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Volumn 32, Issue 1, 2012, Pages 97-104

Nicotine inhibits tumor necrosis factor-α induced IL-6 and IL-8 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

Author keywords

Cytokines; Inflammation; Nicotine; Rheumatoid arthritis; Synoviocytes

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; LACTATE DEHYDROGENASE; MESSENGER RNA; NICOTINE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84857122448     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1549-4     Document Type: Article
Times cited : (50)

References (34)
  • 1
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflamation in rheumatoid arthritis
    • DOI 10.1056/NEJM200103223441207
    • EH Choy GS Panayi 2001 Cytokine pathways and joint inflammation in rheumatoid arthritis N Engl J Med 344 907 916 10.1056/NEJM200103223441207 11259725 10.1056/NEJM200103223441207 1:CAS:528:DC%2BD3MXisFyrur8%3D (Pubitemid 32224400)
    • (2001) New England Journal of Medicine , vol.344 , Issue.12 , pp. 907-916
    • Choy, E.H.S.1    Panayi, G.S.2
  • 2
    • 0036615972 scopus 로고    scopus 로고
    • Cytokines in rheumatoid arthritis
    • 10.1007/s11926-002-0067-0 12010605 10.1007/s11926-002-0067-0
    • MJ Vervoordeldonk PP Tak 2002 Cytokines in rheumatoid arthritis Curr Rheumatol Rep 4 208 217 10.1007/s11926-002-0067-0 12010605 10.1007/s11926-002- 0067-0
    • (2002) Curr Rheumatol Rep , vol.4 , pp. 208-217
    • Vervoordeldonk, M.J.1    Tak, P.P.2
  • 3
    • 33847133943 scopus 로고    scopus 로고
    • Cadherin-11 in synovial lining formation and pathology in arthritis
    • DOI 10.1126/science.1137306
    • DM Lee HP Kiener SK Agarwal EH Noss GF Watts O Chisaka M Takeichi MB Brenner 2007 Cadherin-11 in synovial lining formation and pathology in arthritis Science 315 1006 1010 10.1126/science.1137306 17255475 10.1126/science.1137306 1:CAS:528:DC%2BD2sXhs1Cksr8%3D (Pubitemid 46281192)
    • (2007) Science , vol.315 , Issue.5814 , pp. 1006-1010
    • Lee, D.M.1    Kiener, H.P.2    Agarwal, S.K.3    Noss, E.H.4    Watts, G.F.M.5    Chisaka, O.6    Takeichi, M.7    Brenner, M.B.8
  • 4
    • 27744456525 scopus 로고    scopus 로고
    • Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes
    • 10.1186/ar1706 15899040 10.1186/ar1706 1:CAS:528:DC%2BD2MXivVWqtbc%3D
    • RJ Berckmans R Nieuwland MC Kraan MC Schaap D Pots TJ Smeets A Sturk PP Tak 2005 Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes Arthritis Res Ther 7 R536 R544 10.1186/ar1706 15899040 10.1186/ar1706 1:CAS:528:DC%2BD2MXivVWqtbc%3D
    • (2005) Arthritis Res Ther , vol.7
    • Berckmans, R.J.1    Nieuwland, R.2    Kraan, M.C.3    Schaap, M.C.4    Pots, D.5    Smeets, T.J.6    Sturk, A.7    Tak, P.P.8
  • 5
    • 0032544234 scopus 로고    scopus 로고
    • Regulation of interleukin-1β-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
    • DOI 10.1074/jbc.273.38.24832
    • K Miyazawa A Mori H Miyata M Akahane Y Ajisawa H Okudaira 1998 Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase J Biol Chem 273 24832 24838 10.1074/jbc.273.38.24832 9733787 10.1074/jbc.273.38.24832 1:CAS:528:DyaK1cXmtlyqtbs%3D (Pubitemid 28454988)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.38 , pp. 24832-24838
    • Miyazawa, K.1    Mori, A.2    Miyata, H.3    Akahane, M.4    Ajisawa, Y.5    Okudaira, H.6
  • 6
    • 0038667615 scopus 로고    scopus 로고
    • The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover
    • DOI 10.1002/art.10943
