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Volumn 11, Issue 6, 2016, Pages

[Nle4, D-Phe7 ]-α-MSH inhibits toll-like receptor (TLR)2- and TLR4-Induced microglial activation and promotes a M2-Like phenotype

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN DERIVATIVE; ARGINASE 1; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4 RECEPTOR ALPHA; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ALPHA INTERMEDIN; LIPOPEPTIDE; MSH, 4-NLE-7-PHE-ALPHA-; PAM(3)CSK(4) PEPTIDE; TUMOR NECROSIS FACTOR;

EID: 84977472783     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0158564     Document Type: Article
Times cited : (21)

References (60)
  • 1
    • 84938286568 scopus 로고    scopus 로고
    • Alternatively activated microglia and macrophages in the central nervous system
    • PMID: 26067058.
    • Franco R, Fernandez-Suarez D. Alternatively activated microglia and macrophages in the central nervous system. Prog Neurobiol. 2015; 131:65-86. doi: 10.1016/j.pneurobio.2015.05.003 PMID: 26067058.
    • (2015) Prog Neurobiol , vol.131 , pp. 65-86
    • Franco, R.1    Fernandez-Suarez, D.2
  • 2
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • Epub 2004/09/10. 173/6/3916 [pii]. PMID: 15356140.
    • Olson JK, Miller SD. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol. 2004; 173(6):3916-24. Epub 2004/09/10. 173/6/3916 [pii]. PMID: 15356140.
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 3
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Epub 2011/01/18. PMID: 21235323.
    • Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011; 30(1):16-34. Epub 2011/01/18. doi: 10.3109/08830185.2010.529976 PMID: 21235323.
    • (2011) Int Rev Immunol , vol.30 , Issue.1 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 4
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • PMID: 17032697
    • Bianchi ME. DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol. 2007; 81 (1):1-5. doi: 10.1189/jlb.0306164 PMID: 17032697.
    • (2007) J Leukoc Biol , vol.81 , Issue.1 , pp. 1-5
    • Bianchi, M.E.1
  • 5
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors and 4 in cellular activation by high mobility group box 1 protein
    • Epub 2003/12/09 PMID: 14660645
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, et al. Involvement of toll-like receptors and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem. 2004; 279(9):7370-7. Epub 2003/12/09. doi: 10.1074/jbc.M306793200 M306793200 [pii]. PMID: 14660645.
    • (2004) J Biol Chem , vol.279 , Issue.9 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6
  • 6
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury
    • PMID: 19705460.
    • Lehnardt S. Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury. Glia. 2010; 58(3):253-63. doi: 10.1002/glia.20928 PMID: 19705460.
    • (2010) Glia , vol.58 , Issue.3 , pp. 253-263
    • Lehnardt, S.1
  • 7
    • 47349083019 scopus 로고    scopus 로고
    • Microglia and astrocyte activation by toll-like receptor ligands: Modulation by PPAR-gamma agonists
    • Epub 2008/06/28 PMID: 18584038; PubMed Central PMCID: PMC2435222
    • Gurley C, Nichols J, Liu S, Phulwani NK, Esen N, Kielian T. Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists. PPAR Res. 2008; 2008:453120. Epub 2008/06/28. doi: 10.1155/2008/453120 PMID: 18584038; PubMed Central PMCID: PMC2435222.
    • (2008) PPAR Res , vol.2008 , pp. 453120
    • Gurley, C.1    Nichols, J.2    Liu, S.3    Phulwani, N.K.4    Esen, N.5    Kielian, T.6
  • 8
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • PMID: 18267068.
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell. 2008; 132(3):344-62. doi: 10. 1016/j.cell.2008.01.020 PMID: 18267068.
    • (2008) Cell , vol.132 , Issue.3 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 10
    • 0025260779 scopus 로고
    • Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B
    • PMID: 2181276; PubMed Central PMCID: PMC362253
    • Collart MA, Baeuerle P, Vassalli P. Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B. Molecular and cellular biology. 1990; 10(4):1498-506. PMID: 2181276; PubMed Central PMCID: PMC362253.
    • (1990) Molecular and Cellular Biology , vol.10 , Issue.4 , pp. 1498-1506
    • Collart, M.A.1    Baeuerle, P.2    Vassalli, P.3
  • 11
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Epub 2008/04/22. 180/9/5771 [pii]. PMID: 18424693.
    • Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008; 180(9):5771-7. Epub 2008/04/22. 180/9/5771 [pii]. PMID: 18424693.
