메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; FUSION PROTEIN; GREEN FLUORESCENT PROTEIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

EID: 84978141436     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29523     Document Type: Article
Times cited : (39)

References (47)
  • 1
    • 77953796839 scopus 로고    scopus 로고
    • A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    • Scott, D. A. et al. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci 30, 8083-8095, doi: 10.1523/JNEUROSCI.1091-10.2010 (2010)
    • (2010) J Neurosci , vol.30 , pp. 8083-8095
    • Scott, D.A.1
  • 2
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of alpha-synuclein: From structure and toxicity to therapeutic target
    • Lashuel, H. A., Overk, C. R., Oueslati, A. & Masliah, E. The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci 14, 38-48, doi: 10.1038/nrn3406 (2013)
    • (2013) Nat Rev Neurosci , vol.14 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3    Masliah, E.4
  • 3
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday, G. M., Holton, J. L., Revesz, T. & Dickson, D. W. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 122, 187-204, doi: 10.1007/s00401-011-0852-9 (2011)
    • (2011) Acta Neuropathol , vol.122 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 4
    • 84883174947 scopus 로고    scopus 로고
    • Parkinsons disease dementia: Convergence of alpha-synuclein, tau and amyloid-beta pathologies
    • Irwin, D. J., Lee, V. M. & Trojanowski, J. Q. Parkinsons disease dementia: convergence of alpha-synuclein, tau and amyloid-beta pathologies. Nature reviews. Neuroscience 14, 626-636, doi: 10.1038/nrn3549 (2013)
    • (2013) Nature Reviews. Neuroscience , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 5
    • 84880188930 scopus 로고    scopus 로고
    • Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop
    • McKeith, I. G. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. J Alzheimers Dis 9, 417-423 (2006)
    • (2006) J Alzheimers Dis , vol.9 , pp. 417-423
    • McKeith, I.G.1
  • 6
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinsons disease in mice
    • Chesselet, M. F. & Richter, F. Modelling of Parkinsons disease in mice. Lancet Neurol 10, 1108-1118, doi: 10.1016/S1474- 4422(11)70227-7 (2011)
    • (2011) Lancet Neurol , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, F.2
  • 7
    • 43249106066 scopus 로고    scopus 로고
    • Abnormal colonic motility in mice overexpressing human wild-type alphasynuclein
    • Wang, L., Fleming, S. M., Chesselet, M. F. & Tache, Y. Abnormal colonic motility in mice overexpressing human wild-type alphasynuclein. Neuroreport 19, 873-876, doi: 10.1097/WNR.0b013e3282ffda5e [doi] 00001756-200805280-00016 [pii] (2008)
    • (2008) Neuroreport , vol.19 , pp. 873-876
    • Wang, L.1    Fleming, S.M.2    Chesselet, M.F.3    Tache, Y.4
  • 8
    • 48249109112 scopus 로고    scopus 로고
    • Olfactory deficits in mice overexpressing human wildtype alpha-synuclein
    • Fleming, S. M. et al. Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. Eur J Neurosci 28, 247-256, doi: 10.1111/j.1460-9568.2008.06346.x (2008)
    • (2008) Eur J Neurosci , vol.28 , pp. 247-256
    • Fleming, S.M.1
  • 9
    • 84883533766 scopus 로고    scopus 로고
    • Impaired baroreflex function in mice overexpressing alpha-synuclein
    • Fleming, S. M. et al. Impaired baroreflex function in mice overexpressing alpha-synuclein. Front Neurol 4, 103, doi: 10.3389/ fneur.2013.00103 (2013)
    • (2013) Front Neurol 4 , vol.103 , Issue.2013 , pp. 00103
    • Fleming, S.M.1
  • 10
    • 80053932171 scopus 로고    scopus 로고
