메뉴 건너뛰기




Volumn 1, Issue 1, 2014, Pages 34-43

Neurostimulation of the Cholinergic Antiinflammatory Pathway in Rheumatoid Arthritis and Inflammatory Bowel Disease

Author keywords

Bioelectronic Medicine; Cholinergic Anti inflammatory Pathway; Dysregulated Inflammation; Implantable Medical Devices; Significant Therapeutic Advances

Indexed keywords

BIOMEDICAL EQUIPMENT; PATHOLOGY; PATIENT TREATMENT;

EID: 84977742291     PISSN: None     EISSN: 23328886     Source Type: Journal    
DOI: 10.15424/bioelectronmed.2014.00008     Document Type: Article
Times cited : (12)

References (56)
  • 1
    • 77957196913 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • PID: 20870100
    • Scott DL, Wolfe F, Huizinga TW. (2010) Rheumatoid arthritis. Lancet. 376:1094–108.
    • (2010) Lancet , vol.376 , pp. 1094-1108
    • Scott, D.L.1    Wolfe, F.2    Huizinga, T.W.3
  • 2
    • 84877987938 scopus 로고    scopus 로고
    • Management of active Crohn disease
    • COI: 1:CAS:528:DC%2BC3sXhtVGlsLzK, PID: 23695484
    • Cheifetz AS. (2013) Management of active Crohn disease. JAMA. 309:2150–8.
    • (2013) JAMA , vol.309 , pp. 2150-2158
    • Cheifetz, A.S.1
  • 3
    • 84871767508 scopus 로고    scopus 로고
    • Cardiovascular risk in rheumatoid arthritis: pathogenesis, diagnosis, and management
    • PID: 23188207
    • Gkaliagkousi E, et al. (2012) Cardiovascular risk in rheumatoid arthritis: pathogenesis, diagnosis, and management. J. Clin. Rheumatol. 18:422–30.
    • (2012) J. Clin. Rheumatol. , vol.18 , pp. 422-430
    • Gkaliagkousi, E.1
  • 4
    • 84859398826 scopus 로고    scopus 로고
    • Reflex principles of immunological homeostasis
    • COI: 1:CAS:528:DC%2BC38XmsVKmtbY%3D, PID: 22224768
    • Andersson U, Tracey KJ. (2012) Reflex principles of immunological homeostasis. Annu. Rev. Immunol. 30:313–35.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 313-335
    • Andersson, U.1    Tracey, K.J.2
  • 5
    • 66449111088 scopus 로고    scopus 로고
    • Reflex control of immunity
    • COI: 1:CAS:528:DC%2BD1MXmt1SktLk%3D, PID: 19461672
    • Tracey KJ. (2009) Reflex control of immunity. Nat. Rev. Immunol. 9:418–428.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 418-428
    • Tracey, K.J.1
  • 6
    • 0028857633 scopus 로고
    • Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immunebrain communication
    • COI: 1:CAS:528:DyaK2MXivVOguro%3D, PID: 7746479
    • Watkins LR, et al. (1995) Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immunebrain communication. Neurosci. Lett. 183:27–31.
    • (1995) Neurosci. Lett. , vol.183 , pp. 27-31
    • Watkins, L.R.1
  • 7
    • 0029258451 scopus 로고
    • An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality
    • COI: 1:CAS:528:DyaK2MXlsFyntLw%3D, PID: 8529104
    • Bianchi M, et al. (1995) An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality. Mol. Med. 1:254–266.
    • (1995) Mol. Med. , vol.1 , pp. 254-266
    • Bianchi, M.1
  • 8
    • 0034713266 scopus 로고    scopus 로고
    • Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
    • COI: 1:CAS:528:DC%2BD3cXjslyltbY%3D, PID: 10839541
    • Borovikova L, et al. (2000) Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature. 405:458–62.
    • (2000) Nature , vol.405 , pp. 458-462
    • Borovikova, L.1
  • 9
    • 33745830175 scopus 로고    scopus 로고
    • Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    • COI: 1:CAS:528:DC%2BD28XntVCgsr8%3D, PID: 16785311
    • Huston JM, et al. (2006) Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J. Exp. Med. 203:1623–8.