    • PK Wong IK Campbell PJ Egan M Ernst IP Wicks 2003 The role of the interleukin-6 family of cytokines in inflammatory arthritis and bone turnover Arthritis Rheum 48 1177 1189 10.1002/art.10943 12746890 10.1002/art.10943 1:CAS:528:DC%2BD3sXkt1aksbw%3D (Pubitemid 36554516)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.5 , pp. 1177-1189
    • Wong, P.K.K.1    Campbell, I.K.2    Egan, P.J.3    Ernst, M.4    Wicks, I.P.5
  • 7
    • 0029965602 scopus 로고    scopus 로고
    • Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis
    • DOI 10.1016/S0049-0172(96)80041-2
    • R Badolato JJ Oppenheim 1996 Role of cytokines, acute-phase proteins, and chemokines in the progression of rheumatoid arthritis Semin Arthritis Rheum 26 526 538 10.1016/S0049-0172(96)80041-2 8916297 10.1016/S0049-0172(96)80041-2 1:STN:280:DyaK2s%2FntlGrug%3D%3D (Pubitemid 26367589)
    • (1996) Seminars in Arthritis and Rheumatism , vol.26 , Issue.2 , pp. 526-538
    • Badolato, R.1    Oppenheim, J.J.2
  • 8
    • 0033762619 scopus 로고    scopus 로고
    • Anti-interleukin 6 receptor antibody treatment in rheumatic disease
    • 10.1136/ard.59.suppl-1.i21 11053081 10.1136/ard.59.suppl-1.i21 1:CAS:528:DC%2BD3cXos1ymu7c%3D
    • N Nishimoto T Kishimoto K Yoshizaki 2000 Anti-interleukin 6 receptor antibody treatment in rheumatic disease Ann Rheum Dis 59 Suppl 1 i21 i27 10.1136/ard.59.suppl-1.i21 11053081 10.1136/ard.59.suppl-1.i21 1:CAS:528:DC%2BD3cXos1ymu7c%3D
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. 1
    • Nishimoto, N.1    Kishimoto, T.2    Yoshizaki, K.3
  • 9
    • 1842683014 scopus 로고    scopus 로고
    • Augmented Production of Chemokines by the Interaction of Type II Collagen-Reactive T Cells With Rheumatoid Synovial Fibroblasts
    • DOI 10.1002/art.20133
    • DJ Min ML Cho SH Lee SY Min WU Kim JK Min SH Park CS Cho HY Kim 2004 Augmented production of chemokines by the interaction of type II collagen-reactive T cells with rheumatoid synovial fibroblasts Arthritis Rheum 50 1146 1155 10.1002/art.20133 15077296 10.1002/art.20133 1:CAS:528: DC%2BD2cXjslGqs78%3D (Pubitemid 38480824)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.4 , pp. 1146-1155
    • Min, D.-J.1    Cho, M.-L.2    Lee, S.-H.3    Min, S.-Y.4    Kim, W.-U.5    Min, J.-K.6    Park, S.-H.7    Cho, C.-S.8    Kim, H.-Y.9
  • 10
    • 0037180778 scopus 로고    scopus 로고
    • The inflammatory reflex
    • DOI 10.1038/nature01321
    • KJ Tracey 2002 The inflammatory reflex Nature 420 853 859 10.1038/nature01321 12490958 10.1038/nature01321 1:CAS:528:DC%2BD38XpsFygtLc%3D (Pubitemid 36019638)
    • (2002) Nature , vol.420 , Issue.6917 , pp. 853-859
    • Tracey, K.J.1
  • 11
    • 55849118078 scopus 로고    scopus 로고
    • Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor
    • 10.1002/art.23987 18975306 10.1002/art.23987 1:CAS:528:DC%2BD1cXhsV2hs7bN
    • JM Waldburger DL Boyle VA Pavlov KJ Tracey GS Firestein 2008 Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor Arthritis Rheum 58 3439 3449 10.1002/art.23987 18975306 10.1002/art.23987 1:CAS:528:DC%2BD1cXhsV2hs7bN
    • (2008) Arthritis Rheum , vol.58 , pp. 3439-3449
    • Waldburger, J.M.1    Boyle, D.L.2    Pavlov, V.A.3    Tracey, K.J.4    Firestein, G.S.5
  • 13
    • 33748713337 scopus 로고    scopus 로고
    • Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-κB phosphorylation and nuclear factor-κB transcriptional activity through nicotinic acetylcholine receptor α7
    • DOI 10.1111/j.1365-2249.2006.03169.x