    • Circadian dysfunction in a mouse model of Parkinsons disease
    • Kudo, T., Loh, D. H., Truong, D., Wu, Y. & Colwell, C. S. Circadian dysfunction in a mouse model of Parkinsons disease. Exp Neurol 232, 66-75, doi: 10.1016/j.expneurol.2011.08.003 (2011)
    • (2011) Exp Neurol , vol.232 , pp. 66-75
    • Kudo, T.1    Loh, D.H.2    Truong, D.3    Wu, Y.4    Colwell, C.S.5
  • 11
    • 84900827193 scopus 로고    scopus 로고
    • Phosphorylated alpha-synuclein-immunoreactive retinal neuronal elements in Parkinsons disease subjects
    • Beach, T. G. et al. Phosphorylated alpha-synuclein-immunoreactive retinal neuronal elements in Parkinsons disease subjects. Neuroscience letters 571, 34-38, doi: 10.1016/j.neulet.2014.04.027 (2014)
    • (2014) Neuroscience Letters , vol.571 , pp. 34-38
    • Beach, T.G.1
  • 12
    • 84903711793 scopus 로고    scopus 로고
    • Alpha-synuclein in the inner retina in Parkinson disease
    • Bodis-Wollner, I., Kozlowski, P. B., Glazman, S. & Miri, S. alpha-synuclein in the inner retina in parkinson disease. Ann Neurol 75, 964-966, doi: 10.1002/ana.24182 (2014)
    • (2014) Ann Neurol , vol.75 , pp. 964-966
    • Bodis-Wollner, I.1    Kozlowski, P.B.2    Glazman, S.3    Miri, S.4
  • 13
    • 33646097224 scopus 로고    scopus 로고
    • Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): Implications for Lewy body disorders
    • Tofaris, G. K. et al. Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders. J Neurosci 26, 3942-3950, doi: 10.1523/ JNEUROSCI.4965-05.2006 (2006)
    • (2006) J Neurosci , vol.26 , pp. 3942-3950
    • Tofaris, G.K.1
  • 14
    • 84861692236 scopus 로고    scopus 로고
    • Alpha-synuclein in colonic submucosa in early untreated Parkinsons disease
    • Shannon, K. M. et al. Alpha-synuclein in colonic submucosa in early untreated Parkinsons disease. Mov. Disord. 27, 709-715, doi: 10.1002/mds.23838 (2012)
    • (2012) Mov. Disord , vol.27 , pp. 709-715
    • Shannon, K.M.1
  • 15
    • 0025346316 scopus 로고
    • Parkinsons disease: An immunohistochemical study of Lewy body-containing neurons in the enteric nervous system
    • Wakabayashi, K., Takahashi, H., Ohama, E. & Ikuta, F. Parkinsons disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol 79, 581-583 (1990)
    • (1990) Acta Neuropathol , vol.79 , pp. 581-583
    • Wakabayashi, K.1    Takahashi, H.2    Ohama, E.3    Ikuta, F.4
  • 16
    • 19344366060 scopus 로고    scopus 로고
    • Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinsons disease
    • Michell, A. W., Luheshi, L. M. & Barker, R. A. Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinsons disease. Neuroscience letters 381, 294-298, doi: 10.1016/j.neulet.2005.02.030 (2005)
    • (2005) Neuroscience Letters , vol.381 , pp. 294-298
    • Michell, A.W.1    Luheshi, L.M.2    Barker, R.A.3
  • 17
    • 39749123263 scopus 로고    scopus 로고
    • Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinsons disease
    • Orimo, S. et al. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinsons disease. Brain 131, 642-650, doi: 10.1093/brain/awm302 (2008)
    • (2008) Brain , vol.131 , pp. 642-650
    • Orimo, S.1
  • 18
    • 84898714555 scopus 로고    scopus 로고
    • Submandibular gland needle biopsy for the diagnosis of Parkinson disease
    • Adler, C. H. et al. Submandibular gland needle biopsy for the diagnosis of Parkinson disease. Neurology 82, 858-864, doi: 10.1212/ WNL.0000000000000204 (2014)
    • (2014) Neurology , vol.82 , pp. 858-864
    • Adler, C.H.1
  • 19
    • 4444302997 scopus 로고    scopus 로고
    • Retinal nerve fiber layer thinning in Parkinson disease
