Locked nucleic acid anti-MIR-21 inhibits cell growth and invasive behaviors of a colorectal adenocarcinoma cell line: LNA-anti-MIR as a novel approach

Cancer Gene Therapy

Volumn 23, Issue 8, 2016, Pages 246-253

  Nedaeinia, R ^a   Sharifi, M ^b   Avan, A ^a   Kazemi, M ^b   Rafiee, L ^c   Ghayour Mobarhan, M ^a   Salehi, R ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

LOCKED NUCLEIC ACID; MICRORNA 21; COMPLEMENTARY RNA; MICRORNA; MIRN21 MICRORNA, HUMAN; OLIGONUCLEOTIDE;

ADENOCARCINOMA CELL LINE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL INVASION; CELL VIABILITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MTT ASSAY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ADENOCARCINOMA; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; OLIGONUCLEOTIDES; RNA, ANTISENSE;

EID: 84976580913     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2016.25     Document Type: Article

References (46)

1. Edwards BK, Ward E, Kohler BA, Eheman C, Zauber AG, Anderson RN et al. Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer 2010; 116: 544-573.
2. Bussey HJR. Historical developments in familial polyposis coli. Semin Surg Oncol 1987; 3: 67-70.
3. Gong B, Liu WW, Nie WJ, Li DF, Xie ZJ, Liu C et al. MiR-21/RASA1 axis affects malignancy of colon cancer cells via RAS pathways. World J Gastroenterol 2015; 21: 1488-1497.
4. Yu Y, Sarkar FH, Majumdar AP. Down-regulation of miR-21 induces differentiation of chemoresistant colon cancer cells and enhances susceptibility to therapeutic regimens. Transl Oncol 2013; 6: 180-186.
5. Reddy SDN GR, Pakala SB, Kumar R. MicroRNAs and cancer therapy: The next wave or here to stay? Cancer Biol Ther 2010; 9: 479-482.
6. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-297.
7. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-450.
8. Drakaki A, Iliopoulos D. MicroRNA gene networks in oncogenesis. Curr Genomics 2009; 10: 35-41.
9. Cowland JB, Hother C, GrØNbeaK K. MicroRNAs and cancer. APMIS 2007; 115: 1090-1106.
10. Seto AG. The road toward microRNA therapeutics. Int J Biochem Cell Biol 2010; 42: 1298-1305.
11. Sharifi M, Salehi R, Gheisari Y, Kazemi M. Inhibition of microRNA miR-92a induces apoptosis and inhibits cell proliferation in human acute promyelocytic leukemia through modulation of p63 expression. Mol Biol Rep 2014; 41: 2799-2808.
12. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 2008; 18: 997-1006.
13. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 2007; 133: 647-658.
14. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128-2136.
15. Papagiannakopoulos T, Shapiro A, Kosik KS. MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. Cancer Res 2008; 68: 8164-8172.
16. Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibro-blasts. Nature 2008; 456: 980-984.
17. Sayed D, Rane S, Lypowy J, He M, Chen IY, Vashistha H et al. MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths. Mol Biol Cell 2008; 19: 3272-3282.
18. Wickramasinghe NS, Manavalan TT, Dougherty SM, Riggs KA, Li Y, Klinge CM. Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res 2009; 37: 2584-2595.
19. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol 2008; 28: 5369-5380.
20. Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 2009; 182: 4994-5002.
21. Hashimi ST, Fulcher JA, Chang MH, Gov L, Wang S, Lee B. MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood 2009; 114: 404-414.
22. Liu M, Wu H, Liu T, Li Y, Wang F, Wan H et al. Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. Cell Res 2009; 19: 828-837.
23. Kim YJ, Hwang SJ, Bae YC, Jung JS. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 2009; 27: 3093-3102.
