Tideglusib, a chemical inhibitor of GSK3β, attenuates hypoxic-ischemic brain injury in neonatal mice

Biochimica et Biophysica Acta - General Subjects

Volumn 1860, Issue 10, 2016, Pages 2076-2085

  Wang, Haitao ^a   Huang, Sammen ^a   Yan, Kuipo ^a   Fang, Xiaoyan ^a   Abussaud, Ahmed ^a   Martinez, Ana ^b   Sun, Hong Shuo ^a   Feng, Zhong Ping ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Apoptosis; GSK 3 ; Neonatal hypoxia ischemia; Neuroprotection; Tideglusib

Indexed keywords

CASPASE 3; CASPASE 9; GLIAL FIBRILLARY ACIDIC PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; NOTCH1 RECEPTOR; PROTEIN KINASE B; STAT3 PROTEIN; TIDEGLUSIB; 4 BENZYL 2 METHYL 1,2,4 THIAZOLIDINE 3,5 DIONE; ENZYME INHIBITOR; GSK3B PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; THIADIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN INFARCTION SIZE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; MOUSE; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAINING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN INJURIES; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; HYPOXIA-ISCHEMIA, BRAIN; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN INJURIES; CASPASE 3; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MICE; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; THIADIAZOLES;

EID: 84978284935     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2016.06.027     Document Type: Article

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