JA, Anardi D and Maunder RJ: Clinical risks for development of the acute respiratory distress syndrome. Am J Respir Crit Care Med 151(2 Pt 1): 293-301, 1995.
6. Oliveira RH and Basille Filho A: Incidence of acute lung injury and acute respiratory distress syndrome in the intensive care unit of a university hospital: A prospective study. J Bras Pneumol 32(1): 35-42, 2006.
7. Sheu CC, Gong MN, Zhai R, Chen F, Bajwa EK, Clardy PF, Gallagher DC, Thompson BT and Christiani DC: Clinical characteristics and outcomes of sepsis-related vs. non-sepsisrelated ards. Chest 138(3): 559-567, 2010.
8. Johnston CJ, Rubenfeld GD and Hudson LD: Effect of age on the development of ards in trauma patients. Chest 124(2): 653-659, 2003.
9. Daurat A, Millet I, Roustan JP, Maury C, Taourel P, Jaber S, Capdevila X and Charbit J: Thoracic trauma severity score on admission allows to determine the risk of delayed ARDS in trauma patients with pulmonary contusion. Injury 47(1): 147-153, 2016.
10. Khadaroo RG and Marshall JC: Ards and the multiple organ dysfunction syndrome. Common mechanisms of a common systemic process. Crit Care Clin 18(1): 127-141, 2002.
11. Gando S, Kameue T, Matsuda N, Hayakawa M, Ishitani T, Morimoto Y and Kemmotsu O: Combined activation of coagulation and inflammation has an important role in multiple organ dysfunction and poor outcome after severe trauma. Thromb Haemost 88(6): 943-949, 2002.
12. Gando S, Nanzaki S, Sasaki S, Aoi K and Kemmotsu O: Activation of the extrinsic coagulation pathway in patients with severe sepsis and septic shock. Crit Care Med 26(12): 2005-2009, 1998.
13. Gando S, Kameue T, Nanzaki S and Nakanishi Y: Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome. Thromb Haemost 75(2): 224-228, 1996.
14. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS and Wenzel RP: The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 273(2): 117-123, 1995.
15. Ogura H, Gando S, Iba T, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, Mayumi T, Murata A, Ikeda T, Ishikura H, Ueyama M, Kushimoto S, Saitoh D, Endo S, Shimazaki S and Group JAfAMDICS: SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Shock 28(4): 411-417, 2007.
16. Russwurm S, Vickers J, Meier-Hellmann A, Spangenberg P, Bredle D, Reinhart K and Losche W: Platelet and leukocyte activation correlate with the severity of septic organ dysfunction. Shock 17(4): 263-268, 2002.
17. Katz JN, Kolappa KP and Becker RC: Beyond thrombosis: The versatile platelet in critical illness. Chest 139(3): 658-668, 2011.
18. Leibovici L, Drucker M, Samra Z, Konisberger H and Pitlik SD: Prognostic significance of the neutrophil count in immunocompetent patients with bacteraemia. QJM 88(3): 181-189, 1995.
19. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y and Zychlinsky A: Neutrophil extracellular traps kill bacteria. Science 303(5663): 1532-1535, 2004.
20. Brinkmann V and Zychlinsky A: Neutrophil extracellular traps: Is immunity the second function of chromatin? J Cell Biol 198(5): 773-783, 2012.
21. Yipp BG and Kubes P: Netosis: How vital is it? Blood 122(16): 2784-2794, 2013.
22. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F and Esmon CT: Extracellular histones are major mediators of death in sepsis. Nat Med 15(11): 1318-1321, 2009.
23. Andonegui G, Kerfoot SM, McNagny K, Ebbert KV, Patel KD and Kubes P: Platelets express functional toll-like receptor-4. Blood 106(7): 2417-2423, 2005.
24. Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, Keys EM, Allen-Vercoe E, Devinney R, Doig CJ, Green FH and Kubes P: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13(4): 463-469, 2007.
25. Lu YC, Yeh WC and Ohashi PS: Lps/tlr4 signal transduction pathway. Cytokine 42(2): 145-151, 2008.
26. McDonald B, Urrutia R, Yipp BG, Jenne CN and Kubes P: Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 12(3): 324-333, 2012.
27. Kambas K, Mitroulis I and Ritis K: The emerging role of neutrophils in thrombosis-the journey of TF through NETS. Front Immunol 3: 385, 2012.
28. Martinod K and Wagner DD: Thrombosis: Tangled up in NETS. Blood 123(18): 2768-2776, 2014.
29. Chen R, Kang R, Fan XG and Tang D: Release and activity of histone in diseases. Cell Death Dis 5: e1370, 2014.
30. Cheng OZ and Palaniyar N: Net balancing: A problem in inflammatory lung diseases. Front Immunol 4: 1, 2013.
31. Pugin J, Verghese G, Widmer MC and Matthay MA: The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 27(2): 304-312, 1999.
