Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆ F508CFTR Dysfunction: Impact in Cystic Fibrosis

Journal of Molecular Biology

Volumn 428, Issue 14, 2016, Pages 2898-2915

  Ollero, M ⁱ   Bakouh, Naziha ^b   Lourdel, Stéphane ^c   Odolczyk, Norbert ^d   Premchandar, Aiswarya ^d   Servel, Nathalie ^b   Hatton, Aurélie ^b   Ostrowski, Maciej K ^a   Xu, Haijin ^a   Saul, Frederick A ^e   Moquereau, Christelle ^b   Bitam, Sara ^b   Pranke, Iwona ^b   Planelles, Gabrielle ^b   Teulon, Jacques ^c   Herrmann, Harald ^f,h   Roldan, Ariel ^g   Zielenkiewicz, Piotr ^d   Dadlez, Michal ^d   Lukacs, Gergely L ^g   Sermet Gaudelus, Isabelle ^b   Ollero, Mario ^b   Corringer, Pierre Jean ^a   Edelman, Aleksander ^b   more..

^a CNRS   (France)

^b INSTITUT NECKER ENFANTS MALADES   (France)

^c SORBONNE UNIVERSITÉ   (France)

^d INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^e INSTITUT PASTEUR   (France)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g MCGILL UNIVERSITY   (Canada)

^h UNIVERSITY HOSPITAL ERLANGEN   (Germany)

ⁱ INSERM U955   (France)

Author keywords

biomolecular interactions; chloride channel; crotoxin; cystic fibrosis; phospholipase A2

Indexed keywords

ABC TRANSPORTER; CROTOXIN; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKERATIN 8; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 CB SUBUNIT; SNAKE VENOM; UNCLASSIFIED DRUG; CHLORIDE CHANNEL; CYCLIC AMP; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR DELTA F508; PROTEIN BINDING;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; APPARENT DISSOCIATION CONSTANT; ARTICLE; BINDING SITE; CHLORIDE CURRENT; COLON; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYSTIC FIBROSIS; DEUTERIUM HYDROGEN EXCHANGE; ENZYME ACTIVITY; EX VIVO STUDY; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; MALE; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; MUTATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; SCANNING ELECTRON MICROSCOPY; SHORT CIRCUIT CURRENT; SURFACE PLASMON RESONANCE; XENOPUS LAEVIS; ANIMAL; CHANNEL GATING; CROTALUS; GENE DELETION; GENETICS; KINETICS; METABOLISM; PROCEDURES; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CHLORIDE CHANNELS; CROTALUS; CYCLIC AMP; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; FEMALE; HELA CELLS; HUMANS; ION CHANNEL GATING; KINETICS; MALE; MICE; MOLECULAR DOCKING SIMULATION; MUTATION; OOCYTES; PHOSPHOLIPASES A2; PROTEIN BINDING; SEQUENCE DELETION; SNAKE VENOMS; XENOPUS LAEVIS;

EID: 84977469424     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2016.05.016     Document Type: Article

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