"Heart-cut" bidimensional achiral-chiral liquid chromatography applied to the evaluation of stereoselective metabolism, in vivo biological activity and brain response to chiral drug candidates targeting the central nervous system

Journal of Chromatography A

Volumn 1443, Issue , 2016, Pages 152-161

  Battisti, Umberto M ^a,b   Citti, Cinzia ^c   Larini, Martina ^a   Ciccarella, Giuseppe ^c   Stasiak, Natalia ^a   Troisi, Luigino ^c   Braghiroli, Daniela ^a   Parenti, Carlo ^a   Zoli, Michele ^d   Cannazza, Giuseppe ^a,c  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c UNIVERSITY OF SALENTO   (Italy)

^d Campus Ecotekne of the University of Salento ^*  (Italy)

Author keywords

Bidimensional chromatography; Chiral chromatography; Endogenous neurotransmitters; Microdialysis

Indexed keywords

ANIMALS; BIOACTIVITY; BIOMOLECULES; BLOOD; CHROMATOGRAPHY; DIALYSIS; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; ENANTIOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; MODULATORS; NEUROPHYSIOLOGY; PHYSIOLOGY; STEREOSELECTIVITY;

CHIRAL CHROMATOGRAPHY; CHIRAL LIQUID CHROMATOGRAPHY; ENDOGENOUS NEUROTRANSMITTERS; EXTRACELLULAR CONCENTRATION; MICRO-DIALYSIS; POSITIVE ALLOSTERIC MODULATOR; SELECTED REACTION MONITORING; TRIPLE-QUADRUPOLE MASS SPECTROMETRY;

BRAIN;

1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE DERIVATIVE; 7 CHLORO 5 (3 FURANYL) 3 METHYL 3,4 DIHYDRO 2H 1,2,4 BENZOTHIADIAZINE 1,1 DIOXIDE; ACETYLCHOLINE; DOPAMINE; DRUG METABOLITE; POLYSACCHARIDE; SEROTONIN; SILICON DIOXIDE; UNCLASSIFIED DRUG; 2H-1,2,4-BENZOTHIADIAZINE-1,1-DIOXIDE; BENZOTHIADIAZINE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CHIRALITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BRAIN LEVEL; DRUG PENETRATION; DRUG STRUCTURE; DRUG TARGETING; ELECTROSPRAY; ELUTION; ENANTIOMER; EXTRACELLULAR SPACE; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; LIMIT OF DETECTION; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MALE; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUADRUPOLE MASS SPECTROMETRY; STEREOCHEMISTRY; TRIPLE QUADRUPOLE MASS SPECTROMETRY; TWO DIMENSIONAL ACHIRAL CHIRAL LIQUID CHROMATOGRAPHY; VALIDATION STUDY; ANIMAL; BRAIN; C57BL MOUSE; CENTRAL NERVOUS SYSTEM; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; PRECLINICAL STUDY; PROCEDURES; REPRODUCIBILITY; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

ACETYLCHOLINE; ANIMALS; BENZOTHIADIAZINES; BRAIN; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; MALE; MICE; MICE, INBRED C57BL; MICRODIALYSIS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 84978010712     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2016.03.027     Document Type: Article

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