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 12
    • 52049094806 scopus 로고    scopus 로고
    • Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammatio
    • 1825-35. Epub 2008/ 07/16. S0196-9781(08)00269-00266 PMID: 18625277
    • Lasaga M, Debeljuk L, Durand D, Scimonelli TN, Caruso C. Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides. 2008; 29(10):1825-35. Epub 2008/ 07/16. S0196-9781(08)00269-6 [pii] doi: 10.1016/j.peptides.2008.06.009 PMID: 18625277.
    • (2008) Peptides , vol.29 , Issue.10
    • Lasaga, M.1    Debeljuk, L.2    Durand, D.3    Scimonelli, T.N.4    Caruso, C.5
  • 13
    • 33747127565 scopus 로고    scopus 로고
    • Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils
    • Epub 2006/05/02. S0014-2999(06)00294-00299 PMID: 16647700
    • Giuliani D, Leone S, Mioni C, Bazzani C, Zaffe D, Botticelli AR, et al. Broad therapeutic treatment window of [Nle(4), D-Phe(7)]alpha-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils. Eur J Pharmacol. 2006; 538(1-3):48-56. Epub 2006/05/02. S0014-2999(06)00294-9 [pii] doi: 10.1016/j.ejphar.2006.03.038 PMID: 16647700.
    • (2006) Eur J Pharmacol , vol.538 , Issue.1-3 , pp. 48-56
    • Giuliani, D.1    Leone, S.2    Mioni, C.3    Bazzani, C.4    Zaffe, D.5    Botticelli, A.R.6
  • 14
    • 34547875454 scopus 로고    scopus 로고
    • Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins
    • Epub 2007/06/26. S0014-2999(07)00626-00627 PMID: 17588564
    • Giuliani D, Ottani A, Mioni C, Bazzani C, Galantucci M, Minutoli L, et al. Neuroprotection in focal cerebral ischemia owing to delayed treatment with melanocortins. Eur J Pharmacol. 2007; 570(1-3):57-65. Epub 2007/06/26. S0014-2999(07)00626-7 [pii] doi: 10.1016/j.ejphar.2007.05.025 PMID: 17588564.
    • (2007) Eur J Pharmacol , vol.570 , Issue.1-3 , pp. 57-65
    • Giuliani, D.1    Ottani, A.2    Mioni, C.3    Bazzani, C.4    Galantucci, M.5    Minutoli, L.6
  • 15
    • 3242756910 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats
    • Epub 2004/06/26. PMID: 15218320.
    • Caruso C, Mohn C, Karara AL, Rettori V, Watanobe H, Schioth HB, et al. Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats. Neuroendocrinology. 2004; 79(5):278-86. Epub 2004/06/26. doi: 10.1159/000079321 79321 [pii]. PMID: 15218320.
    • (2004) Neuroendocrinology , vol.79 , Issue.5 , pp. 278-286
    • Caruso, C.1    Mohn, C.2    Karara, A.L.3    Rettori, V.4    Watanobe, H.5    Schioth, H.B.6
  • 16
    • 84889586854 scopus 로고    scopus 로고
    • Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways
    • Epub 2013/10/08 S0197-4580(13)00375-00378 PMID: 24094579.
    • Giuliani D, Bitto A, Galantucci M, Zaffe D, Ottani A, Irrera N, et al. Melanocortins protect against progression of Alzheimer's disease in triple-transgenic mice by targeting multiple pathophysiological pathways. Neurobiol Aging. 2014; 35(3):537-47. Epub 2013/10/08. doi: 10.1016/j.neurobiolaging.2013.08. 030 S0197-4580(13)00375-8 [pii]. PMID: 24094579.
    • (2014) Neurobiol Aging , vol.35 , Issue.3 , pp. 537-547
    • Giuliani, D.1    Bitto, A.2    Galantucci, M.3    Zaffe, D.4    Ottani, A.5    Irrera, N.6
  • 17
    • 67650077092 scopus 로고    scopus 로고
    • Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors
    • Epub 2009/03/12.S0889-1591(09)00069-00065 PMID: 19275930
    • Gonzalez PV, Schioth HB, Lasaga M, Scimonelli TN. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav Immun. 2009; 23 (6):817-22. Epub 2009/03/12. S0889-1591(09)00069-5 [pii] doi: 10.1016/j.bbi.2009.03.001 PMID: 19275930.