    • (2006) J. Exp. Med. , vol.203 , pp. 1623-1628
    • Huston, J.M.1
  • 10
    • 49449091882 scopus 로고    scopus 로고
    • Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    • Rosas-Ballin M, et al. (2008) Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc. Natl. Acad. Sci. U. S. A. 105:11008–13.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 11008-11013
    • Rosas-Ballin, M.1
  • 11
    • 80053593864 scopus 로고    scopus 로고
    • Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
    • COI: 1:CAS:528:DC%2BC3MXht1Gms7%2FE, PID: 21921156
    • Rosas-Ballina M, et al. (2011) Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science. 334:98–101.
    • (2011) Science , vol.334 , pp. 98-101
    • Rosas-Ballina, M.1
  • 12
    • 0037461768 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor [alpha]7 subunit is an essential regulator of inflammation
    • COI: 1:CAS:528:DC%2BD3sXlsVantA%3D%3D, PID: 12508119
    • Wang H, et al. (2003) Nicotinic acetylcholine receptor [alpha]7 subunit is an essential regulator of inflammation. Nature. 421:384–8.
    • (2003) Nature , vol.421 , pp. 384-388
    • Wang, H.1
  • 13
    • 84865654979 scopus 로고    scopus 로고
    • Alpha7 nicotinic acetylcholine receptor (alpha7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex
    • COI: 1:CAS:528:DC%2BC38XosFentL4%3D, PID: 22183893
    • Olofsson PS, et al. (2012) alpha7 nicotinic acetylcholine receptor (alpha7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex. Mol. Med. 18:539–43.
    • (2012) Mol. Med. , vol.18 , pp. 539-543
    • Olofsson, P.S.1
  • 14
    • 84880267231 scopus 로고    scopus 로고
    • The vagal innervation of the gut and immune homeostasis
    • COI: 1:CAS:528:DC%2BC3sXhsVKgsLvF, PID: 23023166
    • Matteoli G, Boeckxstaens GE. (2013) The vagal innervation of the gut and immune homeostasis. Gut. 62:1214–22.
    • (2013) Gut , vol.62 , pp. 1214-1222
    • Matteoli, G.1    Boeckxstaens, G.E.2
  • 15
    • 84893947513 scopus 로고    scopus 로고
    • A distinct vagal antiinflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen
    • COI: 1:CAS:528:DC%2BC2cXhtFektb7N, PID: 23929694
    • Matteoli G, et al. (2014) A distinct vagal antiinflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen. Gut. 63:938–4.
    • (2014) Gut , vol.63 , pp. 934-938
    • Matteoli, G.1
  • 16
    • 84895144365 scopus 로고    scopus 로고
    • Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis
    • COI: 1:CAS:528:DC%2BC3sXhtFGlsrvM, PID: 23881354
    • Ji H, et al. (2014) Central cholinergic activation of a vagus nerve-to-spleen circuit alleviates experimental colitis. Mucosal Immunol. 7:335–47.
    • (2014) Mucosal Immunol. , vol.7 , pp. 335-347
    • Ji, H.1
  • 17
    • 77953508463 scopus 로고    scopus 로고
    • Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3cXpsFSntbs%3D, PID: 20337855
    • Bruchfeld A, et al. (2010) Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis. J. Intern. Med. 268:94–101.
    • (2010) J. Intern. Med. , vol.268 , pp. 94-101
    • Bruchfeld, A.1
  • 18
    • 55049094829 scopus 로고    scopus 로고
    • Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    • COI: 1:CAS:528:DC%2BD1cXht1ems7%2FP, PID: 18584048
    • Parrish WR, et al. (2008) Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling. Mol. Med. 14:567–74.
    • (2008) Mol. Med. , vol.14 , pp. 567-574
    • Parrish, W.R.1
  • 19
    • 23844454674 scopus 로고    scopus 로고
    • Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
    • PID: 16025117
    • de Jonge WJ, et al. (2005) Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 6:844–51.
    • (2005) Nat. Immunol. , vol.6 , pp. 844-851
    • de Jonge, W.J.1
  • 20
    • 33646522174 scopus 로고    scopus 로고
    • The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    • PID: 16697744
    • van Westerloo DJ, et al. (2006) The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology. 130:1822–30.
