-
1
-
-
23944476155
-
Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
Burris HA, Hurwitz HI, Dees EC, Dowlati A, Blackwell KL, O'Neil B, Marcom PK, Ellis MJ, Overmoyer B, Jones SF, Harris JL, Smith DA, Koch KM, Stead A, Mangum S, Spector NL (2005) Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol. 23, 5305 5313.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5305-5313
-
-
Burris, H.A.1
Hurwitz, H.I.2
Dees, E.C.3
Dowlati, A.4
Blackwell, K.L.5
O'Neil, B.6
Marcom, P.K.7
Ellis, M.J.8
Overmoyer, B.9
Jones, S.F.10
Harris, J.L.11
Smith, D.A.12
Koch, K.M.13
Stead, A.14
Mangum, S.15
Spector, N.L.16
-
2
-
-
24644458654
-
FDA drug approval summary: Erlotinib (Tarceva®) tablets
-
Cohen MH, Johnson JR, Chen YF, Sridhara R, Pazdur R (2005) FDA drug approval summary: erlotinib (Tarceva®) tablets. Oncologist 10, 461 466.
-
(2005)
Oncologist
, vol.10
, pp. 461-466
-
-
Cohen, M.H.1
Johnson, J.R.2
Chen, Y.F.3
Sridhara, R.4
Pazdur, R.5
-
3
-
-
12144287534
-
United States Food and Drug Administration Drug Approval Summary Gefitinib (ZD1839; Iressa) Tablets
-
Cohen MH, Williams GA, Sridhara R, Chen G, McGuinn Jr WD, Morse D, Abraham S, Rahman A, Liang C, Lostritto R, Baird A, Pazdur R (2004) United States Food and Drug Administration Drug Approval Summary Gefitinib (ZD1839; Iressa) Tablets. Clin. Cancer Res. 10, 1212 1218.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 1212-1218
-
-
Cohen, M.H.1
Williams, G.A.2
Sridhara, R.3
Chen, G.4
McGuinn, J.W.D.5
Morse, D.6
Abraham, S.7
Rahman, A.8
Liang, C.9
Lostritto, R.10
Baird, A.11
Pazdur, R.12
-
4
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs III WH, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lelias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat. Biotechnol. 23, 329 336.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs, I.I.I.W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
Carter, T.A.7
Ciceri, P.8
Edeen, P.T.9
Floyd, M.10
Ford, J.M.11
Galvin, M.12
Gerlach, J.L.13
Grotzfeld, R.M.14
Herrgard, S.15
Insko, D.E.16
Insko, M.A.17
Lai, A.G.18
Lelias, J.M.19
Mehta, S.A.20
Milanov, Z.V.21
Velasco, A.M.22
Wodicka, L.M.23
Patel, H.K.24
Zarrinkar, P.P.25
Lockhart, D.J.26
more..
-
5
-
-
33748155274
-
Clinical implications of human papillomavirus in head and neck cancers
-
Fakhry C, Gillison M (2006) Clinical implications of human papillomavirus in head and neck cancers. J. Clin. Onc. 24, 2606 2611.
-
(2006)
J. Clin. Onc.
, vol.24
, pp. 2606-2611
-
-
Fakhry, C.1
Gillison, M.2
-
6
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A, Kaufman B, Skarlos D, Campone M, Davidson N, Berger M, Oliva C, Rubin SD, Stein S, Cameron D (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N. Engl. J. Med. 355, 2783 2785.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2783-2785
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
7
-
-
34447309623
-
ASCO Annual Meeting Proceedings Part I, Abstract 5511
-
Gillison ML, Glisson BS, O'Leary E, Murphy BA, Levine MA, Kies MS, Chan D, Forastiere AA (2006) ASCO Annual Meeting Proceedings Part I, Abstract 5511. J. Clin. Oncol. 24, 18S.
-
(2006)
J. Clin. Oncol.
, vol.24
-
-
Gillison, M.L.1
Glisson, B.S.2
O'Leary, E.3
Murphy, B.A.4
Levine, M.A.5
Kies, M.S.6
Chan, D.7
Forastiere, A.A.8
-
8
-
-
0032933182
-
New model of ErbB-2 over-expression in human mammary luminal epithelial cells
-
Harris RA, Eichholtz TJ, Hiles ID, Page MJ, O'Hare MJ (1999) New model of ErbB-2 over-expression in human mammary luminal epithelial cells. Int. J. Cancer 80, 477 484.
-
(1999)
Int. J. Cancer
, vol.80
, pp. 477-484
-
-
Harris, R.A.1
Eichholtz, T.J.2
Hiles, I.D.3
Page, M.J.4
O'Hare, M.J.5
-
9
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD, Venkatesan N, Finn R, Yang G, Rahmeh M, Untch M, Rusnak DW, Spehar G, Mullin RJ, Keith BR, Gilmer TM, Berger M, Podratz KC, Slamon DJ (2006) Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res. 66, 1630 1639.