    • (2009) Brain Behav Immun , vol.23 , Issue.6 , pp. 817-822
    • Gonzalez, P.V.1    Schioth, H.B.2    Lasaga, M.3    Scimonelli, T.N.4
  • 18
    • 84885024415 scopus 로고    scopus 로고
    • Molecular mechanisms involved in interleukin 1-beta (IL-1beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH)
    • Epub 2013/08/24 S0889-1591(13)00418-00412 PMID: 23968970.
    • Gonzalez P, Machado I, Vilcaes A, Caruso C, Roth GA, Schioth H, et al. Molecular mechanisms involved in interleukin 1-beta (IL-1beta)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (alpha-MSH). Brain Behav Immun. 2013; 34:141-50. Epub 2013/08/24. doi: 10.1016/j.bbi.2013.08.007 S0889-1591(13)00418-2 [pii]. PMID: 23968970.
    • (2013) Brain Behav Immun , vol.34 , pp. 141-150
    • Gonzalez, P.1    Machado, I.2    Vilcaes, A.3    Caruso, C.4    Roth, G.A.5    Schioth, H.6
  • 19
    • 84928824567 scopus 로고    scopus 로고
    • Interleukin-1betainduced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and alpha-melanocyte-stimulating hormone prevented these effects
    • PMID: 25637483.
    • Machado I, Gonzalez PV, Vilcaes A, Carniglia L, Schioth HB, Lasaga M, et al. Interleukin-1betainduced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and alpha-melanocyte-stimulating hormone prevented these effects. Brain Behav Immun. 2015; 46:137-46. doi: 10.1016/j.bbi.2015.01.012 PMID: 25637483.
    • (2015) Brain Behav Immun , vol.46 , pp. 137-146
    • Machado, I.1    Gonzalez, P.V.2    Vilcaes, A.3    Carniglia, L.4    Schioth, H.B.5    Lasaga, M.6
  • 20
    • 0031749704 scopus 로고    scopus 로고
    • Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia
    • Epub 1998/06/10. PMID: 9620667.
    • Delgado R, Carlin A, Airaghi L, Demitri MT, Meda L, Galimberti D, et al. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J Leukoc Biol. 1998; 63 (6):740-5. Epub 1998/06/10. PMID: 9620667.
    • (1998) J Leukoc Biol , vol.63 , Issue.6 , pp. 740-745
    • Delgado, R.1    Carlin, A.2    Airaghi, L.3    Demitri, M.T.4    Meda, L.5    Galimberti, D.6
  • 21
    • 84874500180 scopus 로고    scopus 로고
    • Effect of NDP-alpha-MSH on PPAR-gamma and -beta expression and anti-inflammatory cytokine release in rat astrocytes and microglia
    • Epub 2013/03/08 PONE-D-12-28242 PMID: 23468969; PubMed Central PMCID: PMC3582497
    • Carniglia L, Durand D, Caruso C, Lasaga M. Effect of NDP-alpha-MSH on PPAR-gamma and -beta expression and anti-inflammatory cytokine release in rat astrocytes and microglia. PLoS One. 2013; 8 (2):e57313. Epub 2013/03/08. doi: 10.1371/journal.pone.0057313 PONE-D-12-28242 [pii]. PMID: 23468969; PubMed Central PMCID: PMC3582497.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e57313
    • Carniglia, L.1    Durand, D.2    Caruso, C.3    Lasaga, M.4
  • 22
    • 80755187744 scopus 로고    scopus 로고
    • Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway
    • Epub 2011/08/02.S0303-7207(11) 00435-00437 PMID: 21803120
    • Caruso C, Carniglia L, Durand D, Gonzalez PV, Scimonelli TN, Lasaga M. Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway. Mol Cell Endocrinol. 2012; 348(1):47-54. Epub 2011/08/02. S0303-7207(11) 00435-7 [pii] doi: 10.1016/j.mce.2011.07.036 PMID: 21803120.
    • (2012) Mol Cell Endocrinol , vol.348 , Issue.1 , pp. 47-54
    • Caruso, C.1    Carniglia, L.2    Durand, D.3    Gonzalez, P.V.4    Scimonelli, T.N.5    Lasaga, M.6
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Epub 2002/02/16 S1046-2023(01)91262-91269 PMID: 11846609.
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25(4):402-8. Epub 2002/02/16. doi: 10.1006/ meth.2001.1262 S1046-2023(01)91262-9 [pii]. PMID: 11846609.