    • (2006) Gastroenterology , vol.130 , pp. 1822-1830
    • van Westerloo, D.J.1
  • 21
    • 80052278843 scopus 로고    scopus 로고
    • Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis
    • PID: 21783215
    • Krzyzaniak MJ, et al. (2011) Efferent vagal nerve stimulation attenuates acute lung injury following burn: The importance of the gut-lung axis. Surgery. 150:379–89.
    • (2011) Surgery , vol.150 , pp. 379-389
    • Krzyzaniak, M.J.1
  • 22
    • 68949127056 scopus 로고    scopus 로고
    • Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b
    • COI: 1:CAS:528:DC%2BD1MXnsVOqsL0%3D, PID: 19542466
    • Huston JM, et al. (2009) Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J. Immunol. 183:552–9.
    • (2009) J. Immunol. , vol.183 , pp. 552-559
    • Huston, J.M.1
  • 23
    • 67650501700 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis
    • PID: 19337288
    • Van Maanen M, Vervoordeldonk M, Tak P. (2009) The cholinergic anti-inflammatory pathway: towards innovative treatment of rheumatoid arthritis. Nat. Rev. Rheumatol. 5:229–32.
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 229-232
    • Van Maanen, M.1    Vervoordeldonk, M.2    Tak, P.3
  • 24
    • 84856736767 scopus 로고    scopus 로고
    • Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3MXhtlCgsbjN, PID: 21607292
    • Koopman FA, et al. (2011) Restoring the balance of the autonomic nervous system as an innovative approach to the treatment of rheumatoid arthritis. Mol. Med. 17:937–48.
    • (2011) Mol. Med. , vol.17 , pp. 937-948
    • Koopman, F.A.1
  • 25
    • 77955363222 scopus 로고    scopus 로고
    • Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis?
    • COI: 1:CAS:528:DC%2BC3cXhtFOiu7vM, PID: 20506322
    • Bevaart L, Vervoordeldonk MJ, Tak PP. (2010) Evaluation of therapeutic targets in animal models of arthritis: how does it relate to rheumatoid arthritis? Arthritis Rheum. 62:2192–205.
    • (2010) Arthritis Rheum. , vol.62 , pp. 2192-2205
    • Bevaart, L.1    Vervoordeldonk, M.J.2    Tak, P.P.3
  • 26
    • 54349089048 scopus 로고    scopus 로고
    • Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD1cXhtl2gsbbP, PID: 18055474
    • Hegen M, Keith JC Jr, Collins M, Nickerson-Nutter CL. (2008) Utility of animal models for identification of potential therapeutics for rheumatoid arthritis. Ann. Rheum. Dis. 67:1505–15.
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1505-1515
    • Hegen, M.1    Keith, J.C.2    Collins, M.3    Nickerson-Nutter, C.L.4
  • 27
    • 77953542271 scopus 로고    scopus 로고
    • The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis
    • PID: 19890701
    • Li T, et al. (2010) The vagus nerve and nicotinic receptors involve inhibition of HMGB1 release and early pro-inflammatory cytokines function in collagen-induced arthritis. J. Clin. Immunol. 30:213–20.
    • (2010) J. Clin. Immunol. , vol.30 , pp. 213-220
    • Li, T.1
  • 28
    • 84899664963 scopus 로고    scopus 로고
    • Attenuation of collagen induced arthritis via suppression on Th17 response by activating cholinergic anti-inflammatory pathway with nicotine
    • COI: 1:CAS:528:DC%2BC2cXpvFSrtrs%3D, PID: 24755145
    • Wu S, et al. (2014) Attenuation of collagen induced arthritis via suppression on Th17 response by activating cholinergic anti-inflammatory pathway with nicotine. Eur. J. Pharmacol. 735:97–104.
    • (2014) Eur. J. Pharmacol. , vol.735 , pp. 97-104
    • Wu, S.1
  • 29
    • 77956034589 scopus 로고    scopus 로고
    • Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice
    • PID: 20511609
    • van Maanen M, Stoof S, Larosa G, Vervoordeldonk M, Tak P. (2010) Role of the cholinergic nervous system in rheumatoid arthritis: aggravation of arthritis in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice. Ann. Rheum. Dis. 69:1717–23.