    • Inzelberg, R., Ramirez, J. A., Nisipeanu, P. & Ophir, A. Retinal nerve fiber layer thinning in Parkinson disease. Vision Res 44, 2793-2797, doi: 10.1016/j.visres.2004.06.009 (2004)
    • (2004) Vision Res , vol.44 , pp. 2793-2797
    • Inzelberg, R.1    Ramirez, J.A.2    Nisipeanu, P.3    Ophir, A.4
  • 20
    • 39549089096 scopus 로고    scopus 로고
    • Correlation between retinal morphological and functional findings and clinical severity in Parkinsons disease
    • Altintas, O., Iseri, P., Ozkan, B. & Caglar, Y. Correlation between retinal morphological and functional findings and clinical severity in Parkinsons disease. Doc Ophthalmol 116, 137-146, doi: 10.1007/s10633-007-9091-8 (2008)
    • (2008) Doc Ophthalmol , vol.116 , pp. 137-146
    • Altintas, O.1    Iseri, P.2    Ozkan, B.3    Caglar, Y.4
  • 21
    • 84875148881 scopus 로고    scopus 로고
    • Retinal vascular biomarkers for early detection and monitoring of Alzheimers disease
    • Frost, S. et al. Retinal vascular biomarkers for early detection and monitoring of Alzheimers disease. Transl Psychiatry 3, e233, doi: 10.1038/tp.2012.150 (2013)
    • (2013) Transl Psychiatry , vol.3 , pp. e233
    • Frost, S.1
  • 23
    • 84863717137 scopus 로고    scopus 로고
    • Neurodegeneration of the retina in mouse models of Alzheimers disease: What can we learn from the retina?
    • Chiu, K et al. Neurodegeneration of the retina in mouse models of Alzheimers disease: what can we learn from the retina? Age (Dordr) 34, 633-649, doi: 10.1007/s11357-011-9260-2 (2012)
    • (2012) Age (Dordr) , vol.34 , pp. 633-649
    • Chiu, K.1
  • 24
    • 84860217982 scopus 로고    scopus 로고
    • Alzheimers disease in the retina: Imaging retinal abeta plaques for early diagnosis and therapy assessment
    • Koronyo, Y., Salumbides, B. C., Black, K. L. & Koronyo-Hamaoui, M. Alzheimers disease in the retina: imaging retinal abeta plaques for early diagnosis and therapy assessment. Neuro-degenerative diseases 10, 285-293, doi: 10.1159/000335154 (2012)
    • (2012) Neuro-degenerative Diseases , vol.10 , pp. 285-293
    • Koronyo, Y.1    Salumbides, B.C.2    Black, K.L.3    Koronyo-Hamaoui, M.4
  • 25
    • 79956048283 scopus 로고    scopus 로고
    • A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina
    • Park, S. W. et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Investigative ophthalmology & visual science 52, 2837-2843, doi: 10.1167/iovs.09-5010 (2011)
    • (2011) Investigative Ophthalmology & Visual Science , vol.52 , pp. 2837-2843
    • Park, S.W.1
  • 26
    • 21044442669 scopus 로고    scopus 로고
    • Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein
    • Rockenstein, E. et al. Lysosomal pathology associated with alpha-synuclein accumulation in transgenic models using an eGFP fusion protein. J Neurosci Res 80, 247-259 (2005)
    • (2005) J Neurosci Res , vol.80 , pp. 247-259
    • Rockenstein, E.1
  • 27
    • 77956289142 scopus 로고    scopus 로고
    • In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility
    • Unni, V. K. et al. In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. PLoS One 5, e10589, doi: 10.1371/journal.pone.0010589 (2010)
    • (2010) PLoS One 5 , pp. e10589
    • Unni, V.K.1
  • 28
    • 84893488562 scopus 로고    scopus 로고
    • Presynaptic alpha-synuclein aggregation in a mouse model of Parkinsons disease
    • Spinelli, K. J. et al. Presynaptic alpha-synuclein aggregation in a mouse model of Parkinsons disease. J Neurosci 34, 2037-2050, doi: 10.1523/JNEUROSCI.2581-13.2014 (2014)
    • (2014) J Neurosci , vol.34 , pp. 2037-2050
    • Spinelli, K.J.1
  • 29
    • 84871921645 scopus 로고    scopus 로고
    • Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD
    • Spencer, B. et al. Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD. Mol Ther 21, 31-41, doi: 10.1038/mt.2012.66 (2013)
    • (2013) Mol Ther , vol.21 , pp. 31-41
    • Spencer, B.1
  • 30
    • 84890345413 scopus 로고    scopus 로고
    • Optimized protocol for retinal wholemount preparation for imaging and immunohistochemistry
    • Ivanova, E., Toychiev, A. H., Yee, C. W. & Sagdullaev, B. T. Optimized protocol for retinal wholemount preparation for imaging and immunohistochemistry. J Vis Exp. e51018, doi: 10.3791/51018 (2013)
    • (2013) J Vis Exp. , pp. e51018
    • Ivanova, E.1    Toychiev, A.H.2    Yee, C.W.3    Sagdullaev, B.T.4
  • 31
    • 84926209020 scopus 로고    scopus 로고
    • ESCRT-mediated uptake and degradation of brain-targeted alpha-synuclein single chain antibody attenuates neuronal degeneration in vivo
    • Spencer, B. et al. ESCRT-mediated uptake and degradation of brain-targeted alpha-synuclein single chain antibody attenuates neuronal degeneration in vivo. Mol Ther 22, 1753-1767, doi: 10.1038/mt.2014.129 (2014)
    • (2014) Mol Ther , vol.22 , pp. 1753-1767
    • Spencer, B.1
  • 32
    • 84877580799 scopus 로고    scopus 로고
    • Immunotherapy for neurodegenerative diseases: Focus on alpha-synucleinopathies
    • Valera, E. & Masliah, E. Immunotherapy for neurodegenerative diseases: focus on alpha-synucleinopathies. Pharmacology & therapeutics 138, 311-322, doi: 10.1016/j.pharmthera.2013.01.013 (2013)
    • (2013) Pharmacology & Therapeutics , vol.138 , pp. 311-322
    • Valera, E.1    Masliah, E.2
  • 34
    • 17844406856 scopus 로고    scopus 로고
    • Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • Chen, L. & Feany, M. B. Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 8, 657-663 (2005)
    • (2005) Nat Neurosci , vol.8 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 35
    • 84899984461 scopus 로고    scopus 로고
    • Interactions between Tau and alpha-synuclein augment neurotoxicity in a Drosophila model of Parkinsons disease
    • Roy, B. & Jackson, G. R. Interactions between Tau and alpha-synuclein augment neurotoxicity in a Drosophila model of Parkinsons disease. Hum Mol Genet 23, 3008-3023, doi: 10.1093/hmg/ddu011 (2014)
    • (2014) Hum Mol Genet , vol.23 , pp. 3008-3023
    • Roy, B.1    Jackson, G.R.2
  • 36
    • 77953796839 scopus 로고    scopus 로고
    • A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    • Scott, D. A. et al. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. J Neurosci 30, 8083-8095, doi: 10.1523/JNEUROSCI.1091-10.2010 (2010)
    • (2010) J Neurosci , vol.30 , pp. 8083-8095
    • Scott, D.A.1
  • 37
    • 35348932113 scopus 로고    scopus 로고
    • Transgenic animal models of neurodegenerative diseases and their application to treatment development
    • Rockenstein, E., Crews, L. & Masliah, E. Transgenic animal models of neurodegenerative diseases and their application to treatment development. Adv Drug Deliv Rev 59, 1093-1102 (2007)
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 1093-1102
    • Rockenstein, E.1    Crews, L.2    Masliah, E.3
  • 38
    • 80054089850 scopus 로고    scopus 로고
    • Synuclein deposition and non-motor symptoms in Parkinson disease
    • Jellinger, K. A. Synuclein deposition and non-motor symptoms in Parkinson disease. Journal of the neurological sciences 310, 107-111, doi: 10.1016/j.jns.2011.04.012 (2011)
    • (2011) Journal of the Neurological Sciences , vol.310 , pp. 107-111
    • Jellinger, K.A.1
  • 39
    • 0141758431 scopus 로고    scopus 로고
    • Retinal involvement in dementia with Lewy bodies: A clue to hallucinations?
