Central leptin and resistin combined elicit enhanced central effects on renal sympathetic nerve activity

Experimental Physiology

Volumn 101, Issue 7, 2016, Pages 791-800

  Habeeballah, Hamza ^a   Alsuhaymi, Naif ^a   Stebbing, Martin J ^a   Jenkins, Trisha A ^a   Badoer, Emilio ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN FOS; RESISTIN; SODIUM CHLORIDE;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN NUCLEUS; CONTROLLED STUDY; HEART RATE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL; NONHUMAN; OBESITY; QUANTITATIVE ANALYSIS; RAT; RENAL SYMPATHETIC NERVE ACTIVITY; UROGENITAL SYSTEM PARAMETERS;

EID: 84977674107     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/EP085723     Document Type: Article

References (39)

1. Abramson JL, Lewis C & Murrah NV (2011). Body mass index, leptin, and ambulatory blood pressure variability in healthy adults. Atherosclerosis 214, 456–461.
2. Asterholm IW, Rutkowski JM, Fujikawa T, Cho YR, Fukuda M, Tao C, Wang ZV, Gupta RK, Elmquist JK & Scherer PE (2014). Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. Diabetologia 57, 1209–1218.
3. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A & Saruta T (2003). Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11, 997–1001.
4. Baker RA & Herkenham M (1995). Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat. J Comp Neurol 358, 518–530.
5. Bassi M, Furuya WI, Zoccal DB, Menani JV, Colombari E, Hall JE, da Silva AA, do Carmo JM & Colombari DS (2015a). Control of respiratory and cardiovascular functions by leptin. Life Sci 125, 25–31.
6. Bassi M, Furuya WI, Zoccal DB, Menani JV, Colombari DS, Mulkey DK & Colombari E (2016). Facilitation of breathing by leptin effects in the central nervous system. J Physiol 594, 1617–1625.
7. Bassi M, Nakamura NB, Furuya WI, Colombari DS, Menani JV, do Carmo JM, da Silva AA, Hall JE & Colombari E (2015b). Activation of the brain melanocortin system is required for leptin-induced modulation of chemorespiratory function. Acta Physiol (Oxf) 213, 893–901.
8. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD & Low MJ (2001). Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480–484.
9. DiBona GF (1985). Neural regulation of renal tubular sodium reabsorption and renin secretion. Fed Proc 44, 2816–2822.
10. Dunbar JC, Hu Y & Lu H (1997). Intracerebroventricular leptin inreases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 46, 2040–2043.
11. Elias CF, Kelly JF, Lee CE, Ahima RS, Drucker DJ, Saper CB & Elmquist JK (2000). Chemical characterization of leptin-activated neurons in the rat brain. J Comp Neurol 423, 261–281.
12. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS & Saper CB (1997). Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138, 839–842.
13. Haynes WG, Morgan DA, Walsh SA, Mark AL & Sivitz WI (1997a). Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100, 270–278.
14. Haynes WG, Sivitz WI, Morgan DA, Walsh SA & Mark AL (1997b). Sympathetic and cardiorenal actions of leptin. Hypertension 30, 619–623.
15. Jackson EK & Herzer WA (1999). A comparison of the natriuretic/diuretic effects of rat vs. human leptin in the rat. Am J Physiol Renal Physiol 277, F761–F765.
16. Kosari S, Rathner JA & Badoer E (2012). Central resistin enhances renal sympathetic nerve activity via phosphatidylinositol 3-kinase but reduces the activity to brown adipose tissue via extracellular signal-regulated kinase 1/2. J Neuroendocrinol 24, 1432–1439.
17. Kosari S, Rathner JA, Chen F, Kosari S & Badoer E (2011). Centrally administered resistin enhances sympathetic nerve activity to the hindlimb but attenuates the activity to brown adipose tissue. Endocrinology 152, 2626–2633.