32. Pakala R, Sheng WL and Benedict CR: Eicosapentaenoic acid and docosahexaenoic acid block serotonin-induced smooth muscle cell proliferation. Arterioscler Thromb Vasc Biol 19(10): 2316-2322, 1999.
33. Nurden AT: Platelets and tissue remodeling: Extending the role of the blood clotting system. Endocrinology 148(7): 3053-3055, 2007.
34. Lee JH, Lee KH, Kim S, Seol M, Park CJ, Chi HS, Kang W, Kim ST, Kim WK and Lee JS: Plasminogen activator inhibitor-is an independent diagnostic marker as well as severity predictor of hepatic veno-occlusive disease after allogeneic bone marrow transplantation in adults conditioned with busulphan and cyclophosphamide. Br J Haematol 118(4): 1087-1094, 2002.
35. Ghasemzadeh M and Hosseini E: Platelet-leukocyte crosstalk: Linking proinflammatory responses to procoagulant state. Thromb Res 131(3): 191-197, 2013.
36. Li P, Ferrario CM and Brosnihan KB: Losartan inhibits thromboxane a2-induced platelet aggregation and vascular constriction in spontaneously hypertensive rats. J Cardiovasc Pharmacol 32(2): 198-205, 1998.
37. Moerland M, Kemme M, Dijkmans A, Bergougnan L and Burggraaf J: Modulation of vasoactivity and platelet aggregation by selective 5-ht receptor antagonism in humans. J Cardiovasc Pharmacol 58(6): 575-580, 2011.
38. Parenti A, Brogelli L, Filippi S, Donnini S and Ledda F: Effect of hypoxia and endothelial loss on vascular smooth muscle cell responsiveness to VEGF-A: Role of FLT-1/VEGF-receptor-1. Cardiovasc Res 55(1): 201-212, 2002.
39. Fiusa MM, Carvalho-Filho MA, Annichino-Bizzacchi JM and De Paula EV: Causes and consequences of coagulation activation in sepsis: An evolutionary medicine perspective. BMC Med 13: 105, 2015.
40. Taylor FB, Toh CH, Hoots WK, Wada H, Levi M and (ISTH) SSoDICDotISoTaH: Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 86(5): 1327-1330, 2001.
41. Vincent JL and De Backer D: Does disseminated intravascular coagulation lead to multiple organ failure? Crit Care Clin 21(3): 469-477, 2005.
42. van der Poll T and Levi M: Crosstalk between inflammation and coagulation: The lessons of sepsis. Curr Vasc Pharmacol 10(5): 632-638, 2012.
43. Asakura H: Classifying types of disseminated intravascular coagulation: Clinical and animal models. J Intensive Care 2(1): 20, 2014.
44. Nakanuma S, Miyashita T, Hayashi H, Tajima H, Takamura H, Tsukada T, Okamoto K, Sakai S, Makino I, Kinoshita J, Nakamura K, Oyama K, Inokuchi M, Nakagawara H, Ninomiya I, Kitagawa H, Fushida S, Fujimura T and Ohta T: Extravasated platelet aggregation in liver zone 3 may correlate with the progression of sinusoidal obstruction syndrome following living donor liver transplantation: A case report. Exp Ther Med 9(4): 1119-1124, 2015.
45. Pohlers D, Brenmoehl J, Loffler I, Muller CK, Leipner C, Schultze-Mosgau S, Stallmach A, Kinne RW and Wolf G: TGFbeta and fibrosis in different organs - molecular pathway imprints. Biochim Biophys Acta 1792(8): 746-756, 2009.
46. Hotchkiss RS, Coopersmith CM, McDunn JE and Ferguson TA: The sepsis seesaw: Tilting toward immunosuppression. Nat Med 15(5): 496-497, 2009.
47. Sundar KM and Sires M: Sepsis induced immunosuppression: Implications for secondary infections and complications. Indian J Crit Care Med 17(3): 162-169, 2013.
48. Terme M, Tartour E and Taieb J: VEGFA/VEGFR2-targeted therapies prevent the VEGFA-induced proliferation of regulatory t cells in cancer. Oncoimmunology 2(8): e25156, 2013.
49. Santin AD, Hermonat PL, Ravaggi A, Bellone S, Pecorelli S, Roman JJ, Parham GP and Cannon MJ: Interleukin-10 increases TH1 cytokine production and cytotoxic potential in human papillomavirus-specific CD8(+) cytotoxic T lymphocytes. J Virol 74(10): 4729-4737, 2000.
50. Schlom J, Jochems C, Gulley JL and Huang J: The role of soluble CD40l in immunosuppression. Oncoimmunology 2(1): e22546, 2013.
51. Miller TW, Kaur S, Ivins-O'Keefe K and Roberts DD: Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T-cell activation. Matrix Biol 32(6): 316-324, 2013.