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1717-1723
    • van Maanen, M.1    Stoof, S.2    Larosa, G.3    Vervoordeldonk, M.4    Tak, P.5
  • 30
    • 58249121600 scopus 로고    scopus 로고
    • Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice
    • PID: 19116908
    • van Maanen MA. (2009) Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. 60:114–122.
    • (2009) Arthritis Rheum. , vol.60 , pp. 114-122
    • van Maanen, M.A.1
  • 31
    • 51849148885 scopus 로고    scopus 로고
    • Inhibition of the development of collagen-induced arthritis in Wistar rats through vagus nerve suspension: a 3-month observation
    • COI: 1:CAS:528:DC%2BD1cXhtVSrsL%2FP, PID: 18607536
    • Zhang P, Han D, Tang T, Zhang X, Dai K. (2008) Inhibition of the development of collagen-induced arthritis in Wistar rats through vagus nerve suspension: a 3-month observation. Inflamm. Res. 57:322–328.
    • (2008) Inflamm. Res. , vol.57 , pp. 322-328
    • Zhang, P.1    Han, D.2    Tang, T.3    Zhang, X.4    Dai, K.5
  • 32
    • 84905824890 scopus 로고    scopus 로고
    • Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis
    • PID: 25110981
    • Levine YA, et al. (2014) Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis. PLoS One. 9:e104530.
    • (2014) PLoS One , vol.9
    • Levine, Y.A.1
  • 33
    • 84860364397 scopus 로고    scopus 로고
    • Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab
    • COI: 1:CAS:528:DC%2BC38Xmt1Gqur0%3D, PID: 22543469
    • Lacey DL, et al. (2012) Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat. Rev. Drug. Discov. 11:401–19.
    • (2012) Nat. Rev. Drug. Discov. , vol.11 , pp. 401-419
    • Lacey, D.L.1
  • 34
    • 84857122448 scopus 로고    scopus 로고
    • Nicotine inhibits tumor necrosis factor-alpha induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC38Xmt1elsw%3D%3D, PID: 20665032
    • Zhou Y, et al. (2012) Nicotine inhibits tumor necrosis factor-alpha induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Rheumatol. Int. 32:97–104.
    • (2012) Rheumatol. Int. , vol.32 , pp. 97-104
    • Zhou, Y.1
  • 35
    • 66049108135 scopus 로고    scopus 로고
    • The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation
    • PID: 19404936
    • van Maanen MA, et al. (2009) The alpha7 nicotinic acetylcholine receptor on fibroblast-like synoviocytes and in synovial tissue from rheumatoid arthritis patients: a possible role for a key neurotransmitter in synovial inflammation. Arthritis Rheum. 60:1272–81.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1272-1281
    • van Maanen, M.A.1
  • 36
    • 55849118078 scopus 로고    scopus 로고
    • Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor
    • COI: 1:CAS:528:DC%2BD1cXhsV2hs7bN, PID: 18975306
    • Waldburger JM, Boyle DL, Pavlov VA, Tracey KJ, Firestein GS. (2008) Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. Arthritis Rheum. 58:3439–49.
    • (2008) Arthritis Rheum. , vol.58 , pp. 3439-3449
    • Waldburger, J.M.1    Boyle, D.L.2    Pavlov, V.A.3    Tracey, K.J.4    Firestein, G.S.5
  • 37
    • 84874187791 scopus 로고    scopus 로고
    • The effect of snuff (smokeless tobacco) on disease activity and function in rheumatoid arthritis: experiences from the Better Anti-Rheumatic Farmac O Therapy, a longitudinal multicenter study on early rheumatoid arthritis
    • PID: 23319018
    • Andersson ML, Bergman S, Soderlin MK, BARFOT study group (2013) The effect of snuff (smokeless tobacco) on disease activity and function in rheumatoid arthritis: experiences from the Better Anti-Rheumatic Farmac O Therapy, a longitudinal multicenter study on early rheumatoid arthritis. J. Clin. Rheumatol. 19:14–18.