    • H Yoshikawa M Kurokawa N Ozaki K Nara K Atou E Takada H Kamochi N Suzuki 2006 Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7 Clin Exp Immunol 146 116 123 10.1111/j.1365-2249.2006.03169.x 16968406 10.1111/j.1365-2249.2006.03169.x 1:CAS:528:DC%2BD28XhtF2qsbnO (Pubitemid 44393846)
    • (2006) Clinical and Experimental Immunology , vol.146 , Issue.1 , pp. 116-123
    • Yoshikawa, H.1    Kurokawa, M.2    Ozaki, N.3    Nara, K.4    Atou, K.5    Takada, E.6    Kamochi, H.7    Suzuki, N.8
  • 15
    • 0034222072 scopus 로고    scopus 로고
    • An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease
    • 10.1007/s000110050597 10959551 10.1007/s000110050597 1:CAS:528: DC%2BD3cXlvFOkurs%3D
    • AP Sykes C Brampton S Klee CL Chander C Whelan ME Parsons 2000 An investigation into the effect and mechanisms of action of nicotine in inflammatory bowel disease Inflamm Res 49 311 319 10.1007/s000110050597 10959551 10.1007/s000110050597 1:CAS:528:DC%2BD3cXlvFOkurs%3D
    • (2000) Inflamm Res , vol.49 , pp. 311-319
    • Sykes, A.P.1    Brampton, C.2    Klee, S.3    Chander, C.L.4    Whelan, C.5    Parsons, M.E.6
  • 17
    • 67349102252 scopus 로고    scopus 로고
    • Factors affecting bone mineral density in men
    • 10.1007/s00296-008-0768-4 19082599 10.1007/s00296-008-0768-4
    • E Atalar G Aydin I Keles E Inal G Zog A Arslan S Orkun 2009 Factors affecting bone mineral density in men Rheumatol Int 29 1025 1030 10.1007/s00296-008-0768-4 19082599 10.1007/s00296-008-0768-4
    • (2009) Rheumatol Int , vol.29 , pp. 1025-1030
    • Atalar, E.1    Aydin, G.2    Keles, I.3    Inal, E.4    Zog, G.5    Arslan, A.6    Orkun, S.7
  • 18
    • 77954717701 scopus 로고    scopus 로고
    • Smoking, use of moist snuff, and risk of chronic inflammatory diseases
    • 10.1164/rccm.200909-1338OC 20203245 10.1164/rccm.200909-1338OC
    • C Carlens MP Hergens J Grunewald A Ekbom A Eklund CO Hoglund J Askling 2010 Smoking, use of moist snuff, and risk of chronic inflammatory diseases Am J Respir Crit Care Med 181 1217 1222 10.1164/rccm.200909-1338OC 20203245 10.1164/rccm.200909-1338OC
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 1217-1222
    • Carlens, C.1    Hergens, M.P.2    Grunewald, J.3    Ekbom, A.4    Eklund, A.5    Hoglund, C.O.6    Askling, J.7
  • 19
    • 17744389966 scopus 로고    scopus 로고
    • Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture - Primary culture cells markedly differ from fourth-passage cells
    • DOI 10.1186/ar142
    • T Zimmermann E Kunisch R Pfeiffer A Hirth HD Stahl U Sack A Laube E Liesaus A Roth E Palombo-Kinne F Emmrich RW Kinne 2001 Isolation and characterization of rheumatoid arthritis synovial fibroblasts from primary culture-primary culture cells markedly differ from fourth-passage cells Arthritis Res 3 72 76 10.1186/ar142 11178129 10.1186/ar142 1:CAS:528: DC%2BD3MXhslWlt74%3D (Pubitemid 32223808)
    • (2001) Arthritis Research , vol.3 , Issue.1 , pp. 72-76
    • Zimmermann, T.1    Kunisch, E.2    Pfeiffer, R.3    Hirth, A.4    Stahl, H.-D.5    Sack, U.6    Laube, A.7    Liesaus, E.8    Roth, A.9    Palombo-Kinne, E.10    Emmrich, F.11    Kinne, R.W.12
  • 20
    • 0343378913 scopus 로고    scopus 로고
    • The pharmacology of (-)-nicotine and novel cholinergic channel modulators
    • 10.1016/S1054-3589(08)60950-3 8891102 10.1016/S1054-3589(08)60950-3 1:CAS:528:DyaK2sXivVOhtg%3D%3D
    • JD Brioni MW Decker JP Sullivan SP Arneric 1997 The pharmacology of (-)-nicotine and novel cholinergic channel modulators Adv Pharmacol 37 153 214 10.1016/S1054-3589(08)60950-3 8891102 10.1016/S1054-3589(08)60950-3 1:CAS:528:DyaK2sXivVOhtg%3D%3D
