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Volumn 7, Issue 24, 2016, Pages 36956-36970

The AXL receptor tyrosine kinase is associated with adverse prognosis and distant metastasis in esophageal squamous cell carcinoma

Author keywords

AXL; Esophageal cancer; Esophageal squamous cell carcinoma; HER2; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; AXL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FORETINIB; LAPATINIB; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; ANILIDE; AXL RECEPTOR TYROSINE KINASE; ERBB2 PROTEIN, HUMAN; ONCOPROTEIN; QUINOLINE DERIVATIVE; TUMOR MARKER;

EID: 84978043581     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.9231     Document Type: Article
Times cited : (45)

References (58)
  • 2
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 2006; 24:2137-2150.
    • (2006) J Clin Oncol , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 4
    • 76949094319 scopus 로고    scopus 로고
    • Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer
    • Allum WH, Stenning SP, Bancewicz J, Clark PI, Langley RE. Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J Clin Oncol. 2009; 27:5062-5067.
    • (2009) J Clin Oncol , vol.27 , pp. 5062-5067
    • Allum, W.H.1    Stenning, S.P.2    Bancewicz, J.3    Clark, P.I.4    Langley, R.E.5
  • 8
    • 38449111136 scopus 로고    scopus 로고
    • EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases
    • Wei Q, Chen L, Sheng L, Nordgren H, Wester K, Carlsson J. EGFR, HER2 and HER3 expression in esophageal primary tumours and corresponding metastases. Int J Oncol. 2007; 31:493-499.
    • (2007) Int J Oncol , vol.31 , pp. 493-499
    • Wei, Q.1    Chen, L.2    Sheng, L.3    Nordgren, H.4    Wester, K.5    Carlsson, J.6
  • 9
    • 84878330019 scopus 로고    scopus 로고
    • HER2 gene amplification in esophageal squamous cell carcinoma is less than in gastroesophageal junction and gastric adenocarcinoma
    • Huang JX, Zhao K, Lin M, Wang Q, Xiao W, Lin MS, Yu H, Chen P, Qian RY. HER2 gene amplification in esophageal squamous cell carcinoma is less than in gastroesophageal junction and gastric adenocarcinoma. Oncol Lett. 2013; 6:13-18.
    • (2013) Oncol Lett , vol.6 , pp. 13-18
    • Huang, J.X.1    Zhao, K.2    Lin, M.3    Wang, Q.4    Xiao, W.5    Lin, M.S.6    Yu, H.7    Chen, P.8    Qian, R.Y.9
  • 12
    • 46449103344 scopus 로고    scopus 로고
    • TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
    • Linger RMA, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv Cancer Res. 2008; 100:35-83.
    • (2008) Adv Cancer Res , vol.100 , pp. 35-83
    • Linger, R.M.A.1    Keating, A.K.2    Earp, H.S.3    Graham, D.K.4
  • 14
    • 33644876133 scopus 로고    scopus 로고
    • Expression of axl in lung adenocarcinoma and correlation with tumor progression
    • Shieh YS, Lai CY, Kao YR, Shiah SG, Chu YW, Lee HS, Wu CW. Expression of axl in lung adenocarcinoma and correlation with tumor progression. Neoplasia. 2005; 7:1058-1064.
    • (2005) Neoplasia , vol.7 , pp. 1058-1064
    • Shieh, Y.S.1    Lai, C.Y.2    Kao, Y.R.3    Shiah, S.G.4    Chu, Y.W.5    Lee, H.S.6    Wu, C.W.7
  • 15
    • 0032526475 scopus 로고    scopus 로고
    • Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma
    • Tsou AP, Wu KM, Tsen TY, Chi CW, Chiu JH, Lui WY, Hu CP, Chang C, Chou CK, Tsai SF. Parallel hybridization analysis of multiple protein kinase genes: identification of gene expression patterns characteristic of human hepatocellular carcinoma. Genomics. 1998; 50:331-340.