24. Zheng J, Xue H, Wang T, Jiang Y, Liu B, Li J et al. miR-21 downregulates the tumor suppressor P12 CDK2AP1 and stimulates cell proliferation and invasion. J Cell Biochem 2011; 112: 872-880.
25. Yelamanchili SV, Chaudhuri AD, Chen LN, Xiong H, Fox HS. MicroRNA-21 dysre-gulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. Cell Death Dis 2010; 1: e77.
26. Schramedei K, Morbt N, Pfeifer G, Lauter J, Rosolowski M, Tomm JM et al. MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. Oncogene 2011; 30: 2975-2985.
27. Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V, Gonzalez ML et al. MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PloS One 2011; 6: e16979.
28. Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M et al. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Proc Natl Acad Sci USA 2010; 107: 21098-21103.
29. Zhang H, Li P, Ju H, Pesta M, Kulda V, Jin W et al. Diagnostic and prognostic value of microRNA-21 in colorectal cancer: an original study and individual participant data meta-analysis. Cancer Epidemiol Biomarkers Prev 2014; 23: 2783-2792.
30. Slaby O, Svoboda M, Fabian P, Smerdova T, Knoflickova D, Bednarikova M et al. Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clin-icopathologic features of colorectal cancer. Oncology 2008; 72: 397-402.
31. Shibuya H, Iinuma H, Shimada R, Horiuchi A, Watanabe T. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Oncology 2011; 79: 313-320.
32. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008; 299: 425-436.
33. Ruan K, Fang X, Ouyang G. MicroRNAs: novel regulators in the hallmarks of human cancer. Cancer Lett 2009; 285: 116-126.
34. Ghadjar P, Rubie C, Aebersold DM, Keilholz U. The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer. Int J Cancer 2009; 125: 741-745.
35. Najafi Z, Sharifi M, Javadi G. Degradation of miR-21 induces apoptosis and inhibits cell proliferation in human hepatocellular carcinoma. Cancer Gene Ther 2015; 22: 530-535.
36. Sharifi M, Salehi R. Blockage of miR-92a-3p with locked nucleic acid induces apoptosis and prevents cell proliferation in human acute megakaryoblastic leukemia. Cancer Gene Ther 2015; 23: 29-35.
37. Vatandoost N, Ghanbari J, Mojaver M, Avan A, Ghayour-Mobarhan M, Nedaeinia R et al. Early detection of colorectal cancer: from conventional methods to novel biomarkers. J Cancer Res Clin Oncol 2016; 142: 341-351.
38. Wang S, Xiang J, Li Z, Lu S, Hu J, Gao X et al. A plasma microRNA panel for early detection of colorectal cancer. Int J Cancer 2015; 136: 152-161.
39. Wang X, Kuang Y-Y, Hu X-T. Advances in epigenetic biomarker research in colorectal cancer. World J Gastroenterol 2014; 20: 4276.
40. Fung KY, Nice E, Priebe I, Belobrajdic D, Phatak A, Purins L et al. Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled. World J Gastroenterol 2014; 20: 888.
41. Brase JC, Wuttig D, Kuner R, Sultmann H. Serum microRNAs as non-invasive biomarkers for cancer. Mol Cancer 2010; 9: 306.
42. Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y et al. Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst 2013; 105: 849-859.
43. Bu X, Li L, Li N, Tian X, Huang P. Suppression of mucin 2 enhances the proliferation and invasion of LS174T human colorectal cancer cells. Cell Biol Int 2011; 35: 1121-1129.
44. Klinkspoor JH, Mok KS, Van Klinken BJ-W, Tytgat GN, Lee SP, Groen AK. Mucin secretion by the human colon cell line LS174T is regulated by bile salts. Glyco-biology 1999; 9: 13-19.
45. Mirnezami AH, Pickard K, Zhang L, Primrose JN, Packham G. MicroRNAs: key players in carcinogenesis and novel therapeutic targets. Eur J Surg Oncol 2009; 35: 339-347.
46. Stenvang J, Silahtaroglu AN, Lindow M, Elmen J, Kauppinen S. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol 2008; 18: 89-102.