CD4 T cell depletion exacerbates acute mycobacterium tuberculosis while reactivation of latent infection is dependent on severity of tissue depletion in cynomolgus macaques

AIDS Research and Human Retroviruses

Volumn 28, Issue 12, 2012, Pages 1693-1702

  Lin, Philana Ling ^a   Rutledge, Tara ^a   Green, Angela M ^b   Bigbee, Matthew ^b   Fuhrman, Carl ^c   Klein, Edwin ^b   Flynn, Joanne L ^b  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LATENT TUBERCULOSIS; LYMPH NODE; MACACA; MEMORY T LYMPHOCYTE; MIXED INFECTION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; BLOOD; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; LATENT TUBERCULOSIS; LYMPH NODES; LYMPHOCYTE SUBSETS; MACACA FASCICULARIS; RECEPTORS, CXCR3; RESPIRATORY SYSTEM;

EID: 84868134466     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0028     Document Type: Article

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