Pathogenic mutations in the valosin-containing protein/p97(VCP) N-domain inhibit the SUMOylation of VCP and lead to impaired stress response

Journal of Biological Chemistry

Volumn 291, Issue 27, 2016, Pages 14373-14384

  Wang, Tao ^a   Xu, Wangchao ^a,b   Qin, Meiling ^a   Yang, Yi ^a,b   Bao, Puhua ^a   Shen, Fuxiao ^a   Zhang, Zhenlin ^c   Xu, Jin ^b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELL SIGNALING; NEURODEGENERATIVE DISEASES; PROTEINS;

AMYOTROPHIC LATERAL SCLEROSIS; CHROMATIN REMODELING; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FRONTOTEMPORAL DEMENTIAS; MOLECULAR SIGNALING; PROTEIN DEGRADATION; SMALL UBIQUITIN-LIKE MODIFIERS;

DISTRIBUTION FUNCTIONS;

PROTEIN P97; VALOSIN CONTAINING PROTEIN; ADENOSINE TRIPHOSPHATASE; CDC48 PROTEIN; CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; VCP PROTEIN, DROSOPHILA;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CELL GRANULE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DROSOPHILA; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; MOUSE; MUTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; STRESS GRANULE; SUMOYLATION; AMINO ACID SUBSTITUTION; ANIMAL; CELL CULTURE; DROSOPHILA MELANOGASTER; GENETICS; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SUBSTITUTION; ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPLASMIC RETICULUM STRESS; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; SUMOYLATION;

EID: 84976867081     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.729343     Document Type: Article

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