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 84892174249 scopus 로고    scopus 로고
    • Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis
    • Epub 2014/01/09 1742-2094-11-13 PMID: 24397957; PubMed Central PMCID: PMC3895821
    • Karlstetter M, Nothdurfter C, Aslanidis A, Moeller K, Horn F, Scholz R, et al. Translocator protein (18 kDa) (TSPO) is expressed in reactive retinal microglia and modulates microglial inflammation and phagocytosis. J Neuroinflammation. 2014; 11:3. Epub 2014/01/09. doi: 10.1186/1742-2094-11-3 1742-2094-11-3 [pii]. PMID: 24397957; PubMed Central PMCID: PMC3895821.
    • (2014) J Neuroinflammation , vol.11 , Issue.3
    • Karlstetter, M.1    Nothdurfter, C.2    Aslanidis, A.3    Moeller, K.4    Horn, F.5    Scholz, R.6
  • 25
    • 70149084792 scopus 로고    scopus 로고
    • HMGB1 loves company
    • Epub 2009/05/06. PMID: 19414536.
    • Bianchi ME. HMGB1 loves company. J Leukoc Biol. 2009; 86(3):573-6. Epub 2009/05/06. doi: 10. 1189/jlb.1008585 jlb.1008585 [pii]. PMID: 19414536.
    • (2009) J Leukoc Biol , vol.86 , Issue.3 , pp. 573-576
    • Bianchi, M.E.1
  • 26
    • 76749104336 scopus 로고    scopus 로고
    • Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia
    • Epub 2009/11/26 IAI.01110-09 PMID: 19933834; PubMed Central PMCID: PMC2812218
    • Ribes S, Ebert S, Regen T, Agarwal A, Tauber SC, Czesnik D, et al. Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun. 2010; 78(2):865-71. Epub 2009/11/26. doi: 10.1128/ IAI.01110-09 IAI.01110-09 [pii]. PMID: 19933834; PubMed Central PMCID: PMC2812218.
    • (2010) Infect Immun , vol.78 , Issue.2 , pp. 865-871
    • Ribes, S.1    Ebert, S.2    Regen, T.3    Agarwal, A.4    Tauber, S.C.5    Czesnik, D.6
  • 27
    • 84878459933 scopus 로고    scopus 로고
    • Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
    • Epub 2013/06/07 1742-2094-10-71 PMID: 23738865; PubMed Central PMCID: PMC3693974
    • Redlich S, Ribes S, Schutze S, Eiffert H, Nau R. Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells. J Neuroinflammation. 2013; 10:71. Epub 2013/06/07. doi: 10.1186/1742-2094-10-71 1742-2094-10-71 [pii]. PMID: 23738865; PubMed Central PMCID: PMC3693974.
    • (2013) J Neuroinflammation , vol.10 , Issue.71
    • Redlich, S.1    Ribes, S.2    Schutze, S.3    Eiffert, H.4    Nau, R.5
  • 28
    • 84872706357 scopus 로고    scopus 로고
    • Review: Activation patterns of microglia and their identification in the human brain
    • Epub 2012/12/21. PMID: 23252647.
    • Boche D, Perry VH, Nicoll JA. Review: activation patterns of microglia and their identification in the human brain. Neuropathol Appl Neurobiol. 2013; 39(1):3-18. Epub 2012/12/21. doi: 10.1111/nan. 12011 PMID: 23252647.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , Issue.1 , pp. 3-18
    • Boche, D.1    Perry, V.H.2    Nicoll, J.A.3
  • 29
    • 84891373720 scopus 로고    scopus 로고
    • Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
    • Epub 2013/03/05 S0889-1591(13)00127-X PMID: 23454862; PubMed Central PMCID: PMC3694309
    • Chhor V, Le Charpentier T, Lebon S, Ore MV, Celador IL, Josserand J, et al. Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro. Brain Behav Immun. 2013; 32:70-85. Epub 2013/03/05. doi: 10.1016/j.bbi.2013.02.005 S0889-1591(13)00127-X [pii]. PMID: 23454862; PubMed Central PMCID: PMC3694309.
    • (2013) Brain Behav Immun , vol.32 , pp. 70-85
    • Chhor, V.1    Le Charpentier, T.2    Lebon, S.3    Ore, M.V.4    Celador, I.L.5    Josserand, J.6
  • 30
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Epub 2009/08/06 PMID: 19655259; PubMed Central PMCID: PMC2773116
    • Colton CA. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol. 2009; 4(4):399-418. Epub 2009/08/06. doi: 10.1007/s11481-009-9164-4 PMID: 19655259; PubMed Central PMCID: PMC2773116.