52. Fein AM and Calalang-Colucci MG: Acute lung injury and acute respiratory distress syndrome in sepsis and septic shock. Crit Care Clin 16(2): 289-317, 2000.
53. Zeni F, Freeman B and Natanson C: Anti-inflammatory therapies to treat sepsis and septic shock: A reassessment. Crit Care Med 25(7): 1095-1100, 1997.
54. Klok FA, Mos IC, van Kralingen KW, Vahl JE and Huisman MV: Chronic pulmonary embolism and pulmonary hypertension. Semin Respir Crit Care Med 33(2): 199-204, 2012.
55. Sun B, Li H, Shakur Y, Hensley J, Hockman S, Kambayashi J, Manganiello VC and Liu Y: Role of phosphodiesterase type 3a and 3b in regulating platelet and cardiac function using subtypeselective knockout mice. Cell Signal 19(8): 1765-1771, 2007.
56. Lobato EB, Beaver T, Muehlschlegel J, Kirby DS, Klodell C and Sidi A: Treatment with phosphodiesterase inhibitors type III and V: Milrinone and sildenafil is an effective combination during thromboxane-induced acute pulmonary hypertension. Br J Anaesth 96(3): 317-322, 2006.
57. Raghavendran K, Pryhuber GS, Chess PR, Davidson BA, Knight PR and Notter RH: Pharmacotherapy of acute lung injury and acute respiratory distress syndrome. Curr Med Chem 15(19): 1911-1924, 2008.
58. Barradas MA, Jagroop A, O'Donoghue S, Jeremy JY and Mikhailidis DP: Effect of milrinone in human platelet shape change, aggregation and thromboxane a2 synthesis: An in vitro study. Thromb Res 71(3): 227-236, 1993.
59. Manns JM, Brenna KJ, Colman RW and Sheth SB: Differential regulation of human platelet responses by CGMP inhibited and stimulated camp phosphodiesterases. Thromb Haemost 87(5): 873-879, 2002.
60. Schror K: The pharmacology of cilostazol. Diabetes Obes Metab 4(Suppl 2): S14-19, 2002.
61. Mizock BA: Metabolic derangements in sepsis and septic shock. Crit Care Clin 16(2): 319-336, vii, 2000.
62. Taylor JH and Beilman GJ: Hyperglycemia in the intensive care unit: No longer just a marker of illness severity. Surg Infect (Larchmt) 6(2): 233-245, 2005.
63. Georgescu A, Popov D, Dragan E, Dragomir E and Badila E: Protective effects of nebivolol and reversal of endothelial dysfunction in diabetes associated with hypertension. Eur J Pharmacol 570(1-3): 149-158, 2007.
64. Hirasawa H, Oda S and Nakamura M: Blood glucose control in patients with severe sepsis and septic shock. World J Gastroenterol 15(33): 4132-4136, 2009.
65. Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I and Shen CL: Novel insights of dietary polyphenols and obesity. J Nutr Biochem 25(1): 1-18, 2014.
66. Wieser V, Moschen AR and Tilg H: Inflammation, cytokines and insulin resistance: A clinical perspective. Arch Immunol Ther Exp (Warsz) 61(2): 119-125, 2013.
67. Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K and Kadowaki T: Impaired insulin signaling in endothelial cells reduces insulininduced glucose uptake by skeletal muscle. Cell Metab 13(3): 294-307, 2011.
68. Utsunomiya K: Treatment strategy for type 2 diabetes from the perspective of systemic vascular protection and insulin resistance. Vasc Health Risk Manag 8: 429-436, 2012.
69. Sakai S, Tajima H, Miyashita T, Nakanuma S, Makino I, Hayashi H, Nakagawara H, Kitagawa H, Fushida S, Fujimura T, Saito H, Munesue S, Yamamoto Y and Ohta T: Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury. Dig Dis Sci 59(4): 787-794, 2014.
70. Kawahara Y, Ninomiya I, Fujimura T, Funaki H, Nakagawara H, Takamura H, Oyama K, Tajima H, Fushida S, Inaba H and Kayahara M: Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer. Dis Esophagus 23(4): 329-339, 2010.
71. Hayakawa M, Katabami K, Wada T, Sugano M, Hoshino H, Sawamura A and Gando S: Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. Shock 33(1): 14-18, 2010.
72. Eguchi T, Yoshida K, Kondo R, Hamanaka K, Shiina T, Komatsu Y, Yamamoto H, Kubo K, Hasegawa J and Koizumi T: Sivelestat prevents cytoskeletal rearrangements in neutrophils resulting from lung re-expansion following one-lung ventilation during thoracic surgery. Inflammation 36(6): 1479-1484, 2013.
73. Asakura H, Jokaji H, Saito M, Uotani C, Kumabashiri I, Morishita E, Yamazaki M, Aoshima K and Matsuda T: Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers. Blood Coagul Fibrinolysis 5(5): 829-832, 1994.