    • (1998) Genomics , vol.50 , pp. 331-340
    • Tsou, A.P.1    Wu, K.M.2    Tsen, T.Y.3    Chi, C.W.4    Chiu, J.H.5    Lui, W.Y.6    Hu, C.P.7    Chang, C.8    Chou, C.K.9    Tsai, S.F.10
  • 17
    • 0030787169 scopus 로고    scopus 로고
    • Overexpression of protein tyrosine kinases in human esophageal cancer
    • Nemoto T, Ohashi K, Akashi T, Johnson JD, Hirokawa K. Overexpression of protein tyrosine kinases in human esophageal cancer. Pathobiology. 1997; 65:195-203.
    • (1997) Pathobiology , vol.65 , pp. 195-203
    • Nemoto, T.1    Ohashi, K.2    Akashi, T.3    Johnson, J.D.4    Hirokawa, K.5
  • 19
    • 0032820867 scopus 로고    scopus 로고
    • Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)
    • Rochlitz C, Lohri A, Bacchi M, Schmidt M, Nagel S, Fopp M, Fey MF, Herrmann R, Neubauer A. Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK). Leukemia. 1999; 13:1352-1358.
    • (1999) Leukemia , vol.13 , pp. 1352-1358
    • Rochlitz, C.1    Lohri, A.2    Bacchi, M.3    Schmidt, M.4    Nagel, S.5    Fopp, M.6    Fey, M.F.7    Herrmann, R.8    Neubauer, A.9
  • 21
    • 84978067307 scopus 로고    scopus 로고
    • Regulation of Death-Inducing Signaling Complex by Axl Mediates TRAIL Resistance in Esophageal Adenocarcinoma
    • Hong J, Peng DF, El-Rifai W, Belkhiri A. Regulation of Death-Inducing Signaling Complex by Axl Mediates TRAIL Resistance in Esophageal Adenocarcinoma. Gastroenterology. 2013; 144:S144-S144.
    • (2013) Gastroenterology , vol.144 , pp. S144-S144
    • Hong, J.1    Peng, D.F.2    El-Rifai, W.3    Belkhiri, A.4
  • 22
    • 84874643529 scopus 로고    scopus 로고
    • AXL Mediates TRAIL Resistance in Esophageal Adenocarcinoma
    • Hong J, Belkhiri A. AXL Mediates TRAIL Resistance in Esophageal Adenocarcinoma. Neoplasia. 2013; 15:296-+.
    • (2013) Neoplasia , vol.15
    • Hong, J.1    Belkhiri, A.2
  • 23
    • 84871971116 scopus 로고    scopus 로고
    • ABL Regulation by AXL Promotes Cisplatin Resistance in Esophageal Cancer
    • Hong J, Peng DF, Chen Z, Sehdev V, Belkhiri A. ABL Regulation by AXL Promotes Cisplatin Resistance in Esophageal Cancer. Cancer Research. 2013; 73:331-340.
    • (2013) Cancer Research , vol.73 , pp. 331-340
    • Hong, J.1    Peng, D.F.2    Chen, Z.3    Sehdev, V.4    Belkhiri, A.5
  • 24
    • 84923824758 scopus 로고    scopus 로고
    • Inactivation of GSK3beta and activation of NF-kappaB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma
    • Paccez JD, Duncan K, Vava A, Correa RG, Libermann TA, Parker MI, Zerbini LF. Inactivation of GSK3beta and activation of NF-kappaB pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma. Mol Biol Cell. 2015; 26:821-831.
    • (2015) Mol Biol Cell , vol.26 , pp. 821-831
    • Paccez, J.D.1    Duncan, K.2    Vava, A.3    Correa, R.G.4    Libermann, T.A.5    Parker, M.I.6    Zerbini, L.F.7
  • 27
    • 79955781270 scopus 로고    scopus 로고
    • Synergistic effects of foretinib with HER-targeted agents in MET and HER1-or HER2-coactivated tumor cells
    • Liu L, Shi H, Liu Y, Anderson A, Peterson J, Greger J, Martin AM, Gilmer TM. Synergistic effects of foretinib with HER-targeted agents in MET and HER1-or HER2-coactivated tumor cells. Mol Cancer Ther. 2011; 10:518-530.