    • (1997) Adv Pharmacol , vol.37 , pp. 153-214
    • Brioni, J.D.1    Decker, M.W.2    Sullivan, J.P.3    Arneric, S.P.4
  • 22
    • 58249121600 scopus 로고    scopus 로고
    • Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice
    • 10.1002/art.24177 19116908 10.1002/art.24177
    • MA van Maanen MC Lebre T van der Poll GJ LaRosa D Elbaum MJ Vervoordeldonk PP Tak 2009 Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice Arthritis Rheum 60 114 122 10.1002/art.24177 19116908 10.1002/art.24177
    • (2009) Arthritis Rheum , vol.60 , pp. 114-122
    • Van Maanen, M.A.1    Lebre, M.C.2    Van Der Poll, T.3    Larosa, G.J.4    Elbaum, D.5    Vervoordeldonk, M.J.6    Tak, P.P.7
  • 24
    • 0029877828 scopus 로고    scopus 로고
    • Cigarette smoking increases the risk of rheumatoid arthritis: Results from a nationwide study of disease-discordant twins
    • DOI 10.1002/art.1780390504
    • AJ Silman J Newman AJ MacGregor 1996 Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins Arthritis Rheum 39 732 735 10.1002/art.1780390504 8639169 10.1002/art.1780390504 1:STN:280:DyaK283ht1CgsQ%3D%3D (Pubitemid 26140417)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.5 , pp. 732-735
    • Silman, A.J.1    Newman, J.2    MacGregor, A.J.3
  • 25
    • 0034069810 scopus 로고    scopus 로고
    • Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjogren's syndrome?
    • DOI 10.1136/ard.59.1.54
    • R Manthorpe C Benoni L Jacobsson Z Kirtava A Larsson R Liedholm C Nyhagen H Tabery E Theander 2000 Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjogren's syndrome? Ann Rheum Dis 59 54 60 10.1136/ard.59.1.54 10627428 10.1136/ard.59.1.54 1:STN:280:DC%2BD3c%2FpsVKjtQ%3D%3D (Pubitemid 30303898)
    • (2000) Annals of the Rheumatic Diseases , vol.59 , Issue.1 , pp. 54-60
    • Manthorpe, R.1    Benoni, C.2    Jacobsson, L.3    Kirtava, Z.4    Larsson, A.5    Liedholm, R.6    Nyhagen, C.7    Tabery, H.8    Theander, E.9
  • 26
    • 0035097070 scopus 로고    scopus 로고
    • The association of cigarette smoking with disease outcome in patients with early inflammatory polyarthritis
    • DOI 10.1002/1529-0131(200102)44:2<323::AID-ANR49>3.0.CO;2-C
    • Harrison BJ, Silman AJ, Wiles NJ, Scott DG, Symmons DP (2001) The association of cigarette smoking with disease outcome in patients with early inflammatory polyarthritis. Arthritis Rheum 44:323-330. doi: 10.1002/1529-0131(200102)44:2<323:AID-ANR49>3.3.CO;2-3 (Pubitemid 32207025)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.2 , pp. 323-330
    • Harrison, B.J.1    Silman, A.J.2    Wiles, N.J.3    Scott, D.G.I.4    Symmons, D.P.M.5
  • 27
    • 0031750237 scopus 로고    scopus 로고
    • The long-term outcomes of rheumatoid arthritis: A 23-year prospective, longitudinal study of total joint replacement and its predictors in 1,600 patients with rheumatoid arthritis
    • DOI 10.1002/1529-0131(199806)41:6<1072::AID-ART14>3.0.CO;2-G
    • Wolfe F, Zwillich SH (1998) The long-term outcomes of rheumatoid arthritis: a 23-year prospective, longitudinal study of total joint replacement and its predictors in 1, 600 patients with rheumatoid arthritis. Arthritis Rheum 41:1072-1082. doi: 10.1002/1529-0131(199806)41:6<1072:AID-ART14>3.0.CO;2- G (Pubitemid 28265410)
    • (1998) Arthritis and Rheumatism , vol.41 , Issue.6 , pp. 1072-1082
    • Wolfe, F.1    Zwillich, S.H.2
  • 28
    • 34547225631 scopus 로고    scopus 로고
    • Cigarette smoking and radiographic progression in rheumatoid arthritis
