Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer

Journal of Clinical Oncology

Volumn 27, Issue 30, 2009, Pages 5062-5067

  Allum, William H ^a   Stenning, Sally P ^a   Bancewicz, John ^a   Clark, Peter I ^a   Langley, Ruth E ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; FLUOROURACIL;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CAUSE OF DEATH; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS CANCER; ESOPHAGUS SURGERY; FEMALE; HAZARD RATIO; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MINIMAL RESIDUAL DISEASE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PREOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPEATED DRUG DOSE; SURGICAL TECHNIQUE; SURVIVAL RATE; TREATMENT OUTCOME;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; ESOPHAGEAL NEOPLASMS; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 76949094319     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2009.22.2083     Document Type: Article

References (15)

1. Medical Research Council Oesophageal Cancer Working Party: Surgical resection with or without preoperative chemotherapy in oesophageal cancer: A randomised controlled trial. Lancet 359: 1727-1733, 2002
2. Carey RW, Hilgenberg AD, Wilkins EW, et al: Preoperative chemotherapy followed by surgery with possible postoperative radiotherapy in squamous carcinoma of the esophagus evaluation of the chemotherapy component. J Clin Oncol 4:697-701, 1986
3. Forastiere AA, Gennis M, Orringer MB, et al: Cisplatin, vinblastine and mitoguazone chemotherapy for epidermoid and adenocarcinoma of the esophagus. J Clin Oncol 5:1143-1149, 1987
4. Hilgenberg AD, Carey RW, Wilkins EW, et al: Preoperative chemotherapy, surgical resection, and selective post-operative therapy for squamous cell carcinoma of the esophagus. Ann Thorac Surg 45: 357-363, 1988
5. Roth JA, Pass HI, Flanagan MM, et al: Randomized clinical trial of preoperative and postoperative adjuvant chemotherapy with cisplatin, vindesine and bleomycin for carcinoma of the esophagus. J Thorac Cardiovasc Surg 96:242-248, 1988
6. Ajani JA, Roth JA, Ryan B, et al: Evaluation of pre- and post-operative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction. J Clin Oncol 8:1231-1238, 1990
7. Kelsen DP, Minsky B, Smith M, et al: Preoperative therapy for esophageal cancer: A randomized comparison of chemotherapy versus radiation therapy. J Clin Oncol 8:1352-1361, 1990
8. Kelsen DP, Ginsberg R, Pajak TF, et al: Chemotherapy followed by surgery compared with surgery alone for localised oesophageal cancer. N Engl J Med 339:1979-1984, 1998
9. Gebski V, Burmeister B, Smithers BM, et al: Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: A meta-analysis. Lancet Oncol 8:226-234, 2007
10. Thirion P, Michiels S, Le Maitre A, et al: Individual patient data-based meta-analysis assessing the interest of pre-operative chemotherapy in resectable oesophageal carcinoma. J Clin Oncol 25:200s, 2007 (suppl; abstr 4512)
11. Kelsen DP, Winter KA, Gunderson LL, et al: Long-term results of RTOG trial 8911 (USA Intergroup 113): A random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for oesophageal cancer. J Clin Oncol 25:3719-3725, 2007
12. Ott K, Weber WA, Lordick F, et al: Metabolic imaging predicts response, survival and recurrence in adenocarcinomas of the oesophago-gastric junction. J Clin Oncol 24:4692-4698, 2006
13. Lordick F, Ott K, Krause BJ, et al: PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophago-gastric junction: The MUNICON phase II trial. Lancet Oncol 8:797-805, 2007
14. Riddell AM, Allum WH, Thompson JN, et al: The appearances of oesophageal carcinoma demonstrated on high-resolution, T2 weighted MRI, with histopathological correlation. Eur Radiol 17:391-399, 2007
15. Stahl M, Walz MK, Stuschke M, et al: Preoperative chemotherapy (CTX) versus preoperative chemoradiotherapy (CRTX) in locally advanced esophagogastric adenocarcinomas: First results of a randomized phase III trial. J Clin Oncol 25: 2007 (suppl; abstr 4511)