    • (2011) Mol Cancer Ther , vol.10 , pp. 518-530
    • Liu, L.1    Shi, H.2    Liu, Y.3    Anderson, A.4    Peterson, J.5    Greger, J.6    Martin, A.M.7    Gilmer, T.M.8
  • 28
    • 84903948758 scopus 로고    scopus 로고
    • Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy
    • Torka R, Penzes K, Gusenbauer S, Baumann C, Szabadkai I, OrfiL, Keri G, Ullrich A. Activation of HER3 interferes with antitumor effects of Axl receptor tyrosine kinase inhibitors: suggestion of combination therapy. Neoplasia. 2014; 16:301-318.
    • (2014) Neoplasia , vol.16 , pp. 301-318
    • Torka, R.1    Penzes, K.2    Gusenbauer, S.3    Baumann, C.4    Szabadkai, I.5    Orfi, L.6    Keri, G.7    Ullrich, A.8
  • 30
    • 67349188718 scopus 로고    scopus 로고
    • Association of clinical and dosimetric factors with postoperative pulmonary complications in esophageal cancer patients receiving intensity-modulated radiation therapy and concurrent chemotherapy followed by thoracic esophagectomy
    • Hsu FM, Lee YC, Lee JM, Hsu CH, Lin CC, Tsai YC, Wu JK, Cheng JC. Association of clinical and dosimetric factors with postoperative pulmonary complications in esophageal cancer patients receiving intensity-modulated radiation therapy and concurrent chemotherapy followed by thoracic esophagectomy. Ann Surg Oncol. 2009; 16:1669-1677.
    • (2009) Ann Surg Oncol , vol.16 , pp. 1669-1677
    • Hsu, F.M.1    Lee, Y.C.2    Lee, J.M.3    Hsu, C.H.4    Lin, C.C.5    Tsai, Y.C.6    Wu, J.K.7    Cheng, J.C.8
  • 31
    • 80255131318 scopus 로고    scopus 로고
    • Retrospective analysis of outcome differences in preoperative concurrent chemoradiation with or without elective nodal irradiation for esophageal squamous cell carcinoma
    • Hsu FM, Lee JM, Huang PM, Lin CC, Hsu CH, Tsai YC, Lee YC, Chia-Hsien Cheng J. Retrospective analysis of outcome differences in preoperative concurrent chemoradiation with or without elective nodal irradiation for esophageal squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2011; 81:e593-599.
    • (2011) Int J Radiat Oncol Biol Phys , vol.81
    • Hsu, F.M.1    Lee, J.M.2    Huang, P.M.3    Lin, C.C.4    Hsu, C.H.5    Tsai, Y.C.6    Lee, Y.C.7    Chia-Hsien Cheng, J.8
  • 32
    • 33746049823 scopus 로고    scopus 로고
    • Downstaging of T or N predicts long-term survival after preoperative chemotherapy and radical resection for esophageal carcinoma
    • discussion 484-485
    • Korst RJ, Kansler AL, Port JL, Lee PC, Kerem Y, Altorki NK. Downstaging of T or N predicts long-term survival after preoperative chemotherapy and radical resection for esophageal carcinoma. Ann Thorac Surg. 2006; 82:480-484; discussion 484-485.
    • (2006) Ann Thorac Surg , vol.82 , pp. 480-484
    • Korst, R.J.1    Kansler, A.L.2    Port, J.L.3    Lee, P.C.4    Kerem, Y.5    Altorki, N.K.6
  • 34
    • 0022612699 scopus 로고
    • Chromosome analysis on a cell line (CE48T/VGH) derived from a human esophageal carcinoma
    • Wuu KD, Cheng MY, Wang-Wuu S, Hu CP, Chang CM. Chromosome analysis on a cell line (CE48T/VGH) derived from a human esophageal carcinoma. Cancer Genet Cytogenet. 1986; 20:279-285.
    • (1986) Cancer Genet Cytogenet , vol.20 , pp. 279-285
    • Wuu, K.D.1    Cheng, M.Y.2    Wang-Wuu, S.3    Hu, C.P.4    Chang, C.M.5
  • 36
    • 34447310595 scopus 로고    scopus 로고
    • Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines
    • Rusnak DW, Alligood KJ, Mullin RJ, Spehar GM, Arenas-Elliott C, Martin AM, Degenhardt Y, Rudolph SK, Haws TF, Jr., Hudson-Curtis BL, Gilmer TM. Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines. Cell Prolif. 2007; 40:580-594.