-
(2006)
Cancer Res.
, vol.66
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
Venkatesan, N.3
Finn, R.4
Yang, G.5
Rahmeh, M.6
Untch, M.7
Rusnak, D.W.8
Spehar, G.9
Mullin, R.J.10
Keith, B.R.11
Gilmer, T.M.12
Berger, M.13
Podratz, K.C.14
Slamon, D.J.15
-
10
-
-
0033604468
-
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
-
Lu Y, Lin YZ, Lapushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB (1999) The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18, 7034 7045.
-
(1999)
Oncogene
, vol.18
, pp. 7034-7045
-
-
Lu, Y.1
Lin, Y.Z.2
Lapushin, R.3
Cuevas, B.4
Fang, X.5
Yu, S.X.6
Davies, M.A.7
Khan, H.8
Furui, T.9
Mao, M.10
Zinner, R.11
Hung, M.C.12
Steck, P.13
Siminovitch, K.14
Mills, G.B.15
-
12
-
-
3042611780
-
Oncogenic growth factor receptors: Implications for signal transduction therapy
-
Mosesson Y, Yarden Y (2004) Oncogenic growth factor receptors: implications for signal transduction therapy. Semin. Cancer Biol. 14, 262 270.
-
(2004)
Semin. Cancer Biol.
, vol.14
, pp. 262-270
-
-
Mosesson, Y.1
Yarden, Y.2
-
14
-
-
0032445260
-
HER-2/neu as a predictive marker of response to breast cancer therapy
-
Pegram MD, Pauletti G, Slamon DJ (1998) HER-2/neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res. Treat. 52, 65 77.
-
(1998)
Breast Cancer Res. Treat.
, vol.52
, pp. 65-77
-
-
Pegram, M.D.1
Pauletti, G.2
Slamon, D.J.3
-
15
-
-
33746196584
-
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series
-
Petrov KG, Zhang YM, Carter M, Cockerill GS, Dickerson S, Gauthier CA, Guo Y, Mook Jr RA, Rusnak DW, Walker AL, Wood ER, Lackey KE (2006) Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series. Bioorg. Med. Chem. Lett. 16, 4686 4691.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 4686-4691
-
-
Petrov, K.G.1
Zhang, Y.M.2
Carter, M.3
Cockerill, G.S.4
Dickerson, S.5
Gauthier, C.A.6
Guo, Y.7
Mook, J.R.A.8
Rusnak, D.W.9
Walker, A.L.10
Wood, E.R.11
Lackey, K.E.12
-
16
-
-
33751288182
-
Efficacy of lapatinib in patients with high tumor EGFR expression: Results of a phase III trial in advanced renal cell carcinoma (RCC).
-
Ravaud G, Gardner J, Hawkins R, Von der Maase H, Zantl N, Harper P, Rolland F, Audhuy B, Machiels J, El-Hariry I (2006) Efficacy of lapatinib in patients with high tumor EGFR expression: results of a phase III trial in advanced renal cell carcinoma (RCC). J. Clin. Oncol. Suppl. 24, 217s.
-
(2006)
J. Clin. Oncol. Suppl.
, vol.24
-
-
Ravaud, G.1
Gardner, J.2
Hawkins, R.3
Von Der Maase, H.4
Zantl, N.5
Harper, P.6
Rolland, F.7
Audhuy, B.8
MacHiels, J.9
El-Hariry, I.10
-
17
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak DW, Lackey K, Wood ER, Alligood KJ, Rhodes N, Knight WB, Gilmer TM (2001) The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 1, 85 94.
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Wood, E.R.3
Alligood, K.J.4
Rhodes, N.5
Knight, W.B.6
Gilmer, T.M.7
-
18
-
-
17944379907
-
First-line Herceptin monotherapy in metastatic breast cancer
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M, Shak S, Stewart SJ (2001) First-line Herceptin monotherapy in metastatic breast cancer. Oncology 61 (Suppl. 2 37 42.
-
(2001)
Oncology
, vol.61
, Issue.2
, pp. 37-42
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
-
19
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): Relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
-
Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L (2004) A unique structure for epidermal growth factor receptor bound to GW572016 (lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res. 64, 6652 6659.
-
(2004)
Cancer Res.
, vol.64
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
McDonald, O.B.3
Yuan, D.4
Hassell, A.5
Ellis, B.6
Pennisi, C.7
Horne, E.8
Lackey, K.9
Alligood, K.J.10
Rusnak, D.W.11
Gilmer, T.M.12
Shewchuk, L.13
-
20
-
-
23844510061
-
Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer
-
Yeon CH, Pegram MD (2005) Anti-erbB-2 antibody trastuzumab in the treatment of HER2-amplified breast cancer. Invest. New Drugs 23, 391 409.
-
(2005)
Invest. New Drugs
, vol.23
, pp. 391-409
-
-
Yeon, C.H.1
Pegram, M.D.2
|