18. McKinley MJ, Badoer E, Vivas L & Oldfield BJ (1995). Comparison of c-fos expression in the lamina terminalis of conscious rats after intravenous or intracerebroventricular angiotensin. Brain Res Bull 37, 131–137.
19. Mark AL, Correia ML, Rahmouni K & Haynes WG (2002). Selective leptin resistance: a new concept in leptin physiology with cardiovascular implications. J Hypertens 20, 1245–1250.
20. Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD & Haynes WG (1999). Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens 17, 1949–1953.
21. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ & Trayhurn P (1996). Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol 8, 733–735.
22. Montanaro MS, Allen AM & Oldfield BJ (2005). Structural and functional evidence supporting a role for leptin in central neural pathways influencing blood pressure in rats. Exp Physiol 90, 689–696.
23. Morrison SF, Sved AF & Passerin AM (1999). GABA-mediated inhibition of raphe pallidus neurons regulates sympathetic outflow to brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276, R290–R297.
24. Oldfield BJ, Badoer E, Hards DK & McKinley MJ (1994). Fos production in retrogradely labelled neurons of the lamina terminalis following intravenous infusion of either hypertonic saline or angiotensin II. Neuroscience 60, 255–262.
25. Prior LJ, Eikelis N, Armitage JA, Davern PJ, Burke SL, Montani JP, Barzel B & Head GA (2010). Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits. Hypertension 55, 862–868.
26. Rahmouni K, Haynes WG, Morgan DA & Mark AL (2003). Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 41, 763–767.
27. Rahmouni K & Morgan DA (2007). Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension 49, 647–652.
28. Rahmouni K, Morgan DA, Morgan GM, Mark AL & Haynes WG (2005). Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54, 2012–2018.
29. Rahmouni K, Sigmund CD, Haynes WG & Mark AL (2009). Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes 58, 536–542.
30. Rajala MW, Qi Y, Patel HR, Takahashi N, Banerjee R, Pajvani UB, Sinha MK, Gingerich RL, Scherer PE & Ahima RS (2004). Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting. Diabetes 53, 1671–1679.
31. Sapru HN (2013). Role of the hypothalamic arcuate nucleus in cardiovascular regulation. Auton Neurosci 175, 38–50.
32. Shimizu H, Shimomura Y, Hayashi R, Ohtani K, Sato N, Futawatari T & Mori M (1997). Serum leptin concentration is associated with total body fat mass, but not abdominal fat distribution. Int J Obes Relat Metab Disord 21, 536–541.
33. Simonds SE, Pryor JT, Ravussin E, Greenway FL, Dileone R, Allen AM, Bassi J, Elmquist JK, Keogh JM, Henning E, Myers MG Jr, Licinio J, Brown RD, Enriori PJ, O'Rahilly S, Sternson SM, Grove KL, Spanswick DC, Farooqi IS & Cowley MA (2014). Leptin mediates the increase in blood pressure associated with obesity. Cell 159, 1404–1416.
34. Singhal NS, Lazar MA & Ahima RS (2007). Central resistin induces hepatic insulin resistance via neuropeptide Y. J Neurosci 27, 12924–12932.
35. Sly DJ, McKinley MJ & Oldfield BJ (2001). Activation of kidney-directed neurons in the lamina terminalis by alterations in body fluid balance. Am J Physiol Regul Integr Comp Physiol 281, R1637–R1646.
36. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS & Lazar MA (2001). The hormone resistin links obesity to diabetes. Nature 409, 307–312.
37. Tovar S, Nogueiras R, Tung LY, Castañeda TR, Vázquez MJ, Morris A, Williams LM, Dickson SL & Diéguez C (2005). Central administration of resistin promotes short-term satiety in rats. Eur J Endocrinol 153, R1–R5.
38. van Dijk G, Thiele TD, Donahey JCK, Campfield LA, Smith FJ, Burn P, Berstein IL, Woods SC & Seeley RJ (1996). Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am J Physiol Reul Integr Comp Physiol 271, R1096–R1100.
39. Woods AJ & Stock MJ (1996). Leptin activation in hypothalamus. Nature 381, 745.