    • (2007) Cell Prolif , vol.40 , pp. 580-594
    • Rusnak, D.W.1    Alligood, K.J.2    Mullin, R.J.3    Spehar, G.M.4    Arenas-Elliott, C.5    Martin, A.M.6    Degenhardt, Y.7    Rudolph, S.K.8    Haws, T.F.9    Hudson-Curtis, B.L.10    Gilmer, T.M.11
  • 37
    • 79959215032 scopus 로고    scopus 로고
    • Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis
    • Zillhardt M, Park SM, Romero IL, Sawada K, Montag A, Krausz T, Yamada SD, Peter ME, Lengyel E. Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of c-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis. Clin Cancer Res. 2011; 17:4042-4051.
    • (2011) Clin Cancer Res , vol.17 , pp. 4042-4051
    • Zillhardt, M.1    Park, S.M.2    Romero, I.L.3    Sawada, K.4    Montag, A.5    Krausz, T.6    Yamada, S.D.7    Peter, M.E.8    Lengyel, E.9
  • 40
    • 84879689784 scopus 로고    scopus 로고
    • The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells
    • Yang PW, Hung MC, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2013; 28:605-614.
    • (2013) Lasers Med Sci , vol.28 , pp. 605-614
    • Yang, P.W.1    Hung, M.C.2    Hsieh, C.Y.3    Tung, E.C.4    Wang, Y.H.5    Tsai, J.C.6    Lee, J.M.7
  • 41
    • 84948385488 scopus 로고    scopus 로고
    • The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells
    • Yang PW, Chiang TH, Hsieh CY, Huang YC, Wong LF, Hung MC, Tsai JC, Lee JM. The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2015; 30:2353-2361.
    • (2015) Lasers Med Sci , vol.30 , pp. 2353-2361
    • Yang, P.W.1    Chiang, T.H.2    Hsieh, C.Y.3    Huang, Y.C.4    Wong, L.F.5    Hung, M.C.6    Tsai, J.C.7    Lee, J.M.8
  • 42
    • 79952847624 scopus 로고    scopus 로고
    • A Phase 2 Trial of Erlotinib in Patients With Previously Treated Squamous Cell and Adenocarcinoma of the Esophagus
    • Ilson DH, Kelsen D, Shah M, Schwartz G, Levine DA, Boyd J, Capanu M, Miron B, Klimstra D. A Phase 2 Trial of Erlotinib in Patients With Previously Treated Squamous Cell and Adenocarcinoma of the Esophagus. Cancer. 2011; 117:1409-1414.
    • (2011) Cancer , vol.117 , pp. 1409-1414
    • Ilson, D.H.1    Kelsen, D.2    Shah, M.3    Schwartz, G.4    Levine, D.A.5    Boyd, J.6    Capanu, M.7    Miron, B.8    Klimstra, D.9
  • 45
    • 77649085714 scopus 로고    scopus 로고
    • A Phase II Study of Perioperative Concurrent Chemotherapy, Gefitinib, and Hyperfractionated Radiation Followed by Maintenance Gefitinib in Locoregionally Advanced Esophagus and Gastroesophageal Junction Cancer
    • Rodriguez CP, Adelstein DJ, Rice TW, Rybicki LA, Videtic GMM, Saxton JP, Murthy SC, Mason DP, Ives DI. A Phase II Study of Perioperative Concurrent Chemotherapy, Gefitinib, and Hyperfractionated Radiation Followed by Maintenance Gefitinib in Locoregionally Advanced Esophagus and Gastroesophageal Junction Cancer. Journal of Thoracic Oncology. 2010; 5:229-235.
