Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression

Endocrine-Related Cancer

Volumn 23, Issue 4, 2016, Pages 281-293

  Croisé, Pauline ^a   Houy, Sébastien ^a   Gand, Mathieu ^a   Lanoix, Joël ^b   Calco, Valérie ^a   Tóth, Petra ^a   Brunaud, Laurent ^c   Lomazzi, Sandra ^c   Paramithiotis, Eustache ^b   Chelsky, Daniel ^b   Ory, Stéphane ^a   Gasman, Stéphane ^a  

^a CNRS   (France)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c CHU NANCY BRABOIS   (France)

Author keywords

Mass spectrometry; Pheochromocytoma; Rho GEF; Rho GTPases

Indexed keywords

ARHGEF1 PROTEIN; FARP1 PROTEIN; PROTEIN CDC42; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ARHGEF1 PROTEIN, HUMAN; FARP1 PROTEIN, HUMAN; RAC1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PC12 CELL LINE; PHEOCHROMOCYTOMA; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; RAT; TANDEM MASS SPECTROMETRY; ADRENAL TUMOR; ANIMAL; GENETICS; METABOLISM;

ADRENAL GLAND NEOPLASMS; ANIMALS; CDC42 GTP-BINDING PROTEIN; HUMANS; PC12 CELLS; PHEOCHROMOCYTOMA; RAC1 GTP-BINDING PROTEIN; RATS; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RNA, SMALL INTERFERING;

EID: 84976902193     PISSN: 13510088     EISSN: 14796821     Source Type: Journal    
DOI: 10.1530/ERC-15-0502     Document Type: Article

References (40)