    • Maurage, C. A., Ruchoux, M. M., de Vos, R., Surguchov, A. & Destee, A. Retinal involvement in dementia with Lewy bodies: a clue to hallucinations? Ann Neurol 54, 542-547, doi: 10.1002/ana.10730 (2003)
    • (2003) Ann Neurol , vol.54 , pp. 542-547
    • Maurage, C.A.1    Ruchoux, M.M.2    De Vos, R.3    Surguchov, A.4    Destee, A.5
  • 40
    • 78650679174 scopus 로고    scopus 로고
    • Protein aggregation in the aging retina
    • Leger, F. et al. Protein aggregation in the aging retina. J Neuropath Exp Neurol 70, 63-68, doi: 10.1097/NEN.0b013e31820376cc (2011)
    • (2011) J Neuropath Exp Neurol , vol.70 , pp. 63-68
    • Leger, F.1
  • 41
    • 84890786320 scopus 로고    scopus 로고
    • Beta-amyloid phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimers and Parkinsons disease patients
    • Ho, C. Y., Troncoso, J. C., Knox, D., Stark, W. & Eberhart, C. G. Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimers and Parkinsons disease patients. Brain Pathol 24, 25-32, doi: 10.1111/ bpa.12070 (2014)
    • (2014) Brain Pathol , vol.24 , pp. 25-32
    • Ho, C.Y.1    Troncoso, J.C.2    Knox, D.3    Stark, W.4    Eberhart, C.G.5
  • 42
    • 0037150751 scopus 로고    scopus 로고
    • Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimers disease amyloid, in human cerebral blood vessels
    • Tamo, W. et al. Expression of alpha-synuclein, the precursor of non-amyloid beta component of Alzheimers disease amyloid, in human cerebral blood vessels. Neuroscience letters 326, 5-8 (2002)
    • (2002) Neuroscience Letters , vol.326 , pp. 5-8
    • Tamo, W.1
  • 43
    • 84961202639 scopus 로고    scopus 로고
    • Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimers diseaserelated microvascular cerebral amyloid angiopathy
    • Merlini, M., Wanner, D. & Nitsch, R. M. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimers diseaserelated microvascular cerebral amyloid angiopathy. Acta Neuropathol 131, 737-752, doi: 10.1007/s00401-016-1560-2 (2016)
    • (2016) Acta Neuropathol , vol.131 , pp. 737-752
    • Merlini, M.1    Wanner, D.2    Nitsch, R.M.3
  • 44
    • 0036221254 scopus 로고    scopus 로고
    • Synucleins in glaucoma: Implication of gamma-synuclein in glaucomatous alterations in the optic nerve
    • Surgucheva, I. et al. Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve. J Neurosci Res 68, 97-106 (2002)
    • (2002) J Neurosci Res , vol.68 , pp. 97-106
    • Surgucheva, I.1
  • 47
    • 78650832181 scopus 로고    scopus 로고
    • Identification of amyloid plaques in retinas from Alzheimers patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model
    • Koronyo-Hamaoui, M. et al. Identification of amyloid plaques in retinas from Alzheimers patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. NeuroImage 54 Suppl 1, S204-S217, doi: 10.1016/j.neuroimage.2010.06.020 (2011)
    • (2011) NeuroImage 54 Suppl , vol.1 , pp. S204-S217
    • Koronyo-Hamaoui, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.