    • (2010) Journal of Thoracic Oncology , vol.5 , pp. 229-235
    • Rodriguez, C.P.1    Adelstein, D.J.2    Rice, T.W.3    Rybicki, L.A.4    Videtic, G.M.M.5    Saxton, J.P.6    Murthy, S.C.7    Mason, D.P.8    Ives, D.I.9
  • 46
    • 84940351792 scopus 로고    scopus 로고
    • Targeted treatments for metastatic esophageal squamous cell cancer
    • Digklia A, Voutsadakis IA. Targeted treatments for metastatic esophageal squamous cell cancer. World J Gastrointest Oncol. 2013; 5:88-96.
    • (2013) World J Gastrointest Oncol , vol.5 , pp. 88-96
    • Digklia, A.1    Voutsadakis, I.A.2
  • 47
    • 48549094691 scopus 로고    scopus 로고
    • Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia
    • Hong CC, Lay JD, Huang JS, Cheng AL, Tang JL, Lin MT, Lai GM, Chuang SE. Receptor tyrosine kinase AXL is induced by chemotherapy drugs and overexpression of AXL confers drug resistance in acute myeloid leukemia. Cancer Lett. 2008; 268:314-324.
    • (2008) Cancer Lett , vol.268 , pp. 314-324
    • Hong, C.C.1    Lay, J.D.2    Huang, J.S.3    Cheng, A.L.4    Tang, J.L.5    Lin, M.T.6    Lai, G.M.7    Chuang, S.E.8
  • 49
    • 84923824758 scopus 로고    scopus 로고
    • Inactivation of GSK3 beta and activation of NF-kappa B pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma
    • Paccez JD, Duncan K, Vava A, Correa RG, Libermann TA, Parker MI, Zerbini LF. Inactivation of GSK3 beta and activation of NF-kappa B pathway via Axl represents an important mediator of tumorigenesis in esophageal squamous cell carcinoma. Mol Biol Cell. 2015; 26:821-831.
    • (2015) Mol Biol Cell , vol.26 , pp. 821-831
    • Paccez, J.D.1    Duncan, K.2    Vava, A.3    Correa, R.G.4    Libermann, T.A.5    Parker, M.I.6    Zerbini, L.F.7
  • 50
    • 84870276714 scopus 로고    scopus 로고
    • Identification of Axl as a downstream effector of TGF-beta 1 during Langerhans cell differentiation and epidermal homeostasis
    • Bauer T, Zagorska A, Jurkin J, Yasmin N, Koffel R, Richter S, Gesslbauer B, Lemke G, Strobl H. Identification of Axl as a downstream effector of TGF-beta 1 during Langerhans cell differentiation and epidermal homeostasis. J Exp Med. 2012; 209:2033-2047.
    • (2012) J Exp Med , vol.209 , pp. 2033-2047
    • Bauer, T.1    Zagorska, A.2    Jurkin, J.3    Yasmin, N.4    Koffel, R.5    Richter, S.6    Gesslbauer, B.7    Lemke, G.8    Strobl, H.9
  • 52
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGFbeta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille S, Derynck R. Cell size and invasion in TGFbeta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 2007; 178:437-451.
    • (2007) J Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 55
    • 84939204845 scopus 로고    scopus 로고
    • Role of Areca Nut Induced TGF-beta and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis
    • Pant I, Kumar N, Khan I, Rao SG, Kondaiah P. Role of Areca Nut Induced TGF-beta and Epithelial-Mesenchymal Interaction in the Pathogenesis of Oral Submucous Fibrosis. Plos One. 2015; 10.
    • (2015) Plos One , pp. 10
    • Pant, I.1    Kumar, N.2    Khan, I.3    Rao, S.G.4    Kondaiah, P.5
  • 56
    • 84871318315 scopus 로고    scopus 로고
    • Activation of TGF-beta Pathway by Areca Nut Constituents: A Possible Cause of Oral Submucous Fibrosis
    • Khan I, Kumar N, Pant I, Narra S, Kondaiah P. Activation of TGF-beta Pathway by Areca Nut Constituents: A Possible Cause of Oral Submucous Fibrosis. Plos One. 2012; 7.
    • (2012) Plos One , pp. 7
    • Khan, I.1    Kumar, N.2    Pant, I.3    Narra, S.4    Kondaiah, P.5


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