    • (2009) J Neuroimmune Pharmacol , vol.4 , Issue.4 , pp. 399-418
    • Colton, C.A.1
  • 31
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • PMID: 12401408.
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends in immunology. 2002; 23(11):549-55. PMID: 12401408.
    • (2002) Trends in immunology , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 32
    • 79952249408 scopus 로고    scopus 로고
    • Localized retinal neuropeptide regulation of macrophage and microglial cell functionality
    • PMID: 20965575; PubMed Central PMCID: PMC3030990
    • Kawanaka N, Taylor AW. Localized retinal neuropeptide regulation of macrophage and microglial cell functionality. J Neuroimmunol. 2011; 232(1-2):17-25. doi: 10.1016/j.jneuroim.2010.09.025 PMID: 20965575; PubMed Central PMCID: PMC3030990.
    • (2011) J Neuroimmunol , vol.232 , Issue.1-2 , pp. 17-25
    • Kawanaka, N.1    Taylor, A.W.2
  • 33
    • 34249788716 scopus 로고    scopus 로고
    • Arginine metabolism: Boundaries of our knowledge
    • PMID: 17513435.
    • Morris SM Jr. Arginine metabolism: boundaries of our knowledge. The Journal of nutrition. 2007; 137(6 Suppl 2):1602S-9S. PMID: 17513435.
    • (2007) The Journal of Nutrition , vol.137 , Issue.6 , pp. 1602S-1619S
    • Morris, S.M.1
  • 34
    • 84873242419 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: Role of TLR4 in hypoxic microglia
    • PMID: 23388509; PubMed Central PMCID: PMC3575244
    • Yao L, Kan EM, Lu J, Hao A, Dheen ST, Kaur C, et al. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation. 2013; 10:23. doi: 10.1186/1742-2094-10-23 PMID: 23388509; PubMed Central PMCID: PMC3575244.
    • (2013) J Neuroinflammation , vol.10 , pp. 23
    • Yao, L.1    Kan, E.M.2    Lu, J.3    Hao, A.4    Dheen, S.T.5    Kaur, C.6
  • 35
    • 33751554878 scopus 로고    scopus 로고
    • A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide
    • PMID: 17114485.
    • Zhou H, Lapointe BM, Clark SR, Zbytnuik L, Kubes P. A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide. J Immunol. 2006; 177(11):8103-10. PMID: 17114485.
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 8103-8110
    • Zhou, H.1    Lapointe, B.M.2    Clark, S.R.3    Zbytnuik, L.4    Kubes, P.5
  • 36
    • 84920280756 scopus 로고    scopus 로고
    • HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the early stage of obstructive injury
    • PMID: 25377911; PubMed Central PMCID: PMC4281691.
    • Tian S, Zhang L, Tang J, Guo X, Dong K, Chen SY. HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the earlystage of obstructive injury. American journal of physiology Renal physiology. 2015; 308(1):F69-75. doi: 10.1152/ajprenal.00484.2014 PMID: 25377911; PubMed Central PMCID: PMC4281691.
    • (2015) American journal of physiology Renal physiology , vol.308 , Issue.1 , pp. F69-F75
    • Tian, S.1    Zhang, L.2    Tang, J.3    Guo, X.4    Dong, K.5    Chen, S.Y.6
  • 37
    • 36049033394 scopus 로고    scopus 로고
    • Signaling to NF-kappaB by Toll-like receptors
    • Epub 2007/11/22. S1471-4914(07)00184-00180 PMID: 18029230
    • Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med. 2007; 13(11):460-9. Epub 2007/11/22. S1471-4914(07)00184-0 [pii] doi: 10.1016/j.molmed.2007.09.002 PMID: 18029230.
    • (2007) Trends Mol Med , vol.13 , Issue.11 , pp. 460-469
    • Kawai, T.1    Akira, S.2
  • 38
    • 0032531035 scopus 로고    scopus 로고
    • Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents
    • Epub 1998/09/22. PMID: 9743348.
    • Manna SK, Aggarwal BB. Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents. J Immunol. 1998; 161(6):2873-80. Epub 1998/09/22. PMID: 9743348.
    • (1998) J Immunol , vol.161 , Issue.6 , pp. 2873-2880
    • Manna, S.K.1    Aggarwal, B.B.2
  • 39
    • 0142231439 scopus 로고    scopus 로고
    • Alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages
    • Epub 2003/10/24.S0014579303010299 PMID: 14572638.
