Structural and kinetic analysis of miscoding opposite the DNA Adduct 1,N6 -Ethenodeoxyadenosine by human translesion DNA polymerase η

Journal of Biological Chemistry

Volumn 291, Issue 27, 2016, Pages 14134-14145

  Patra, Amritraj ^a   Su, Yan ^a   Zhang, Qianqian ^a,b   Johnson, Kevin M ^a   Guengerich, F Peter ^a   Egli, Martin ^a,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Shanghai CP Guojian Pharmaceutical Co   (China)

^c Department of Medicine and Pharmacology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN BONDS; OLIGONUCLEOTIDES; SPECTRUM ANALYSIS;

ANTI-CONFORMATIONS; HUMAN DNA POLYMERASE; KINETIC ANALYSIS; MASS-SPECTRAL ANALYSIS; STAGGERED CONFIGURATION; STEADY-STATE KINETICS; TERNARY COMPLEX; X RAY CRYSTAL STRUCTURES;

DNA;

1,N6 ETHENODEOXYADENOSINE; ADENOSINE TRIPHOSPHATE; DEOXYADENOSINE DERIVATIVE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DNA DIRECTED DNA POLYMERASE ETA; PURINE; THYMIDINE TRIPHOSPHATE; UNCLASSIFIED DRUG; ADENOSINE; DNA ADDUCT; DNA DIRECTED DNA POLYMERASE; DNA POLYMERASE N, HUMAN;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DNA ADDUCT; HYDROGEN BOND; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; STEADY STATE; ANALOGS AND DERIVATIVES; CHEMISTRY; HUMAN; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ADENOSINE; CRYSTALLOGRAPHY, X-RAY; DNA ADDUCTS; DNA-DIRECTED DNA POLYMERASE; HUMANS; MASS SPECTROMETRY; PROTEIN STRUCTURE, TERTIARY;

EID: 84976877678     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.732487     Document Type: Article

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