Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients

Brain Pathology

Volumn 24, Issue 1, 2014, Pages 25-32

  Ho, Cheng Ying ^a   Troncoso, Juan C ^a   Knox, David ^a   Stark, Walter ^a   Eberhart, Charles G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid; eye; lens; synuclein; tau

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BRAIN LEVEL; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; EYE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEWY BODY; MALE; NEURITE; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RETINA; TISSUE LEVEL; VASCULAR AMYLOIDOSIS;

AMYLOID; EYE; LENS; SYNUCLEIN; TAU;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; CASE-CONTROL STUDIES; EYE; FEMALE; HUMANS; LEWY BODIES; MALE; MIDDLE AGED; PARKINSON DISEASE; PHOSPHORYLATION; PLAQUE, AMYLOID;

EID: 84890786320     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/bpa.12070     Document Type: Article

References (31)

1. Alexandrov PN, Pogue A, Bhattacharjee S, Lukiw WJ, (2011) Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease. Neuroreport 22: 623-627.
2. Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH, (2012) Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. J Alzheimers Dis 32: 291-305.
3. Blanks JC, Hinton DR, Sadun AA, Miller CA, (1989) Retinal ganglion cell degeneration in Alzheimer's disease. Brain Res 501: 364-372. (Pubitemid 19259642)
4. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K, (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112: 389-404. (Pubitemid 44469160)
5. Dutescu RM, Li QX, Crowston J, Masters CL, Baird PN, Culvenor JG, (2009) Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer's disease. Graefes Arch Clin Exp Ophthalmol 247: 1213-1221.
6. Frost S, Martins RN, Kanagasingam Y, (2010) Ocular biomarkers for early detection of Alzheimer's disease. Int J Alzheimers Dis 22: 1-16.
7. Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, (2003) Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet 361: 1258-1265. (Pubitemid 36428580)
8. Herholz K, Ebmeier K, (2011) Clinical amyloid imaging in Alzheimer's disease. Lancet Neurol 10: 667-670.
9. Hinton DR, Sadun AA, Blanks JC, Miller CA, (1986) Optic-nerve degeneration in Alzheimer's disease. N Engl J Med 315: 485-487. (Pubitemid 16034149)
10. Jellinger KA, (2009) Formation and development of Lewy pathology: a critical update. J Neurol 256 (Suppl 3): S270-S279.
11. Kesler A, Vakhapova V, Korczyn AD, Naftaliev E, Neudorfer M, (2011) Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Clin Neurol Neurosurg 113: 523-526.
12. Kopke E, Tung YC, Shaikh S, Alonso AC, Iqbal K, Grundke-Iqbal I, (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268: 24374-24384. (Pubitemid 23335430)
13. Koronyo Y, Salumbides BC, Black KL, Koronyo-Hamaoui M, (2012) Alzheimer's disease in the retina: imaging retinal aβ plaques for early diagnosis and therapy assessment. Neurodegener Dis 10: 285-293.
14. Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, et al (2011) Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage 54 (Suppl 1): S204-S217.
15. Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, et al (2011) Towards a pharmacophore for amyloid. Plos Biol 9: 1-13.
16. Leger F, Fernagut PO, Canron MH, Léoni S, Vital C, Tison F, (2011) Protein aggregation in the aging retina. J Neuropathol Exp Neurol 70: 63-68.
17. Loffler KU, Edward DP, Tso MO, (1995) Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. Invest Ophthalmol Vis Sci 36: 24-31.
18. Lu Y, Li Z, Zhang X, Ming B, Jia J, Wang R, Ma D, (2010) Retinal nerve fiber layer structural abnormalities in early Alzheimer's disease: evidence in optical coherence tomography. Neurosci Lett 480: 69-72.
19. Maurage CA, Ruchoux MM, de Vos R, Surguchov A, Destee A, (2003) Retinal involvement in dementia with Lewy bodies: a clue to hallucinations? Ann Neurol 54: 542-547. (Pubitemid 37176555)
20. McKeith IG, Dickson DW, Lowe J, Emre M, O′Brien JT, Feldman H, (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology 65: 1863-1872. (Pubitemid 43970103)
21. Michael R, Rosandic̈ J, Montenegro GA, Lobato E, Tresserra F, Barraquer RI, Vrensen GF, (2013) Absence of beta-amyloid in cortical cataracts of donors with or without Alzheimer's disease. Exp Eye Res 106: 5-13.
22. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al (2005) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II: standardization of neuropathological assessment of Alzheimer's disease. Neurology 65: 1863-1872.
23. Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, et al (2010) Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome. PLoS ONE 5: e10659.
24. Moschos MM, Markopoulos I, Chatziralli I, Rouvas A, Papageorgiou SG, Ladas I, Vassilopoulos D, (2012) Structural and functional impairment of the retina and optic nerve in Alzheimer's disease. Curr Alzheimer Res 9: 782-788.
25. Muchowski PJ, Ramsden R, Nguyen Q, Arnett EE, Greiling TM, Anderson SK, Clark JI, (2008) Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens. J Biol Chem 283: 6330-6336.
26. Nussbaum RL, Ellis CE, (2003) Alzheimer's disease and Parkinson's disease. N Engl J Med 348: 1356-1364. (Pubitemid 36384104)
27. Parnell M, Guo L, Abdi M, Cordeiro MF, (2012) Ocular manifestations of Alzheimer's disease in animal models. Int J Alzheimers Dis 2012:786494.
28. Schon C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, (2012) Long-term in vivo imaging of fibrillary tau in the retina of P301S transgenic mice. PLoS ONE 7: e53547.
29. Selkoe DJ, (1994) Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu Rev Cell Biol 10: 373-403. (Pubitemid 24372824)
30. Surguchov A, McMahan B, Masliah E, Surgucheva I, (2001) Synucleins in ocular tissues. J Neurosci Res 65: 68-77. (Pubitemid 32601312)
31. Thompson PM, Vinters HV, (2012) Pathologic lesions in neurodegenerative diseases. Prog Mol Biol Transl Sci 107: 1-40.