1. Alan JK & Lundquist EA 2013 Mutationally activated Rho GTPases in cancer.Small GTPases 4 159-163.(doi:10.4161/sgtp.26530)
2. Carr AL, Sun L, Lee E, Li P, Antonacci C, Gorbea E, Finlay C & Li L 2014 The human oncogene SCL/TAL1 interrupting locus is required for mammalian dopaminergic cell proliferation through the Sonic hedgehog pathway.Cellular Signalling 26 306-312.(doi:10.1016/j.cellsig.2013.11.010)
3. Cheadle L & Biederer T 2012 The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization.Journal of Cell Biology 199 985-1001.(doi:10.1083/jcb.201205041)
4. Cherfils J & Zeghouf M. 2013. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiological Review 93 269-309. (doi 10.1152/physrev.00003.2012)
5. Chew TW, Liu XJ, Liu L, Spitsbergen JM, Gong Z & Low BC 2014 Crosstalk of Ras and Rho: Activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.Oncogene 33 2717-2727.(doi:10.1038/onc.2013.240)
6. Cleverley SC, Costello PS, Henning SW & Cantrell DA 2000 Loss of Rho function in the thymus is accompanied by the development of thymic lymphoma.Oncogene 19 13-20.(doi:10.1038/sj.onc.1203259)
7. Dutt P, Nguyen N & Toksoz D 2004 Role of Lbc RhoGEF in Galpha12/13-induced signals to Rho GTPase.Cellular Signalling 16 201-209.(doi:10.1016/s0898-6568(03)00132-3)
8. Ellenbroek SI & Collard JG 2007 Rho GTPases: Functions and association with cancer.Clinical & Experimental Metastasis 24 657-672.(doi:10.1007/s10585-007-9119-1)
9. Francis SA, Shen X, Young JB, Kaul P & Lerner DJ 2006 Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils.Blood 107 1627-1635.(doi:10.1182/blood-2005-03-1164)
10. Gasman S, Chasserot-Golaz S, Malacombe M, Way M & Bader MF 2004 Regulated exocytosis in neuroendocrine cells: A role for subplasmalemmal Cdc42/N-WASP-induced actin filaments.Molecular Biology of the Cell 15 520-531.(doi:10.1091/mbc.E03-06-0402)
11. Glaven JA, Whitehead IP, Nomanbhoy T, Kay R & Cerione RA 1996 Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein.Journal of Biological Chemistry 271 27374-27381.(doi:10.1074/jbc.271.44.27374)
12. Greene LA & Tischler AS 1976 Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.PNAS 73 2424-2428.(doi:10.1073/pnas.73.7.2424)
13. Grise F, Bidaud A & Moreau V 2009 Rho GTPases in hepatocellular carcinoma.Biochimica et Biophysica Acta 1795 137-151.(doi:10.1016/j.bbcan.2008.12.003)
14. Jaiswal M, Dvorsky R & Ahmadian MR 2013 Deciphering the molecular and functional basis of Dbl family proteins: A novel systematic approach toward classification of selective activation of the Rho family proteins.Journal of Biological Chemistry 288 4486-4500.(doi:10.1074/jbc.M112.429746)
15. Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K & Ahmadian MR 2011 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs)p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).Journal of Biological Chemical 286 18202-18212.(doi:10.1074/jbc.M111.226431)
16. Jelen F, Lachowicz P, Apostoluk W, Mateja A, Derewenda ZS & Otlewski J 2009 Dissecting the thermodynamics of GAP-RhoA interactions.Journal of Structural Biology 165 10-18.(doi:10.1016/j.jsb.2008.09.007)
17. Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, et al.2014 Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma.Nature Genetics 46 583-587.(doi:10.1038/ng.2984)
18. Karlsson R, Pedersen ED, Wang Z & Brakebusch C 2009 Rho GTPase function in tumorigenesis.Biochimica et Biophysica Acta 1796 91-98.(doi:10.1016/j.bbcan.2009.03.00)
19. Keshishian H, Addona T, Burgess M, Kuhn E & Carr SA 2007 Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution.Molecular & Cellular Proteomics 6 2212-2229.(doi:10.1074/mcp.M700354-MCP200)
20. Koyano Y, Kawamoto T, Kikuchi A, Shen M, Kuruta Y, Tsutsumi S, Fujimoto K, Noshiro M, Fujii K & Kato Y 2001 Chondrocyte-derived ezrin-like domain containing protein (CDEP), a rho guanine nucleotide exchange factor, is inducible in chondrocytes by parathyroid hormone and cyclic AMP and has transforming activity in NIH3T3 cells.Osteoarthritis Cartilage 9 (Supplement A)S64-S68.(doi:10.1053/joca.2001.0446)
21. Koyano Y, Kawamoto T, Shen M, Yan W, Noshiro M, Fujii K & Kato Y 1997 Molecular cloning and characterization of CDEP, a novel human protein containing the ezrin-like domain of the band 4.1 superfamily and the Dbl homology domain of Rho guanine nucleotide exchange factors.Biochemical and Biophysical Research Communications 241 369-375.(doi:10.1006/bbrc.1997.7826)
22. Livak KJ & Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method.Methods 25 402-408.(doi:10.1006/meth.2001.1262)
23. Ljubimova JY, Khazenzon NM, Chen Z, Neyman YI, Turner L, Riedinger MS & Black KL 2001 Gene expression abnormalities in human glial tumors identified by gene array.International Journal of Oncology 18 287-295.(doi:10.3892/ijo.18.2.287)
24. Malliri A, van der Kammen RA, Clark K, van der Valk M, Michiels F & Collard JG 2002 Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.Nature 417 867-871.(doi:10.1038/nature00848)
25. Orgaz JL, Herraiz C & Sanz-Moreno V 2014 Rho GTPases modulate malignant transformation of tumor cells.Small GTPases 5 e29019.
26. Parri M & Chiarugi P 2010 Rac and Rho GTPases in cancer cell motility control.Cell Commununication and Signalling 8 23.(doi:10.1186/1478-811X-8-23)
27. Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, et al.2014 Arhgap36-dependent activation of Gli transcription factors.PNAS 111 11061-11066.(doi:10.1073/pnas.1322362111)
28. Siehler S 2009 Regulation of RhoGEF proteins by G12/13-coupled receptors.British Journal of Pharmacology 158 41-49.(doi:10.1111/j.1476-5381.2009.00121.x)
29. Siu KW, DeSouza LV, Scorilas A, Romaschin AD, Honey RJ, Stewart R, Pace K, Youssef Y, Chow TF & Yousef GM 2009 Differential protein expressions in renal cell carcinoma: New biomarker discovery by mass spectrometry.Journal of Proteome Research 8 3797-3807.(doi:10.1021/pr800389e)
30. Song JY, Lee JK, Lee NW, Jung HH, Kim SH & Lee KW 2008 Microarray analysis of normal cervix, carcinoma in situ, and invasive cervical cancer: Identification of candidate genes in pathogenesis of invasion in cervical cancer.International Journal of Gynecological Cancer 18 1051-1059.(doi:10.1111/j.1525-1438.2007.01164.x)
31. Taal BG & Visser O 2004 Epidemiology of neuroendocrine tumours.Neuroendocrinology 80 (Supplement 1)3-7.(doi:10.1159/000080731)
32. Tsirlin A, Oo Y, Sharma R, Kansara A, Gliwa A & Banerji MA 2014 Pheochromocytoma: A review.Maturitas 77 229-238.(doi:10.1016/j.maturitas.2013.12.009)
33. Valentijn LJ, Koppen A, van Asperen R, Root HA, Haneveld F & Versteeg R 2005 Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.Cancer Research 65 3136-3145.(doi:10.1158/0008-5472.CAN-04-2469)
34. van Hengel J, D'Hooge P, Hooghe B, Wu X, Libbrecht L, De Vos R, Quondamatteo F, Klempt M, Brakebusch C & van Roy F 2008 Continuous cell injury promotes hepatic tumorigenesis in cdc42- deficient mouse liver.Gastroenterology 134 781-792.(doi:10.1053/j.gastro.2008.01.002)
35. Vega FM & Ridley AJ 2008 Rho GTPases in cancer cell biology.FEBS Letters 582 2093-2101.(doi:10.1016/j.febslet.2008.04.039)
36. Vigil D, Cherfils J, Rossman KL & Der CJ 2010 Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy? Natural Review of Cancer 10 842-857.(doi:10.1038/nrc2960)
37. Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA & Zheng Y 2007 Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.Blood 110 3853-3861.(doi:10.1182/blood-2007-03-079582)
38. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, et al.2008 One hundred years after 'carcinoid': Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States.Journal of Clinical Oncology 26 3063-3072.(doi:10.1200/JCO.2007.15.4377)
39. Yoo HY, Sung MK, Lee SH, Kim S, Lee H, Park S, Kim SC, Lee B, Rho K, Lee JE, et al.2014 A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.Natural Genetics 46 371-375.(doi:10.1038/ng.2916)
40. Zhuang B, Su YS & Sockanathan S 2009 FARP1 promotes the dendritic growth of spinal motor neuron subtypes through transmembrane Semaphorin6A and PlexinA4 signaling.Neuron 61 359-372.(doi:10.1016/j.neuron.2008.12.022)