    • DOI 10.1136/ard.2006.065060
    • A Finckh S Dehler KH Costenbader C Gabay 2007 Cigarette smoking and radiographic progression in rheumatoid arthritis Ann Rheum Dis 66 1066 1071 17237117 10.1136/ard.2006.065060 1:STN:280:DC%2BD2svgslGhsQ%3D%3D (Pubitemid 47122321)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.8 , pp. 1066-1071
    • Finckh, A.1    Dehler, S.2    Costenbader, K.H.3    Gabay, C.4
  • 29
    • 67649884060 scopus 로고    scopus 로고
    • Smoking and nicotine exposure delay development of collagen-induced arthritis in mice
    • 10.1136/ard.2006.065060 19519907 10.1186/ar2728
    • SS Lindblad P Mydel IM Jonsson RM Senior A Tarkowski M Bokarewa 2009 Smoking and nicotine exposure delay development of collagen-induced arthritis in mice Arthritis Res Ther 11 R88 10.1136/ard.2006.065060 19519907 10.1186/ar2728
    • (2009) Arthritis Res Ther , vol.11 , pp. 88
    • Lindblad, S.S.1    Mydel, P.2    Jonsson, I.M.3    Senior, R.M.4    Tarkowski, A.5    Bokarewa, M.6
  • 30
    • 0034746919 scopus 로고    scopus 로고
    • NF-κB: A key role in inflammatory diseases
    • PP Tak GS Firestein 2001 NF-kappaB: a key role in inflammatory diseases J Clin Invest 107 7 11 10.1172/JCI11830 11134171 10.1172/JCI11830 1:CAS:528:DC%2BD3MXitVOhtg%3D%3D (Pubitemid 32047405)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.1 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 31
    • 0030044619 scopus 로고    scopus 로고
    • Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α
    • DOI 10.1002/art.1780390205
    • K Fujisawa H Aono T Hasunuma K Yamamoto S Mita K Nishioka 1996 Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha Arthritis Rheum 39 197 203 10.1002/art.1780390205 8849369 10.1002/art.1780390205 1:CAS:528:DyaK28Xhs1OhtLw%3D (Pubitemid 26065259)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.2 , pp. 197-203
    • Fujisawa, K.1    Aono, H.2    Hasunuma, T.3    Yamamoto, K.4    Mita, S.5    Nishioka, K.6
  • 32
    • 0029563524 scopus 로고
    • Nuclear factor-κB in rheumatoid synovium: Localization of p50 and p65
    • DOI 10.1002/art.1780381209
    • ML Handel LB McMorrow EM Gravallese 1995 Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65 Arthritis Rheum 38 1762 1770 10.1002/art.1780381209 8849348 10.1002/art.1780381209 1:STN:280: DyaK287htVKrsg%3D%3D (Pubitemid 26010277)
    • (1995) Arthritis and Rheumatism , vol.38 , Issue.12 , pp. 1762-1770
    • Handel, M.L.1    McMorrow, L.B.2    Gravallese, E.M.3
  • 33
    • 0031886794 scopus 로고    scopus 로고
    • Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: Spontaneous activation of NF-κB and CBF1
    • K Miyazawa A Mori K Yamamoto H Okudaira 1998 Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1 Am J Pathol 152 793 803 9502421 1:CAS:528:DyaK1cXitFent7g%3D (Pubitemid 28110726)
    • (1998) American Journal of Pathology , vol.152 , Issue.3 , pp. 793-803
    • Miyazawa, K.1    Mori, A.2    Yamamoto, K.3    Okudaira, H.4
  • 34
    • 0029842020 scopus 로고    scopus 로고
    • Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin
    • DOI 10.1093/intimm/8.10.1483
    • S Sakurada T Kato T Okamoto 1996 Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-l-cysteine and aspirin Int Immunol 8 1483 1493 10.1093/intimm/8.10.1483 8921427 10.1093/intimm/8.10.1483 1:CAS:528: DyaK28Xmslegs7c%3D (Pubitemid 26341088)
    • (1996) International Immunology , vol.8 , Issue.10 , pp. 1483-1493
    • Sakurada, S.1    Kato, T.2    Okamoto, T.3


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