Tuberculosis therapy modifies the cytokine profile, maturation state, and expression of inhibitory molecules on mycobacterium tuberculosis-specific CD4+ T-Cells

PLoS ONE

Volumn 11, Issue 7, 2016, Pages

  Saharia, Kapil K ^a,b   Petrovas, Constantinos ^b   Ferrando Martinez, Sara ^b,c,d,e   Leal, Manuel ^e   Luque, Rafael ^e   Ive, Prudence ^f   Luetkemeyer, Anne ^g   Havlir, Diane ^g   Koup, Richard A ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^e HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^f UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; CELL PROTEIN; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 2; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROGRAMMED DEATH 1; TUBERCULOSTATIC AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

ARTICLE; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CELL MATURATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MEDICAL PROCEDURES; MEMORY T LYMPHOCYTE; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; T LYMPHOCYTE MATURATION; TUBERCULOSIS; TUBERCULOSIS THERAPY; DRUG EFFECTS; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPECIES DIFFERENCE;

ANTITUBERCULAR AGENTS; CD4-POSITIVE T-LYMPHOCYTES; CTLA-4 ANTIGEN; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; MYCOBACTERIUM TUBERCULOSIS; PROGRAMMED CELL DEATH 1 RECEPTOR; SPECIES SPECIFICITY; TUBERCULOSIS;

EID: 84978036746     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0158262     Document Type: Article

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