    • (2013) J. Clin. Rheumatol. , vol.19 , pp. 14-18
    • Andersson, M.L.1    Bergman, S.2    Soderlin, M.K.3
  • 38
    • 84889077298 scopus 로고    scopus 로고
    • The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BC2cXksVSrsg%3D%3D, PID: 23989010
    • Valatas V, Vakas M, Kolios G. (2013) The value of experimental models of colitis in predicting efficacy of biological therapies for inflammatory bowel diseases. Am. J. Physiol. Gastrointest. Liver Physiol. 305:G763–85.
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.305 , pp. G763-G785
    • Valatas, V.1    Vakas, M.2    Kolios, G.3
  • 39
    • 59449094473 scopus 로고    scopus 로고
    • T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade
    • COI: 1:CAS:528:DC%2BD1MXitVaqtrw%3D, PID: 19033538
    • Ostanin DV, et al. (2009) T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G135–46.
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296 , pp. G135-G146
    • Ostanin, D.V.1
  • 40
    • 84862297537 scopus 로고    scopus 로고
    • Dextran sodium sulphate colitis mouse model: traps and tricks
    • PID: 22665990
    • Perse M, Cerar A. (2012) Dextran sodium sulphate colitis mouse model: traps and tricks. J. Biomed. Biotechnol. 2012:718617.
    • (2012) J. Biomed. Biotechnol. , vol.2012 , pp. 718617
    • Perse, M.1    Cerar, A.2
  • 41
    • 33749343778 scopus 로고    scopus 로고
    • Critical appraisal of the current practice in murine TNBS-induced colitis
    • te Velde AA, Verstege MI, Hommes DW. (2006) Critical appraisal of the current practice in murine TNBS-induced colitis. Inflamm Bowel Dis 12:995–9.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 995-999
    • te Velde, A.A.1    Verstege, M.I.2    Hommes, D.W.3
  • 42
    • 0033948508 scopus 로고    scopus 로고
    • Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(−/−) mice and intestinal inflammation
    • COI: 1:CAS:528:DC%2BD3cXks1Kntbw%3D, PID: 10859210
    • Rennick DM, Fort MM. (2000) Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(−/−) mice and intestinal inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 278:G829–33.
    • (2000) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.278 , pp. G829-G833
    • Rennick, D.M.1    Fort, M.M.2
  • 43
    • 0032436993 scopus 로고    scopus 로고
    • Effect of chronic nicotine administration on trinitrobenzene sulphonic acid-induced colitis
    • COI: 1:STN:280:DyaK1M7htVegug%3D%3D, PID: 9895047
    • Eliakim R, Karmeli F, Rachmilewitz D, Cohen P, Fich A. (1998) Effect of chronic nicotine administration on trinitrobenzene sulphonic acid-induced colitis. Eur. J. Gastroenterol. Hepatol. 10:1013–9.
    • (1998) Eur. J. Gastroenterol. Hepatol. , vol.10 , pp. 1013-1019
    • Eliakim, R.1    Karmeli, F.2    Rachmilewitz, D.3    Cohen, P.4    Fich, A.5
  • 44
    • 77951687995 scopus 로고    scopus 로고
    • Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis
    • COI: 1:CAS:528:DC%2BC3cXpslyqsL0%3D, PID: 20423343
    • Snoek SA, et al. (2010) Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis. Br. J. Pharmacol. 160:322–33.
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 322-333
    • Snoek, S.A.1
  • 45
    • 79551515079 scopus 로고    scopus 로고
    • Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease
    • COI: 1:STN:280:DC%2BC3M7mvFSqtA%3D%3D, PID: 21071287
    • Meregnani J, et al. (2011) Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease. Auton. Neurosci. 160:82–9.
    • (2011) Auton. Neurosci. , vol.160 , pp. 82-89
    • Meregnani, J.1
  • 46
    • 84881000371 scopus 로고    scopus 로고
    • Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation
    • COI: 1:CAS:528:DC%2BC3sXht12mt73I, PID: 23936328
    • Sun P, et al. (2013) Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation. PLoS One. 8:e69424.
    • (2013) PLoS One , vol.8
    • Sun, P.1
  • 47
    • 84876227647 scopus 로고    scopus 로고
    • Drug discovery: a jump-start for electroceuticals
    • COI: 1:CAS:528:DC%2BC3sXlsl2itLk%3D, PID: 23579662
    • Famm K, Litt B, Tracey KJ, Boyden ES, Slaoui M. (2013) Drug discovery: a jump-start for electroceuticals. Nature. 496:159–61.