    • Sarkar A, Sreenivasan Y, Manna SK. alpha-Melanocyte-stimulating hormone inhibits lipopolysaccharide-induced biological responses by downregulating CD14 from macrophages. FEBS Lett. 2003; 553 (3):286-94. Epub 2003/10/24. S0014579303010299 [pii]. PMID: 14572638.
    • (2003) FEBS Lett. , vol.553 , Issue.3 , pp. 286-294
    • Sarkar, A.1    Sreenivasan, Y.2    Manna, S.K.3
  • 40
    • 0036738421 scopus 로고    scopus 로고
    • Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
    • PMID: 12235116; PubMed Central PMCID: PMC151124
    • Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou HC, et al. Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. The Journal of clinical investigation. 2002; 110(6):843-50. doi: 10.1172/JCI15254 PMID: 12235116; PubMed Central PMCID: PMC151124.
    • (2002) The Journal of Clinical Investigation , vol.110 , Issue.6 , pp. 843-850
    • Hilliard, B.A.1    Mason, N.2    Xu, L.3    Sun, J.4    Lamhamedi-Cherradi, S.E.5    Liou, H.C.6
  • 41
    • 0033748023 scopus 로고    scopus 로고
    • Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages
    • PMID: 11058167; PubMed Central PMCID: PMC18828
    • Sanjabi S, Hoffmann A, Liou HC, Baltimore D, Smale ST. Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages. Proc Natl Acad Sci U S A. 2000; 97(23):12705-10. doi: 10.1073/ pnas.230436397 PMID: 11058167; PubMed Central PMCID: PMC18828.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.23 , pp. 12705-12710
    • Sanjabi, S.1    Hoffmann, A.2    Liou, H.C.3    Baltimore, D.4    Smale, S.T.5
  • 42
    • 0042375986 scopus 로고    scopus 로고
    • The biology of IL-12: Coordinating innate and adaptive immune responses
    • PMID: 12948519.
    • Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine & growth factor reviews. 2003; 14(5):361-8. PMID: 12948519.
    • (2003) Cytokine & Growth Factor Reviews , vol.14 , Issue.5 , pp. 361-368
    • Watford, W.T.1    Moriguchi, M.2    Morinobu, A.3    O'Shea, J.J.4
  • 43
    • 33646417072 scopus 로고    scopus 로고
    • The IL-23/IL-17 axis in inflammation
    • PMID: 16670765; PubMed Central PMCID: PMC1451213
    • Iwakura Y, Ishigame H. The IL-23/IL-17 axis in inflammation. The Journal of clinical investigation. 2006; 116(5):1218-22. doi: 10.1172/JCI28508 PMID: 16670765; PubMed Central PMCID: PMC1451213.
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.5 , pp. 1218-1222
    • Iwakura, Y.1    Ishigame, H.2
  • 44
    • 44849128371 scopus 로고    scopus 로고
    • The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy
    • Epub 2008/01/04. S0889-1591(07)00274-00277 PMID: 18171609; PubMed Central PMCID: PMC3337335
    • Taylor AW, Kitaichi N. The diminishment of experimental autoimmune encephalomyelitis (EAE) by neuropeptide alpha-melanocyte stimulating hormone (alpha-MSH) therapy. Brain Behav Immun. 2008; 22 (5):639-46. Epub 2008/01/04. S0889-1591(07)00274-7 [pii] doi: 10.1016/j.bbi.2007.11.001 PMID: 18171609; PubMed Central PMCID: PMC3337335.
    • (2008) Brain Behav Immun , vol.22 , Issue.5 , pp. 639-646
    • Taylor, A.W.1    Kitaichi, N.2
  • 45
    • 0034646787 scopus 로고    scopus 로고
    • Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB
    • PMID: 10814840.
    • Heyen JR, Ye S, Finck BN, Johnson RW. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-kappaB. Brain research Molecular brain research. 2000; 77(1):138-47. PMID: 10814840.
    • (2000) Brain research Molecular brain research , vol.77 , Issue.1 , pp. 138-147
    • Heyen, J.R.1    Ye, S.2    Finck, B.N.3    Johnson, R.W.4
  • 46
    • 42249083091 scopus 로고    scopus 로고
    • Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors
    • PMID: 18200499; PubMed Central PMCID: PMC2430329
    • Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. Eur J Immunol. 2008; 38(2):500-6. doi: 10.1002/eji.200737741 PMID: 18200499; PubMed Central PMCID: PMC2430329.
