Genetics and bitter taste responses to goitrin, a plant toxin found in vegetables

Chemical Senses

Volumn 35, Issue 8, 2010, Pages 685-692

  Wooding, Stephen ^a   Gunn, Howard ^a   Ramos, Purita ^a   Thalmann, Sophie ^b   Xing, Chao ^a   Meyerhof, Wolfgang ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

5 vinyloxazolidine 2 thione; Allele; Goiter; Goitrogen; Phytotoxin; TAS2R38

Indexed keywords

GOITRIN; PHENYLTHIOUREA; PROPYLTHIOURACIL;

ARTICLE; BITTER TASTE; CONTROLLED STUDY; GENE; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TAS2R38 GENE; TASTE BUD; VEGETABLE;

ALLELES; GENOTYPE; HUMANS; OXAZOLIDINONES; PHENOTYPE; PHENYLTHIOUREA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROPYLTHIOURACIL; RECEPTORS, G-PROTEIN-COUPLED; TASTE; TASTE THRESHOLD;

BRASSICA OLERACEA VAR. ITALICA;

EID: 77957254718     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjq061     Document Type: Article

References (30)

1. Ames BN, Profet M, Gold LS. 1990a. Dietary pesticides (99.99% all natural). Proc Natl Acad Sci U S A. 87:7777-7781.
2. Ames BN, Profet M, Gold LS. 1990b. Nature's chemicals and synthetic chemicals: comparative toxicology. Proc Natl Acad Sci U S A. 87: 7782-7786.
3. Bartoshuk L, Duffy V, Miller I. 1994. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol Behav. 56:1165-1171.
4. Basson MD, Bartoshuk LM, Dichello SZ, Panzini L, Weiffenbach JM, Duffy VB. 2005. Association between 6-n-propylthiouracil (PROP) bitterness and colonic neoplasms. Dig Dis Sci. 50:483-489.
5. Bones AM, Rossiter JT. 1996. The myrosinase-glucosinolate system, its organization and biochemistry. Physiologia Plantarum. 97:194-208.
6. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W. 2005a. Supplement: the molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 15:S1-S4.
7. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W. 2005b. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 15:322-327.
8. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. 2002. The human TAS2R16 receptor mediates bitter taste in response to betaglucopyranosides. Nat Genet. 32:397-401.
9. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ. 2000. T2Rs function as bitter taste receptors. Cell. 100: 703-711.
10. Coley PD, Barone JA. 1996. Herbivory and plant defenses in tropical forests. Annu Rev Ecol Syst. 27:305-335.
11. Dinehart M, Hayes J, Bartoshuk L, Lanier S, Duffy V. 2006. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol Behav. 87:304-313.
12. Drayna D. 2005. Human taste genetics. Annu Rev Genomics Hum Genet. 6:217-235.
13. Drewnowski A, Rock CL. 1995. The influence of genetic taste markers on food acceptance. Am J Clin Nutr. 62:506-511.
14. Duffy V, Bartoshuk L. 2000. Food acceptance and genetic variation in taste. J Am Diet Assoc. 100:647-655.
15. Duffy VB. 2007. Variation in oral sensation: implications for diet and health. Curr Opin Gastroenterol. 23:171-177.
16. Fahey JW, Zalcmann AT, Talalay P. 2001. The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. Phytochemistry. 56:5-51.
17. Gaitan E. 1990. Goitrogens in food and water. Annu Rev Nutr. 10:21-39.
18. Greene LS. 1973. Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. Am J Phys Anthropol. 38:119-134.
19. Greene LS. 1974. Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. II. PTC taste sensitivity and neurological maturation. Am J Phys Anthropol. 41:139-152.
20. Guo SW, Reed DR. 2001. The genetics of phenylthiocarbamide perception. Ann Hum Biol. 28:111-142.
21. Harris H, Kalmus H. 1949. The measurement of taste sensitivity to phenylthiourea (P.T.C.). Annals of Eugenics. 15:24-31.
22. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. 2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 299:1221-1225.
23. Kissen R, Rossiter J, Bones A. 2009. The 'mustard oil bomb': not so easy to assemble?! Localization, expression and distribution of the components of the myrosinase enzyme system. Phytochem Rev. 8:69-86.
24. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 35:157-170.
25. Mithen R. 2006. Sulfur-containing compounds. In: Crozier A, Clifford MN, Asihara H, editors. Plant secondary metabolites: occurrence, structure, and role in the human diet. Oxford: Blackwell Publishing, Ltd. p. 25-46.
26. Reed DR, Nanthakumar E, North M, Bell C, Bartoshuk LM, Price RA. 1999. Localization of a gene for bitter-taste perception to human chromosome 5p15. Am J Hum Genet. 64:1478-1480.
27. Sandell M, Breslin P. 2006. Variability in a taste-receptor gene determines whether we taste toxins in food. Curr Biol. 16:R792-R794.
28. Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 68: 978-989.
29. Vanderpas J. 2006. Nutritional epidemiology and thyroid hormone metabolism. Annu Rev Nutr. 26:293-322.
30. Wooding S, Kim UK, Bamshad MJ, Larsen J, Jorde LB, Drayna D. 2004. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet. 74:637-646.