Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a drosophila IBMPFD model

PLoS Genetics

Volumn 7, Issue 2, 2011, Pages

  Chang, Ya Chu ^a   Hung, Wan Tzu ^a   Chang, Yun Chin ^a   Chang, Henry C ^b   Wu, Chia Lin ^a   Chiang, Ann Shyn ^a   Jackson, George R ^c,d   Sang, Tzu Kang ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; PROTEASOME; PROTEIN TER94; UBIQUITIN; UNCLASSIFIED DRUG; VALOSIN CONTAINING PROTEIN; CDC48 PROTEIN; CELL CYCLE PROTEIN; DROSOPHILA PROTEIN; TER94 PROTEIN, DROSOPHILA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CELL LEVEL; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DROSOPHILA; ENDOPLASMIC RETICULUM; ENERGY EXPENDITURE; GENE MUTATION; GENE OVEREXPRESSION; INCLUSION BODY MYOPATHY WITH PAGET DISEASE OF BONE AND FRONTOTEMPORAL DEMENTIA; MUSCLE; NERVE DEGENERATION; NERVOUS SYSTEM; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TISSUE DEGENERATION; TISSUE SPECIFICITY; WILD TYPE; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL DEMENTIA; GENETICS; HUMAN; INCLUSION BODY MYOSITIS; METABOLISM; MUTATION; PAGET BONE DISEASE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ALLELES; ANIMALS; CELL CYCLE PROTEINS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FRONTOTEMPORAL DEMENTIA; HUMANS; MUTATION; MYOSITIS, INCLUSION BODY; OSTEITIS DEFORMANS; UBIQUITIN;

EID: 79952255326     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1001288     Document Type: Article

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