    • (2008) Eur J Immunol , vol.38 , Issue.2 , pp. 500-506
    • Dennehy, K.M.1    Ferwerda, G.2    Faro-Trindade, I.3    Pyz, E.4    Willment, J.A.5    Taylor, P.R.6
  • 47
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • PMID: 1940799; PubMed Central PMCID: PMC2119001
    • de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. The Journal of experimental medicine. 1991; 174(5):1209-20. PMID: 1940799; PubMed Central PMCID: PMC2119001.
    • (1991) The Journal of experimental medicine , vol.174 , Issue.5 , pp. 1209-1220
    • De Waal, M.R.1    Abrams, J.2    Bennett, B.3    Figdor, C.G.4    De Vries, J.E.5
  • 48
    • 84864281192 scopus 로고    scopus 로고
    • Temperature- and time-dependent changes in TLR2-activated microglial NF-kappaB activity and concentrations of inflammatory and antiinflammatory factors
    • PMID: 22653369
    • Matsui T, Tasaki M, Yoshioka T, Motoki Y, Tsuneoka H, Nojima J. Temperature- and time-dependent changes in TLR2-activated microglial NF-kappaB activity and concentrations of inflammatory and antiinflammatory factors. Intensive care medicine. 2012; 38(8):1392-9. doi: 10.1007/s00134-012-2591-3 PMID: 22653369.
    • (2012) Intensive care medicine , vol.38 , Issue.8 , pp. 1392-1399
    • Matsui, T.1    Tasaki, M.2    Yoshioka, T.3    Motoki, Y.4    Tsuneoka, H.5    Nojima, J.6
  • 49
    • 80052467105 scopus 로고    scopus 로고
    • The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human beta-defensin-3 differentially induce interleukin-10 and nuclear factor-kappaB signalling patterns in human monocytes
    • PMID: 21896010; PubMed Central PMCID: PMC3194223
    • Funderburg NT, Jadlowsky JK, Lederman MM, Feng Z, Weinberg A, Sieg SF. The Toll-like receptor 1/2 agonists Pam(3) CSK(4) and human beta-defensin-3 differentially induce interleukin-10 and nuclear factor-kappaB signalling patterns in human monocytes. Immunology. 2011; 134(2):151-60. doi: 10. 1111/j.1365-2567.2011.03475.x PMID: 21896010; PubMed Central PMCID: PMC3194223.
    • (2011) Immunology , vol.134 , Issue.2 , pp. 151-160
    • Funderburg, N.T.1    Jadlowsky, J.K.2    Lederman, M.M.3    Feng, Z.4    Weinberg, A.5    Sieg, S.F.6
  • 50
    • 33748756806 scopus 로고    scopus 로고
    • NF-kappaB1 (p50) homodimers differentially regulate proand anti-inflammatory cytokines in macrophages
    • PMID: 16835236; PubMed Central PMCID: PMC2642587
    • Cao S, Zhang X, Edwards JP, Mosser DM. NF-kappaB1 (p50) homodimers differentially regulate proand anti-inflammatory cytokines in macrophages. J Biol Chem. 2006; 281(36):26041-50. doi: 10.1074/ jbc.M602222200 PMID: 16835236; PubMed Central PMCID: PMC2642587.
    • (2006) J Biol Chem , vol.281 , Issue.36 , pp. 26041-26050
    • Cao, S.1    Zhang, X.2    Edwards, J.P.3    Mosser, D.M.4
  • 51
    • 0031944393 scopus 로고    scopus 로고
    • IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity
    • PMID: 9603479.
    • Clarke CJ, Hales A, Hunt A, Foxwell BM. IL-10-mediated suppression of TNF-alpha production is independent of its ability to inhibit NF kappa B activity. Eur J Immunol. 1998; 28(5):1719-26. PMID: 9603479.
    • (1998) Eur J Immunol , vol.28 , Issue.5 , pp. 1719-1726
    • Clarke, C.J.1    Hales, A.2    Hunt, A.3    Foxwell, B.M.4
  • 52
    • 0030858764 scopus 로고    scopus 로고
    • Lipopolysaccharide induction of the tumor necrosis factoralpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors
    • PMID: 9211933.
    • Yao J, Mackman N, Edgington TS, Fan ST. Lipopolysaccharide induction of the tumor necrosis factoralpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors. J Biol Chem. 1997; 272(28):17795-801. PMID: 9211933.
    • (1997) J Biol Chem , vol.272 , Issue.28 , pp. 17795-17801
    • Yao, J.1    Mackman, N.2    Edgington, T.S.3    Fan, S.T.4
  • 53
    • 0032516519 scopus 로고    scopus 로고
    • Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes
    • PMID: 9694874.
