RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Xu, Yang ^a   Wang, Jingye ^b   Song, Xinghui ^c   Qu, Lindi ^b   Wei, Ruili ^a   He, Fangping ^a   Wang, Kai ^b   Luo, Benyan ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3-METHYLADENINE; ACETYL-ASPARTYL-METHIONYL-GLUTAMINYL-ASPARTYL-ALDEHYDE; ADENINE; APOPTOSIS INDUCING FACTOR; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; NECROSTATIN-1; OLIGOPEPTIDE; PDCD8 PROTEIN, RAT; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RECEPTOR-INTERACTING PROTEIN 3, RAT;

ANALOGS AND DERIVATIVES; ANIMAL; BRAIN ISCHEMIA; CELL NUCLEUS; DISEASE MODEL; DNA DEGRADATION; GENETICS; MALE; METABOLISM; MORTALITY; NERVE CELL; PATHOLOGY; RAT; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ADENINE; ANIMALS; APOPTOSIS INDUCING FACTOR; BRAIN ISCHEMIA; CELL NUCLEUS; DISEASE MODELS, ANIMAL; DNA DEGRADATION, NECROTIC; IMIDAZOLES; INDOLES; MALE; NEURONS; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; REPERFUSION INJURY;

EID: 84977103541     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep29362     Document Type: Article

References (33)

1. Fuchs, Y., Steller, H. Programmed cell death in animal development and disease. Cell 147, 742-758 (2011).
2. Fuchs, Y., Steller, H. Live to die another way: modes of programmed cell death and the signals emanating from dying cells. Nature reviews. Molecular cell biology 16, 329-344 (2015).
3. Broughton, B. R., Reutens, D. C., Sobey, C. G. Apoptotic mechanisms after cerebral ischemia. Stroke; a journal of cerebral circulation 40, e331-339 (2009).
4. Artus, C. et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. The EMBO journal 29, 1585-1599 (2010).
5. Joza, N. et al. AIF: not just an apoptosis-inducing factor. Annals of the New York Academy of Sciences 1171, 2-11 (2009).
6. Delavallee, L., Cabon, L., Galan-Malo, P., Lorenzo, H. K., Susin, S. A. AIF-mediated caspase-independent necroptosis: a new chance for targeted therapeutics. IUBMB life 63, 221-232 (2011).
7. Baritaud, M. et al. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell death & disease 3, e390 (2012).
8. Degterev, A. et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature chemical biology 1, 112-119 (2005).
9. Zhang, D. W. et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336 (2009).
10. Pasparakis, M., Vandenabeele, P. Necroptosis and its role in inflammation. Nature 517, 311-320 (2015).
11. He, S. et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137, 1100-1111 (2009).
12. Cho, Y. S. et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123 (2009).
13. Kaiser, W. J. et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471, 368-372 (2011).
14. Wang, J. Y. et al. Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. Journal of neuropathology and experimental neurology 70, 314-322 (2011).
15. Yin, B. et al. Inhibition of receptor-interacting protein 3 upregulation and nuclear translocation involved in Necrostatin-1 protection against hippocampal neuronal programmed necrosis induced by ischemia/reperfusion injury. Brain research 1609, 63-71 (2015).
16. Liu, T. et al. Therapeutic hypothermia attenuates tissue damage and cytokine expression after traumatic brain injury by inhibiting necroptosis in the rat. Scientific reports 6, 24547 (2016).
17. Trichonas, G. et al. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proceedings of the National Academy of Sciences of the United States of America 107, 21695-21700 (2010).
18. Rodriguez-Hernandez, A. et al. Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Apoptosis: an international journal on programmed cell death 11, 131-139 (2006).
19. Hayashi, Y. et al. Immunohistochemical investigation of caspase-1 and effect of caspase-1 inhibitor in delayed neuronal death after transient cerebral ischemia. Brain research 893, 113-120 (2001).
20. Gunther, C. et al. Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis. Nature 477, 335-339 (2011).
21. Oberst, A. et al. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature 471, 363-367 (2011).
22. Yamanaka, K., Saito, Y., Yamamori, T., Urano, Y., Noguchi, N. 24(S)-hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. The Journal of biological chemistry 286, 24666-24673 (2011).
23. Melo-Lima, S., Celeste Lopes, M., Mollinedo, F. Necroptosis is associated with low procaspase-8 and active RIPK1 and-3 in human glioma cells. Oncoscience 1, 649-664 (2014).
24. Kavanagh, E. et al. Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model. Aging 7, 673-689 (2015).
25. Burguillos, M. A. et al. Caspase signalling controls microglia activation and neurotoxicity. Nature 472, 319-324 (2011).
26. Xu, X. et al. Necrostatin-1 protects against glutamate-induced glutathione depletion and caspase-independent cell death in HT-22 cells. Journal of neurochemistry 103, 2004-2014 (2007).
27. Zhang, Y. F. et al. Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during acetaminophen-evoked acute liver failure in mice. Toxicology letters 225, 445-453 (2014).
28. Xu, Y., Huang, S., Liu, Z. G., Han, J. Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. The Journal of biological chemistry 281, 8788-8795 (2006).
29. Wang, Z., Jiang, H., Chen, S., Du, F., Wang, X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148, 228-243 (2012).
30. Sun, L. et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227 (2012).
31. Cai, Z. et al. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. Nature cell biology 16, 55-65 (2014).
32. Wang, H. et al. Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3. Molecular cell 54, 133-146 (2014).
33. Akdemir, O. et al. Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury. Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia 15, 672-678 (2008).