    • (2013) Nature , vol.496 , pp. 159-161
    • Famm, K.1    Litt, B.2    Tracey, K.J.3    Boyden, E.S.4    Slaoui, M.5
  • 48
    • 58249121600 scopus 로고    scopus 로고
    • Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice
    • PID: 19116908
    • van Maanen M, et al. (2009) Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum. 60:114–22.
    • (2009) Arthritis Rheum. , vol.60 , pp. 114-122
    • van Maanen, M.1
  • 49
    • 0034222072 scopus 로고    scopus 로고
    • An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD3cXlvFOkurs%3D, PID: 10959551
    • Sykes AP, et al. (2000) An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease. Inflamm. Res. 49:311–9.
    • (2000) Inflamm. Res. , vol.49 , pp. 311-319
    • Sykes, A.P.1
  • 50
    • 0036085525 scopus 로고    scopus 로고
    • Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice
    • COI: 1:CAS:528:DC%2BD38XlsF2js7o%3D, PID: 12072594
    • Eliakim R, Fan QX, Babyatsky MW. (2002) Chronic nicotine administration differentially alters jejunal and colonic inflammation in interleukin-10 deficient mice. Eur. J. Gastroenterol. Hepatol. 14:607–14.
    • (2002) Eur. J. Gastroenterol. Hepatol. , vol.14 , pp. 607-614
    • Eliakim, R.1    Fan, Q.X.2    Babyatsky, M.W.3
  • 51
    • 0038554368 scopus 로고    scopus 로고
    • Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats
    • COI: 1:CAS:528:DC%2BD3sXjsVCjsLo%3D, PID: 12742187
    • Miceli PC, Jacobson K. (2003) Cholinergic pathways modulate experimental dinitrobenzene sulfonic acid colitis in rats. Auton. Neurosci. 105:16–24.
    • (2003) Auton. Neurosci. , vol.105 , pp. 16-24
    • Miceli, P.C.1    Jacobson, K.2
  • 52
    • 33749321161 scopus 로고    scopus 로고
    • The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model
    • PID: 17030182
    • Ghia JE, Blennerhassett P, Kumar-Ondiveeran H, Verdu EF, Collins SM. (2006) The vagus nerve: a tonic inhibitory influence associated with inflammatory bowel disease in a murine model. Gastroenterology. 131:1122–30.
    • (2006) Gastroenterology , vol.131 , pp. 1122-1130
    • Ghia, J.E.1    Blennerhassett, P.2    Kumar-Ondiveeran, H.3    Verdu, E.F.4    Collins, S.M.5
  • 53
    • 35348942843 scopus 로고    scopus 로고
    • The effect of the cholinergic anti-inflammatory pathway on experimental colitis
    • COI: 1:CAS:528:DC%2BD2sXhtlOhtb7J, PID: 17953529
    • Bai A, Guo Y, Lu N. (2007) The effect of the cholinergic anti-inflammatory pathway on experimental colitis. Scand. J. Immunol. 66:538–45.
    • (2007) Scand. J. Immunol. , vol.66 , pp. 538-545
    • Bai, A.1    Guo, Y.2    Lu, N.3
  • 54
    • 66149086109 scopus 로고    scopus 로고
    • Reactivation of inflammatory bowel disease in a mouse model of depression
    • COI: 1:CAS:528:DC%2BD1MXotVequrw%3D, PID: 19272381
    • Ghia JE, et al. (2009) Reactivation of inflammatory bowel disease in a mouse model of depression. Gastroenterology. 136:2280–8.
    • (2009) Gastroenterology , vol.136 , pp. 2280-2288
    • Ghia, J.E.1
  • 56
    • 80052661771 scopus 로고    scopus 로고
    • Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis
    • COI: 1:CAS:528:DC%2BC3MXhtVGmsbzM, PID: 21784975
    • Galitovskiy V, et al. (2011) Cytokine-induced alterations of alpha7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis. J. Immunol. 187:2677–87.
    • (2011) J. Immunol. , vol.187 , pp. 2677-2687
    • Galitovskiy, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.