    • Udalova IA, Knight JC, Vidal V, Nedospasov SA, Kwiatkowski D. Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes. J Biol Chem. 1998; 273 (33):21178-86. PMID: 9694874.
    • (1998) J Biol Chem , vol.273 , Issue.33 , pp. 21178-21186
    • Udalova, I.A.1    Knight, J.C.2    Vidal, V.3    Nedospasov, S.A.4    Kwiatkowski, D.5
  • 54
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • PMID: 17913905.
    • Ponomarev ED, Maresz K, Tan Y, Dittel BN. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci. 2007; 27(40):10714-21. doi: 10.1523/JNEUROSCI.1922-07.2007 PMID: 17913905.
    • (2007) J Neurosci , vol.27 , Issue.40 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 55
    • 0028026864 scopus 로고
    • Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
    • Epub 1994/09/01. PMID: 8071435.
    • Suzumura A, Sawada M, Itoh Y, Marunouchi T. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J Neuroimmunol. 1994; 53(2):209-18. Epub 1994/09/01. PMID: 8071435.
    • (1994) J Neuroimmunol , vol.53 , Issue.2 , pp. 209-218
    • Suzumura, A.1    Sawada, M.2    Itoh, Y.3    Marunouchi, T.4
  • 56
    • 55549128746 scopus 로고    scopus 로고
    • High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease
    • Epub 2008/ 07/05. ar2440 PMID: 18598385; PubMed Central PMCID: PMC2483460
    • Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther. 2008; 10(3):209. Epub 2008/ 07/05. ar2440 [pii] doi: 10.1186/ar2440 PMID: 18598385; PubMed Central PMCID: PMC2483460.
    • (2008) Arthritis Res Ther , vol.10 , Issue.3 , pp. 209
    • Pisetsky, D.S.1    Erlandsson-Harris, H.2    Andersson, U.3
  • 57
    • 50549094596 scopus 로고    scopus 로고
    • HMGB1: A two-headed signal regulating tumor progression and immunity
    • Epub 2008/07/05.S0952-7915(08)00054-X PMID: 18599281
    • Campana L, Bosurgi L, Rovere-Querini P. HMGB1: a two-headed signal regulating tumor progression and immunity. Curr Opin Immunol. 2008; 20(5):518-23. Epub 2008/07/05. S0952-7915(08)00054-X [pii] doi: 10.1016/j.coi.2008.04.012 PMID: 18599281.
    • (2008) Curr Opin Immunol , vol.20 , Issue.5 , pp. 518-523
    • Campana, L.1    Bosurgi, L.2    Rovere-Querini, P.3
  • 58
    • 59349112140 scopus 로고    scopus 로고
    • Microglial clearance function in health and disease
    • PMID: 18644426.
    • Napoli I, Neumann H. Microglial clearance function in health and disease. Neuroscience. 2009; 158 (3):1030-8. doi: 10.1016/j.neuroscience.2008.06.046 PMID: 18644426.
    • (2009) Neuroscience , vol.158 , Issue.3 , pp. 1030-1038
    • Napoli, I.1    Neumann, H.2
  • 59
    • 79955008182 scopus 로고    scopus 로고
    • Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death
    • Epub 2011/03/16 jimmunol.1003600 PMID: 21402900.
    • Neher JJ, Neniskyte U, Zhao JW, Bal-Price A, Tolkovsky AM, Brown GC. Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death. J Immunol. 2011; 186(8):4973-83. Epub 2011/03/16. doi: 10.4049/jimmunol.1003600 jimmunol.1003600 [pii]. PMID: 21402900.
    • (2011) J Immunol , vol.186 , Issue.8 , pp. 4973-4983
    • Neher, J.J.1    Neniskyte, U.2    Zhao, J.W.3    Bal-Price, A.4    Tolkovsky, A.M.5    Brown, G.C.6
  • 60
    • 84886434703 scopus 로고    scopus 로고
    • Phagocytosis executes delayed neuronal death after focal brain ischemia
    • PMID: 24101459; PubMed Central PMCID: PMC3808587
    • Neher JJ, Emmrich JV, Fricker M, Mander PK, Thery C, Brown GC. Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A. 2013; 110(43):E4098-107. doi: 10.1073/pnas.1308679110 PMID: 24101459; PubMed Central PMCID: PMC3808587.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.43 , pp. E4098-E4107
    • Neher, J.J.1    Emmrich, J.V.2    Fricker, M.3    Mander, P.K.4    Thery, C.5    Brown, G.C.6


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